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Portoroz, Slovenia

The Euro-Mediterranean University or EMUNI University is the first international University in Slovenia. It has 115 member institutions from 32 countries. Wikipedia.

Majcen S.,Euro-Mediterranean University
Environmental Science and Pollution Research | Year: 2016

In the times when the acquis of the European Union (EU) has developed so far as to reach a high level of technical complexity, in particular in certain policy fields such as environmental legislation, it is important to look at what kind of information and data policy decisions are based on. This position paper looks at the extent to which evidence-based decision-making process is being considered in the EU institutions when it comes to adopting legislation in the field of environment at the EU level. The paper calls for closer collaboration between scientists and decision-makers in view of ensuring that correct data is understood and taken into consideration when drafting, amending, negotiating and adopting new legal texts at all levels of the EU decision-making process. It concludes that better awareness of the need for such collaboration among the decision-makers as well as the scientific community would benefit the process and quality of the final outcomes (legislation). © 2016 Springer-Verlag Berlin Heidelberg

El-Kadib A.,Euro-Mediterranean University
ChemSusChem | Year: 2016

Such sweet support: Metal-polysaccharide interplay affords, after pyrolytic transformation, highly active catalysts based on anisotropically oriented nanoparticles supported on graphene sheets. © 2016 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.

Abdelkrim E.K.,Euro-Mediterranean University
ChemSusChem | Year: 2015

Increased demand for more sustainable materials and chemical processes has tremendously advanced the use of polysaccharides, which are natural biopolymers, in domains such as adsorption, catalysis, and as an alternative chemical feedstock. Among these biopolymers, the use of chitosan, which is obtained by deacetylation of natural chitin, is on the increase due to the presence of amino groups on the polymer backbone that makes it a natural cationic polymer. The ability of chito-san-based materials to form open-network, macroporous, high-surface-area hydrogels with accessible basic surface sites has enabled their use not only as macrochelating ligands for active metal catalysts and as a support to disperse nanosized particles, but also as a direct organocatalyst. This review provides a concise overview of the use of native and modified chitosan, possessing different textural properties and chemical properties, as organocatalysts. Organocatalysis with chitosan is primarily focused on carbon-carbon bond-forming reactions, multicomponent heterocycle formation reactions, biodiesel production, and carbon dioxide fixation through [3+2] cycloaddition. Furthermore, the chiral, helical organization of the chitosan skeleton lends itself to use in enantioselective catalysis. Chitosan derivatives generally display reactivity similar to homogeneous bases, ionic liquids, and organic and inorganic salts. However, the introduction of cooperative acid-base interactions at active sites substantially enhances reactivity. These functional biopolymers can also be easily recovered and reused several times under solvent-free conditions. These accomplishments highlight the important role that natural biopolymers play in furthering more sustainable chemistry. ©2015 Wiley-VCH Verlag GmbH & Co. KGaA , Weinheim.

Mignani S.,University of Paris Descartes | Kazzouli S.E.,Mohammed V University | Bousmina M.,Euro-Mediterranean University | Bousmina M.,Hassan II Academy of Science and Technology | Majoral J.-P.,CNRS Coordination Chemistry
Progress in Polymer Science | Year: 2013

Over the last decade, various nanomaterial systems have been developed as important and powerful strategies to deliver conventional drugs, recombinant proteins, vaccines, aptamers, siRNA, nucleotides and genes. In particular, alongside polymeric, solid-lipid, magnetic and metal based nanoparticles, polymeric micelles and linear polymers, dendrimer nanostructures represent useful nano-carriers in medicine. Today's challenge to find safe and innovative drugs remains as critical as ever. In this review, for the first time, we define the term dendrimer space concept as an approach that affords a new paradigm of thought for medicinal chemists and opens new and promising avenues toward the identification of original dendrimer-based drugs. Thus, the dendrimer space defines a new 'druggable' cluster that is included within the vast volume of chemical space. The dendrimer space concept took its inspiration from both the concepts of 'druglikeness' and 'druggability', which are fully and practically integrated into the drug discovery process, and from different methods of exploration and navigation, such as the 'chemography' approach, in chemical space. It was further influenced by the large number of biomedical applications using dendrimers that were developed from only a handful existing in the early 1990s. To define the boundaries of the dendrimer space, this review first focuses on the recent progress in the exploration of specific sub-chemical spaces (clusters within the continuum of chemical space). Chemical space is defined as the entire collection of all meaningful chemical compounds, and its full examination is insuperable. The compounds included in these different clusters can be mapped onto the coordinates of a multidimensional descriptor space, with such variables as physicochemical properties or topological characteristics, and are based on the concepts of 'druglikeness' (drug-like space) and 'leadlikeness'. In addition, the discrete areas occupied by specific biologically active compounds define the boundaries of the 'target class' clusters, which can overlap the drug-like space. Second, this review gives an overview of the nanopharmaceutical properties of dendrimers, both as biologically active derivatives per se and as drug delivery systems. Finally, several perspectives using dendrimers as new delivery platforms based on the concept of dendrimer space are presented. © 2013 Elsevier Ltd.

Mignani S.,University of Paris Descartes | El Kazzouli S.,Euro-Mediterranean University | Bousmina M.M.,Euro-Mediterranean University | Bousmina M.M.,Hassan II Academy of Science and Technology | Majoral J.-P.,CNRS Coordination Chemistry
Chemical Reviews | Year: 2014

The progress made in the inhibition of protein-protein interactions (PPIs) by use of dendrimers as drugs is studied. Specific protein-protein molecular recognition is critical for cellular function, programmed cell death, signal transduction, and viral self-assembly. These PPI signatures suggest that large ligands may be required to compete effectively with one of the two interfacial areas and suggest the inappropriateness of the druglike small-molecule approach. Two main different strategies have been used for their identification of PPI, screening, including in silico screening, and drug design approaches, including nanoparticles for protein surface recognition. As already proposed by Lipinski and Hopkins, one of the foremost challenges facing drug discovery is the identification and development of specific chemical areas. Dendritic polymers are often referred to as artificial globular proteins, based on their closely matched size and contours of important proteins and bioassemblies and their electrophoretic properties and other biomimetic properties.

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