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PubMed | European University of Applied Sciences and Italian National Cancer Institute
Type: | Journal: Frontiers in psychology | Year: 2017

To measure the rates of distress in a sample of patients referring to a multidisciplinary day surgery division in a comprehensive cancer center based in Northern Italy.

PubMed | Institute of Clinical Chemistry and Laboratory Medicine, University of Greifswald, European University of Applied Sciences, Institute Of Clinical Chemistry And Laboratory Medicine Electronic Address and Institute for Community Medicine
Type: Journal Article | Journal: Metabolism: clinical and experimental | Year: 2016

Despite associations of sex hormones in women with increased cardiometabolic risk and mortality, the clinical correlates of altered sex hormone concentrations in women are less clearly understood. We investigated a broad range of clinical correlates of sex hormones in women from a large population-based sample.Data from 2560 women from two cohorts of the Study of Health in Pomerania were used. Stepwise multivariable regression models were implemented to investigate a broad range of behavioral, socio-demographic, and cardiometabolic clinical correlates related to total testosterone (TT), free testosterone (fT), androstenedione (ASD), dehydroepiandrosterone-sulfate (DHEAS), estrone (E1), estradiol (E2), and sex hormone-binding globulin (SHBG).Waist circumference and BMI (-coefficient: -0.03; 95% CI: -0.04; 0.03) were inversely related to SHBG, and BMI was positively related to TT (-coefficient: 0.005; 95% CI: 0.001; 0.009), fT, E1, and E2. Smoking was positively related to TT (-coefficient: 0.04; 95% CI: 0.01; 0.06), ASD, and fT. Systolic blood pressure (TT: -coefficient: 0.002; 95% CI: 0.001; 0.003), hypertension (TT: -coefficient: 0.05; 95% CI: 0.003; 0.11), low-density lipoprotein (LDL) cholesterol (TT: -coefficient: 0.02; 95% CI: 0.01; 0.05), and total cholesterol (TT: -coefficient: -0.03; 95% CI: 0.01; 0.05) were positively related to TT and ASD. Finally, type 2 diabetes mellitus (T2DM), and metabolic syndrome (MetS) were positively related to fT, but inversely related to SHBG.Our population-based study, with sex hormone concentrations measured by liquid chromatography tandem mass spectrometry, revealed associations between clinical correlates including waist circumference, smoking, cohabitation, systolic blood pressure, cholesterol, and MetS with sex hormones. Thus, sex hormones and SHBG may play a role in the cardiovascular risk profile of women.

Gruschka N.,NEC Laboratories Europe | Iacono L.L.,European University of Applied Sciences
Proceedings - 8th IEEE European Conference on Web Services, ECOWS 2010 | Year: 2010

The W3C recommendation MTOM is the defacto standard for transferring binary data in SOAP protocol elements as attachments. The distinguished feature provided by MTOM is - compared to other SOAP attachment specifications - the efficient transfer of binary data without breaking the XML infoset. This property allows e.g. the application of XML Security mechanisms to the SOAP message including the attachment parts. The efficiency of SOAP processing, especially when SOAP messages include security primitives, is an active area of research. However, the work available on the efficient processing of secured SOAP attachments is sparse. This paper aims to close this gap and contributes a scheme to process secured MTOM attachments on the server-side in a streaming manner. The proposed approach is in conformance with the underlying standards and compatible with the major research and development activities in stream-based SOAP security processing. Evaluations based on a prototype implementation, show that the introduced scheme increases the performance by a factor of at least 2 and reduces the memory requirements for large attachments by a factor of approximately 20. © 2010 IEEE.

Jensen M.,Ruhr University Bochum | Schwenk J.,Ruhr University Bochum | Bohli J.-M.,NEC Laboratories Europe | Gruschka N.,NEC Laboratories Europe | Iacono L.L.,European University of Applied Sciences
Proceedings - 2011 IEEE 4th International Conference on Cloud Computing, CLOUD 2011 | Year: 2011

Clouds impose new security challenges, which are amongst the biggest obstacles when considering the usage of cloud services. This triggered a lot of research activities in this direction, resulting in a quantity of proposals targeting the various security threats. Besides the security issues coming with the cloud paradigm, it can also provide a new set of unique features which open the path towards novel security approaches, techniques and architectures. This paper initiates this discussion by contributing a concept which achieves security merits by making use of multiple distinct clouds at the same time. © 2011 IEEE.

