Euroimmun Medizinische Labordiagnostika AG

Lübeck, Germany

Euroimmun Medizinische Labordiagnostika AG

Lübeck, Germany
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Patent
Euroimmun Medizinische Labordiagnostika AG | Date: 2017-07-26

The present invention relates to a polypeptide comprising a macadamia protein selected from the group comprising a protein running in a 2D SDS PAGE at pH 6.3 to 8.7 and 53 to 67 kDa and a protein running in a 2D SDS PAGE at pH 6.5 to 7.9 and 20 to 25 kDa or an antigenic variant thereof, preferably the protein running at pH 6.3 to 8.7 and 53 to 67 kDa or an antigenic variant thereof.


Patent
Euroimmun Medizinische Labordiagnostika AG | Date: 2017-02-01

The present invention relates to a method comprising the steps contacting in a reaction mixture a liquid sample comprising antibodies from a subject with a ganglioside and detecting a complex comprising the ganglioside and an autoantibody to the ganglioside, wherein the first step is carried out in the presence of an isolated ganglioside-binding protein; a reaction mixture comprising a ganglioside, and a liquid sample comprising antibodies from a subject and an isolated ganglioside-binding protein, preferably further comprising an autoantibody to the ganglioside; a complex comprising a ganglioside and an autoantibody to the ganglioside in the presence of an isolated ganglioside-binding protein, wherein the complex is preferably purified; and a use of a ganglioside-binding protein, preferably an isolated, ganglioside-binding protein for increasing the sensitivity of an assay detecting autoantibodies to a ganglioside for the purpose of diagnosing a disease.


Patent
Euroimmun Medizinische Labordiagnostika AG | Date: 2017-05-31

The present invention relates to the protein THSD7A (Thrombospondin, Type I, Domain Containing 7A) as a biomarker autoantigen in membranous nephropathy, particularly idiopathic membranous nephropathy. The invention provides diagnostic, prognostic and monitoring methods for membranous nephropathy in a patient based on the detection of autoantibodies recognizing the THSD7A protein (anti-THSD7A autoantibodies) and associated kits. The invention also provides diagnostic methods and kits based on the detection of the THSD7A level. The invention further provides therapeutic methods for membranous nephropathy.


Patent
Euroimmun Medizinische Labordiagnostika Ag | Date: 2017-01-24

Provided is a polypeptide comprising a macadamia protein running in a 2D SDS PAGE at pH 6.3 to 8.7 and 53 to 67 kDa or a protein running in a 2D SDS PAGE at pH 6.5 to 7.9 and 20 to 25 kDa or an antigenic variant thereof, and a tag for detection and/or purification, a polypeptide fused with the macadamia protein, or the macadamia protein is modified by glycosylation, phosphorylation, acetylation, decarboxylation, citrullination, or hydroxylation.


Patent
Euroimmun Medizinische Labordiagnostika AG | Date: 2017-05-03

The present invention relates to a pressure-tight storage vessel containing a liquid, wherein the storage vessel has an inner floor and an upper side and is closed in a pressure-sealing manner by a closure, and wherein the nature of the storage vessel allows pressure-sealing piercing with at least two hollow needles; and to a method for transferring a liquid from a storage vessel to a reaction vessel, the method comprising the following steps: supplying the storage vessel according to the invention, pressure-sealing piercing with a first hollow needle, which is connected to a rinsing-liquid tank, and pressure-sealing piercing with a second hollow needle, which is connected to the reaction vessel, introducing rinsing liquid from the rinsing-liquid tank, via the first hollow needle, into the storage vessel, the liquid being driven out of the storage vessel, via the second hollow needle, into the reaction vessel; and to an apparatus which is suitable for implementing the method according to the invention.


Patent
EUROIMMUN Medizinische Labordiagnostika AG | Date: 2016-12-23

The present invention relates to a pressure-tight storage vessel containing a liquid, wherein the storage vessel has an inner floor and an upper side and is closed in a pressure-sealing manner by a closure, and wherein the nature of the storage vessel allows pressure-sealing piercing with at least two hollow needles; and to a method for transferring a liquid from a storage vessel to a reaction vessel, the method comprising the following steps: supplying the storage vessel according to the invention, pressure-sealing piercing with a first hollow needle, which is connected to a rinsing-liquid tank, and pressure-sealing piercing with a second hollow needle, which is connected to the reaction vessel, introducing rinsing liquid from the rinsing-liquid tank, via the first hollow needle, into the storage vessel, the liquid being driven out of the storage vessel, via the second hollow needle, into the reaction vessel; and to an apparatus which is suitable for implementing the method according to the invention.


