Zurich, Switzerland
Zurich, Switzerland

ETH Zürich is an engineering, science, technology, mathematics and management university in the city of Zürich, Switzerland. Like its sister institution Swiss Federal Institute of Technology in Lausanne , it is an integral part of the Swiss Federal Institutes of Technology Domain that is directly subordinate to Switzerland's Federal Department of Economic Affairs, Education and Research.ETH Zürich is consistently rated among the top universities in the world. It is currently ranked 4th in Europe overall, and 3rd best university in the world in engineering, science and technology. Twenty-one Nobel Prizes have been awarded to students or professors of the Institute in the past, the most famous of which is Albert Einstein in 1921, and the most recent is Richard F. Heck in 2010. It is a founding member of the IDEA League and the International Alliance of Research Universities and a member of the CESAER network.The school was founded by the Swiss Federal Government in 1854 with the stated mission to educate engineers and scientists, serve as a national center of excellence in science and technology and provide a hub for interaction between the scientific community and industry. Wikipedia.


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The invention relates to a mineralized wood material comprising at least one metal salt MA in the lumina of the mineralized wood material, in particular in the lumina and the cell walls of the mineralized wood material and methods for providing said mineralized wood material.


The present invention relates to a recombinant polynucleotide encoding a polygene coding for at least three polypeptides wherein at least one of the genes constituting the polygene is of non-viral origin, at least two of the polypeptides encoded by the genes constituting the polygene are each capable of at least transiently interacting with at least one other polypeptide encoded by a gene of said polygene, and the genes constituting the polygene are each connected to one another by a sequence coding for at least one protease cleavage site. The present invention also relates to polyproteins encoded by the polygene. Further embodiments of the present invention are a vector containing the recombinant polypeptide, a host cell containing the recombinant polypeptide and/or the vector and a non-human transgenic animal transformed with the recombinant polypeptide and/or the vector. The present invention also relates to methods for the production of the polynucleotide and for the manufacture of multiprotein complexes. The embodiments of the present invention are particularly useful in gene therapy, drug candidate screening, vaccine production and crystallisation of multiprotein complexes for structural investigations.


The present invention relates to a method for the production of a library comprising recombinant derivatives of the SH3 domain of the Fyn kinase of SEQ ID NO: 1 as well as a method for selecting from a library comprising recombinant derivatives of the SH3 domain of the Fyn kinase of SEQ ID NO: 1 one or more of said derivatives having a specific binding affinity to a protein or peptide.


A method to measure the vibrational characteristics of an oscillating system (1) uses a control system (6, 7a, 7b, 7c). The oscillating system comprises a resonator, at least one vibration exciter and at least one sensor. The resonator is excited by the vibration exciter, and the motion of the resonator is measured by the sensor. The control system uses the sensor to control the motion of the resonator by the vibration exciter. The motion of the resonator is a superposition of at least two harmonic motions, and the control system comprises at least two subcontrollers (7a, 7b, 7c). Each harmonic motion is controlled independently by one of the subcontrollers. The harmonic motions are controlled by the subcontrollers simultaneously. A corresponding device is also disclosed.


Patent
ETH Zurich | Date: 2015-02-06

A method for the generation of oligomers or a mixture of oligomers to form a chemical library by amide-forming oligomerization comprises the steps of 1) reacting a mixture of at initiator (I) with monomer (M) to form a dimer of the initiator (I) and the monomer (M) or a pre-oligomer with an initiator (I) attached to a chain of more than one monomer (M) or a mixture thereof by amide-bond formation; 2) optionally adding at least one terminator (T) for the formation of a linear oligomer or a mixture of linear oligomers by amide-bond formation; or, for the formation of a cyclic oligomer or a mixture of cyclic oligomers by amide-bond formation, changing the reaction conditions relative to step 1) so as to form a linking covalent bond between the at least one initiator (I).


Realistic ultrasound imaging simulation requires modeling of scatterers corresponding to different imaging speckle appearances. A scatterer generator acquires a plurality of ultrasound signal samples, each corresponding to a different ultrasound capture and reconstructs a scatterer representation from the ultrasound signal samples and associated Point Spread Functions. Point Spread Functions (PSFs) may be estimated from multiple image acquisitions at the same reference position resulting from beam-steering. Reconstructed scatterers may then directly be used in ultrasound simulation or an additional step of modeling the scatterers may be applied. Statistical distribution parametrization or texture synthesis may be used to model the scatterers. Different scatterer models may be used for different homogeneous regions. The reconstructed scatterers and/or the scatterer models may be registered into a library of scatterers by the scatterer generator.


Patent
ETH Zurich | Date: 2017-03-01

A hand-held medical ultrasound apparatus (10), in particular for ultrasound computed tomography of the breast, comprises an ultrasound transducer (1), a reflector (2) and an indicator (311,321, 312) enabling the indication of a relative position and/or orientation between the transducer and the reflector. In a first embodiment, the transducer and the reflector are attached to a mechanical structure comprising a first frame (33) and a second frame (34), which allow to adjust the distance (d) between the transducer and the reflector in order to adapt to the shape of the breast. In a second embodiment, the tranducer and the reflector are not mechanically connected and a position and/or orientation sensor is provided to determine a relative position and/or orientation between the transducer and the reflector. In a third embodiment, thin resonant reflector layers are applied to introduce acoustic signatures in the tracked reflector signals.


A method for manufacturing a three-dimensional object (16) comprises the steps of (a) bringing at least one nozzle (15a) in a first position close to a surface (12a) of a substrate (12), (b) delivering through said at least one nozzle (15a) at least one reactant (17) to said surface (12a), (c) effecting a solid forming reaction of said at least one delivered reactant (17) such that said at least one delivered reactant (17) undergoes a transition to become a growing solid deposit (16) on said surface (12a) under said at least one nozzle (15a), and (d) detecting an interaction of said growing solid deposit (16) with said at least one nozzle (15a).


Patent
ETH Zurich | Date: 2017-03-08

The invention relates to a method for treatment of cellulose-based material comprising a coupling step and a hydrophobization step. The coupling step comprises the provision of a coupling solution comprising titanium(IV) isopropoxide (TTIP) or a basic solution of zinc oxide and the immersion of the cellulose-based material into the coupling solution. The following hydrophobization step comprises the provision of a hydrophobization solution comprising a hydrophobic compound and the immersion of the cellulose-based material in the hydrophobization solution, yielding a hydrophobic cellulose-based material, followed by drying of the hydrophobic cellulose-based material. According to a second aspect of the invention a cellulose-based material is provided characterized by its omniphobic properties, a cellulose-TTIP hybrid layer and/or ZnO hybrid layer.


Patent
ETH Zurich | Date: 2017-01-25

The present invention relates to a thermal storage system (10) comprising at least two heat storage modules (1, 2, 3),wherein at least one of the heat storage modules is at least one thermochemical storage module (2), which is spatially separated from the at least one further heat storage module (1, 2, 3), wherein the at least two heat storage modules (1, 2, 3) are provided in series such that each heat storage module (1, 2, 3) is passed by the at least one heat transfer fluid. The invention also relates to a method for storing heat and releasing heat using said storage system.


A device for measuring the elastic deformability of soft tissue (5) comprises a probe (1) with a port and a probe channel (13), the port being configured to be attached to a pressure unit that provides a vacuum and the probe channel (13) being arranged in a housing (16). The housing (16) extends beyond the probe (1) along a distal direction and has a lower closed loop surface (17) so as to form a cavity (19). The probe channel (13) is in connection with the pressure unit and extends preferably partly into the cavity (19) along the distal direction. A plug (110, 127) is displaceably arranged within the cavity (19). The plug (110, 127) is displaceable along a proximal direction towards a distal end (14) of the probe channel (13) when the housing (16) is attached to the soft tissue (5). The plug (110, 127) completely covers the distal end (14) of the probe channel (13) when the housing (16) is attached to the soft tissue (5) in a final position.


Patent
ETH Zurich | Date: 2017-03-01

A thermal interface element (200) comprising a thermal interface material (100) and a circulating fluid (4). The thermal interface material (100) comprises a first graphene sheet (1), a second graphene sheet (2), and an array of carbon nanotubes (3). The array of carbon nanotubes (3) is arranged between the first graphene sheet (1) and the second graphene sheet (2), such that the carbon nanotubes of the array (3) are in thermal contact with the first graphene sheet (1) and the second graphene sheet (2). The circulating fluid (4) is in fluid communication with the array of carbon nanotubes (3).


The transparency control method (100) for robotic devices where a master dynamics (91) controls a slave dynamics (81) to minimize interaction forces and/or lag, comprising feedback controllers (202, 203) and a feedforward controller (204) connected with the slave dynamics (81). The master (91) is configured to provide a master acceleration value (92) as input for the feedforward controller (204) and also to the feedback controller (203), and the slave (81) is configured to provide a slave acceleration value (82) as input for the feedback controller (203), wherein the two acceleration values are subtracted one from the other. The outputs of the slave dynamics (81) as well as of the master dynamics (91) are also connected with a state estimator module (201) providing an estimated interaction force value (51) as input for a force feedback controller (202).


