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Patent
Euroimmun Medizinische Labordiagnostika AG | Date: 2017-02-01

The present invention relates to a method comprising the steps contacting in a reaction mixture a liquid sample comprising antibodies from a subject with a ganglioside and detecting a complex comprising the ganglioside and an autoantibody to the ganglioside, wherein the first step is carried out in the presence of an isolated ganglioside-binding protein; a reaction mixture comprising a ganglioside, and a liquid sample comprising antibodies from a subject and an isolated ganglioside-binding protein, preferably further comprising an autoantibody to the ganglioside; a complex comprising a ganglioside and an autoantibody to the ganglioside in the presence of an isolated ganglioside-binding protein, wherein the complex is preferably purified; and a use of a ganglioside-binding protein, preferably an isolated, ganglioside-binding protein for increasing the sensitivity of an assay detecting autoantibodies to a ganglioside for the purpose of diagnosing a disease.


Patent
Euroimmun Medizinische Labordiagnostika AG | Date: 2016-06-01

The present inventions relates to a method for diagnosing a disease, preferably a disease associated with neurological symptoms, comprising the step detecting in a sample from a patient an autoantibody binding to NBC1; an immobilized polypeptide comprising NBC1 or a variant thereof, preferably immobilized on a solid carrier; a use of a polypeptide comprising NBC1 or a variant thereof for the diagnosis of a disease, preferably comprising the step detecting an autoantibody binding to NBC1; a polypeptide comprising NBC1 or a variant thereof, preferably immobilized, more preferably on a solid carrier, for use in the treatment of a disease; an autoantibody, preferably an isolated autoantibody, binding to a polypeptide comprising NBC1, wherein the autoantibody is preferably in complex with said polypeptide, preferably for use in the diagnosis of a disease; a method for isolating an autoantibody binding to NBC1, comprising the steps contacting a sample comprising the autoantibody with a polypeptide comprising NBC1 or a variant thereof under conditions compatible with formation of a complex, wherein said autoantibody binds to said polypeptide, isolating the complex formed, dissociating the complex isolated in step b), and separating the autoantibody from the polypeptide; a pharmaceutical composition comprising a polypeptide comprising NBC1 or a variant thereof, preferably for the treatment of a disease; a medical or diagnostic device comprising a polypeptide comprising NBC1 or a variant thereof; and a test kit for the diagnosis of a disease, comprising a polypeptide comprising NBC1 or a variant thereof, wherein preferably the test kit comprises, in addition, a means for detecting the complex comprising an autoantibody binding to NBC1.


Patent
Euroimmun Medizinische Labordiagnostika AG | Date: 2016-10-26

The present inventions relates to a method for diagnosing a disease, preferably a disease associated with neurological symptoms and/or a cancer, comprising the step detecting in a sample from a patient an autoantibody binding to Neurochondrin; a polypeptide comprising Neurochondrin or a variant thereof, which is immobilized, preferably on a solid carrier; a use of a polypeptide comprising Neurochondrin or a variant thereof for the diagnosis of a disease, preferably comprising the step detecting autoantibodies binding to Neurochondrin; a polypeptide comprising Neurochondrin or a variant thereof, preferably immobilized, more preferably on a solid carrier, for use in the treatment of a disease; an autoantibody, preferably an isolated autoantibody, binding to a polypeptide comprising Neurochondrin, wherein the autoantibody is preferably in complex with said polypeptide or a variant thereof; A method for isolating an autoantibody binding to Neurochondrin, comprising the steps a) contacting a sample comprising the autoantibody with a polypeptide comprising Neurochondrin or a variant thereof under conditions compatible with formation of a complex, wherein said autoantibody binds to said polypeptide, b) isolating the complex formed in step a), c) dissociating the complex isolated in step b), and d) separating the autoantibody from the polypeptide; a pharmaceutical composition comprising a polypeptide comprising Neurochondrin or a variant thereof; a medical or diagnostic device comprising a polypeptide comprising Neurochondrin or a variant thereof; and a test kit for the diagnosis of a disease, comprising a polypeptide comprising Neurochondrin or a variant thereof, wherein preferably the test kit comprises, in addition, a means for detecting the complex comprising an autoantibody binding to Neurochondrin.


Patent
Euroimmun Medizinische Labordiagnostika Ag | Date: 2016-06-03

A method for diagnosing a disease by detecting an autoantibody that binds to flotillin1 and/or flotillin2 in a sample, a polypeptide comprising flotillin1 and/or flotillin2 or a variant thereof, which may be immobilized, a method of treating a disease by applying to a subject the polypeptide that binds to an autoantibody, an autoantibody binding to flotillin1 and/or flotillin2, a method for isolating the autoantibody, a pharmaceutical composition, a medical device and test kit comprising the polypeptide, are provided. A method for detecting the presence of an autoantibody is also provided.