Patent
Euroimmun Medizinische Labordiagnostika AG | Date: 2017-05-10

The invention relates to a method for detecting an abnormity in a fluid of a human or animal sample, to a computer program, to a machine-readable storage unit and to the use of a pressure sensor adapted for performing the steps of the method in at least one of the following applications: analyzing a serum or a fluid sample, diagnosing an abnormity in a human or animal sample and detecting abnormities when aspiring or dispensing a liquid or a fluid of a human or animal sample. The method comprises the steps: a) aspiring or dispensing (1) the fluid, thereby utilizing a needle for pipetting the fluid; b) measuring (2) a pressure in proximity of the needle; and c) detecting (3) the abnormity based on the result of the previous step. In this way, a possibility for detecting abnormities in life science applications is provided that is accurate, reproducible and adapted for minimizing external influences, such as disturbances and noise, while being simple and cost-effective to realize.


Patent
Euroimmun Medizinische Labordiagnostika AG | Date: 2017-04-19

The present invention relates to a diagnostically useful carrier comprising a means for specifically capturing an antibody to p21 from Echinococcus multilocularis in a sample from a subject; a kit comprising the diagnostically useful carrier, preferably further comprising a means for detecting any captured antibody; a method comprising the step detecting the presence or absence of an antibody to p21 from Echinococcus multilocularis in a sample from a subject; a use of p21 from Echinococcus multilocularis or a variant thereof for increasing the diagnostic reliability, preferably the sensitivity of an assay for the detection of an Echinococcus infection, preferably for distinguishing an Echinococcus multilocularis infection from an Echinococcus granulosus infection; a polypeptide running at a molecular weight of 21 kDa from Echinococcus multilocularis, obtainable by separating according to molecular weight an extract from Echinococcus multilocularis using gel electrophoresis, or a variant thereof, or an antibody to said polypeptide.


Patent
Euroimmun Medizinische Labordiagnostika AG | Date: 2016-06-01

The present inventions relates to a method for diagnosing a disease, preferably a disease associated with neurological symptoms, comprising the step detecting in a sample from a patient an autoantibody binding to NBC1; an immobilized polypeptide comprising NBC1 or a variant thereof, preferably immobilized on a solid carrier; a use of a polypeptide comprising NBC1 or a variant thereof for the diagnosis of a disease, preferably comprising the step detecting an autoantibody binding to NBC1; a polypeptide comprising NBC1 or a variant thereof, preferably immobilized, more preferably on a solid carrier, for use in the treatment of a disease; an autoantibody, preferably an isolated autoantibody, binding to a polypeptide comprising NBC1, wherein the autoantibody is preferably in complex with said polypeptide, preferably for use in the diagnosis of a disease; a method for isolating an autoantibody binding to NBC1, comprising the steps contacting a sample comprising the autoantibody with a polypeptide comprising NBC1 or a variant thereof under conditions compatible with formation of a complex, wherein said autoantibody binds to said polypeptide, isolating the complex formed, dissociating the complex isolated in step b), and separating the autoantibody from the polypeptide; a pharmaceutical composition comprising a polypeptide comprising NBC1 or a variant thereof, preferably for the treatment of a disease; a medical or diagnostic device comprising a polypeptide comprising NBC1 or a variant thereof; and a test kit for the diagnosis of a disease, comprising a polypeptide comprising NBC1 or a variant thereof, wherein preferably the test kit comprises, in addition, a means for detecting the complex comprising an autoantibody binding to NBC1.


Patent
Euroimmun Medizinische Labordiagnostika Ag | Date: 2016-06-03

A method for diagnosing a disease by detecting an autoantibody that binds to flotillin1 and/or flotillin2 in a sample, a polypeptide comprising flotillin1 and/or flotillin2 or a variant thereof, which may be immobilized, a method of treating a disease by applying to a subject the polypeptide that binds to an autoantibody, an autoantibody binding to flotillin1 and/or flotillin2, a method for isolating the autoantibody, a pharmaceutical composition, a medical device and test kit comprising the polypeptide, are provided. A method for detecting the presence of an autoantibody is also provided.

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