Patent
ETH Zurich | Date: 2017-03-08

The invention relates to a method for treatment of wood material. In a first treatment step comprises the provision of a solution comprising zinc oxide or titanium(IV) isopropoxide and immersion of the wood material into the solution. After drying of the wood material a second treatment step is following in case of the first solution comprising zinc oxide. The second treatment step comprises the provision of a solution comprising a zinc compound and immersion of the wood material from the first treatment step into the solution followed by drying of the wood material. In a second aspect the invention relates to a wood material characterized by the visibility of the natural appearance of the surface and at least one other property relating to UV resistance, weathering resistance, mechanical resistance or hydrophobic properties.


Patent
ETH Zurich | Date: 2017-04-19

The invention relates to a pointing device (1) for controlling an apparatus, wherein the pointing device (1) comprises a chamber (2) comprising a cavity (21), an elastomer (3), which is arranged in the cavity (21) in order to provide a restoring force, and a manipulation member (4) having a manipulation section (41) and an embedded section (42), wherein the manipulation section (41) and the embedded section (42) are positioned along a longitudinal axis (5) of the manipulation member (4), and the embedded section (42) is positioned in the cavity (21) and embedded by the elastomer (3), wherein the elastomer (3) essentially fills the cavity (21). The invention further relates to a method for manufacturing a pointing device (1) according to the present invention and a method for controlling an apparatus by means of a pointing device (1) according to the present invention.


The present invention is notably directed to a computerized method for providing real-time feedback to a user from states of a model physical system, or MPS, via a computerized system comprising one or more processors and a user interface system, or UIS. The method comprises the following steps, each performed via the one or more processors. Configuration inputs are repeatedly received, to modify a configuration of the MPS, said inputs including user inputs received via said UIS. While receiving said configuration inputs: configurations of the MPS are updated based on the configuration inputs received; and a state of the MPS is repeatedly computed, whereby each computed state corresponds to a latest updated configuration that was available before starting to compute said each computed state. While repeatedly computing a state of the MPS: a surrogate function is obtained, upon completion of each computation, which surrogate function approximates a function of said each computed state; and at least one type of feedback is repeatedly provided via the UIS in respect to said user inputs received. Said at least one type of feedback is provided by sampling the configurations being updated and by evaluating a last surrogate function obtained, and/or a function derived from it, according to the sampled configurations, at a frequency compatible with real-time user-interactivity. The present invention is further directed to related computerized systems and computer program products.


D'Souza R.M.,University of California at Davis | Nagler J.,ETH Zurich
Nature Physics | Year: 2015

The emergence of large-scale connectivity on an underlying network or lattice, the so-called percolation transition, has a profound impact on the system's macroscopic behaviours. There is thus great interest in controlling the location of the percolation transition to either enhance or delay its onset and, more generally, in understanding the consequences of such control interventions. Here we review explosive percolation, the sudden emergence of large-scale connectivity that results from repeated, small interventions designed to delay the percolation transition. These transitions exhibit drastic, unanticipated and exciting consequences that make explosive percolation an emerging paradigm for modelling real-world systems ranging from social networks to nanotubes. © 2015 Macmillan Publishers Limited. All rights reserved.


Corti D.,Institute for Research in Biomedicine IRB | Corti D.,Humabs Biomedical SA | Lanzavecchia A.,Institute for Research in Biomedicine IRB | Lanzavecchia A.,ETH Zurich
Annual Review of Immunology | Year: 2013

A fascinating aspect of viral evolution relates to the ability of viruses to escape the adaptive immune response. The widely held view has been that the great variability of viral glycoproteins would be an absolute obstacle to the development of antibody-based therapies or vaccines that could confer broad and long-lasting protection. In the past five years, new approaches have been developed to interrogate human memory B cells and plasma cells with high efficiency and to isolate several broadly neutralizing antiviral antibodies against highly variable pathogens such as HIV-1 and influenza virus. These antibodies not only provide new tools for prophylaxis and therapy for viral diseases but also identify conserved epitopes that may be used to design new vaccines capable of conferring broader protection. © Copyright 2013 by Annual Reviews. All rights reserved.


Ackermann M.,ETH Zurich | Ackermann M.,Eawag - Swiss Federal Institute of Aquatic Science and Technology
Nature Reviews Microbiology | Year: 2015

Most microbial communities consist of a genetically diverse assembly of different organisms, and the level of genetic diversity plays an important part in community properties and functions. However, biological diversity also arises at a lower level of biological organization, between genetically identical cells that reside in the same microenvironment. In this Review, I outline the molecular mechanisms responsible for phenotypic heterogeneity and discuss how phenotypic heterogeneity allows genotypes to persist in fluctuating environments. I also describe how it promotes interactions between phenotypic subpopulations in clonal groups, providing microbial groups with new functionality. © 2015 Macmillan Publishers Limited. All rights reserved.


Cheng Z.,Kraft Foods Inc. | Ristow M.,ETH Zurich
Antioxidants and Redox Signaling | Year: 2013

Mitochondrial function is fundamental to metabolic homeostasis. In addition to converting the nutrient flux into the energy molecule ATP, the mitochondria generate intermediates for biosynthesis and reactive oxygen species (ROS) that serve as a secondary messenger to mediate signal transduction and metabolism. Alterations of mitochondrial function, dynamics, and biogenesis have been observed in various metabolic disorders, including aging, cancer, diabetes, and obesity. However, the mechanisms responsible for mitochondrial changes and the pathways leading to metabolic disorders remain to be defined. In the last few years, tremendous efforts have been devoted to addressing these complex questions and led to a significant progress. In a timely manner, the Forum on Mitochondria and Metabolic Homeostasis intends to document the latest findings in both the original research article and review articles, with the focus on addressing three major complex issues: (1) mitochondria and mitochondrial oxidants in aging-the oxidant theory (including mitochondrial ROS) being revisited by a hyperfunction hypothesis and a novel role of SMRT in mitochondrion-mediated aging process being discussed; (2) impaired mitochondrial capacity (e.g., fatty acid oxidation and oxidative phosphorylation [OXPHOS] for ATP synthesis) and plasticity (e.g., the response to endocrine and metabolic challenges, and to calorie restriction) in diabetes and obesity; (3) mitochondrial energy adaption in cancer progression-a new view being provided for H+-ATP synthase in regulating cell cycle and proliferation by mediating mitochondrial OXPHOS, oxidant production, and cell death signaling. It is anticipated that this timely Forum will advance our understanding of mitochondrial dysfunction in metabolic disorders. Antioxid. Redox Signal. 19, 240-242. © 2013, Mary Ann Liebert, Inc.


Alexander J.M.,ETH Zurich | Diez J.M.,University of California at Riverside | Levine J.M.,ETH Zurich
Nature | Year: 2015

Understanding how species respond to climate change is critical for forecasting the future dynamics and distribution of pests, diseases and biological diversity. Although ecologists have long acknowledged species' direct physiological and demographic responses to climate, more recent work suggests that these direct responses can be overwhelmed by indirect effects mediated via other interacting community members. Theory suggests that some of the most dramatic impacts of community change will probably arise through the assembly of novel species combinations after asynchronous migrations with climate. Empirical tests of this prediction are rare, as existing work focuses on the effects of changing interactions between competitors that co-occur today. To explore how species' responses to climate warming depend on how their competitors migrate to track climate, we transplanted alpine plant species and intact plant communities along a climate gradient in the Swiss Alps. Here we show that when alpine plants were transplanted to warmer climates to simulate a migration failure, their performance was strongly reduced by novel competitors that could migrate upwards from lower elevation; these effects generally exceeded the impact of warming on competition with current competitors. In contrast, when we grew the focal plants under their current climate to simulate climate tracking, a shift in the competitive environment to novel high-elevation competitors had little to no effect. This asymmetry in the importance of changing competitor identity at the leading versus trailing range edges is best explained by the degree of functional similarity between current and novel competitors. We conclude that accounting for novel competitive interactions may be essential to predict species' responses to climate change accurately. © 2015 Macmillan Publishers Limited.


Ritsch H.,University of Innsbruck | Domokos P.,Hungarian Academy of Sciences | Brennecke F.,ETH Zurich | Esslinger T.,ETH Zurich
Reviews of Modern Physics | Year: 2013

This is a review of state-of-the-art theory and experiment of the motion of cold and ultracold atoms coupled to the radiation field within a high-finesse optical resonator in the dispersive regime of the atom-field interaction with small internal excitation. The optical dipole force on the atoms together with the backaction of atomic motion onto the light field gives rise to a complex nonlinear coupled dynamics. As the resonator constitutes an open driven and damped system, the dynamics is nonconservative and in general enables cooling and confining the motion of polarizable particles. In addition the emitted cavity field allows for real-time monitoring of the particle's position with minimal perturbation up to subwavelength accuracy. For many-body systems, the resonator field mediates controllable long-range atom-atom interactions, which set the stage for collective phenomena. Besides the correlated motion of distant particles, one finds critical behavior and nonequilibrium phase transitions between states of different atomic order in conjunction with superradiant light scattering. Quantum-degenerate gases inside optical resonators can be used to emulate optomechanics as well as novel quantum phases such as supersolids and spin glasses. Nonequilibrium quantum phase transitions as predicted by, e.g., the Dicke Hamiltonian can be controlled and explored in real time via monitoring the cavity field. In combination with optical lattices, the cavity field can be utilized for nondestructive probing Hubbard physics and tailoring long-range interactions for ultracold quantum systems. © 2013 American Physical Society.


