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Caroling G.,Ethiraj College for Women Autonomous | Tiwari S.K.,Ethiraj College for Women Autonomous | Mercy Ranjitham A.,Ethiraj College for Women Autonomous | Suja R.,Ethiraj College for Women Autonomous
Asian Journal of Pharmaceutical and Clinical Research | Year: 2013

OBJECTIVE- The synthesis of metal nanoparticles is a growing area of research due to its potentiality in the application and development of advanced technologies. In general, nanoparticles are synthesized by using chemical methods which are not eco-friendly. Vegetable mediated synthesis of nanoparticles is a green chemistry approach that connects the nanotechnology and biotechnology. In the present investigation we report a green chemistry approach, for the biological synthesis of silver nanoparticles using Broccoli floret aqueous extract under optimum conditions METHOD- Here we have used a fast, convenient and environment friendly method for the synthesis of silver nanoparticles by biologically reducing AgNO3 with aqueous extract of Broccoli florets (Brassica Oleracea L. var. Italica) under optimum conditions (pH-6-7). The formation of silver nanoparticles was indicated by the colour change from colourless to reddish brown. Biosynthesized nanoparticles were characterized by UV-VIS, FT-IR, XRD, SEM, TEM and EDAX analysis. The free radical scavenging activity was assessed by DPPH assay. These biologically synthesised Ag nanoparticles were tested for antimicrobial activity against four human pathogens viz. Klebsiella Pneumonia, Staphylococcus Saprophyticus, Bacillus Cereus and Escheria Coli. These nanoparticles were assessed further for cytotoxic activity on MCF-7 cell line. RESULT- The reduction process was simple and convenient to handle and monitored by UV-Vis spectroscopy which showed surface plasmon resonance at 425nm. The presence of active proteins and phenolic groups present in biomass before and after reduction was identified by FT-IR. The crystalline morphology and size of the nanoparticles were determined by TEM, SEM AND X-ray diffraction studies, which showed the average particle size of silver nanoparticles was in the range 40- 50nm as well as revealed their FCC structure. Presence of elemental silver was revealed by EDAX analysis. These biologically synthesised Ag nanoparticles were found to be effective in controlling growth of human pathogens viz. Klebsiella Pneumonia, Staphylococcus Saprophyticus and Escheria Coli. These nanoparticles showed high % toxicity against MCF-7 cell line. The reducing property of aqueous extract is due to the presence of antioxidant viz. ascorbic acid, polyphenols which is confirmed by quantitative assay and scavenging effect of free radicals proved by DPPH scavenging activity. CONCLUSION- The present investigation revealed that the fresh Broccoli floret aqueous extract is capable of producing silver nanoparticles that are quiet stable for 15 days at room temperature without any sign of precipitation.


Vidyalakshmi A.,Ethiraj College for Women Autonomous | Kruthika K.,Ethiraj College for Women Autonomous
Asian Pacific Journal of Tropical Biomedicine | Year: 2012

Objective: To test efficacy of Parmelia perlata (P. perlata), which is used in traditional medicine for rapid wound healing against test bacteria that cause wound infections. Methods: Different solvents such as methanol, ethyl acetate and acetone were used for extraction of P. perlata. The sensitivity of the test bacteria to solvent extracts of P. perlata was tested by measuring the zone of inhibition on growth media and by determining the minimal inhibitory concentration and minimal bactericidal concentration. Results: Methanol, ethyl acetate and acetone extracts of P. perlata have shown inhibitory activity against Staphylococcus aureus (S. aureus). Conclusions: The results of the present study indicate that P. perlata has potential antibacterial compounds against S. aureus that causes multitude of skin infections among human beings. Development of drugs from natural compounds can help us to combat antibiotic-resistant bacteria. © 2012 Asian Pacific Tropical Biomedical Magazine.


Mahalakshmi S.,SRM University | Mahalakshmi S.,Ethiraj College for Women Autonomous | SrinivasaManja K.,Pondicherry University | Nithiyanantham S.,Bharathidasan University
Journal of Materials Science: Materials in Electronics | Year: 2016

In the present investigation, copper nickel ferrites CuxNi(1−x)Fe2O4 (where x = 0.2, 0.4, 0.6) particles are prepared successfully through solid state reaction method with 0.5 % of Nd as added an dopant. The prepared samples were investigated; the structural and morphological studies show the presence of rare earth ion and their influence on the lattices at high sintered temperature at 850 °C which indicates smooth grains from SEM micro graph. Addition of rare earths, less percentage has affected the lattice which in turn shows the variation in lattice constant. Based on the results from XRD confirms the secondary phase observed in the peak. The structural properties are discussed with XRD and SEM analysis. The elemental analysis carried out by EDS. The electrical conductivity increases with increase in applied frequency, decreases in dielectric constant for all the compositions and reaches a constant value. The dielectric properties further interpreted with dielectric loss measurements. © 2016 Springer Science+Business Media New York


Jayanthi C.,Ethiraj College for Women Autonomous | Revathi K.,Ethiraj College for Women Autonomous
Biochemical and Cellular Archives | Year: 2016

The scope of the present work is to analyze the effect of SAAf 75% (Carbendazim 12% + Mancozeb 63%) on carbohydrate and glucose metabolism in fresh water fish Labeorohita(rohu) exposed to SAAf 75% for a period of 21 days. Preliminary acute toxicity tests were carried out to find the median lethal tolerance limit (LC50) of the fish to the pesticide mixture for 96hrs and 95% confidence limits were calculated. The 96hr LC50value for 75% was found to be 16.62 mg/L. One fortieth (0.41 mg/L)and one-twentieth (0.83 mg/L) value was taken as the two sub-lethal concentrations for the study. The fishes were maintained in two different sub-lethal concentrations for a period of 21 days anda control group was also maintained for the same period. An overall significant reduction (P < 0.01) was witnessed in the total carbohydrate and glucose content of all the tissues exposed to both the sub-lethal concentration when compared to the control group of fishes, at regular intervals of 7, 14, and 21 days.


