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Vukasinovic Z.,University of Belgrade | Spasovski D.,University of Belgrade | Kralj-Iglic V.,University of Ljubljana | Marinkovic-Eric J.,University of Belgrade | And 3 more authors.
International Orthopaedics | Year: 2013

Purpose: We studied changes of contact stress distribution in the hip joint after Tonnis triple pelvic osteotomy applied in the treatment of dysplasia and hip joint incongruence in adolescents. Methods: In a group of 75 patients, 54 (72 %) female, who underwent surgery by triple pelvic osteotomy in adolescence for developmental disorder of the hip and avascular necrosis of the femoral head, a three-dimensional hip joint model was used based on the radiography of the pelvis with hips. The following biomechanical parameters were calculated: resultant hip force normalised to body weight (R/Wb), inclination of the resultant hip force (θ-R), the position of the stress pole (θ), peak contact hip stress (Pmax), and peak contact hip stress normalised to body weight (Pmax/Wb). Gait quality was also assessed. Results: After surgery the Wiberg CE angle was increased by 17.85 (114 %), resultant hip force normalised to body weight (R/Wb) was decreased by 0.107 (3.3 %), the position of the stress pole was shifted medially by 27.59 (63.5 %), and peak contact hip stress normalised to body weight (Pmax/Wb) was decreased by 2249.74 (55.9 %). Waddling gait was reduced from 17 (23.9 %) to four cases (5.6 %). All changes were statistically highly significant (p<0.01). Conclusions: The effect of Tonnis triple pelvic osteotomy lies in the improvement of stress distribution across the acetabular cartilage of the hip joint, thus slowing down the degenerative damage of the hip joint. © 2012 Springer-Verlag Berlin Heidelberg.


Dimic G.,European University at Belgrade
Elektronika ir Elektrotechnika | Year: 2010

The model and architecture of a multimedia environment for the realization of interactive tasks by Bayesian approach is described. Interactive tasks are developed with the basic aim to make it easier for students to acquire practical knowledge in the field of digital design and implementation of complex programmable logic circuits. Exploring the impact of interactive tasks on students' success in acquiring the knowledge about complex logic devices operating principles and their implementation, at the end of the course we conducted a survey. Survey included all students who had classes in subject Programmable logic devices in the academic year 2009.


Strippoli M.-P.F.,University of Bern | Frischer T.,Universitatsklinik For Kinder Und Jugendheilkunde | Barbato A.,University of Padua | Snijders D.,University of Padua | And 10 more authors.
European Respiratory Journal | Year: 2012

The European Respiratory Society Task Force on primary ciliary dyskinesia (PCD) in children recently published recommendations for diagnosis and management. This paper compares these recommendations with current clinical practice in Europe. Questionnaires were returned by 194 paediatric respiratory centres caring for PCD patients in 26 countries. In most countries, PCD care was not centralised, with a median (interquartile range) of 4 (2-9) patients treated per centre. Overall, 90% of centres had access to nasal or bronchial mucosal biopsy. Samples were analysed by electron microscopy (77%) and ciliary function tests (57%). Nasal nitric oxide was used for screening in 46% of centres and saccharine tests in 36%. Treatment approaches varied widely, both within and between countries. European region, size of centre and the country's general government expenditure on health partly defined availability of advanced diagnostic tests and choice of treatments. In conclusion, we found substantial heterogeneity in management of PCD within and between countries, and poor concordance with current recommendations. This demonstrates how essential it is to standardise management and decrease inequality between countries. Our results also demonstrate the urgent need for research: to simplify PCD diagnosis, to understand the natural history and to test the effectiveness of interventions. Copyright©ERS 2012.