Zeeman S.C.,ETH Zurich | Kossmann J.,Stellenbosch University | Smith A.M.,John Innes Center
Annual Review of Plant Biology | Year: 2010

Starch is the most widespread and abundant storage carbohydrate in plants. We depend upon starch for our nutrition, exploit its unique properties in industry, and use it as a feedstock for bioethanol production. Here, we review recent advances in research in three key areas. First, we assess progress in identifying the enzymatic machinery required for the synthesis of amylopectin, the glucose polymer responsible for the insoluble nature of starch. Second, we discuss the pathways of starch degradation, focusing on the emerging role of transient glucan phosphorylation in plastids as a mechanism for solubilizing the surface of the starch granule. We contrast this pathway in leaves with the degradation of starch in the endosperm of germinated cereal seeds. Third, we consider the evolution of starch biosynthesis in plants from the ancestral ability to make glycogen. Finally, we discuss how this basic knowledge has been utilized to improve and diversify starch crops. Copyright © 2010 by Annual Reviews. All rights reserved.


Patent
Sinvent AS, University of Groningen and ETH Zurich | Date: 2013-01-25

The present invention relates to a nucleic acid molecule, which encodes a polypeptide having alcohol dehydrogenase activity, in particular methanol dehydrogenase activity, comprising having a nucleotide sequence selected from the group consisting of: (i) a nucleotide sequence as set forth in any one of SEQ ID NOs: 1 (mdh2-MGA3), 3 (mdh3-MGA3), or 5 (mdh2-PB1); (ii) a nucleotide sequence having at least 90% sequence identity, more particularly at least 91, 92, 93, 94, 95, 96, 97, 98 or 99% sequence identity, with a nucleotide sequence as set forth in any one of SEQ ID NOs: 1, 3 or 5; (iii) a nucleotide sequence which is degenerate with any one of the nucleotide sequences of SEQ ID NOs: 1, 3 or 5; (iv) a nucleotide sequence which is a part of the nucleotide sequence of any one of SEQ ID NOs: 1, 3 or 5, or of a nucleotide sequence which is degenerate with a sequence of SEQ ID NOs: 1, 3 or 5; (v) a nucleotide sequence encoding all or part of a polypeptide whose amino acid sequence is set forth in any one of SEQ ID NOs: 2 (Mdh2-MGA3), 4 (Mdh3-MGA3) or 6 (Mdh2-PB1); and (vi) a nucleotide sequence encoding all or part of a polypeptide which has an amino acid sequence having at least 90% sequence identity, preferably at least 91, 92, 93, 94, 95, 96, 97, 98 or 99% sequence identity, with an amino acid sequence as set forth in any one of SEQ ID NOs: 2, 4 or 6; or a nucleic acid molecule comprising a nucleotide sequence which is complementary to the nucleotide sequence of any one of (i) to (vi). Also provided are recombinant constructs, vectors and host cells comprising such a nucleic acid molecule and polypeptides encoded thereby. Such molecules may advantageously be used in the genetic modification of host cells, for example to introduce or modify methanol dehydrogenase activity.


Grant
Agency: Cordis | Branch: FP7 | Program: CP | Phase: ENERGY.2009.8.1.1 | Award Amount: 8.47M | Year: 2010

Primary aluminium production industry is the worlds larger industrial consumer of energy and ranked among the most CO2 intensive industries. It also generates enormous quantities of wastes that further decrease the exergy efficiency of its production process. However, this industry is one of the most vital sectors from economic and social point of view, not only for EU but also for the entire world. In order to remain viable and competitive, primary aluminium industry has to operate in a smarter way, be more energy efficient and meet the environmental requirements of our times. This can be achieved only through radical new technologies and novel business strategies, which will enable the industry to maintain its competitiveness and fasten its viability in the worlds markets, and explore new business opportunities. The main goal of this project is to provide primary aluminium industry with green innovative technological and economical solutions, focusing on the: (i) significant improvement of energy and exergy efficiencies of the production process; (ii) substantial reduction of GHG emissions; and (iii) complete elimination of the solid wastes. In order to achieve this goal within the project, novel technologies for the reduction of alumina to aluminium and the complete utilization of the red mud will be demonstrated and validated in pilot-scale. These technologies are energy-efficient and environmental-friendly, ensuring the competitiveness of the industry. A site optimization study of the new industry, integrating the novel technologies, is expected to achieve further reduction of energy and CO2 emissions and improve the energy and exergy efficiency of the whole process. It is aimed that the novel technologies will play a key-role on the sustainability, competitiveness and viability of primary aluminium production industry, so as to render it a leader industry for energy-efficient technologies and products in Europe and worldwide.


Grant
Agency: Cordis | Branch: FP7 | Program: BSG-CSO | Phase: ENV.2011.4.2.3-1 | Award Amount: 2.25M | Year: 2011

The CiVi.net project aims to analyse, transfer and disseminate successful and sustainable community based solutions with regard to ecosystem service management in Latin America. The main focus is placed on institutional settings in terms of original rules and related governance models which help to prevent and resolve tensions arising from a necessary new repartition and use of natural resources. Thereby, the role of civil society organisations (CSOs) within these governance models is in the core of the research. To meet these challenges, CiVi.net takes an action research and case study approach. The project has chosen four case study regions in Brazil and Costa Rica where successful solutions have been worked out. These will be analysed with respect to the following questions: - What kinds of management instruments are used to solve environmental problems and how effective are they? - What kinds of original rules and institutional arrangements are implemented and which economic governance models have been established? - What crucial aspects must be considered when transferring these solutions to other communities that face similar problems? - What is the capacity of CSOs and their networks for contributing to finding, implementing and transferring such solutions? Based on the findings, CiVi.net wants to facilitate the transfer of successful solutions to at least one other community for each selected case study region confronted with similar environmental challenges. To do so, CiVi.net will develop an ex-ante assessment approach to test the transferability of institutional solutions and of successful governance models. One of the final outputs will be a manual to assist practitioners and scientists on how to design and manage the knowledge transfer. CiVi.net will put much emphasis on the dissemination of the produced knowledge. Thus, another of its final outputs will be an innovative web-based data portal for providing and trading knowledge.


Grant
Agency: Cordis | Branch: FP7 | Program: CP | Phase: ICT-2011.8.1 | Award Amount: 3.10M | Year: 2012

Innovation and creativity are predictors of success in a knowledge-based. Yet the fuzziness and unpredictability of the creative workflow remains an obstacle for effective ICT support. Tools that require users to formalize and structure their ideas and working processes to a degree at odds with creative practice are frequently rejected. The IdeaGarden project therefore starts from an understanding of creative problem solving as a complex and situated knowledge practice rather than as a set of well-defined methods and techniques.\n\nThe project will develop a creative learning environment, capitalizing on the notion of visual information mash-ups as catalysts for creative working and learning. Adopting a practice-oriented approach will further the understanding of creativity in different settings and open up new perspectives for ICT support. This perspective will also give rise to new methods for seeding and cultivating creative knowledge practices in workplace and educational settings. To leverage the capabilities of current ICT systems, new interactions techniques will be devised that enable users to stay in control and collaboratively navigate the creative process, handling multiple types of resources. In addition, taking benefit of the Linked Data paradigm will provide new possibilities for creative search, the construction of knowledge as well as the reflection of the collaborative process.\n\nThe R&D work starts with research into creative knowledge work in industry (at LEGO and EOOS) and education (at the Muthesius Academy of Fine Arts and Design). Based on the careful analysis of creative practices, we will envision and implement working demonstrators. Formative evaluation combined with a two-round development process will ensure that the IdeaGarden system fits its users needs while summative evaluation will validate the overall utility of the approach to promote nonlinear, non-standard thinking and problem solving among experts and novices.


Grant
Agency: Cordis | Branch: FP7 | Program: CPCSA | Phase: ICT-2013.9.9 | Award Amount: 74.61M | Year: 2013

This Flagship aims to take graphene and related layered materials from a state of raw potential to a point where they can revolutionize multiple industries from flexible, wearable and transparent electronics, to new energy applications and novel functional composites.\nOur main scientific and technological objectives in the different tiers of the value chain are to develop material technologies for ICT and beyond, identify new device concepts enabled by graphene and other layered materials, and integrate them to systems that provide new functionalities and open new application areas.\nThese objectives are supported by operative targets to bring together a large core consortium of European academic and industrial partners and to create a highly effective technology transfer highway, allowing industry to rapidly absorb and exploit new discoveries.\nThe Flagship will be aligned with European and national priorities to guarantee its successful long term operation and maximal impact on the national industrial and research communities.\nTogether, the scientific and technological objectives and operative targets will allow us to reach our societal goals: the Flagship will contribute to sustainable development by introducing new energy efficient and environmentally friendly products based on carbon and other abundant, safe and recyclable natural resources, and boost economic growth in Europe by creating new jobs and investment opportunities.


