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Seoul, South Korea

Lee J.H.,Eulji General Hospital
The American journal of emergency medicine | Year: 2012

Instantaneous rigor as muscle stiffening occurring in the moment of death (or cardiac arrest) can be confused with rigor mortis. If trismus is caused by instantaneous rigor, orotracheal intubation is impossible and a surgical airway should be secured. Here, we report 2 patients who had emergency cricothyrotomy for trismus caused by instantaneous rigor. This case report aims to help physicians understand instantaneous rigor and to emphasize the importance of securing a surgical airway quickly on the occurrence of trismus. Copyright © 2012 Elsevier Inc. All rights reserved. Source

Kang J.Y.,Eulji General Hospital | Kim E.K.,Eulji General Hospital | Kim K.M.,Seoul National University
Korean Journal of Urology | Year: 2013

Purpose: We investigated the effects of mirodenafil, a phosphodiesterase-5 inhibitor developed in South Korea, on the female rat bladder in a partial bladder outlet obstruction (BOO) model. Materials and Methods: Thirty-six female Sprague-Dawley rats were divided into four groups: the control group, BOO without medication group, BOO with mirodenafil 1 mg/kg group, and BOO with mirodenafil 4 mg/kg group. Mirodenafil was administered orally for 2 weeks after the induction of BOO. Two weeks after BOO, the rats in each group underwent cystometry under urethane anesthesia. After cystometry, the bladder was excised to perform immunohistochemical staining for connexin 43. Results: The three BOO groups showed significant increases in mean bladder weight compared with the control group. Baseline pressure, threshold pressure, and maximum contraction pressure were not significantly different between the four groups. Although the contraction interval was decreased in all BOO groups compared with the control group, it was prolonged in the two groups treated with mirodenafil compared with the untreated BOO group. In the immunohistochemical examination, connexin 43 staining intensity in the lamina propria increased in the three BOO groups compared with the control group. The two groups treated with mirodenafil, however, showed decreased connexin 43 staining compared with the untreated BOO group. Conclusions: Mirodenafil may increase the contraction intervals of female rat bladders in a partial BOO model. Decreasing bladder overactivity by mirodenafil may be related to intracellular communication mechanisms involving connexin 43. © The Korean Urological Association, 2013. Source

Gopal R.,Chosun University | Kim Y.G.,Chosun University | Lee J.H.,Chosun University | Lee S.K.,Chosun University | And 4 more authors.
Antimicrobial Agents and Chemotherapy | Year: 2014

The increasing prevalence of drug-resistant pathogens highlights the need to identify novel antibiotics. Here we investigated the efficacies of four new antimicrobial peptides (AMPs) for potential drug development. The antibacterial activities, synergistic effects, and antibiofilm properties of the four chimeric AMPs were tested against Acinetobacter baumannii, an emerging Gram-negative, nosocomial, drug-resistant pathogen. Nineteen A. baumannii strains resistant to ampicillin, cefotaxime, ciprofloxacin, tobramycin, and erythromycin were isolated at a hospital from patients with cholelithiasis. All four peptides exhibited significant antibacterial effects (MIC = 3.12 to 12.5 μM) against all 19 strains, whereas five commercial antibiotics showed little or no activity against the same pathogens. An exception was polymyxin, which was effective against all of the strains tested. Each of the peptides showed synergy against one or more strains when administered in combination with cefotaxime, ciprofloxacin, or erythromycin. The peptides also exhibited an ability to prevent biofilm formation, which was not seen with cefotaxime, ciprofloxacin, or erythromycin, though polymyxin also inhibited biofilm formation. Indeed, when administered in combination with ciprofloxacin, the AMP HPMA exerted a potent synergistic effect against A. baumannii biofilm formation. Collectively, our findings indicate that the AMPs tested have no cytotoxicity but possess potent antibacterial and antibiofilm activities and may act synergistically with commercial antibiotics. Copyright © 2014, American Society for Microbiology. All Rights Reserved. Source

Kang K.,Eulji General Hospital | Kim Y.-J.,Seoul National University | Lee S.-H.,Seoul National University | Yoon B.-W.,Seoul National University
Neurological Research | Year: 2014

Objective: Application of lithium induces neurogenesis in the damaged brain in the global cerebral ischemia rat model. In a previous study of rats subjected to intracerebral hemorrhage (ICH), we have found that lithium treatment improves functional recovery and reduces acute brain swelling. In this follow-up study, we investigate whether the known beneficial effect of lithium on functional recovery after ICH can be explained by neurorestorative effect. Methods: Intracerebral hemorrhage was induced using infusion of collagenase into the striatum in adult rats. Rats were treated by intraperitoneal injection with lithium chloride (1, 2, or 4 mEq/kg/day) or saline for 2 weeks leading to and 2 weeks following ICH induction. From post-ICH days 4-14, 5-bromo-20- deoxyuridine (BrdU) was administered daily. At 2 weeks post-ICH, immunohistochemical staining was performed for BrdU and doublecortin (Dcx). Results: The neurological scores for lithium-treated rats improved significantly at 2 weeks post-ICH compared to saline-treated rats. In the subgranular zone (SGZ) and lateral subventricular zone (SVZ), numbers of BrdU-positive cells were not significantly different between the saline-treated and pooled lithium-treated groups. No significant differences in numbers of BrdU-positive cells in the SVZ were detected between the saline-treated and any of the lithium-treated groups. No significant differences in numbers of BrdU-positive cells in the SGZ were detected between the saline-treated and 1 mEq/kg lithium-treated group. Rats treated with ≥ 2 mEq/kg lithium had lower numbers of BrdU-positive cells in the SGZ than did rats treated with saline, although this difference was not statistically significant. Numbers of Dcx-positive cells in the medial striatum were not significantly different between the 1 mEq/kg lithium-treated and saline-treated groups. Conclusion: The present study shows that lithium does not enhance neurogenesis after ICH in rats, and high dose lithium suppresses neurogenesis in the SGZ. Functional recovery after ICH may be attributable to neuroprotective effect, not neuroregenerative effect of lithium. © W. S. Maney & Son Ltd 2014. Source

Yoo B.R.,Eulji University | Han H.Y.,Eulji University | Cho Y.K.,Eulji General Hospital | Park S.J.,Eulji University
Journal of Clinical Ultrasound | Year: 2012

Both middle colic artery (MCA) aneurysm and spontaneous dissection of the superior mesenteric artery (SMA) are rare. We report the first case of concomitancy of both conditions, diagnosed by ultrasonography and CT angiography. A 56-year-old man with abrupt abdominal pain and hypovolemic shock was diagnosed initially with ruptured MCA aneurysm by color Doppler ultrasonography. Computed tomography and angiography confirmed MCA aneurysm and showed that it was arising from the false lumen of an SMA dissection and was probably associated with segmental arterial mediolysis. The MCA aneurysm was treated successfully by transcatheter coil embolization, and the SMA dissection was treated conservatively. © 2012 Wiley Periodicals, Inc. Source

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