Drazic R.,Clinic of Oral Surgery | Sopta J.,University of Belgrade | Minic A.J.,European University at Belgrade
Journal of Oral Pathology and Medicine | Year: 2010

Objective: The aim of this study was to qualitatively and semi-quantitatively analyze mast cells in periapical lesions. Materials and methods: Biopsy specimens of 96 periapical lesions were stained with hematoxylin-eosin, histochemical Giemsa and immunohistochemical CD 117 (C kit) antibody. Mast cell count below 100 mast cells on 1000 fields of high power magnification was noted as 'negative', 101-400 as 'mild', 401-800 cells as 'moderate', and over 800 cells as 'severe'. Results: Mast cells are found in 68 (70.8%) lesions. The presence of mast cells was greater in cysts than in granulomas (P < 0.0028). There was no difference in semi-quantitative expression of CD 117 in granulomas and cysts (P > 0.05). Mast cells were placed in both: inflammatory infiltrate and in fibroblastic areas of periapical lesions, and their presence was most frequently mild to moderate. Conclusions: The findings of present study could suggest a role of mast cells in regulation of cellular immune mechanisms in periapical lesions, balancing between alterative and reparatory processes in inflamed periapical tissue. © 2010 John Wiley & Sons A/S.


Sibalija T.V.,European University at Belgrade | Majstorovic V.D.,University of Belgrade
International Journal of Advanced Manufacturing Technology | Year: 2012

This paper presents a generic optimisation methodology for the selection of optimal process parameters in multiresponse processes that consists of two stages: The first stage is based on a quality loss function and multivariate statistical methods in order to adequately present responses, uncorrelate and synthesise them into a single process performance measure; the second stage uses artificial neural networks to build a process model and a simulated annealing (SA) algorithm to find the optimal process parameter conditions. The initial point of the SA algorithm is generated in such a way as to improve the convergence to the actual global optimum. The most important SA algorithm parameters are varied to assess the algorithm's robustness in terms of the effect of the algorithm setting on the quality of the final solution (optimal process parameters and the corresponding process performance measure). The results are benchmarked to genetic algorithm (GA) performance within the proposed methodology, and the quality of a final solution, the robustness of the optimisation algorithm, the speed of a convergence to the optimum and the computational time are evaluated. Four case studies are presented to illustrate the effectiveness of the proposed methodology in comparison to several commonly used approaches from the literature and also to the GA-based performance. © Springer-Verlag London Limited 2011.


Dickov V.,European University at Belgrade
Central European Journal of Medicine | Year: 2012

The basis of the discovery process for a new pharmaceutical product is in understanding the mechanism of action of a particular disease or processes in the organism related to the disease and/or its symptoms. The essence of a pharmaceutical is in the active ingredient capable of affecting processes within the organism beneficially. The discovery process includes a particular sequence of activities of various profiles of experts, about which various authors agree. The history of pharmaceutical industry (and pharmacy) is measured from one discovery of an innovative drug or approach to treatment of a particular disease to the next one. The cost of pharmaceutical products is one of the key causes of controversy related to this industry. Numerous cultures have proverbs expressing the opinion that health is priceless or that health is the greatest wealth. What if health does have a price? One of the basic premises of marketing is that price should reflect consumer value. © Versita Sp. z o.o.


Scepanovic M.,European University at Belgrade
European Journal of Cancer Prevention | Year: 2016

Colorectal cancer (CRC) is becoming a major public health problem in the Republic of Serbia. Organized mass screening has been shown to decrease CRC mortality and even its incidence. The aim of this study was to assess the acceptability of a faecal immunochemical test for haemoglobin proposed by primary care physicians. From August to November 2013, a pilot study for CRC screening was organized in individuals aged 50 to 74 years. The study included 50 primary healthcare centres from all 25 administrative regions of Serbia. A qualitative immunochromatographic faecal immunochemical test for human haemoglobin detection was used. Overall, 50 894 individuals were invited. The participation rate was 67.8 and 3.4% of the tests were positive. Among individuals with a positive test, 69.7% agreed to undergo colonoscopy. The positive predictive value was 27.1% for adenoma and 14.6% for carcinoma. This was the first CRC screening project encompassing approximately one-third of primary healthcare facilities in all regions across the country. It showed a good response of the target population and satisfactory cooperation of the healthcare professionals involved. Copyright © 2016 Wolters Kluwer Health, Inc. All rights reserved.


