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Mangalore, India

Muthulakshmi A.,Vo Chidambaram College | Jothibai Margret R.,Pope s college | Mohan V.R.,Ethnopharmacology Unit
Journal of Applied Pharmaceutical Science | Year: 2012

Feronia elephantum belongs to the family Rutaceae is well known in Indian traditional system for its traditional uses. The present investigation was carried out to determine the possible bioactive components of leaves and bark of F. elephantum using GC-MS analysis. 18 components from leaves and 14 components from bark of the above said plant were identified. The prevailing compounds in the ethanol extract of leaves of F. elephantum were 7- Norbornadienyl t-butyl ether (17.26%), 2-isopropyl-5-methyl-1- heptanol (11.40%), 1- Octanol,2-butyl (8.47%), Phenol, 4-[2-(dimethylamino)-ethyl]- (4.56%), 2,3- Dimethylquinolin-4(1H)-one (3.58%), Ethyl iso-allocholate (1.63%). The ethanol extract of F. elephantum bark contained, 2-Propenenitrile, 3-(3.4-dimethoxyphenyl)-(60.72%) was found as major component followed by phenol, 4-(3-hydroxy-I-propenyl)-2-methoxy-(9.35%), 3-(2-NAcetyl- N-methylaminoethyl)indol (1.15%), cholesta-8,24-dine-3-ol, 4-methyl-(3a'- 4a')- (0.86%) as the major components. Source


Tresina P.S.,Ethnopharmacology Unit | Mohan V.R.,Ethnopharmacology Unit
International Journal of Food Science and Technology | Year: 2011

Effect of gamma irradiation on Vigna unguiculata subsp. unguiculata seeds (maroon-coloured seed coat) at various doses (2, 5, 10, 15 and 25kGy) on the physicochemical properties, proximate composition, vitamins (niacin and ascorbic acid) and antinutritional factors were analysed. No significant changes were recorded in the physicochemical properties of irradiated seeds. Gamma irradiation resulted in a significant increase in crude protein, while the crude lipid, crude fibre and ash contents resulted in a dose-dependent decrease. Gamma-irradiated seeds presented a significant decrease in the ascorbic acid and niacin content. Irradiation processing significantly reduced the level of L-DOPA, phytic acid, hydrogen cyanide, trypsin inhibitor activity, oligosaccharides and lectins. The total free phenolics, tannins and in vitro protein digestibility on irradiation showed a significant dose-dependent increase. Gamma irradiation seems to be a good procedure to improve the quality of legume seeds from the nutritional point of view. © 2011 The Authors. International Journal of Food Science and Technology © 2011 Institute of Food Science and Technology. Source


Kalidass C.,Ethnopharmacology Unit | Mohan V.R.,Ethnopharmacology Unit
Tropical and Subtropical Agroecosystems | Year: 2011

Five accessions of the underutilized legume itching bean (Mucuna pruriens (L.) DC.) var. pruriens), collected from five different agroclimatic regions in Western Ghats, Tamil Nadu, India were analysed for their proximate and mineral composition, vitamins (niacin and ascorbic acid), fatty acid profiles, amino acid profiles of total seed proteins, in vitro protein digestibility (IVPD) and certain antinutritional factors, to determine their potential as an alternative source to alleviate protein-energy-malnutrition among the people of Tamil Nadu. The crude protein ranged from 27.5 - 31.2%, crude lipid 6.6 - 8.8%, total dietary fibre 6.5 - 9.7%, ash 4.3 - 6.0% and carbohydrates 46.1 - 52.5%. The energy level of the seed (1576 - 1620 kJ100g -1 DM) was comparable with commonly consumed Indian pulses. The investigated seeds were rich in minerals such as Na, K, Ca, Mg and P. The fatty acid profiles revealed that the seed lipids contained higher concentrations of linoleic acid and palmitic acid. The essential amino acid profile of total seed proteins compared favourably with FAO/WHO (1991) requirement pattern, except that there were deficiencies of sulphur containing amino acids in all the five accessions. The IVPD of the five accessions ranged from 70.1 - 76.5%. The range of antinutritional factors were as follows: total free phenolics, 3.4 - 4.8%, tannins, 0.14 - 0.23%, L-Dopa, 5.4 - 7.0%, phytic acid, 478 - 648 mg100g -1, hydrogen cyanide, 0.24 - 0.38 mg100g -1 and trypsin inhibitor activity, 40.4 - 48.2 TIU mg -1 protein. Verbascose was the principal oligosaccharides in all accessions. Lower levels of phytohaemagglutinating activity for human erythrocytes of 'O' blood group than for 'A' and 'B' blood groups were found. The antinutritional fatty acid, behenic acid (1.28 - 2.74%) was also detected. Source


Nishanthini A.,Ethnopharmacology Unit | Mohan V.R.,Ethnopharmacology Unit
Asian Pacific Journal of Tropical Biomedicine | Year: 2012

Objective: To evaluate the total phenolic, flavonoid contents and in vitro antioxidant activity of methanol extract of Xanthosoma sagittifolium corm. Methods: Total phenolic content was estimated using the Folin Ciocalteu method. The flavonoid content was determined using aluminium chloride. In vitro antioxidant activities were evaluated by studying DPPH radical scavenging activity, hydroxyl radical scavenging activity, superoxide radical scavenging activity, ABTS radical cation scavenging activity and reducing power capacity were determined using standard procedure. Results: Xanthosoma sagittifolium corm exhibited 0.32g100g-1 total phenolic; 0.26g100g-1 flavonoid and better scavenging activity of DPPH (78.22±0.56%), hydroxyl radical (69.11±0.21%), superoxide radical (83.27±0.08%) and ABTS radical cations(76.11±0.07%). Conclusions: The present studies confirm the methanol extracts have potential in vitro antioxidant activity. © 2012 Asian Pacific Tropical Biomedical Magazine. Source


Murugan M.,Ethnopharmacology Unit | Mohan V.R.,Ethnopharmacology Unit
Asian Pacific Journal of Tropical Biomedicine | Year: 2012

Objective: To evaluate the total phenolic, flavonoid contents and in vitro antioxidant activity of methanol extract of Dioscorea esculenta (Lour). Burkill. Methods: Total phenolic content was estimated using the Folin Ciocalteu method. The flavonoid content was determined using aluminium chloride. In vitro antioxidant activities and reducing power capacity were determined using standard methods. Results: Total phenolic content in methanol extract of Dioscorea esculenta was found to be 0.79g/100g and flavonoids content was found to be 0.26 g/100g. The extract was screened for its potential antioxidant activities using tests such as DPPH radical scavenging activity, hydroxyl radical scavenging activity, superoxide radical scavenging activity, ABTS radical cation scavenging activity and reducing power activity. Conclusions: The present studies confirm the methanol extracts have potential in vitro antioxidant activity. The phytochemical phenols and flavonoids could be the reason for its antioxidant activity. © 2012 Asian Pacific Tropical Biomedical Magazine. Source

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