Vinyoles E.,European University at Madrid
Journal of Hypertension | Year: 2017
OBJECTIVE:: The European Guidelines on Hypertension define an office pulse pressure (PP) at least 60?mmHg in the elderly patient as asymptomatic organ damage. Our objective was to estimate the cutoff point of 24-h PP that best predicts office PP associated with higher cardiovascular risk (≥60?mmHg) in hypertensive older patients. METHODS:: We studied all hypertensive patients at least 60 years with a first valid ambulatory blood pressure monitoring drawn from the Spanish ambulatory blood pressure monitoring registry. Receiver operating characteristic curves were used to estimate the best 24-h PP cutoff predictor of office PP at least 60?mmHg that maximized the sum of sensitivity and specificity. RESULTS:: We included 52?246 hypertensive patients [52.4%, female; mean age (SD) 69.0 (7.0) years]. From these, 34?530 (66.1%) patients had an office PP at least 60?mmHg. The value of 24-h PP that best predicts higher risk clinic PP is 54.9?mmHg [sensitivity: 69.2%; specificity: 70.3%; area under the receiver operating characteristic curve of 0.761 (95% confidence interval 0.756–0.765)]. Mean clinic and 24-h PPs were progressively higher as the study participants were classified at higher cardiovascular risk group. Some 20.5% of patients presented isolated office high PP and 10% a masked high 24-h PP. CONCLUSION:: In a large clinical sample of older hypertensive patients, the cutoff point of 24-h PP that best predicts office PP at least 60?mmHg is 55?mmHg. In 30.5% of cases, there is a discrepancy between office PP and ambulatory 24-h PP. Copyright © 2017 Wolters Kluwer Health, Inc. All rights reserved.
Garatachea N.,University of Zaragoza |
Lucia A.,European University at Madrid
Age | Year: 2013
Western populations are living longer. Ageing decline in muscle mass and strength (i.e. sarcopenia) is becoming a growing public health problem, as it contributes to the decreased capacity for independent living. It is thus important to determine those genetic factors that interact with ageing and thus modulate functional capacity and skeletal muscle phenotypes in older people. It would be also clinically relevant to identify 'unfavourable' genotypes associated with accelerated sarcopenia. In this review, we summarized published information on the potential associations between some genetic polymorphisms and muscle phenotypes in older people. A special emphasis was placed on those candidate polymorphisms that have been more extensively studied, i.e. angiotensin-converting enzyme (ACE) gene I/D, α-actinin-3 (ACTN3) R577X, and myostatin (MSTN) K153R, among others. Although previous heritability studies have indicated that there is an important genetic contribution to individual variability in muscle phenotypes among old people, published data on specific gene variants are controversial. The ACTN3 R577X polymorphism could influence muscle function in old women, yet there is controversy with regards to which allele (R or X) might play a 'favourable' role. Though more research is needed, up-to-date MSTN genotype is possibly the strongest candidate to explain variance among muscle phenotypes in the elderly. Future studies should take into account the association between muscle phenotypes in this population and complex gene-gene and gene-environment interactions. © 2011 American Aging Association.
Sanchis-Gomar F.,Hospital 12 Of Octubre I12 |
Lucia A.,Hospital 12 Of Octubre I12 |
Lucia A.,European University at Madrid
Trends in Molecular Medicine | Year: 2015
Reactivating the telomerase gene through gene therapy after acute myocardial infarction (AMI) has been recently reported to improve survival in mice. Given that regular physical exercise also activates this gene, therapeutic and lifestyle interventions targeting telomerase need to be explored as possible additions to the current armamentarium for myocardial regeneration. © 2015 Elsevier Ltd.
