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Potter T.,Royal Veterinary College | Potter T.,Westpoint Veterinary Group | Illambas J.,Royal Veterinary College | Illambas J.,European Service Center | And 3 more authors.
Veterinary Journal | Year: 2013

The pharmacokinetics (PK) and pharmacodynamics (PD) of marbofloxacin were established in calves for six strains of each of the pneumonia pathogens Mannheimia haemolytica and Pasteurella multocida. The distribution of marbofloxacin into inflamed (exudate) and non-inflamed (transudate) tissue cage fluids allowed comparison with the serum concentration-time profile. To establish the PD profile, minimum inhibitory concentration (MIC) was determined in Mueller-Hinton broth (MHB) and calf serum.Moderately higher MICs were obtained for serum compared to MHB. An initial integration of PK-PD data established Cmax/MIC ratios of 45.0 and AUC24h/MIC values of 174.7h, based on serum MICs, for both bacterial species. Using bacterial time-kill curves, generated ex vivo for serum marbofloxacin concentrations, PK-PD modelling established three levels of growth inhibition: AUC24h/MIC ratios for no reduction, 3 log10 and 4 log10 reductions in bacterial count from the initial inoculum count were 41.9, 59.5 and 68.0h for M. haemolytica and 48.6, 64.9 and 74.8h for P. multocida, on average respectively. Inter-strain variability for 3 log10 and 4 log10 reductions in bacterial count was smaller for P. multocida than for M. haemolytica. In conjunction with literature data on MIC90 values, the present results allowed prediction of dosages for efficacy for each organism for the three levels of growth inhibition. © 2012 Elsevier Ltd.


Knezevic S.,Institute of Meteorology | Tosic I.,Institute of Meteorology | Unkasevic M.,Institute of Meteorology | Pejanovic G.,European Service Center
Theoretical and Applied Climatology | Year: 2014

In this study, the influence of the East Atlantic Oscillation (EAO) on the climate indices based on the daily minimum temperature at eight stations in Serbia was examined. The following climate indices were analyzed: frost days (FD), cold nights (TN10p), warm nights (TN90p), minimum value of daily minimum temperature (TNn), tropical nights (TR), and cold spell duration indice (CSDI). Analysis of correlation between the East Atlantic Index (EAI) and the geopotential at 500 hPa, as well as between the EAI and climate indices was realized for all seasons and months during the period 1950-2009. Two characteristic situations for the extreme positive and negative values of the EAI were analyzed. Seasonal and monthly trend analyses of climate indices were performed. Decreases of FD and TN10p and increases of TN90p and TR were observed. It was found that the negative correlation prevailed between the EAI and TN10p/FD, and positive one between the EAI and TN90p/TR for all seasons and months. The highest correlation was observed between the EAI and TN90p in February. © 2013 Springer-Verlag Wien.


Testa C.,European Service Center
PPCJ Polymers Paint Colour Journal | Year: 2012

An experiment was conducted to demonstrate that Texanol ester alcohol significantly improves the wet scrub resistance of matte interior wall paints applied at temperatures above the polymer's glass transition temperature (T g). The formulated paints were based on Acronal S 790, a styrene acrylic binder from BASF, with a Tg of 22°C and W673 a Va/VeoVa binder from Synthomer, with a Tg of 14°C. The two paints were divided into three parts. Two parts had Texanol added at 0.57% and 1.16% on total weight of paint; and the third sample had no coalescent added. The wet scrub resistance of the paints was determined via the ASTM D2486 method to assess the integrity of the films formed at the varying application temperatures after two and six weeks. Wet scrub resistance was improved when paint was applied at temperatures that were higher than the Tg of the polymers.


Malinovic-Milicevic S.B.,University of Novi Sad | Mihailovic D.T.,University of Novi Sad | Dreskovic N.M.,University of Sarajevo | Djurdjevic V.S.,University of Belgrade | And 3 more authors.
Thermal Science | Year: 2015

In this article we considered the extreme temperatures, precipitation and UV-B radiation in Vojvodina region, Serbia. We describe the actual climate conditions for the period 1981-2007 and applied a dynamic downscaling technique using the EBU-POM regional coupled climate model under the SRES-A2 scenario to assess the changes for the period 2021-2100. The results indicate that a warmer and drier climate in the Vojvodina region can be expected at the end of the century. Projection of climate indicates to a strong increase in the mean annual minimum temperatures, and much smaller increase in the mean annual maximum temperatures. The increase of both extreme temperatures is predicted to be the highest in the winter and the lowest in the summer. Mean annual precipitation is projected to increase toward the end of the first half of the 21st century and to decrease for the last 30 years of the 21st century. Precipitation amount will be the highest during the winter and spring. The model simulations show that, by the end of this century, annual mean UV-B dose will recover by 5.2%. Recovery will be faster in the first half of the 21st century and more slowly later on. The UV-B doses recovery is expected to be the highest during the autumn and spring.


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