Grant
Agency: Cordis | Branch: H2020 | Program: SGA-RIA | Phase: FETFLAGSHIP | Award Amount: 89.00M | Year: 2016

This project is the second in the series of EC-financed parts of the Graphene Flagship. The Graphene Flagship is a 10 year research and innovation endeavour with a total project cost of 1,000,000,000 euros, funded jointly by the European Commission and member states and associated countries. The first part of the Flagship was a 30-month Collaborative Project, Coordination and Support Action (CP-CSA) under the 7th framework program (2013-2016), while this and the following parts are implemented as Core Projects under the Horizon 2020 framework. The mission of the Graphene Flagship is to take graphene and related layered materials from a state of raw potential to a point where they can revolutionise multiple industries. This will bring a new dimension to future technology a faster, thinner, stronger, flexible, and broadband revolution. Our program will put Europe firmly at the heart of the process, with a manifold return on the EU investment, both in terms of technological innovation and economic growth. To realise this vision, we have brought together a larger European consortium with about 150 partners in 23 countries. The partners represent academia, research institutes and industries, which work closely together in 15 technical work packages and five supporting work packages covering the entire value chain from materials to components and systems. As time progresses, the centre of gravity of the Flagship moves towards applications, which is reflected in the increasing importance of the higher - system - levels of the value chain. In this first core project the main focus is on components and initial system level tasks. The first core project is divided into 4 divisions, which in turn comprise 3 to 5 work packages on related topics. A fifth, external division acts as a link to the parts of the Flagship that are funded by the member states and associated countries, or by other funding sources. This creates a collaborative framework for the entire Flagship.


Grant
Agency: Cordis | Branch: FP7 | Program: CP | Phase: ICT-2013.3.1 | Award Amount: 5.85M | Year: 2014

Modular interposer architecture providing scalable heat removal, power delivery and communicationCarrICool will deliver a game-changing 3D packaging platform for scale-up of future, many-core, Exascale computing systems. The project will also develop a strategic supplier base in Europe for high-end HPC components and systems integration capabilities in the Exascale era. In CarrICool, advanced More-than-Moore components required to scale to energy efficient ExaFLOP computing performance will be developed and integrated into a modular and multifunctional interposer. Four critical packaging elements are implemented on the CarrICool interposer: i) Improved structural and electrical performance will be provided by expansion matching and high wiring density. ii) low thermal gradients for Beyond-CMOS and silicon photonic devices will be provided by integrated, single-phase, water-cooling cavities. iii) High granularity, distributed Buck-converters using integrated, high-quality power inductors will support energy-efficient power delivery to heterogeneous chip stacks. iv) Off-chip bandwidth will be enabled through low-cost and low-loss passive optical coupling to silicon photonic wave guides. CarrICool is targeting 2-fold improvement in heat removal, 10-fold higher voltage granularity and a 10-fold cost reduction in photonic packaging.Advanced characterization and simulation techniques will be implemented using physics-of-failure-based lifetime modelling to provide design-rules for improved system architecture. The performance of the four packaging elements of the modular interposer will be validated on three separate demonstrators and then integrated on the main CarrICool demonstrator. The CarrICool consortium pools interdisciplinary excellence, uniting ten partners from global companies (2), European SMEs (3), institutes (3) and academia (2) across seven European countries. An Advisory Board ensures the alignment of the project goals with user needs.


Grant
Agency: Cordis | Branch: FP7 | Program: CP | Phase: ICT-2011.5.1 | Award Amount: 3.52M | Year: 2011

REWIRE develops, integrates and field tests an innovative virtual reality based rehabilitation platform, which allows patients, discharged from the hospital, to continue intensive rehabilitation at home under remote monitoring by the hospital itself. The main idea is to assemble off the shelf components in a robust and reliable way to get a platform system that can be to be deployed massively at the patients homes. The platform is constituted of three hierarchical components: a patient station (PS), deployed installed at home, a hospital station (HS) and a networking station (NS) at a the health provider site. The PS is based on video-based tracking (through a mix of 2D and 3D cameras) and virtual reality. The patient sees on the display himself or an avatar moving and interacting in real-time with a virtual game with his movements tracked in real-time. Game variety of scenarios, balanced scoring system, quantitative exercise evaluation, audio-visual feed-back aims at maximum patients motivation. A robust and reliable auto-calibration and spatial synchronization with the graphics is developed. Patients daily activity is monitored by a Body Sensor Networks and his activity is profiled through eigenbehaviors. Environmental, physiological and motion data are combined to tune the rehabilitation exercise level, to assess potential risks and advice clinicians on the therapy. The HS main role is the definition and monitoring of the treatment. Data mining in the NS discovers common features and trends of rehabilitation treatment among hospitals and regions. A virtual community is setup to educate and motivate patients. A pilot is designed both for the clinical evaluation of effectiveness and suitability of REWIRE, and the study of the most appropriate model to seamlessly connect long-term at home rehabilitation to that at hospital, appropriate service settings and adequate business models. Using advanced DTI imaging it is tested whether REWIRE meets the rationale of rehabilitation, that it triggers brain adaptations that mediate recovery.


Grant
Agency: Cordis | Branch: FP7 | Program: CP | Phase: ICT-2011.9.7 | Award Amount: 7.86M | Year: 2012

Future advancements in ICT domain are closely linked to the understanding about how multi-level complex systems function. Indeed, multi-level dependencies may amplify cascade failures or make more sudden the collapse of the entire system. Recent large-scale blackouts resulting from cascades in the power-grid coupled to the control communication system witness this point very clearly. A better understanding of multi-level systems is essential for future ICTs and for improving life quality and security in an increasingly interconnected and interdependent world. In this respect, complex networks science is particularly suitable for the many challenges that we face today, from critical infrastructures and communication systems, to techno-social and socio-economic networks.MULTIPLEX proposes a substantial paradigm shift for the development of a mathematical, computational and algorithmic framework for multi-level complex networks. Firstly, this will lead to a significant progress in the understanding and the prediction of complex multi-level systems. Secondly, it will enable a better control, and optimization of their dynamics. By combining mathematical analyses, modelling approaches and the use of massive heterogeneous data sets, we shall address several prominent aspects of multi-level complex networks, i.e. their topology, dynamical organization and evolution.


Grant
Agency: Cordis | Branch: FP7 | Program: CP | Phase: ICT-2011.6.6 | Award Amount: 3.13M | Year: 2011

Ecological issues in traffic become more and more pressing as personal transportation is one of the greatest contributors of CO2 emissions. Means to help people reducing their ecological impact are urgently needed. To answer this need Peacox provides travellers with personalized multi-modal navigation tools that allow, help and persuade them to travel and drive ecological friendlier. To convince users in making more sustainable travel choices Peacox will enrich navigation systems with innovative approaches and features:\tPeacox integrates automated travel mode detection based on real-time GPS data into the trip planning thereby minimizing the need for explicit user input.\tPeacox has the capability to automatically detect users trip purpose through the analysis of behavioural patterns allowing tailoring trip suggestions to these purposes.\tPeacox builds dynamic user models allowing personalizing recommendations based on prior trip choices and individual preferences.\tPeacox develops advanced door-to-door emissions models that provide accurate feedback on the ecological/carbon footprint and exposure levels in planning as well as during travelling and car driving activities.\tPeacox develops and utilizes persuasive interface strategies to give feedback about the ecological impact of individuals behavior as well as make the ecological friendliest behavioral pattern visible and attractive.The system will be developed in two iterations following user-centred and agile design approaches, and extensive field trials in Vienna and Dublin will ensure high quality and impact of the developed Peacox system. The Peacox consortium unites expertise from navigation systems, transportation sciences, environmental modelling, artificial intelligence, persuasive technology, human-computer interaction to software development.


Grant
Agency: Cordis | Branch: FP7 | Program: CSA | Phase: ICT-2011.9.5 | Award Amount: 2.16M | Year: 2011

The ultimate goal of the FuturICT Flagship is to understand and manage complex, global, socially interactive systems, with a focus on sustainability and resilience. Revealing the hidden laws and processes underlying societies constitutes the most pressing scientific grand challenge of our century and is equally important for the development of novel robust, trustworthy and adaptive information and communication technologies (ICT), based on socially inspired paradigms.\n\nIntegrating ICT, Complexity Science and the Social Sciences will unleash a paradigm shift, facilitating a symbiotic co-evolution of ICT and society. Data from our complex globe-spanning ICT system will be leveraged to develop models of techno-socio-economic systems. In turn, insight from these models will inform the development of a new generation of socially adaptive, self-organised ICT systems.\n\nFuturICT as a whole will act as a Knowledge Accelerator, turning massive data into knowledge and technological progress. In this way, FuturICT will create the scientific methods and ICT platforms needed to address planetary-scale challenges and opportunities in the 21st century. Specifically, FuturICT will build a sophisticated simulation, visualization and participation platform, known as the Living Earth Platform. This platform will power Crisis Observatories, to detect and mitigate crises, and Participatory Platforms, to support decision-making for policy-makers and citizens.\n\nIn this Coordination Action, we propose activities to develop our scientific vision and roadmap, secure stakeholder commitment, establish the FuturICT legal and operational infrastructure, and build on our remarkable success in uniting previously fragmented research communities. Through these activities, the Coordination Action will allow Europe to grasp this unique opportunity for groundbreaking progress in science and ICT, with great impacts for society, governance and industry by launching the FuturICT Flagship in 2013.


