Euglena Co.

Tokyo, Japan

Euglena Co.

Tokyo, Japan
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Provided are a novel renal failure progression inhibitor, prophylactic agent for renal failure, and indoxyl sulfate production inhibitor, intended for human use, in particular, for a patient with renal failure. The renal failure progression inhibitor, prophylactic agent for renal failure, and indoxyl sulfate production inhibitor each comprises paramylon derived from Euglena or a processed product thereof as an active ingredient. In the case of the renal failure progression inhibitor, for example, paramylon is continuously orally administered to a patient suffering from chronic renal failure, undergoing a dialysis therapy, several times per day in a dose of 1 to 5 g per intake. In particular, the renal failure progression inhibitor is singly administered to the patient in a capsule or powdered preparation at a prescribed time interval before and after administration of other drugs.


Patent
Euglena Co. and Shimizu Corporation | Date: 2015-04-16

An algae culture method capable of efficiently producing an osmotic pressure adjusting substance, a production method of the substance, and an algae culture method for recovering carbon dioxide from a mixed gas containing carbon dioxide and sulfurous acid gas. The methods involve preparing a plurality of enrichment cultures each containing betaine by culturing a culture of microalgae derived from an environmental specimen under a photoautotrophic condition and under a plurality of culture conditions; making a cultivation plan in which an optimum enrichment culture suitable for a main culture is selected from the plurality of enrichment cultures; producing a main culture that contains betaine under the photoautotrophic condition and a salt concentration of 10 wt. % or more; and separating betaine. In the main culture, the algae containing betaine are cultured while the mixed gas containing sulfurous acid gas and carbon dioxide is blown to a culture solution of the algae.


Patent
Nippon Oil Corporation and Euglena Co. | Date: 2013-04-10

The present invention provides a production method for biofuel based on a technology to convert carbon-dioxide as a carbon source through photosynthesis by photosynthetic microorganisms to biomass and produce biofuel of the biomass. The production method for biofuel of the present invention comprises a culturing process (S1) of culturing in a culture solution photosynthetic microorganisms which store oils, fats and carbohydrates in cells of the photosynthetic microorganisms, an oil and fat conversion process (S2) of converting the carbohydrates stored in the cells of the photosynthetic microorganisms cultured in the culture apparatus to oils and fats, an extraction process (S3) of extracting the oils and fats out of the cells of the photosynthetic microorganisms, and a reforming process (S4) to reform the extracted oils and fats.


Patent
euglena Co. and Nippon Oil Corporation | Date: 2013-01-31

Provided is a method that is for producing Euglena having a high wax ester content, capable of more efficiently producing the Euglena having a high wax ester content by adding a nutrient before anaerobic fermentation to restore the efficiency of wax ester fermentation. The present invention relates to a method for producing Euglena having a high wax ester content. The main configuration of the method is that there is at least a first step of aerobically culturing microalga Euglena under nitrogen starvation conditions and a second step of holding the cells in an anaerobic state; and adding, before the second step, a nutrient source to the culture liquid which has passed through the first step.


Patent
Kinki University and Euglena Co. | Date: 2014-02-28

The present invention provides a method for introducing a gene into Euglena, which can stably maintain a foreign gene, and a transformant therefrom. In this method of introducing a gene into Euglena, a DNA fragment containing an amino acid sequence for encoding a protein is introduced into a Euglena cell. The method includes a step of producing a binary vector containing a DNA fragment, a step of obtaining a linear gene fragment that includes a T-DNA region including the DNA fragment in the binary vector, and a direct gene introduction step of directly introducing the linear gene fragment into the Euglena cell.


Patent
Euglena Co. | Date: 2015-04-08

The present invention provides a novel immune balance regulator that regulates an immune balance in a living body. The immune balance regulator contains a Euglena-derived material and regulates an immune balance between Th1, Th2, and Th17, which is a balance between immune responses individually induced by Th1, Th2, and Th17 in a living body. The immune balance regulator regulates the immune balance between Th1, Th2, and Th17 so that immune responses induced by Th1 become relatively dominant over immune responses induced by Th2 or Th17 to improve a physical constitution that has an immune imbalance of Th1, Th2, and Th17 shifted towards Th2 and to prevent or treat a disease associated with the immune imbalance of Th1, Th2, and Th17 shifted towards a Th2 dominance. The immune balance regulator is administered prior to expected onset of a disease associated with the immune imbalance of Th1, Th2, and Th17 shifted towards the Th2 dominance.


A -1,3-glucanase that exhibits decomposition activity with respect to paramylon derived from the genus Euglena. The -1,3-glucanase is derived from the genus Euglena and exhibits the properties indicated below: (1) effect: hydrolyzing the -1,3-bond of -1,3-glucan; and (2) substrate specificity: decomposing at least paramylon. The -1,3-glucanase additionally exhibits the properties indicated below: (3) decomposition activity: the ratio of paramylon decomposition activity with respect to laminarin decomposition activity is 20% or higher; (4) optimum pH: 3.7-7.0; and (5) optimum temperature: 30-70 C.


Provided is a method for producing a euglena highly containing a wax ester, comprising aerobically culturing a microalga euglena by photosynthesis using carbon dioxide as a carbon source, then further culturing the microalga euglena under nitrogen-starvation conditions to increase paramylon accumulation per cell, and subsequently putting the microalga euglena under anaerobic conditions, so that a euglena highly containing a wax ester can be produced; and a method for producing a wax ester. The present invention relates to a method for producing a euglena highly containing a wax ester. The method comprises a first step of aerobically culturing a microalga euglena, a second step of further culturing a medium under nitrogen-starvation conditions, and a third step of retaining the cells under anaerobic conditions.


Patent
Osaka Prefecture University and euglena Co. | Date: 2013-12-25

A Euglena carrying a foreign gene of interest in an expressible manner is provided. A Euglena carrying a drug resistance gene and a foreign gene of interest in an expressible manner.


A medium for culturing Euglena includes a cell membrane-permeable electron mediator that includes a biocompatible moiety and a redox-active moiety. A method for culturing Euglena includes culturing Euglena in a medium including a cell membrane-permeable electron mediator that includes a biocompatible moiety and a redox-active moiety. The medium is placed in a fermenter system that includes a device for extracting electrons from the medium. A method for reducing photoinhibition in Euglena includes electrochemically culturing Euglena in a medium including a cell membrane-permeable electron mediator that includes a biocompatible moiety and a redox-active moiety. The medium is placed in a fermenter system that includes a device for extracting electrons from the medium.

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