Patent
Euroimmun Medizinische Labordiagnostika AG | Date: 2016-12-21

The invention relates to a traction arrangement configured for driving a belt, to a method for driving a belt and to the use of the traction arrangement in at least one of the following applications: in a crane, in a plotter, for driving a steel cable, a rope, a chain and a ball path. The traction arrangement (1) comprises a first guideway (3) and a second guideway (4), wherein each guideway (3, 4) is fixed to mounting means (5), wherein the first and the second guideway (3, 4) are spaced parallel on a surface of the traction arrangement (1), a slide (6) movable on the surface and configured for spanning the surface through a lateral motion along a first axis, wherein the slide (6) is arranged essentially perpendicular to the first and the second guideway (3, 4), a jack (7) connected to the slide (6), wherein the jack (7) is movable along the slide (6) through a lateral motion along a second axis, the second axis being perpendicular to the first axis, and a first motor (8) for driving a first belt (2), wherein the first motor (8) is rotatably arranged and controls traction of the first belt (2) such that when the first motor (8) rotates in counterclockwise direction or in clockwise direction, the jack (7) moves along the second axis such that a second position coordinate of the jack (7) along the second axis is adjustable. In this way, a possibility for driving a belt is provided that is simple, accurate, requires no adjustment in action, in which no cable spans have to be dragged and an unwanted diagonal motion of a slide is suppressed.


Patent
EUROIMMUN Medizinische Labordiagnostika AG | Date: 2016-04-29

The present invention relates to a polypeptide comprising an antigenic fragment having a sequence of at least seven amino acids from a hydrophilic domain of an oil body-associated protein, wherein the polypeptide comprises a truncated hydrophobic domain of the oil body-associated protein or does not comprise such a domain, and wherein the oil body-associated protein is selected from the group comprising oleosin, caleosin and steroleosin, to a pharmaceutical composition or a vaccine comprising the polypeptide, to a complex comprising the polypeptide and an antibody bound thereto, to a medical or diagnostic device comprising the polypeptide, to a nucleic acid encoding the polypeptide or a cell comprising said nucleic acid, to a test kit comprising the polypeptide, and to a method for detecting an antibody which binds to the polypeptide.


Patent
Euroimmun Medizinische Labordiagnostika Ag | Date: 2016-03-23

Polypeptides including Neurochondrin and autoantibodies binding to polypeptides including Neurochondrin are provided. Methods for diagnosing or treating diseases associated with neurological symptoms or cancers are also provided. The methods of diagnosis may include detecting an autoantibody binding to Neurochondrin in a sample from a patient. The methods of treatment may include administering a polypeptide comprising Neurochondrin to a patient.


Patent
Euroimmun Medizinische Labordiagnostika Ag | Date: 2015-12-01

The present invention relates to a storage container for liquids, comprising a liquid-tight tank with an upwardly directed opening, wherein the opening is closed in a leaktight fashion by a protective film comprising an outer layer and an inner layer, wherein the outer layer is an aluminium foil and the inner layer is a plastic film, wherein the outer layer can be removed from the storage container separately from the inner layer, and wherein the inner layer can be pierced by a hollow needle;


Patent
Euroimmun Medizinische Labordiagnostika AG | Date: 2016-05-11

The present invention relates to a method for diagnosing a disease, preferably a disease associated with neurological symptoms, comprising the step detecting in a sample from a patient an autoantibody binding to ITPR1; a polypeptide comprising ITPR1 or a variant thereof, which is immobilized, preferably on a solid carrier; a use of a polypeptide comprising ITPR1 or a variant thereof for the diagnosis of a disease, preferably comprising the step detecting autoantibodies binding to ITPR1; a polypeptide comprising ITPR1 or a variant thereof, preferably immobilized, more preferably on a solid carrier, for use in the treatment of a disease; an autoantibody, preferably an isolated autoantibody, binding to a polypeptide comprising ITPR1, wherein the autoantibody is preferably in complex with said polypeptide; a method for isolating an autoantibody binding to ITPR1, comprising the steps contacting a sample comprising the autoantibody with a polypeptide comprising ITPR1 or a variant thereof under conditions compatible with formation of a complex, wherein said autoantibody binds to said polypeptide, isolating the complex formed in step a), dissociating the complex isolated in step b), and separating the autoantibody from the polypeptide; a pharmaceutical composition comprising a polypeptide comprising ITPR1 or a variant thereof; a medical or diagnostic device comprising a polypeptide comprising ITPR1 or a variant thereof; and a test kit for the diagnosis of a disease, comprising a polypeptide comprising ITPR1 or a variant thereof, wherein preferably the test kit comprises, in addition, a means for detecting the complex comprising an autoantibody binding to ITPR1


Patent
Euroimmun Medizinische Labordiagnostika AG | Date: 2016-12-07

The present invention relates to method for diagnosing a disease comprising the step detecting in a sample from a patient an autoantibody binding to flotillin1 and/or flotillin2, a polypeptide comprising flotillin1 and/or flotillin2 or a variant thereof, which is preferably immobilized, a use of said polypeptide for the diagnosis of a disease, an autoantibody binding to flotillin1 and/or flotillin2, a method for isolating said autoantibody, and a pharmaceutical composition, medical device or test kit comprising said polypeptide.

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