Portoroz, Slovenia

Euro-Mediterranean University

Portoroz, Slovenia

The Euro-Mediterranean University or EMUNI University is the first international University in Slovenia. It has 115 member institutions from 32 countries. Wikipedia.

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El Kazzouli S.,Euro-Mediterranean University | Koubachi J.,University Ibn Zohr | El Brahmi N.,Euro-Mediterranean University | Guillaumet G.,CNRS Institute of Organic and Analytical Chemistry
RSC Advances | Year: 2015

Direct arylation is a useful method for the preparation of (hetero)aryl-aryl systems by C-H bond cleavage. This procedure has several advantages such as the reduction of cost, time and waste. This report aims at reviewing the advances made in C-H arylation of 5,6, 6,6 and 5,5 fused-heterocyclic systems including: indole, azaindole, imidazo[1,2-a]pyridine, imidazo[1,2-a]pyrimidine, imidazo[1,2-a]pyrazine, imidazo[1,2-b]pyridazine, pyrazolo[1,5-a]pyrimidine, imidazo[1,2-b][1,2,4,5]tetrazine, indolizine, pyrrolo[1,2-a]pyrazine, indazole, benzothiadiazole, benzotriazole, benzoxazole, benzofuran, benzothiophene, benzimidazole, benzothiazole, thieno[3,4-b]pyrazine, indolizine-2-carboxylate, thieno[3,4-b]pyrazine, quinoline and derivatives, chromanone, coumarin, quinoxaline, thieno[2,3-b]thiophene, thieno[3,4-b]thiophene, imidazo[2,1-b]thiazole, imidazo[1,2-b]pyrazole, thiazolo[3,2-b][1,2,4]triazoles and pyrrolo[3,2-b]pyrrole. © 2015 The Royal Society of Chemistry.

Koubachi J.,University Ibn Zohr | El Kazzouli S.,Euro-Mediterranean University | Bousmina M.,Euro-Mediterranean University | Bousmina M.,Hassan II Academy of Science and Technology | Guillaumet G.,CNRS Institute of Organic and Analytical Chemistry
European Journal of Organic Chemistry | Year: 2014

This review surveys recent developments (reported in the last fifteen years) in organometallic-chemistry-based methods for the functionalization of imidazo[1,2-a]pyridines, in particular the decoration of the pyridine and imidazole rings by means of reactions such as Sonogashira, Heck, Negishi, Suzuki-Miyaura, and Stille cross-coupling, as well as by C-H activation, C-arylation, C-alkenylation, and carbonylation. Results relating to one-pot double functionalization of two different positions on the imidazo[1,2-a] pyridine system are also reviewed. Procedures in which metal-based catalysis is not involved in the functionalization of imidazo[1,2-a]pyridines are not included. Copyright © 2014 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.

Alaoui C.,Euro-Mediterranean University
Journal of Energy Storage | Year: 2017

This paper is about the design and implementation of a thermal management of an energy storage system (ESS) for smart grid. It uses refurbished lithium-ion (li-ion) batteries that are disposed from electric vehicles (EVs) as they can hold up to 80% of their initial rated capacity. This system is aimed at prolonging the usable life of li-ion EV batteries by reusing them for energy storage. However, the high value of the internal resistance of refurbished batteries generates more heat and consequently accelerates further their aging process as their operating temperature plays a vital role on their reliability, lifespan, safety and performance. Battery Thermal Management System (BTMS) must keep the operating temperature of the battery pack between −10 °C and 40 °C in order to achieve good performances and long lifespan. Active BTMS consumes energy from the pack and reduces its available capacity. In order to reduce this adverse impact, this paper presents a novel approach that takes advantage of the non-uniform surface distribution of li-ion battery cell, which results from complex reactions inside the cell. First, li-ion hotspots were identified and found next to the positive and negative tabs. Then, thermoelectric coolers (TECs) are mounted next to the tabs and in the center of the li-ion battery. A control circuit is designed to turn on and off TECs in order to reduce the parasitic power feeding the proposed system, referred to as modular battery thermal management system (MBTMS). Experimental results show the performance of the MBTMS under normal conditions, such as an ambient temperature of 25 °C and a discharge rate of C/1 to 2C, and under extreme conditions, such as 40 °C and 3C discharge rate. Finally, its performance is compared against a compatible BTMS based on forced air flow. The experimental results show the feasibility of the proposed system. © 2017 Elsevier Ltd

