Daejeon, South Korea
Daejeon, South Korea

Eulji University is a private university in Seongnam City, Gyeonggi-do, South Korea and central Daejeon, South Korea. It opened its doors as a college in March 1997. Instruction focuses on medical fields. The school was established by Dr. Park Jun-yeong and the Eulji Educational Foundation, which in turn grew out of the Eulji Hospital, which opened in 1981. Wikipedia.


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News Article | November 16, 2016
Site: www.eurekalert.org

Researchers from the University of Colorado Boulder and Northwestern University have developed a tiny, soft and wearable acoustic sensor that measures vibrations in the human body, allowing them to monitor human heart health and recognize spoken words. The stretchable device captures physiological sound signals from the body, has physical properties well-matched with human skin and can be mounted on nearly any surface of the body, said CU Boulder Assistant Professor Jae-Woong Jeong, one of three lead study authors. The sensor, which resembles a small Band-Aid, weighs less than one-hundredth of an ounce and can gather continuous physiological data. "This device has a very low mass density and can be used for cardiovascular monitoring, speech recognition and human-machine interfaces in daily life," said Jeong of the Department of Electrical, Computer and Energy Engineering. "It is very comfortable and convenient - you can think of it as a tiny, wearable stethoscope." A paper on the subject was published Nov. 16 in Science Advances, a sister journal of Science. The other two co-corresponding authors are Professors Yonggang Huang and John Rogers of Northwestern. "The thin, soft, skin-like characteristics of these advanced wearable devices provide unique capabilities for 'listening in' to the intrinsic sounds of vital organs of the body, including the lungs and heart, with important consequences in continuous monitoring of physiological health," said Rogers, the Simpson Querrey Professor of Materials Science and Engineering, Biomedical Engineering and Neurological Surgery. Rogers also is director of Northwestern's Center for Bio-Integrated Electronics. The researchers say the new device can pick up mechanical waves that propagate through tissues and fluids in the human body due to natural physiological activity, revealing characteristic acoustical signatures of individual events. They include the opening and closing of heart valves, vibrations of the vocal cords and even movements in gastrointestinal tracts. The sensor can also integrate electrodes that can record electrocardiogram (ECG) signals that measure the electrical activity of the heart as well electromyogram (EMG) signals that measure the electrical activity of muscles at rest and during contraction. While the sensor was wired to an external data acquisition system for the tests, it can easily be converted into a wireless device, said Jeong. Such sensors could be of use in remote, noisy places - including battlefields - producing quiet, high-quality cardiology or speech signals that can be read in real time at distant medical facilities. "Using the data from these sensors, a doctor at a hospital far away from a patient would be able to make a fast, accurate diagnosis," said Jeong. Vocal cord vibration signals also could be used by the military personnel or civilians to control robots, vehicles or drones. The speech recognition capabilities of the sensor also have implications for improving communication for people suffering from speech impairments, he said. As part of the study, the team used the device to measure cardiac acoustic responses and ECG activity -including the detection of heart murmurs - in a group of elderly volunteers at Camp Lowell Cardiology, a private medical clinic in Tucson, Arizona collaborating with the University of Arizona, a project partner. The researchers also were able to detect the acoustical signals of blood clots in a related lab experiment, said Jeong. Other CU Boulder study co-authors on the Science Advances paper include Assistant Professor Jianliang Xiao and doctoral student Zhanan Zou of mechanical engineering and doctoral student Raza Qazi of electrical engineering. The sticky, flexible polymer encapsulating the tiny device is stretchable enough to follow skin deformation, said study first author Yuhao Liu, who earned his doctorate and the University of Illinois-Urbana Champaign and now works at Lam Research, headquartered in Fremont, California. The device contains a tiny commercial accelerometer to measure the vibration of the body acoustics and allows for the evaporation of human sweat. The researchers also showed vocal cord vibrations gathered when the device is on one's throat can be used to control video games and other machines. As part of the study a test subject was able to control a Pac-Man game using vocal cord vibrations for the words "up," "down," "left" and "right." "While other skin electronics devices have been developed by researchers, what has not been demonstrated before is the mechanical-acoustic coupling of our device to the body through the skin," Jeong said. "Our goal is to make this device practical enough to use in our daily lives." The study also included the Eulji University College of Medicine in Korea.


