Zurich, Switzerland
Zurich, Switzerland

ETH Zürich is an engineering, science, technology, mathematics and management university in the city of Zürich, Switzerland. Like its sister institution Swiss Federal Institute of Technology in Lausanne , it is an integral part of the Swiss Federal Institutes of Technology Domain that is directly subordinate to Switzerland's Federal Department of Economic Affairs, Education and Research.ETH Zürich is consistently rated among the top universities in the world. It is currently ranked 4th in Europe overall, and 3rd best university in the world in engineering, science and technology. Twenty-one Nobel Prizes have been awarded to students or professors of the Institute in the past, the most famous of which is Albert Einstein in 1921, and the most recent is Richard F. Heck in 2010. It is a founding member of the IDEA League and the International Alliance of Research Universities and a member of the CESAER network.The school was founded by the Swiss Federal Government in 1854 with the stated mission to educate engineers and scientists, serve as a national center of excellence in science and technology and provide a hub for interaction between the scientific community and industry. Wikipedia.

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The present invention relates to a recombinant polynucleotide encoding a polygene coding for at least three polypeptides wherein at least one of the genes constituting the polygene is of non-viral origin, at least two of the polypeptides encoded by the genes constituting the polygene are each capable of at least transiently interacting with at least one other polypeptide encoded by a gene of said polygene, and the genes constituting the polygene are each connected to one another by a sequence coding for at least one protease cleavage site. The present invention also relates to polyproteins encoded by the polygene. Further embodiments of the present invention are a vector containing the recombinant polypeptide, a host cell containing the recombinant polypeptide and/or the vector and a non-human transgenic animal transformed with the recombinant polypeptide and/or the vector. The present invention also relates to methods for the production of the polynucleotide and for the manufacture of multiprotein complexes. The embodiments of the present invention are particularly useful in gene therapy, drug candidate screening, vaccine production and crystallisation of multiprotein complexes for structural investigations.

The present invention relates to a method for the production of a library comprising recombinant derivatives of the SH3 domain of the Fyn kinase of SEQ ID NO: 1 as well as a method for selecting from a library comprising recombinant derivatives of the SH3 domain of the Fyn kinase of SEQ ID NO: 1 one or more of said derivatives having a specific binding affinity to a protein or peptide.

Realistic ultrasound imaging simulation requires modeling of scatterers corresponding to different imaging speckle appearances. A scatterer generator acquires a plurality of ultrasound signal samples, each corresponding to a different ultrasound capture and reconstructs a scatterer representation from the ultrasound signal samples and associated Point Spread Functions. Point Spread Functions (PSFs) may be estimated from multiple image acquisitions at the same reference position resulting from beam-steering. Reconstructed scatterers may then directly be used in ultrasound simulation or an additional step of modeling the scatterers may be applied. Statistical distribution parametrization or texture synthesis may be used to model the scatterers. Different scatterer models may be used for different homogeneous regions. The reconstructed scatterers and/or the scatterer models may be registered into a library of scatterers by the scatterer generator.

ETH Zurich | Date: 2017-03-01

A hand-held medical ultrasound apparatus (10), in particular for ultrasound computed tomography of the breast, comprises an ultrasound transducer (1), a reflector (2) and an indicator (311,321, 312) enabling the indication of a relative position and/or orientation between the transducer and the reflector. In a first embodiment, the transducer and the reflector are attached to a mechanical structure comprising a first frame (33) and a second frame (34), which allow to adjust the distance (d) between the transducer and the reflector in order to adapt to the shape of the breast. In a second embodiment, the tranducer and the reflector are not mechanically connected and a position and/or orientation sensor is provided to determine a relative position and/or orientation between the transducer and the reflector. In a third embodiment, thin resonant reflector layers are applied to introduce acoustic signatures in the tracked reflector signals.