Clemente-Suarez V.J.,European University at Madrid
Applied Physiology, Nutrition and Metabolism | Year: 2015
Many studies have researched the psychophysiological response and energy balance of athletes in numerous ultraendurance probes, but none has investigated an ultraendurance mountain running event. The current study aims to analyze changes in blood lactate concentration, rating of perceived exertion, heart rate, heart rate variability, and energy balance after the performance of an ultraendurance mountain running event. The parameters in the 6 participants who finished the event were analyzed (age, 30.8 ± 3.1 years; height, 176.2 ± 8.6 cm; body mass, 69.2 ± 3.7 kg). The race covered 54 km, with 6441 m of altitude change, 3556 m downhill and 2885 m uphill. The athletes completed together the race in 14 h and 6 min. After the ultraendurance event, the athletes presented a negative energy balance of 4732 kcal, a blood lactate concentration of 2.8 ± 0.3 mmol/L, a heart rate mean/heart rate maximum ratio of 0.64, a heart rate mean of 111.4 ± 5.9 beats/min, a decrease in vagal modulation, and an increase in sympathetic modulation, and recorded 19.5 ± 1.5 points on the 6–20 rating of perceived exertion scale. The event was a stressful stimulus for the athletes despite the low intensity measured by blood lactate concentration and heart rate. The results obtained may be used by coaches as a reference parameter of heart rate, heart rate variability, rating of perceived exertion, and lactate concentration to develop specific training programs. In addition, the energy balance data obtained in this research may improve nutritional intake strategies. ©, 2006 National Research Council of Canada. All rights reserved.
Garcia-Benitez S.,European University at Madrid
Journal of child neurology | Year: 2013
Owing to the risk of severe rhabdomyolysis, clinicians advise McArdle disease patients to refrain from strenuous exercise, particularly weight lifting. A 15-year-old male McArdle disease patient performed a 6-week, supervised, light- to moderate-intensity (~65-70% of one-repetition-maximum) resistance (weight lifting) training program (2 sessions/week). Training resulted in ~27% and ~6% increase in one-repetition-maximum bench press and multipower squat performance while inducing no myoglobinuria. The patient changed to a lower disease severity class, that is, he became virtually asymptomatic in terms of exercise limitations. The authors' preliminary data suggest that supervised, light to moderate resistance training is feasible in children with McArdle disease and has potential clinical benefits.
Aliane N.,European University at Madrid
IEEE Transactions on Education | Year: 2010
This paper presents an interactive module for learning both the fundamental and practical issues of servo systems. This module, developed using Simulink in conjunction with the Matlab graphical user interface (Matlab-GUI) tool, is used to supplement conventional lectures in control engineering and robotics subjects. First, the paper introduces the theoretical background of servo systems. Then, the interactive module is presented, with a description of its main features as well some hints on how to integrate Simulink models within Matlab-GUI. Some of the module's capabilities are illustrated through classroom examples. Finally, the experience of putting this into use and student assessment of the tool are also addressed. © 2009 IEEE.
Fernandez-Lucas J.,European University at Madrid
Applied Microbiology and Biotechnology | Year: 2015
Living cells are most perfect synthetic factory. The surprising synthetic efficiency of biological systems is allowed by the combination of multiple processes catalyzed by enzymes working sequentially. In this sense, biocatalysis tries to reproduce nature’s synthetic strategies to perform the synthesis of different organic compounds using natural catalysts such as cells or enzymes. Nowadays, the use of multienzymatic systems in biocatalysis is becoming a habitual strategy for the synthesis of organic compounds that leads to the realization of complex synthetic schemes. By combining several steps in one pot, a significant step economy can be realized and the potential for environmentally benign synthesis is improved. Using this sustainable synthetic system, several work-up steps can be avoided and pure products are ideally isolated after a series of reactions in one single vessel after just one straightforward purification step. In recent years, enzymatic methodology for the preparation of nucleic acid derivatives (NADs) has become a standard technique for the synthesis of a wide variety of natural NADs. Enzymatic methods have been shown to be an efficient alternative for the synthesis of nucleoside and nucleotide analogs to the traditional multistep chemical methods, since chemical glycosylation reactions include several protection–deprotection steps and the use of chemical reagents and organic solvents that are expensive and environmentally harmful. In this minireview, we want to illustrate what we consider the most current relevant examples of in vivo and in vitro multienzymatic systems used for the synthesis of nucleic acid derivatives showing advantages and disadvantages of each methodology. Finally, a detailed perspective about the impact of -omics in multienzymatic systems has been described. © 2015, Springer-Verlag Berlin Heidelberg.