Djurovic-Petrovic M.D.,European University at Belgrade
Thermal Science | Year: 2015

The hygrothermal properties related to rockwool insulation material structure with different additives are presented using rockwool insulation products obtained from row material of southern Serbia (Vranje region) in the wide range of reference temperatures (10 °C to 70 °C). The hygrothermal properties of basic sample (without additives) are compared to two samples with different additives for two sets of rockwool insulation samples namely: light-soft-panels with density of 50 kg/m3, and middle-weight-panels with density of 80 kg/m3. It is shown that there is significant (approximately 10%) improvement of thermal conductivity for additives based on zeolite. Also, correlation of thermal conductivity and sorption properties of selected samples are presented.


Golusin M.,University of Novi Sad | Ivanovic O.M.,European University at Belgrade | Bagaric I.,University of Novi Sad | Vranjes S.,Tarkett
Renewable and Sustainable Energy Reviews | Year: 2010

The actual global economic crisis, including all other well-known problems of sustainable development, reflects the direction of development of all countries in the world. Serbia, as a European country in its early stage of development, is trying to synchronize its progress with experience of other countries from the field of sustainable development and in accordance with rules in the field of energetic and energetic efficiency, and, as well as to promote and develop the sector of use of renewable sources of energy. On the other hand, Serbia is a country which largely depends on import of all forms of energy, which to a great extent affects its economic stability. Therefore, in Serbia the strategy for development of energetic was imposed and it considers all the aspects of development of energetic until 2015 and it also defines the priorities which can be mostly seen in the choice of forms of alternative sources of energy. These sources, based on some criteria, can be considered the most convenient for a gradual substitution of energy which is gotten from the conventional sources. Taking into account strategically defined goals and domestic potentials which are at disposal, as well as economic parameters, an alternative source of energy of basic importance for the future exploitation on the territory of Serbia geothermal energy, was chosen. The research points to the fact that Serbia will be capable to respond adequately to Kyoto protocol demands and to the European rules regarding the substitution of a certain amounts of fossil fuels by the fuel origin from the raw biological materials. The research defines the existent and non-existent capacities and the assessment of positive effects of usage of geothermal energy. At the moment, 160 long holes are being exploited whose water temperature is around 60 °C (140 °F) and their heat power reach 160 MJ/s. It was stated that adequate exploitation of existing and new geothermal sources a yearly would save about 500,000 tons of fossil fuels what is proportional to the 10% of the today's heating system. The total amount of heat accumulated at geothermal deposit sites in Serbia, up to 3 km of depth, is two times greater than the total amount of heat that may be generated by burring all available coal reserves in Serbia. Price of electrical energy produced from geothermal springs is estimated to be between 9.2 US cents/kWh and 11.5 US cents/kWh. In order to support exploitation of geothermal energy (as well as all other renewable sources of energy) the decision that all the producers of energy from renewable sources get a status of privileged producers were made. © 2009.


Dickov V.,European University at Belgrade | Dickov A.,Institute of Psychiatry | Martinovic-Mitrovic S.,Institute of Psychiatry
European Review for Medical and Pharmacological Sciences | Year: 2011

The issue of applying marketing on the pharmaceutical market has the features of subject-based approach, with the intention to appreciate the specific nature of the products, as well as the special characteristics of the complexly formed demand. The relevance of the issue is related to the aboveaverage performance of the pharmaceutical industry, its role in the generation of humanity's demographic transition, and specific development routes of marketing as a scientific and practical discipline. The sensitive nature of a pharmaceutical product on the one hand generates the intense legislation on this market, whereas on the other, the circumstances of its use generate a specific environment in which the production/consumption of the products of pharmaceutical industry is intensively reflected as a specific medical, cultural, economic and even political phenomenon.

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