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Subramanian D.,European Molecular Biology Institute | Laketa V.,European Molecular Biology Institute | Muller R.,European Molecular Biology Institute | Tischer C.,European Molecular Biology Institute | And 3 more authors.
Nature Chemical Biology | Year: 2010

Phosphatidylinositol 3-phosphate (PtdIns(3)P) is a phospholipid residing on early endosomes, where it is proposed to be involved in endosomal fusion. We synthesized membrane-permeant derivatives of PtdIns(3)P, including a caged version that is to our knowledge the first photoactivatable phosphoinositide derivative developed so far. In living cells, photoactivation of caged PtdIns(3)P induced rapid endosomal fusion in an EEA1-dependent fashion, thus providing in vivo evidence that PtdIns(3)P is a sufficient signal for driving this process. Source

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