Krinner W.,European University at Madrid
Water Resources Management | Year: 2014
This research gives an overview of water sector finances in Spain on a national scale. A methodology is presented which allows to estimate the total financial cost of water services and the rate of cost recovery, based on financial and budget information of administrations, agencies, companies and users' associations involved in water resources management and water service provision. Financial records of organisations are analysed and the overall amounts of expenditure, cost and revenue determined. Cost recovery rates are calculated for different organisations and water services, and the net contribution of public funds received by the water sector in addition to tariff revenue is determined. © 2014 Springer Science+Business Media Dordrecht.
Cabrera P.M.,European University at Madrid
Journal of endourology / Endourological Society | Year: 2013
To present the feasibility of laparoendoscopic single-site (LESS) nephron-sparing surgery (NSS) using new reusable umbilical single-port system and instruments. A prospective study was performed to evaluate operative data and patient outcomes after LESS-NSS with KeyPort®, a tri-channel single-port placed through a 2.5-cm umbilical incision, and specific DuoRotate® instruments. Patient characteristics, operative time, estimated blood loss (EBL), complications, visual analog pain scale (VAPS), and visual analogue wound satisfaction scale (VAWSS) scores were registered. Six consecutive nonselected patients with indication of NSS and normal contralateral kidney were offered LESS-NSS. An accessory 3.5 mm port that facilitated renoraphy and unclamped technique was used in 4 (66.7%) cases each. Median tumor maximum size was 4.0 (1-7.5) cm; age 64 (31-76) years; body mass index 28.4 (22.1-39.3) kg/m(2); operative time 233.5 (140-250) min; EBL 500 (200-500) mL; difference in hemoglobin 2.3 (0.1-4.6) g/dL. VAPS at day 2 was 0.7/10 and the median length of stay 3 (2-4) days. One case (16.7%) needed transfusion. None required conversion to standard laparoscopy or use of other additional ports. Postoperative complications occurred in 3 (50%) and major complications in 1 (16.7%). Incisions were totally hidden in the umbilicus. Pathology revealed angiomyolipoma (3), renal cell carcinoma (2), and chronic inflammation (1). Tumor margins were negative in all cases with malignancy. VAWSS at first month was 9.4 (8.1-10). At a median follow-up of 24 (10-32) weeks, no patient developed complications related to the approach. Umbilical LESS-NSS through a new single-port system of reusable nature, with or without the help of an accessory port and occasionally without clamping, can be effectively and very economically performed with minimum postoperative pain. Good candidates are patients with presumed benign renal masses that appreciate the cosmetic advantage of the approach.
Yazdani M.,European University at Madrid
International Journal of Industrial Engineering Computations | Year: 2014
Supplier selection management has been considered as an important subject for industrial organizations. In order to remain on the market, to gain profitability and to retain competitive advantage, business units need to establish an integrated and structured supplier selection system. In addition, environmental protection problems have been big solicitudes for organizations to consider green approach in supplier selection problem. However, finding proper suppliers involves several variables and it is critically a complex process. In this paper, the main attention is focused on finding the right supplier based on fuzzy multi criteria decision making (MCDM) process. The weights of criteria are calculated by analytical hierarchical process (AHP) and the final ranking is achieved by fuzzy technique for order preference by similarity to an ideal solution (TOPSIS). TOPSIS advantage among the other similar methods is to obtain the best solution close to ideal solution. The paper attempts to express better understanding by an example of an automobile manufacturing supply chain. © 2014 Growing Science Ltd. All rights reserved.