A method for manufacturing a three-dimensional object (16) comprises the steps of (a) bringing at least one nozzle (15a) in a first position close to a surface (12a) of a substrate (12), (b) delivering through said at least one nozzle (15a) at least one reactant (17) to said surface (12a), (c) effecting a solid forming reaction of said at least one delivered reactant (17) such that said at least one delivered reactant (17) undergoes a transition to become a growing solid deposit (16) on said surface (12a) under said at least one nozzle (15a), and (d) detecting an interaction of said growing solid deposit (16) with said at least one nozzle (15a).

ETH Zurich | Date: 2017-03-08

The invention relates to a method for treatment of cellulose-based material comprising a coupling step and a hydrophobization step. The coupling step comprises the provision of a coupling solution comprising titanium(IV) isopropoxide (TTIP) or a basic solution of zinc oxide and the immersion of the cellulose-based material into the coupling solution. The following hydrophobization step comprises the provision of a hydrophobization solution comprising a hydrophobic compound and the immersion of the cellulose-based material in the hydrophobization solution, yielding a hydrophobic cellulose-based material, followed by drying of the hydrophobic cellulose-based material. According to a second aspect of the invention a cellulose-based material is provided characterized by its omniphobic properties, a cellulose-TTIP hybrid layer and/or ZnO hybrid layer.

Prins R.,ETH Zurich
Chemical Reviews | Year: 2012

An overview of articles that were written on the topic of spillover after 1996 is presented. A direct measure of H spillover was exchange between species adsorbed on the support and those in the gas phase. It is shown that hydrogen spillover onto the surface of a defect-free nonreducible support is energetically improbable and that H-D exchange of OH groups on such a support provides no proof of spillover. The overview discusses spillover from metal particles to insulating supports and to defects on such insulators. Spillover of hydrogen from metal particles on a reducible M xO y support can lead to full or partial reduction of the support. Hydrogen spillover means that a hydrogen atom goes from the metal surface to the support surface and that a strong M-H bond is broken.

Hilvert D.,ETH Zurich
Annual Review of Biochemistry | Year: 2013

Diverse engineering strategies have been developed to create enzymes with novel catalytic activities. Among these, computational approaches hold particular promise. Enzymes have been computationally designed to promote several nonbiological reactions, including a Diels-Alder cycloaddition, proton transfer, multistep retroaldol transformations, and metal-dependent hydrolysis of phosphotriesters. Although their efficiencies (kcat/KM =0.1-100 M -1 s-1) are typically low compared with those of the best natural enzymes (106-108 M-1 s-1), these catalysts are excellent starting points for laboratory evolution. This review surveys recent progress in combining computational and evolutionary approaches to enzyme design, together with insights into enzyme function gained from studies of the engineered catalysts. © 2013 by Annual Reviews. All rights reserved.

Benenson Y.,ETH Zurich
Nature Reviews Genetics | Year: 2012

The task of information processing, or computation, can be performed by natural and man-made 'devices'. Man-made computers are made from silicon chips, whereas natural 'computers', such as the brain, use cells and molecules. Computation also occurs on a much smaller scale in regulatory and signalling pathways in individual cells and even within single biomolecules. Indeed, much of what we recognize as life results from the remarkable capacity of biological building blocks to compute in highly sophisticated ways. Rational design and engineering of biological computing systems can greatly enhance our ability to study and to control biological systems. Potential applications include tissue engineering and regeneration and medical treatments. This Review introduces key concepts and discusses recent progress that has been made in biomolecular computing. © 2012 Macmillan Publishers Limited. All rights reserved.

Haller G.,ETH Zurich
Annual Review of Fluid Mechanics | Year: 2015

Typical fluid particle trajectories are sensitive to changes in their initial conditions. This makes the assessment of flow models and observations from individual tracer samples unreliable. Behind complex and sensitive tracer patterns, however, there exists a robust skeleton of material surfaces, Lagrangian coherent structures (LCSs), shaping those patterns. Free from the uncertainties of single trajectories, LCSs frame, quantify, and even forecast key aspects of material transport. Several diagnostic quantities have been proposed to visualize LCSs. More recent mathematical approaches identify LCSs precisely through their impact on fluid deformation. This review focuses on the latter developments, illustrating their applications to geophysical fluid dynamics. Copyright © 2015 by Annual Reviews. All rights reserved.

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