Patent
Eulji University, Electronics and Telecommunications Research Institute | Date: 2011-06-16

Provided is a vital sign measuring apparatus capable of measuring vital signs such as a temperature of a human body, breathing, acceleration, oxygen saturation, voice, etc. to analyze and display a health index. The diaper-type vital sign measuring apparatus includes a vital sign measuring part for detecting variation in abdominal circumference according to breathing of a wearer to measure a vital sign of the breathing of the wearer, a vital sign analysis part for analyzing the vital sign measured by the vital sign measuring part to calculate a health index of the wearer, and a display part for displaying the health index calculated by the vital sign analysis part.


Hwang D.-K.,Eulji University | Choi H.-J.,Eulji University
Osteoporosis International | Year: 2010

We examined the relationship between low bond mass and metabolic syndrome in 2,475 Korean women. After adjustment for all covariates, mean vertebral BMD was significantly lower in women with metabolic syndrome. Moreover, age and weight adjusted vertebral BMD was significantly decreased with additional components of the metabolic syndrome. Introduction: Obesity-induced chronic inflammation is a key component in the pathogenesis of insulin resistance and metabolic syndrome. It has been suggested that proinflammatory cytokines and low-grade systemic inflammation activate bone resorption and may lead to reduced bone mineral density (BMD). The objective of this study was to determine the relationship between low bone mass and metabolic syndrome in Korean women. Methods: This is a cross-sectional study of 2,548 women aged 18 years and over who had visited the Health Promotion Center. Physical examination and laboratory tests were performed. Vertebral BMD was measured using dual-energy X-ray absorptiometry. Metabolic syndrome was defined by National Cholesterol Education Program-Adult Treatment Panel III criteria. Results: Among 2,475 women, 511 (21.0%) women had metabolic syndrome. Women with abdominal obesity or hypertriglyceridemia had significantly lower vertebral BMD than women without respective components after adjustment for age, weight, and height. After adjustment for all covariates, mean vertebral BMD was significantly lower in women with metabolic syndrome (p = 0.031). Moreover, age- and weight-adjusted vertebral BMD were significantly decreased with additional components of the metabolic syndrome (p = 0.004). Conclusions: These findings suggest that metabolic syndrome might be another risk factor for osteoporosis and related fractures. © 2009 International Osteoporosis Foundation and National Osteoporosis Foundation.


Chung M.Y.,Eulji University
The Korean journal of hepatology | Year: 2010

The present study aimed to determine the role of cystatin C as a prognostic factor for acute kidney injury and survival in cirrhotic patients. The study investigated 53 liver cirrhosis patients. The renal function was evaluated by serum creatinine, serum and urine cystatin C, and 24-hour creatinine clearance on admission. Acute kidney injury was defined as a serum creatinine level exceeding the normal range (>1.2 mg/dl) and an increase of at least 50% from the baseline value. Multivariate analysis, receiver operating characteristic curve, and survival analysis were used to investigate prognostic factors for acute kidney injury and survival. Nine of the 53 cirrhotic patients (17.0%) developed acute kidney injury within 3 months. Both serum creatinine and cystatin C were predictive factors for acute kidney injury in univariate analysis, with a diagnostic accuracy of 0.735 (95% confidence interval (CI), 0.525-0.945; p=0.028) for serum cystatin C and 0.698 (95% CI, 0.495-0.901, p=0.063) for creatinine. In multivariate analysis, only serum cystatin C was an independent risk factor for acute kidney injury. The sensitivity and specificity of a serum cystatin C level of >1.23 mg/L to acute kidney injury were 66% and 86%, respectively. Serum cystatin C was positively correlated with the Model for End-Stage Liver Disease (MELD) and MELD-Na scores (r=0.346 and p=0.011, and r=0.427 and p=0.001, respectively). Comparison of the survival rates over the observation period revealed that a serum cystatin C level of >1.23 mg/L was a useful marker for short-term mortality (p<0.001). The accuracy in predicting acute kidney injury and short-term mortality was higher for a serum cystatin C level of >1.23 mg/L than for the serum creatinine concentration in patients with cirrhosis.