Grant
Agency: Cordis | Branch: H2020 | Program: RIA | Phase: NFRP-06-2014 | Award Amount: 9.66M | Year: 2015

The Modern2020 project aims at providing the means for developing and implementing an effective and efficient repository operational monitoring programme, taking into account the requirements of specific national programmes. The work allows advanced national radioactive waste disposal programmes to design monitoring systems suitable for deployment when repositories start operating in the next decade and supports less developed programmes and other stakeholders by illustrating how the national context can be taken into account in designing dedicated monitoring programmes tailored to their national needs. The work is established to understand what should be monitored within the frame of the wider safety cases and to provide methodology on how monitoring information can be used to support decision making and to plan for responding to monitoring results. Research and development work aims to improve and develop innovative repository monitoring techniques (wireless data transmission, alternative power supply sources, new sensors, geophysical methods) from the proof of feasibility stage to the technology development and demonstration phase. Innovative technical solutions facilitate the integration and flexibility of required monitoring components to ease the final implementation and adaptation of the monitoring system. Full-scale in-situ demonstrations of innovative monitoring techniques will further enhance the knowledge on the operational implementation of specific disposal monitoring and will demonstrate the performance of the state-of-the-art, the innovative techniques and their comparison with conventional ones. Finally, Modern2020 has the ambition to effectively engage local citizen stakeholders in the R&D monitoring activity by involving them at an early stage in a repository development programme in order to integrate their concerns and expectations into monitoring programmes.


The EURAXESS TOP III consortium includes partners from almost all EURAXESS countries (either as beneficiaries or associated partners, from altogether 39 countries), in order to ensure the widest possible coverage as well as increased impact. The project has been divided into eight work packages. Two WPs are devoted to the development, testing and pilot introduction of new services on career development within the EURAXESS network. The remaining WPs will focus on the environment of researchers including the institutional context, the integration of third country researchers and reaching out to researchers beyond the EU; researchers within and outside academia, most notably industry; the consolidation of the ongoing services portfolio, be it personal or electronic; the further capacity building of the EURAXESS network members and meeting the challenge posed by staff turnover by trainings, twinning and study visits; networking and knowledge exchange with a wide range of other networks; implementation of a consistent quality assurance and monitoring system operating on several levels on the project, and working out a future vision for EURAXESS in light of the policy goals of the EC set for the period up to 2020. The project will significantly contribute to matching research talents with R&I needs and capacity on a European scale and it will help the circulation of researchers within Europe and among sectors. As a result of the project, members of the EURAXESS network will have better and broader knowledge and more integrated good practices regarding service provision for researchers. EURAXESS national portals throughout the EURAXESS member countries will offer tailor made information in line with Horizon 2020 objectives on making science careers attractive for researchers, especially young researchers.


Grant
Agency: Cordis | Branch: H2020 | Program: RIA | Phase: INFRAIA-1-2014-2015 | Award Amount: 5.92M | Year: 2015

One of the most pressing and fascinating challenges scientists face today, is understanding the complexity of our globally interconnected society. The big data arising from the digital breadcrumbs of human activities promise to let us scrutinize the ground truth of individual and collective behaviour at an unprecedented detail and scale. There is an urgent need to harness these opportunities for scientific advancement and for the social good. The main obstacle to this accomplishment, besides the scarcity of data scientists, is the lack of a large-scale open infrastructure, where big data and social mining research can be carried out. To this end, SoBigData proposes to create the Social Mining & Big Data Ecosystem: a research infrastructure (RI) providing an integrated ecosystem for ethic-sensitive scientific discoveries and advanced applications of social data mining on the various dimensions of social life, as recorded by big data. Building on several established national infrastructures, SoBigData will open up new research avenues in multiple research fields, including mathematics, ICT, and human, social and economic sciences, by enabling easy comparison, re-use and integration of state-of-the-art big social data, methods, and services, into new research. It will not only strengthen the existing clusters of excellence in social data mining research, but also create a pan-European, inter-disciplinary community of social data scientists, fostered by extensive training, networking, and innovation activities. In addition, as an open research infrastucture, SoBigData will promote repeatable and open science. Although SoBigData is primarily aimed at serving the needs of researchers, the openly available datasets and open source methods and services provided by the new research infrastructure will also impact industrial and other stakeholders (e.g. government bodies, non-profit organisations, funders, policy makers).


Grant
Agency: Cordis | Branch: H2020 | Program: RIA | Phase: FETHPC-1-2014 | Award Amount: 8.63M | Year: 2015

ExaNoDe will investigate, develop and pilot (technology readiness level 7) a highly efficient, highly integrated, multi-way, high-performance, heterogeneous compute element aimed towards exascale computing and demonstrated using hardware-emulated interconnect. It will build on multiple European initiatives for scalable computing, utilizing low-power processors and advanced nanotechnologies. ExaNoDe will draw heavily on the Unimem memory and system design paradigm defined within the EUROSERVER FP7 project, providing low-latency, high-bandwidth and resilient memory access, scalable to Exabyte levels. The ExaNoDe compute element aims towards exascale compute goals through: Integration of the most advanced low-power processors and accelerators across scalar, SIMD, GPGPU and FPGA processing elements supported by research and innovation in the deployment of associated nanotechnologies and in the mechanical requirements to enable the development of a high-density, high-performance integrated compute element with advanced thermal characteristics and connectivity to the next generation of system interconnect and storage; Undertaking essential research to ensure the ExaNoDe compute element provides necessary support of HPC applications including I/O and storage virtualization techniques, operating system and semantically aware runtime capabilities and PGAS, OpenMP and MPI paradigms; The development of an instantiation of a hardware emulation of interconnect to enable the evaluation of Unimem for the deployment of multiple compute elements and the evaluation, tuning and analysis of HPC mini-apps. Each aspect of ExaNoDE is aligned with the goals of the ETP4HPC. The work will be steered by first-hand experience and analysis of high-performance applications, their requirements and the tuning of their kernels.


Grant
Agency: Cordis | Branch: H2020 | Program: RIA | Phase: FETHPC-1-2014 | Award Amount: 7.97M | Year: 2015

The main target of the Mont-Blanc 3 project European Scalable and power efficient HPC platform based on low-power embedded technology is the creation of a new high-end HPC platform (SoC and node) that is able to deliver a new level of performance / energy ratio whilst executing real applications. The technical objectives are: 1. To design a well-balanced architecture and to deliver the design for an ARM based SoC or SoP (System on Package) capable of providing pre-exascale performance when implemented in the time frame of 2019-2020. The predicted performance target must be measured using real HPC applications. 2. To maximise the benefit for HPC applications with new high-performance ARM processors and throughput-oriented compute accelerators designed to work together within the well-balanced architecture. 3. To develop the necessary software ecosystem for the future SoC. This additional objective is important to maximize the impact of the project and make sure that this ARM architecture path will be successful in the market. The project shall build upon the previous Mont-Blanc & Mont-Blanc 2 FP7 projects, with ARM, BSC & Bull being involved in Mont-Blanc 1, 2 and 3 projects. It will adopt a co-design approach to make sure that the hardware and system innovations are readily translated into benefits for HPC applications. This approach shall integrate architecture work (WP3 & 4 - on balanced architecture and computing efficiency) together with a simulation work (to feed and validate the architecture studies ) and work on the needed software ecosystem.


Grant
Agency: Cordis | Branch: H2020 | Program: RIA | Phase: SC5-16-2014 | Award Amount: 15.99M | Year: 2015

Terrestrial and marine ecosystems provide essential services to human societies. Anthropogenic pressures, however, cause serious threat to ecosystems, leading to habitat degradation, increased risk of collapse and loss of ecosystem services. Knowledge-based conservation, management and restoration policies are needed to improve ecosystem benefits in face of increasing pressures. ECOPOTENTIAL makes significant progress beyond the state-of-the-art and creates a unified framework for ecosystem studies and management of protected areas (PA). ECOPOTENTIAL focuses on internationally recognized PAs in Europe and beyond in a wide range of biogeographic regions, and it includes UNESCO, Natura2000 and LTER sites and Large Marine Ecosystems. Best use of Earth Observation (EO) and monitoring data is enabled by new EO open-access ecosystem data services (ECOPERNICUS). Modelling approaches including information from EO data are devised, ecosystem services in current and future conditions are assessed and the requirements of future protected areas are defined. Conceptual approaches based on Essential Variables, Macrosystem Ecology and cross-scale interactions allow for a deeper understanding of the Earths Critical Zone. Open and interoperable access to data and knowledge is assured by a GEO Ecosystem Virtual Laboratory Platform, fully integrated in GEOSS. Support to transparent and knowledge-based conservation and management policies, able to include information from EO data, is developed. Knowledge gained in the PAs is upscaled to pan-European conditions and used for planning and management of future PAs. A permanent stakeholder consultancy group (GEO Ecosystem Community of Practice) will be created. Capacity building is pursued at all levels. SMEs are involved to create expertise leading to new job opportunities, ensuring long-term continuation of services. In summary, ECOPOTENTIAL uses the most advanced technologies to improve future ecosystem benefits for humankind.