Naas M.,CNRS Institute of Chemistry | Naas M.,Mohammed V University | El Kazzouli S.,Euro-Mediterranean University | Essassi E.M.,Mohammed V University | And 2 more authors.
Organic Letters | Year: 2015

The first palladium-catalyzed oxidative alkenylation of (1H)- and (2H)-indazole derivatives with various olefins is described. The use of Pd(OAc)2 as the catalyst and Ag2CO3 as the oxidant promoted the selective C3-monoalkenylation of (1H)-indazoles and (2H)-indazoles, affording the desired products in good yields. An original oxidative C7-alkenylation of 3-substituted (1H)-indazoles was also developed. The oxidative alkenylation of (1H)-indazole was successfully applied to the total synthesis of the drug candidate gamendazole in a step- and atom-economical fashion. © 2015 American Chemical Society.

Mignani S.,University of Paris Descartes | El Kazzouli S.,Euro-Mediterranean University | Bousmina M.M.,Euro-Mediterranean University | Bousmina M.M.,Hassan II Academy of Science and Technology | Majoral J.-P.,CNRS Coordination Chemistry
Chemical Reviews | Year: 2014

The progress made in the inhibition of protein-protein interactions (PPIs) by use of dendrimers as drugs is studied. Specific protein-protein molecular recognition is critical for cellular function, programmed cell death, signal transduction, and viral self-assembly. These PPI signatures suggest that large ligands may be required to compete effectively with one of the two interfacial areas and suggest the inappropriateness of the druglike small-molecule approach. Two main different strategies have been used for their identification of PPI, screening, including in silico screening, and drug design approaches, including nanoparticles for protein surface recognition. As already proposed by Lipinski and Hopkins, one of the foremost challenges facing drug discovery is the identification and development of specific chemical areas. Dendritic polymers are often referred to as artificial globular proteins, based on their closely matched size and contours of important proteins and bioassemblies and their electrophoretic properties and other biomimetic properties.

Kadib A.E.,INANOTECH Institute of Nanomaterials and Nanotechnology | Bousmina M.,Euro-Mediterranean University | Bousmina M.,Hassan II Academy of Science and Technology | Brunel D.,Charles Gerhardt Institute
Journal of Nanoscience and Nanotechnology | Year: 2014

Polysaccharides are a new class of pervasive biopolymers that display many advantages including wide availability, sustainability, inherent inclusion of chemical functionality, biocompatibility and biodegradability. Current efforts are focused on the catalytic transformation of these macromolecules into fuels and platform chemicals. However, there is growing interest in using biopolymers directly to create functional materials. Particularly, the ability of some polysaccharides to form physical and chemical porous hydrogels has opened new avenues for material synthesis and has been the driving force for rethinking the strategies used to create value-added nanomaterials from naturally available biomass. Among them, chitosan is on the rise due to the presence of amino groups on the polymer backbone that distinguishes it as a unique natural cationic polymer. This contribution sheds light on the opportunities offered by engineering the secondary structure of chitosan fibrillar hydrogels. The optimization and stabilization of the open framework structure of these soft-materials are crucial to designing novel functional hybrid materials, dispersed chitosan-metal nanoparticles and hierarchical porous inorganic materials. Copyright © 2014 American Scientific Publishers All rights reserved.

Mignani S.,University of Paris Descartes | Kazzouli S.E.,Mohammed V University | Bousmina M.,Euro-Mediterranean University | Bousmina M.,Hassan II Academy of Science and Technology | Majoral J.-P.,CNRS Coordination Chemistry
Progress in Polymer Science | Year: 2013