Lee D.-H.,Eulji University
Journal of the Optical Society of Korea | Year: 2010

In the present study, an optical system is proposed for maskless lithography using a digital micromirror device (DMD). The system consists of an illumination optical system, a DMD, and a projection lens system. The illumination optical system, developed for 95% uniformity, is composed of fly's eye lens plates, a 405 nm narrow band pass filter (NBPF), condensing lenses, a field lens and a 250W halogen lamp. The projection lens system, composed of 8 optical elements, is developed for 4 μm resolution. The proposed system plays a role of an optical engine for PCB and/or FPD maskless lithography. Furthermore, many problems arising from the presence of masks in a conventional lithography system, such as expense and time in fabricating the masks, contamination by masks, disposal of masks, and the alignment of masks, may be solved by the proposed system. The proposed system is verified by lithography experiments which produce a line pattern with the resolution of 4 μm line width.


Lee H.K.,Eulji University
Diabetes and Metabolism Journal | Year: 2011

Persistent organic pollutants (POPs) are known to cause mitochondrial dysfunction and this in turn is linked to insulin resistance, a key biochemical abnormality underlying the metabolic syndrome. To establish the cause and effect relationship between exposure to POPs and the development of the metabolic syndrome, Koch's postulates were considered. Problems arising from this approach were discussed and possible solutions were suggested. In particular, the difficulty of establishing a cause and effect relationship due to the vagueness of the metabolic syndrome as a disease entity was discussed. Recently a bioassay, aryl-hydrocarbon receptor (AhR) trans-activation activity using a cell line expressing AhR-luciferase, showed that its activity is linearly related with the parameters of the metabolic syndrome in a population. This finding suggests the possible role of bioassays in the analysis of multiple pollutants of similar kinds in the pathogenesis of several closely related diseases, such as type 2 diabetes and the metabolic syndrome. Understanding the effects of POPs on mitochondrial function will be very useful in understanding the integration of various factors involved in this process, such as genes, fetal malnutrition and environmental toxins and their protectors, as mitochondria act as a unit according to the metabolic scaling law. © 2011 Korean Diabetes Association.


Park B.S.,Eulji University | Lee J.-O.,Korea Advanced Institute of Science and Technology
Experimental and Molecular Medicine | Year: 2013

Lipopolysaccharide (LPS) is a major component of the outer membrane of Gram-negative bacteria. Minute amounts of LPS released from infecting pathogens can initiate potent innate immune responses that prime the immune system against further infection. However, when the LPS response is not properly controlled it can lead to fatal septic shock syndrome. The common structural pattern of LPS in diverse bacterial species is recognized by a cascade of LPS receptors and accessory proteins, LPS binding protein (LBP), CD14 and the Toll-like receptor4 (TLR4)-MD-2 complex. The structures of these proteins account for how our immune system differentiates LPS molecules from structurally similar host molecules. They also provide insights useful for discovery of anti-sepsis drugs. In this review, we summarize these structures and describe the structural basis of LPS recognition by LPS receptors and accessory proteins. © 2013 KSBMB.