PubMed | University of Greifswald, European University of Applied Sciences, University of Regensburg and University of Manchester
Type: | Journal: Maturitas | Year: 2016

Despite associations between total testosterone (TT) concentrations and increased cardiometabolic risk, the impact of serum androgens on health care utilization and costs among women is unknown.We used data from 1521 women in the population-based cohort Study of Health in Pomerania (SHIP) to investigate the associations of serum TT (measured by liquid chromatography-tandem mass spectrometry), sex hormone-binding globulin (SHBG), and free testosterone (free T) with health care utilization and costs at baseline and five-year follow-up (N=1210), implementing multivariable-adjusted econometric models.Cross-sectional analyses showed no association of TT, SHBG, or free T with hospitalization or total health costs (outpatient as well as inpatient costs). Prospective analyses revealed an inverse association of baseline SHBG with follow-up total health care costs (% change per standard deviation (SD): -26.2%, 95% confidence interval (CI): -42.2%; -8.9%) and inpatient costs (% change per SD: -26.5%%, 95% CI: -45.5%; -2.5%). Baseline free T was positively associated with total health care costs at the five-year follow-up (% change per SD: +37.7%, 95% CI: +4.6%; +81.4%).In this first cost analysis among women from the general population, we observed no association of androgen serum concentration with health care utilization and costs. However, baseline SHBG appeared to be inversely correlated and free T positively correlated with long-term health care costs.

PubMed | Charité - Medical University of Berlin, European University of Applied Sciences, University of Hildesheim and University of Cologne
Type: Journal Article | Journal: The journal of pain : official journal of the American Pain Society | Year: 2016

Relatively new evidence suggests that movement representation techniques (ie, therapies that use the observation and/or imagination of normal pain-free movements, such as mirror therapy, motor imagery, or movement and/or action observation) might be effective in reduction of some types of limb pain. To summarize the evidence regarding the efficacy of those techniques, a systematic review with meta-analysis was performed. We searched Cochrane Central Register of Controlled Trials, MEDLINE, EMBASE, CINAHL, AMED, PsychINFO, Physiotherapy Evidence Database, and OT-seeker up to August 2014 and hand-searched further relevant resources for randomized controlled trials that studied the efficacy of movement representation techniques in reduction of limb pain. The outcomes of interest were pain, disability, and quality of life. Study selection and data extraction were performed by 2 reviewers independently. We included 15 trials on the effects of mirror therapy, (graded) motor imagery, and action observation in patients with complex regional pain syndrome, phantom limb pain, poststroke pain, and nonpathological (acute) pain. Overall, movement representation techniques were found to be effective in reduction of pain (standardized mean difference [SMD]=-.82, 95% confidence interval [CI], -1.32 to -.31, P=.001) and disability (SMD=.72, 95% CI, .22-1.22, P=.004) and showed a positive but nonsignificant effect on quality of life (SMD=2.61, 85% CI, -3.32 to 8.54, P=.39). Especially mirror therapy and graded motor imagery should be considered for the treatment of patients with complex regional pain syndrome. Furthermore, the results indicate that motor imagery could be considered as a potential effective treatment in patients with acute pain after trauma and surgery. To date, there is no evidence for a pain reducing effect of movement representation techniques in patients with phantom limb pain and poststroke pain other than complex regional pain syndrome.In this systematic review we synthesize the evidence for the efficacy of movement representation techniques (ie, motor imagery, mirror therapy, or action observation) for treatment of limb pain. Our findings suggest effective pain reduction in some types of limb pain. Further research should address specific questions on the optimal type and dose of therapy.

Kische H.,Universitatsmedizin Greifswald | Haring R.,European University of Applied Sciences
Gynakologe | Year: 2016

Low testosterone concentrations in men are associated with a higher cardiovascular risk factor burden. Also in women, cardiovascular risk increases after menopause. The aim of this work was to analyze potential associations between androgen concentrations in women and cardiovascular risk factors, including clinical correlates and sleep, metabolic syndrome (MetS), type 2 diabetes mellitus (T2DM), as well as subclinical and clinical cardiovascular disease (CVD) and mortality. Data from 2000 women of the population-based, longitudinal Study of Health in Pomerania (SHIP) and multivariable regression models were analyzed. Cardiovascular risk factors including obesity, hypertension, dyslipidemia, and poor sleep quality were associated with androgen concentration. Furthermore, cross-sectional and long-term analyses yielded inverse associations between sex hormone-binding globulin (SHBG) and MetS as well as T2DM. No independent, significant associations between androgen concentrations and incidence of CVD, CVD mortality, or all-cause mortality were detected. In this epidemiological study, clinical correlates of androgens in women and associations between androgens and sleep were identified. Associations between androgens, subclinical CVD, and mortality confirmed the relative impact of cofactors. SHBG might represent a potential biomarker for cardiovascular risk factors, especially among postmenopausal women. © 2016 Springer-Verlag Berlin Heidelberg