Over the last decade, various nanomaterial systems have been developed as important and powerful strategies to deliver conventional drugs, recombinant proteins, vaccines, aptamers, siRNA, nucleotides and genes. In particular, alongside polymeric, solid-lipid, magnetic and metal based nanoparticles, polymeric micelles and linear polymers, dendrimer nanostructures represent useful nano-carriers in medicine. Today's challenge to find safe and innovative drugs remains as critical as ever. In this review, for the first time, we define the term dendrimer space concept as an approach that affords a new paradigm of thought for medicinal chemists and opens new and promising avenues toward the identification of original dendrimer-based drugs. Thus, the dendrimer space defines a new 'druggable' cluster that is included within the vast volume of chemical space. The dendrimer space concept took its inspiration from both the concepts of 'druglikeness' and 'druggability', which are fully and practically integrated into the drug discovery process, and from different methods of exploration and navigation, such as the 'chemography' approach, in chemical space. It was further influenced by the large number of biomedical applications using dendrimers that were developed from only a handful existing in the early 1990s. To define the boundaries of the dendrimer space, this review first focuses on the recent progress in the exploration of specific sub-chemical spaces (clusters within the continuum of chemical space). Chemical space is defined as the entire collection of all meaningful chemical compounds, and its full examination is insuperable. The compounds included in these different clusters can be mapped onto the coordinates of a multidimensional descriptor space, with such variables as physicochemical properties or topological characteristics, and are based on the concepts of 'druglikeness' (drug-like space) and 'leadlikeness'. In addition, the discrete areas occupied by specific biologically active compounds define the boundaries of the 'target class' clusters, which can overlap the drug-like space. Second, this review gives an overview of the nanopharmaceutical properties of dendrimers, both as biologically active derivatives per se and as drug delivery systems. Finally, several perspectives using dendrimers as new delivery platforms based on the concept of dendrimer space are presented. © 2013 Elsevier Ltd.

Majcen S.,Euro-Mediterranean University
Environmental Science and Pollution Research | Year: 2016

In the times when the acquis of the European Union (EU) has developed so far as to reach a high level of technical complexity, in particular in certain policy fields such as environmental legislation, it is important to look at what kind of information and data policy decisions are based on. This position paper looks at the extent to which evidence-based decision-making process is being considered in the EU institutions when it comes to adopting legislation in the field of environment at the EU level. The paper calls for closer collaboration between scientists and decision-makers in view of ensuring that correct data is understood and taken into consideration when drafting, amending, negotiating and adopting new legal texts at all levels of the EU decision-making process. It concludes that better awareness of the need for such collaboration among the decision-makers as well as the scientific community would benefit the process and quality of the final outcomes (legislation). © 2016 Springer-Verlag Berlin Heidelberg

Abdelkrim E.K.,Euro-Mediterranean University
ChemSusChem | Year: 2015

Increased demand for more sustainable materials and chemical processes has tremendously advanced the use of polysaccharides, which are natural biopolymers, in domains such as adsorption, catalysis, and as an alternative chemical feedstock. Among these biopolymers, the use of chitosan, which is obtained by deacetylation of natural chitin, is on the increase due to the presence of amino groups on the polymer backbone that makes it a natural cationic polymer. The ability of chito-san-based materials to form open-network, macroporous, high-surface-area hydrogels with accessible basic surface sites has enabled their use not only as macrochelating ligands for active metal catalysts and as a support to disperse nanosized particles, but also as a direct organocatalyst. This review provides a concise overview of the use of native and modified chitosan, possessing different textural properties and chemical properties, as organocatalysts. Organocatalysis with chitosan is primarily focused on carbon-carbon bond-forming reactions, multicomponent heterocycle formation reactions, biodiesel production, and carbon dioxide fixation through [3+2] cycloaddition. Furthermore, the chiral, helical organization of the chitosan skeleton lends itself to use in enantioselective catalysis. Chitosan derivatives generally display reactivity similar to homogeneous bases, ionic liquids, and organic and inorganic salts. However, the introduction of cooperative acid-base interactions at active sites substantially enhances reactivity. These functional biopolymers can also be easily recovered and reused several times under solvent-free conditions. These accomplishments highlight the important role that natural biopolymers play in furthering more sustainable chemistry. ©2015 Wiley-VCH Verlag GmbH & Co. KGaA , Weinheim.

El-Kadib A.,Euro-Mediterranean University
ChemSusChem | Year: 2016

Such sweet support: Metal-polysaccharide interplay affords, after pyrolytic transformation, highly active catalysts based on anisotropically oriented nanoparticles supported on graphene sheets. © 2016 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.

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