Purpose: Laparoendoscopic single-site (LESS) surgery was used to treat various urological operations by a single surgeon who was skilled in conventional laparoscopic surgery. The effectiveness and safety of the procedure were examined. Patients and Methods: LESS surgery was performed on 70 patients by using a homemade single port device composed of an Alexis® wound retractor and a powder-free surgical glove. There were 29 cases of varicocelectomy (including two bilateral cases), 21 cases of renal cyst marsupialization (including one bilateral case), 16 cases of ureterolithotomy, 3 cases of radical nephrectomy, and 1 case of radical nephroureterectomy. The mean patient age was 42.90 ± 17.58 years (range, 11 to 74 years), and the male-to-female ratio was 55:15. Results: In two cases (one ureterolithotomy and one radical nephrectomy), the LESS surgery was converted to conventional laparoscopic surgery. The mean operative time was 96.02 minutes (range, 30 to 285 minutes), the estimated blood loss was 60.80 mL (range, 0 to 500 mL), and the mean hospital stay was 5.10 days (range, 3 to 15 days). Only one patient had to use patient-controlled anesthesia due to pain; none of the patients developed major complications; and all patients were satisfied, with 85.7% expressing a high degree of satisfaction. Conclusion: In the urological field, LESS surgery using a homemade single-port device appears to be a feasible and safe surgical treatment option that could replace conventional laparoscopic surgery. Copyright 2011, Mary Ann Liebert, Inc.


Summary We investigated the prognostic significance of heme oxygenase-1 (HO-1), S100 calcium-binding protein A4 (S100A4), and syndecan-1 (SYND1) expression in patients with primary non-muscle-invasive bladder cancer (NMIBC). Immunohistochemical studies were performed on tissue specimens from 109 patients diagnosed with primary NMIBC following complete transurethral resection, with the expression dichotomized as negative/mild ("low") versus moderate/strong ("high") according to scores based on staining area and intensity. The effect of each biomarker on recurrence-free survival (RFS) and progression-free survival (PFS) was analyzed. The predictive accuracy for RFS and PFS in multivariate Cox regression models with or without (the baseline model) biomarkers was estimated using the Harrell concordance index. High HO-1, S100A4, and SYND1 expressions were observed in 33.0%, 36.7%, and 63.3% cases, respectively. High HO-1 and S100A4 expressions were significantly associated with various adverse pathological characteristics (high T stage and grade); SYND1 expression was inversely correlated with these characteristics (all, P <.05). In the baseline multivariate model, multifocality, intravesical therapy, and T stage were significant predictors for RFS, whereas intravesical therapy and T stage had marginal statistical significance in predicting PFS. In the multivariate model with the biomarkers, the 3 biomarkers were significant predictors for RFS; and HO-1 expression was a significant predictor for PFS. Addition of the 3 biomarkers to the baseline model significantly increased the predictive accuracy for RFS from 0.754 to 0.828 (P =.043). Our findings suggest that HO-1, S100A4, and SYND1 expressions have prognostic value in primary NMIBC; thus, their evaluation might be useful for determining treatment strategies. © 2014 Elsevier Inc.


Patent
Aram Huvis Co. and Eulji University | Date: 2011-01-26

The present invention relates to a portable clinical thermometer capable of providing visual images, and more particularly, to a portable clinical thermometer capable of providing visual images, which can take a body temperature, and simultaneously photographs a living body region where occurrence of a problem is suspected and then provides the photographed image such that any emergency can be handled easily. A portable clinical thermometer capable of providing visual images according to the present invention comprises a body having an insert provided to protrude at one side thereof so that the insert is inserted into a living body; a clinical thermometer module provided at an inner distal end of the insert to detect infrared emitted from the living body and generate an electric signal corresponding to an intensity of the detected infrared; a camera module provided at the inner distal end of the insert to take an image of an interior of the living body and generate an image signal; a microprocessor for receiving the electric signal generated in the clinical thermometer module to calculate a body temperature and receiving the image signal generated in the camera module to generate an image; a memory for receiving and storing the body temperature information and the image information from the microprocessor; and a display for displaying the body temperature and the image respectively calculated and generated in the microprocessor, wherein the body temperature information and the image information are displayed when being measured, and also changes in body temperature and living body image with the passage of time are displayed using the body temperature information and the image information stored in the memory.

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