Fox-Boyer A.,European University of Applied Sciences | Konopatsch S.,European University of Applied Sciences
Padiatrische Praxis | Year: 2015

Children growing up with more than one language become more and more common in Germany. In general bilingualism is very common worldwide and can be considered an unproblematic typical condition in many countries. However, societies being mainly monolingual {i.e. in Germany) do not necessarily consider bilingualism as a positive and typical condition and concerns about possible negative interactions with language development in general, educational success or the development of intelligence are still common. Even more insecurity exists when it comes to growing up multilingual while language, hearing or cognitive disorders are present. The manuscript aims to describe the special condition of multilingual language development and its advantages and its possible risks. It also aims at changing still existing incorrect prejudices to- wards multilingual language situations.

Oeser G.,European University of Applied Sciences | Romano P.,University of Udine
International Journal of Production Research | Year: 2015

The Square Root Law (SRL) is a popular formula for assessing inventory levels at varying numbers of warehouses. Its popularity is probably due to its simplicity and the ample opportunities for its application to the managerial dilemma of inventory centralisation vs. decentralisation. However, researchers disagree about which parts of inventory it can be applied to and its underlying assumptions. To address these questions, this study algebraically derives the assumptions necessary for the SRL to apply to regular, safety and total stock. Afterwards, the paper empirically examines to what extent these assumptions hold in practice by analysing four case studies and data from a sample of 280 German manufacturing and trading companies. Most companies do not fulfil the assumptions of the SRL and therefore cannot apply it with accurate results. Trading companies, however, seem to fulfil more assumptions than manufacturing ones, retailers more than wholesalers, industrial goods manufacturers more than consumer goods manufacturers. Although the SRL has traditionally been mainly considered for safety stock, companies, especially trading companies, appear to rather fulfil the assumptions for applying the SRL to cycle stock. Some assumptions seem to be complementary, whereas others appear to be competing, so that it is difficult to fulfil all of them. © 2015 Taylor & Francis

PubMed | European University of Applied Sciences
Type: Journal Article | Journal: The Journal of clinical endocrinology and metabolism | Year: 2016

Associations between sex hormones and sleep habits originate mainly from small and selected patient-based samples. We examined data from a population-based sample with various sleep characteristics and the major part of sex hormones measured by mass spectrometry.We used data from 204 men and 213 women of the cross-sectional Study of Health in Pomerania-TREND.Associations of total T (TT) and free T, androstenedione (ASD), estrone, estradiol (E2), dehydroepiandrosterone-sulphate, SHBG, and E2 to TT ratio with sleep measures (including total sleep time, sleep efficiency, wake after sleep onset, apnea-hypopnea index [AHI], Insomnia Severity Index, Epworth Sleepiness Scale, and Pittsburgh Sleep Quality Index) were assessed by sex-specific multivariable regression models.In men, age-adjusted associations of TT (odds ratio 0.62; 95% confidence interval (CI) 0.46-0.83), free T, and SHBG with AHI were rendered nonsignificant after multivariable adjustment. In multivariable analyses, ASD was associated with Epworth Sleepiness Scale (-coefficient per SD increase in ASD: -0.71; 95% CI: -1.18 to -0.25). In women, multivariable analyses showed positive associations of dehydroepiandrosterone-sulphate with wake after sleep onset (-coefficient: .16; 95% CI 0.03-0.28) and of E2 and E2 to TT ratio with Epworth Sleepiness Scale. Additionally, free T and SHBG were associated with AHI in multivariable models among premenopausal women.The present cross-sectional, population-based study observed sex-specific associations of androgens, E2, and SHBG with sleep apnea and daytime sleepiness. However, multivariable-adjusted analyses confirmed the impact of body composition and health-related lifestyle on the association between sex hormones and sleep.

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