Grant
Agency: Cordis | Branch: FP7 | Program: MC-ITN | Phase: FP7-PEOPLE-2012-ITN | Award Amount: 3.76M | Year: 2013

Over the last decade, enormous progress has been made on recording the health state of an individual patient down to the molecular level of gene activity and genomic information even sequencing a patients genome for less than 1000 dollars is no longer an unrealistic goal. However, the ultimate hope to use all this information for personalized medicine, that is to tailor medical treatment to the needs of an individual, remains largely unfulfilled. To turn the vision of personalized medicine into reality, many methodological problems remain to be solved: there is a lack of methods that allow us to gain a causal understanding of the underlying disease mechanisms, including gene-gene and gene-environment interactions. Similarly, there is an urgent need for integration of the heterogeneous patient data currently available, for improved and robust biomarker discovery for disease diagnosis, prognosis and therapy outcome prediction. The field of machine learning, which tries to detect patterns, rules and statistical dependencies in large datasets, has also witnessed dramatic progress over the last decade and has had a profound impact on the Internet. Amongst others, advanced methods for high-dimensional feature selection, causality inference, and data integration have been developed or are topics of current research. These techniques address many of the key methodological challenges that personalized medicine faces today and keep it from rising to the next level. Despite this rich potential of machine learning in personalized medicine, its impact on data-driven medicine remains low, due to a lack of experts with knowledge in both machine learning and in statistical genetics. Our ITN aims to close this gap by bringing together leading European research institutes in Machine Learning and Statistical Genetics, both from the private and public sector, to train 14 early stage researchers.


Grant
Agency: Cordis | Branch: FP7 | Program: MC-ITN | Phase: FP7-PEOPLE-2010-ITN | Award Amount: 4.57M | Year: 2011

The central goal of the COHERENCE network is the training of Early Stage Researchers (ESRs) and Experienced Researchers (ERs) to the highest level of international excellence within the rapidly growing field of electronically highly excited (Rydberg) gases and aggregates. The systems range from single atoms to large mesoscopic ensembles with full control over motional and internal degrees of freedom. Recent scientific progress has primarily been made by a number of European experimental and theoretical groups which are all assembled within the network. The field of Rydberg gases is at the crossroads between various scientific areas, including condensed matter physics, biophysics, molecular physics, quantum optics and quantum information, surface science, plasma physics, and laser technology. As perspective applications of Rydberg systems are already in sight, two optics and laser development companies have joined the network delivering technological expertise and in-depth training in business matters. The elaborate and well-structured training programme includes a schedule of workshops, schools, and conferences. The training will be strongly focused on the individual researchers by assigning each of them an international Thesis Advisory Board and by designing Individual Career Development Plans. Based on the interdisciplinary character of the research, the training content will include a blend of broad scientific, technological, and complimentary skills providing excellent perspectives for successful careers in both academia and industry. ESRs will also profit from the extensive exchage programme among the participating teams based on cotutelles, short- and long-term secondments. The COHERENCE network will thus ensure that Europe maintains the leading role within an important area of research and will stimulate transformation of the generated knowledge into new technologies.


Grant
Agency: Cordis | Branch: FP7 | Program: CSA | Phase: ICT-2011.4.4 | Award Amount: 1.59M | Year: 2012

VISCERAL is a support action that will organize two competitions on information extraction and retrieval involving medical image data and associated text that will benchmark the state of the art and define the next big challenges in large scale data processing in medical image analysis.The increasing amounts of medical imaging data acquired in clinical practice hold a tremendous body of diagnostically relevant information. Only a small portion of these data are accessible during clinical routine or research due to the complexity, richness, high dimensionality and size of the data.There is consensus in the community that leaps in this regard are hampered by the lack of large bodies of data shared across research groups and an associated definition of joint challenges on which development should focus. VISCERAL will provide the means to jump-start this process with two competitions (1) providing access to unprecedented amounts of real world imaging data annotated through experts and (2) using a community effort to generate a large corpus of automatically generated standard annotations. The goal of the project is to formulate relevant and challenging tasks, to provide the necessary data for research and evaluation, and to conduct competitions for identifying successful computational strategies and highlighting directions of future research.To this end, VISCERAL will conduct two competitions. The first competition will focus on automatic identification, localization and segmentation of anatomical structures in medical imaging data, the second competition will comprise retrieval tasks that aim at identifying similar cases relevant for diagnosis. In addition to the direct evaluation, the project will result in two data corpora - one gold corpus of expert manual annotations, and a silver corpus that will be computed from the competition entries. Both data sets will be made available to challenge participants and, afterwards, to the scientific community.


Grant
Agency: Cordis | Branch: FP7 | Program: CSA | Phase: ICT-2011.9.5 | Award Amount: 1.71M | Year: 2011

Guardian Angels (GA) are future zero-power, intelligent, autonomous systems-of-systems featuring sensing, computation, and communication beyond human aptitudes. GA will assist humans from their infancy to old age in complex life situations and environments. Zero-power reflects system-of-systems ability to scavenge energy in dynamic environments by disruptive harvesting techniques. The project prepares zero-power technologies based on future energy-efficient technologies, heterogeneous design, and disruptive energy scavengers.\nThree zero-power generations of GAs are foreseen: Physical Guardian Angels are zero-power, on-body networks or implantable devices that monitor vital health signals and take appropriate actions to preserve human health. Environmental Guardian Angels extend monitoring to dynamic environments, using disruptive scavengers, personalized data communication, and first thinking algorithms. They are personal assistants that protect their wearers from environment dangers. Emotional Guardian Angels are intelligent personal companions with disruptive zero-power, manmachine interfaces deployed at large scale. They sense and communicate using non-verbal languages playing an important role in health, education, and security worldwide. This project addresses the following scientific challenges for energy-efficient visionary Guardian Angel autonomous systems: (i) energy-efficient computing (down to E=10-100kT), (ii) and communication (approaching the limit of 1pJ/bit), (iii) low-power sensing, (iv) disruptive scavenging (bio-inspired, thermoelectric, etc, targeting energy densities of tens of mW/cm2), and (v) zero-power man-machine interfaces. A selection of emerging technologies based on energy efficiency is proposed. We will also develop design tools that integrate electrical, mechanical, optical, thermal, and chemical simulation tools over length and time scales currently not achievable.


Grant
Agency: Cordis | Branch: FP7 | Program: MC-ITN | Phase: FP7-PEOPLE-2013-ITN | Award Amount: 3.90M | Year: 2013

Marine sponges harbour extremely diverse populations of microbes, and are world record holders for the production of a plethora of bioactive molecules. Previous studies, however, aiming at the growth of sponges or their associated microbes for the production of bioactive compounds to supply biological material for clinical trials, have been largely unsuccessful. BLUEPHARMTRAIN is a multi-disciplinary alliance of 20 academic and industrial partners that will excel in research and training through integration of complementary expertise in cell biology, microbiology, natural product chemistry, genomics & transcriptomics (omics) and socio-economics. We will adopt cutting-edge omics technologies to give a new boost to the more traditional disciplines: microbial isolation, cell culture and natural product chemistry to go beyond the current scientific frontiers. For example, metagenomic and transcriptomic data will be applied to identify the metabolic potential and restrictions of -yet- uncultured microbes and will serve for the design of tailor-made cultivation conditions. In addition, heterologous expression of bioactive gene clusters and enzymes able to perform unusual modifications will serve as an alternative strategy to unlock the bioactive potential of sponges. Thus we aim to develop an extensive technology platform that is applicable for obtaining a wide variety of bioactive compounds from distinct sponges and their microbes. BLUEPHARMTRAIN will provide a complementary set of experimental and conceptual local and network-wide training modules and workshops to 15 young researchers. The recruited fellows will work towards personalized training plans to meet individual needs and interests, generating a critical mass of young researchers in the emerging field of blue biotechnology. The presence of a large consortium of versatile biotechnology, pharmaceutical and consultancy firms ensures a good balance between academic and transferable skills acquired by the fellows.


Grant
Agency: Cordis | Branch: FP7 | Program: CP-CSA-Infra | Phase: INFRA-2012-1.1.17. | Award Amount: 8.57M | Year: 2014

Solar Energy, as the primary source of renewable energy, will contribute a major part of this share, and its conversion by concentrating technologies for concentrating solar power (CSP) and heat generation has long been proven cost-effective for a wide range of applications. Several CSP projects have recently been put into operation. Some 2.400 MW are under construction and several GW are in advanced stages of planning, particularly in Spain, but also in other Southern European countries, like France, Greece and Portugal. In view of this challenge for research, development and application of concentrating solar systems involving a growing number of European industries and utilities in global business opportunities, the purpose of this project is to integrate, coordinate and further focus scientific collaboration among the leading European research institutions in solar concentrating systems that are the partners of this project and offer European research and industry access to the best-qualified research and test infrastructures. This proposal deals with the continuation of the successful SFERA, now looking for a closer approach to the European CSP industry.