Kothai S.,Ethiraj College for Women Autonomous | Jayanthi B.,Amjain College
International Journal of ChemTech Research | Year: 2015

Stingless beekeeping is very rare in Tamilnadu. Propolis of Stingless bees is a mixture of plant resins and bee secretions – it possesses a wide spectrum of medicinal properties. The chemical composition and the bio medical applications of stingless bee propolis vary depending on the geographicallocation of the region, itsClimate, season and the availability of the botanical sources from which the bees forage.This present study compares the impact of environment on the Total phenolic,Flavonoid contents and anti-bacterial activity of two stingless bee propolis sample, one reared from Pudukottai region of Tamilnadu and other one reared from the most commercial hub of Chennai region, namely Thyagarayar Nagar. Total polyphenol content of the Chennai sample is 10 μg/ml of Gallic acid equivalent (GAE) and the flavonoid content is 48μg /ml of Quercetin equivalent (QE). This is very low when compared to the pudukottai sample, total poly phenol of which is 150μg/ml of Gallic acid equivalent (GAE) and the flavonoid content is 6mg/g of Quercetin equivalent (QE). This is reflected in their antibacterial activity against different human pathogens also.This study shows the impact of highly polluted environment on the quality of the Chennai propolis sample and reveals that the environment is unsuitable for the existence of Stingless bees. © 2015 Sphinx Knowledge House. All Rights Reserved.


Gangadharan R.,Ethiraj College for Women Autonomous | Haribabu J.,National Institute of Technology Tiruchirappalli | Karvembu R.,National Institute of Technology Tiruchirappalli | Sethusankar K.,RKM Vivekananda College Autonomous
Acta Crystallographica Section E: Structure Reports Online | Year: 2014

In the title compound, C17H20ClN3OS, the mean plane of the central thiourea core makes dihedral angles of 26.56(9) and 47.62(12)° with the mean planes of the chromene moiety and the cyclohexyl ring, respectively. The cyclohexyl ring adopts a chair conformation. The N-H atoms of the thiourea unit adopt an anti conformation. The chromene group is positioned trans, whereas the cyclohexyl ring lies in the cis position to the thione S atom, with respect to the thiourea C-N bond. In the crystal, molecules are linked by N-H⋯S hydrogen bonds, forming inversion dimers enclosing R 22(8) ring motifs. The dimers are linked by C-H⋯Cl hydrogen bonds, enclosing R 66(44) ring motifs, forming sheets lying parallel to (010).


Gangadharan R.,Ethiraj College for Women Autonomous | Sethusankar K.,Rkm Vivekananda College Autonomous | Murugan G.,University of Madras | Bakthadoss M.,University of Madras
Acta Crystallographica Section E: Structure Reports Online | Year: 2011

In the title compound, C22H18N2O 2, the pyran ring of the chromene unit is fused with an isoxazole ring, which adopts an N-envelope conformation with the N atom lying 1.3291 (14) Å from the mean plane of the remaining ring atoms [maximum deviation = 0.341 (2) Å]. The dihedral angle between the isoxazole and chromene units is 43.74 (8)° and that between the iosxazole ring and the naphthalene ring system is 58.82 (8)°. In the crystal, the molecules are linked by weak C - H⋯π interactions.


Kothai S.,Ethiraj College for Women Autonomous | Jayanthi B.,Amjain College
International Journal of ChemTech Research | Year: 2014

Ultrasonic waves appear as an interesting way to improve process productivity.The present study reports a facileultrasonicsintensified greensynthesis of silver nano particles from the extract of Camellia Sinensisfortified with lemon and honey. The extract is acting both as reducing agentas well as capping agent.The synthesized silver nano particles have been characterized by UV-Vis spectroscopy, Scanning Electron Microscopy(SEM) and Energy Dispersive X-ray (EDX) Analysis. The active organic groups responsible for the reduction of Ag+ ions to elemental silver were identified by Fourier Transform Infrared spectroscopy(FT-IR).The effect of ultrasound on the reduction reaction rate was found andwas found to get enhanced with ultrasonic irradiation.Polydispersity of synthesized silver nano particles is minimized and alsocontrolled by ultrasonication method. This novel method is rapid, facile and combines the advantage of both sonochemistry and green chemistry.


PubMed | RKM Vivekananda College Autonomous, Ethiraj College for Women Autonomous and University of Madras
Type: Journal Article | Journal: Acta crystallographica. Section E, Crystallographic communications | Year: 2016

The three title compounds, C


PubMed | RKM Vivekananda College Autonomous, National Institute of Technology Tiruchirappalli and Ethiraj College for Women Autonomous
Type: Journal Article | Journal: Acta crystallographica. Section E, Crystallographic communications | Year: 2016

In the asymmetric unit of the title compound, C16H17N3O2S, there are two independent mol-ecules (A and B), which show an E conformation with respect to the C=N bond. An intra-molecular O-HN hydrogen bond with an S(6) motif stabilizes the mol-ecular structure. The terminal phenyl and benzene rings are almost orthogonal to each other, the dihedral angle being 87.47(13) for mol-ecule A and 89.86(17) for mol-ecule B. In the crystal, weak bifurcated N-H(O,O) hydrogen bonds link the two independent mol-ecules, forming a supra-molecular chain with a C (2) 1(14)[R (2) 1(5)] motif along the b axis. A weak C-HO inter-action is also observed in the chain.

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