Grant
Agency: Cordis | Branch: H2020 | Program: RIA | Phase: PHC-08-2014 | Award Amount: 25.06M | Year: 2015

The TBVAC2020 proposal builds on the highly successful and long-standing collaborations in subsequent EC-FP5-, FP6- and FP7-funded TB vaccine and biomarker projects, but also brings in a large number of new key partners from excellent laboratories from Europe, USA, Asia, Africa and Australia, many of which are global leaders in the TB field. This was initiated by launching an open call for Expressions of Interest (EoI) prior to this application and to which interested parties could respond. In total, 115 EoIs were received and ranked by the TBVI Steering Committee using proposed H2020 evaluation criteria. This led to the prioritisation of 52 R&D approaches included in this proposal. TBVAC2020 aims to innovate and diversify the current TB vaccine and biomarker pipeline while at the same time applying portfolio management using gating and priority setting criteria to select as early as possible the most promising TB vaccine candidates, and accelerate their development. TBVAC2020 proposes to achieve this by combining creative bottom-up approaches for vaccine discovery (WP1), new preclinical models addressing clinical challenges (WP2) and identification and characterisation of correlates of protection (WP5) with a directive top-down portfolio management approach aiming to select the most promising TB vaccine candidates by their comparative evaluation using objective gating and priority setting criteria (WP6) and by supporting direct, head-to head or comparative preclinical and early clinical evaluation (WP3, WP4). This approach will both innovate and diversify the existing TB vaccine and biomarker pipeline as well as accelerate development of most promising TB vaccine candidates through early development stages. The proposed approach and involvement of many internationally leading groups in the TB vaccine and biomarker area in TBVAC2020 fully aligns with the Global TB Vaccine Partnerships (GTBVP).


Grant
Agency: Cordis | Branch: H2020 | Program: RIA | Phase: LCE-06-2015 | Award Amount: 17.86M | Year: 2016

By 2020, several areas of the HVAC pan-European transmission system will be operated with extremely high penetrations of Power Electronics(PE)-interfaced generators, thus becoming the only generating units for some periods of the day or of the year due to renewable (wind, solar) electricity. This will result in i) growing dynamic stability issues for the power system (possibly a new major barrier against future renewable penetration), ii) the necessity to upgrade existing protection schemes and iii) measures to mitigate the resulting degradation of power quality due to harmonics propagation. European TSOs from Estonia, Finland, France, Germany, Iceland, Ireland, Italy, Netherlands, Slovenia, Spain and UK have joined to address such challenges with manufacturers (Alstom, Enercon, Schneider Electric) and universities/research centres. They propose innovative solutions to progressively adjust the HVAC system operations. Firstly, a replicable methodology is developed for appraising the distance of any EU 28 control zone to instability due to PE proliferation and for monitoring it in real time, along with a portfolio of incremental improvements of existing technologies (the tuning of controllers, a pilot test of wide-area control techniques and the upgrading of protection devices with impacts on the present grid codes). Next, innovative power system control laws are designed to cope with the lack of synchronous machines. Numerical simulations and laboratory tests deliver promising control solutions together with recommendations for new PE grid connection rules and the development of a novel protection technology and mitigation of the foreseen power quality disturbances. Technology and economic impacts of such innovations are quantified together with barriers to be overcome in order to recommend future deployment scenarios. Dissemination activities support the deployment schemes of the project outputs based on knowledge sharing among targeted stakeholders at EC level.


Grant
Agency: Cordis | Branch: H2020 | Program: CSA | Phase: SC5-10a-2014 | Award Amount: 3.13M | Year: 2015

Mapping and assessment of ecosystems and their services (ES) are core to the EU Biodiversity (BD) Strategy. They are essential if we are to make informed decisions. Action 5 sets the requirement for an EU-wide knowledge base designed to be: a primary data source for developing Europes green infrastructure; resource to identify areas for ecosystem restoration; and, a baseline against which the goal of no net loss of BD and ES can be evaluated. In response to these requirements, ESMERALDA aims to deliver a flexible methodology to provide the building blocks for pan-European and regional assessments. The work will ensure the timely delivery to EU member states in relation to Action 5 of the BD Strategy, supporting the needs of assessments in relation to the requirements for planning, agriculture, climate, water and nature policy. This methodology will build on existing ES projects and databases (e.g. MAES, OpenNESS, OPERAs, national studies), the Millennium Assessment (MA) and TEEB. ESMERALDA will identify relevant stakeholders and take stock of their requirements at EU, national and regional levels. The objective of ESMERALDA is to share experience through an active process of dialogue and knowledge co-creation that will enable participants to achieve the Action 5 aims. The mapping approach proposed will integrate biophysical, social and economic assessment techniques. Flexibility will be achieved by the creation of a tiered methodology that will encompass both simple (Tier 1) and more complex (Tier 3) approaches. The work will exploit expert- and land cover-based methods, existing ES indicator data and more complex ES models. As a result the outcomes will be applicable in different contexts. The strength of the ESMERALDA consortium lies in its ability to make solutions for mapping and assessment problems available to stakeholders from the start of the project, because our expertise allows us to build on existing research projects and data sharing systems.


Grant
Agency: Cordis | Branch: H2020 | Program: RIA | Phase: INFRADEV-3-2015 | Award Amount: 31.03M | Year: 2015

The nations of Europe are distributed around some of the most complex and dynamic geological systems on the planet and understanding these is essential to the security of livelihoods and economic power of Europeans. Many of the solutions to the grand challenges in the geosciences have been led by European scientists the understanding of stratigraphy (the timing and distribution of layers of sediment on Earth) and the discovery of the concept of plate tectonics being among the most significant. Our ability to monitor the Earth is rapidly evolving through development of new sensor technology, both on- and below-ground and from outer space; we are able to deliver this information with increasing rapidity, integrate it, provide solutions to geological understanding and furnish essential information for decision makers. Earth science monitoring systems are distributed across Europe and the globe and measure the physico-chemical characteristics of the planet under different geological regimes. EPOS will bring together 24 European nations and combine national Earth science facilities, the associated data and models together with the scientific expertise into one integrated delivery system for the solid Earth. This infrastructure will allow the Earth sciences to achieve a step change in our understanding of the planet; it will enable us to prepare for geo-hazards and to responsibly manage the subsurface for infrastructure development, waste storage and the use of Earths resources. With a European Research Infrastructure Consortium (ERIC) to be located in Rome (Italy), EPOS will provide an opportunity for Europe to maintain world-leading European Earth sciences and will represent a model for pan-European federated infrastructure.


Grant
Agency: Cordis | Branch: FP7 | Program: CP | Phase: ICT-2009.2.1 | Award Amount: 4.41M | Year: 2011

This project will develop advanced technologies for automation in minimally invasive and open surgery. The introduction of more and more complex surgical devices, such as surgical robots, and single-port minimally invasive instruments, highlights the need of new control technologies in the operating room. On the one hand, the complexity of these devices requires new coordination methods to ensure their smooth operation; on the other hand, it also requires new interfaces that could simplify their use for surgeons. Automation may thus provide a solution to improve performance and efficiency in the operating room without increasing operating costs.\nCurrently, automation is not used in the operating room for a number of technical and legal reasons. The anatomical environment is particularly difficult to handle by classical automation. Furthermore, the execution of a surgical intervention is not only controlled by a set of physical and geometrical set points, describing the anatomical area and its properties, but also and especially by the medical and surgical knowledge that the surgeon uses in deciding what to do and how to do it, during the intervention. These control and cognitive challenges are also coupled to a legal barrier that currently prevents the use of an automatic intervention device in the operating room. In fact, liability issues of automatic products are known to have stopped many successful research projects in several Countries.\nThus, the I-SUR project aims at breaking new ground in the above areas related to automation in surgical intervention, in particular design of robotic surgical instruments, task modeling and control in highly uncertain and variable environments, medical situation awareness and its interaction with task control, surgeon-robot communication, and legal barrier identification.\nTo narrow the scope of the work the project will focus on simple surgical actions, such as puncturing, cutting and suturing. Success metrics will be defined for those actions and methods developed that abide by safety requirements, formulated in terms of those metrics. The project will demonstrate that an autonomous robotic surgical action, carried out with the developed technologies, can be as safe as currently achievable by traditional surgery. Furthermore, pre-operative task planning will be included in the project, to make sure that each surgeon is able to develop automatic procedures with his/her own surgical style.\nThe I-SUR consortium is composed of the following partners: two University Hospitals, at the University of Verona and at the San Raffaele Institute (Milano); the e-Services department of the San Raffaele Hospital; the ETH in Zurich; the BioRobotics Laboratory of the Tallinn University of Technology; the Interventional Center of the Oslo University Hospital; the Yeditepe University in Istanbul; and the Universities of Verona Ferrara and Modena-Reggio Emilia. The University of Verona coordinates the project.


Grant
Agency: Cordis | Branch: FP7 | Program: CP | Phase: ICT-2011.3.3 | Award Amount: 4.01M | Year: 2011

Pushed by economical and ecological stakes, embedded systems from the avionics, automotive and automation domains, featuring real-time, safety and critical capabilities have to face increasing performance needs that will no more be satisfied by existing architectures based on single-cores. Current trends are to take benefit from multi-core processors high performance in replacing single-cores by multi-cores which raises predictability and isolation challenges for timing and mixed criticality aspects. This is mainly due to the inadequateness and inability of current approaches to effectively handle reliability and the cause of non-deterministic behaviour on multi-cores.\nFacing multi-core architectures inevitable use, CERTAINTY will introduce a disruptive methodology for the design of complex critical applications allowing safety and time criticality aspects composition, taking into account unpredictability of shared resource availability as elements of the problem space, identify analysis methods and techniques supporting this new approach and demonstrate the applicability of these techniques through meaningful examples of complex control functions.\nNew methodology and design tools, applicable in diverse industrial sectors, will be validated in an avionics application on a multi-core architecture: an existing Flight Management System will be analyzed using the CERTAINTY Methodology and Analysis Tools to specify which part could be at which critical level redesigned and composed according to the methodology. The system design will be evaluated to show that relevant safety requirements are met (i.e. ability to ensure partitioning/isolation, ability to provide a WCET, system determinism and incrementality), contributing to the certification process on new architecture generations. The major result will be a Proof of Concept of a design methodology, resultant Analysis Methodologies and associated synthesis tools: CERTAINTY Methodology and prototypes.\nThe impact of CERTAINTY will be to contribute to the certification of mixed criticality applications on multi cores in more efficient and effective ways (performance improvement regarding strict temporal partitioning), and provide recommendations to standardization working groups preparing the way for new standards in this area.


Grant
Agency: Cordis | Branch: H2020 | Program: SGA-RIA | Phase: FETFLAGSHIP | Award Amount: 89.00M | Year: 2016

Understanding the human brain is one of the greatest scientific challenges of our time. Such an understanding can provide profound insights into our humanity, leading to fundamentally new computing technologies, and transforming the diagnosis and treatment of brain disorders. Modern ICT brings this prospect within reach. The HBP Flagship Initiative (HBP) thus proposes a unique strategy that uses ICT to integrate neuroscience data from around the world, to develop a unified multi-level understanding of the brain and diseases, and ultimately to emulate its computational capabilities. The goal is to catalyze a global collaborative effort. During the HBPs first Specific Grant Agreement (SGA1), the HBP Core Project will outline the basis for building and operating a tightly integrated Research Infrastructure, providing HBP researchers and the scientific Community with unique resources and capabilities. Partnering Projects will enable independent research groups to expand the capabilities of the HBP Platforms, in order to use them to address otherwise intractable problems in neuroscience, computing and medicine in the future. In addition, collaborations with other national, European and international initiatives will create synergies, maximizing returns on research investment. SGA1 covers the detailed steps that will be taken to move the HBP closer to achieving its ambitious Flagship Objectives.


Grant
Agency: Cordis | Branch: H2020 | Program: RIA | Phase: EE-08-2016 | Award Amount: 1.99M | Year: 2016

The project aims at improving our understanding on behavioural mechanisms in energy efficiency, following an interdisciplinary and broad behavioural science approach. The project will provide an empirical and numerical assessment of the psychological, social, economic and financial factors that influence energy efficiency in the residential and industry sectors By paring with energy utilities and retailers in different European countries, the project will conduct scientific experiments (A/B testing) which will enhance the design of policies aiming at maximizing energy efficient behaviors. The project will use novel data from different European countries to take into consideration institutional and political factors. The project will analyze consumers behavior related to the consumption of energy, the investment in energy efficient products, as well as the renovation of buildings. Finally, ex ante assessment will be executed using improved energy economy models, which will generate quantitative information with regard to expected impacts of EU and global policies.


Grant
Agency: Cordis | Branch: H2020 | Program: MSCA-ITN-ETN | Phase: MSCA-ITN-2016 | Award Amount: 3.91M | Year: 2017

The EU currently is negotiating a controversial Transatlantic Trade and Investment Partnership (TTIP) agreement with the USA, the main features of which will be the abolition of tariffs, the reduction of non-tariff barriers to trade between the EU and the USA and the introduction of a dispute settlement mechanism. The objective of the proposed TTIP Innovative Training Network (TTIP-ITN) is to foster interdisciplinary research into TTIP with a view to create a significantly increased European knowledge base and research capacity on TTIP, thus helping Europe to reap the benefits of TTIP (wealth, jobs, etc.) while addressing its challenges (democracy, accountability, environmental- and labour standards, etc.).The network is an interdisciplinary, intersectoral collaboration pooling world-leading researchers and practitioners from all relevant disciplines of law - EU constitutional, internal market, and external relations law, international trade law, and international law, as well as political science, international relations, business studies, and economics. TTIP-ITN fully integrates non-academic Beneficiaries and Partner Organisations, including think tanks, lobbyists, regulatory bodies, law firms, US academic institutions, and an international organisation. Furthermore, the network will support and enhance the process of converting research results into policy papers through partnership with high-impact policy research units at the forefront of European policy research and policy making. The work package consists of 3 substantive work packages on (1) transatlantic governance, (2) transatlantic regulation, and (3) multilateralism and regionalism. 15 PhD research projects will be supervised by academics of the 11 Beneficiaries with an interdisciplinary training programme covering the legal, political and economic foundations of TTIP and an interdisciplinary and intersectoral programme of secondments involving 22 Partner Organisations.


Grant
Agency: Cordis | Branch: H2020 | Program: RIA | Phase: GV-02-2016 | Award Amount: 12.06M | Year: 2016

PaREGEn addresses the short term scope of the GV-02 call via research into and the innovation of gasoline engines for light duty vehicles. Specifically, engines used in mid to premium passenger cars will be addressed. With the electrification smaller vehicles, focusing on larger cars is especially important: the need for clean, efficient & economic engines for inter-urban transport is more urgent and effective to resolve the challenges of air quality, decarbonisation & cost-effective mobility. Through using state of the art techniques, like optical engines, modelling & simulation tools (for new control strategies or understanding particle formation) and applying new engine componentry, the optimal trade-off between efficiency & emissions will be found. Of attention will be the control of particle numbers between 10 to 23nm. This learning will be used in two, manufacturer lead vehicle demonstrations. These demonstrators will use downsized engines not yet on the market. The two approaches will use different combustion, dilution, fuel injection, boosting and aftertreatment systems. Completion of the project will show the way forward to a 15% CO2 reduction along with real driving emissions limits. If adopted across all light vehicles these short term engine innovations will reduce the EU vehicle parc emissions by ~2MtCO2 in 2025, <10MtCO2 & ~10% PN>10nm in 2030. As well as improving EU competitiveness, a valuable contribution from PaREGEn will be new tools: to benefit engine design, development & control in general, long after project completion. PaREGEn has partners from EUCAR, CLEPA & EARPA; it is organized so learning from other projects in GV02 can be integrated. Experience from the PMP project and those proposed on particle measurement systems will be included via the partners & suppliers of PN-PEMS. PaREGEns partners give a global link to other nationally funded activities and, specifically, specialists in advisory roles will bring expertise from USA & Japan.


Grant
Agency: Cordis | Branch: H2020 | Program: MSCA-ITN-ETN | Phase: MSCA-ITN-2016 | Award Amount: 3.93M | Year: 2016

Industries are in need of highly skilled academically trained experts and powerful sets of tools enabling the design, control & prediction of optimized & efficient production process of future high-value products such as chiral pharmaceuticals. The CORE Network will in parallel train 15 ESRs and develop tools, approaches and methods within the area of Continuous Resolution (CORE), the process to obtain enantiopure molecules of chiral compounds. The training objective of the CORE network is to deliver a CORE skills toolbox of knowledge, personal, organizational and impact skills to a core of multi-disciplinary scientists and engineers in the interdisciplinary and cross-sectional field of Continuous Resolution. Each ESR obtains dedicated training through their research project, network events, a webinar course, management involvement and an academic & industrial secondment. The research objective of the CORE Network is to jointly construct a CORE Industrial Toolbox on Continuous Resolution that provides next generation tools, approaches and methods to industry for the development continuous resolution processes. The strongly involved industrial partners will ensure that the CORE Industrial Toolbox fulfils their requirements in the skills gap areas Towards Continuous, Hybrid Resolution and Enabling Resolution. CORE brings together 8 academic and 7 industrial partners resulting in an unparalleled combination of chirality, synthesis and crystallization training and research covering the areas of Chemical Engineering, Chemistry and Applied Physics.


Grant
Agency: Cordis | Branch: FP7 | Program: CP | Phase: ICT-2013.3.4 | Award Amount: 3.43M | Year: 2013

The wellbeing of the citizens in Europe depends on the reliable and efficient functioning of large interconnected systems, such as electric power systems, air traffic control, railway systems, large industrial production plants, etc. Such large systems consist of many interacting components, e.g. generation plants, distribution systems, and large and small consumers. The subsystems are usually managed locally and independently, according to different policies and priorities. The dynamic interaction of the locally managed components gives rise to complex behaviour and can lead to largescale disruptions as e.g. black outs in the electric grid.\n\n\nLarge interconnected systems with autonomously acting subunits are called systems of systems. DYMASOS addresses systems of systems where the elements of the overall system are coupled by flows of physical quantities, e.g. electric power, steam or hot water, materials in a chemical plant, gas, potable water, etc. Within the project, new methods for the distributed management of large physically connected systems with local management and global coordination will be developed.\n\n\nThe approaches explored are:\n\n\tModelling and control of large systems analogously to the evolution of the behaviour of populations in biological systems;\n\tMarketlike mechanisms to coordinate independent systems with local optimisation functions;\n\tCoalition games where agents that control the subsystems dynamically group to pursue common goals.\n\n\nThe properties of the distributed management and control techniques for large systems of systems are investigated theoretically and validated in largescale simulations of case studies provided by industrial partners in the fields of electric grid management and industrial production management.\n\n\nFrom the experience gained in the case studies, conclusions will be drawn about the suitability of the proposed management and control mechanisms for certain classes of systems of systems.\n\n\nThe expected technical outcomes of the project are:\n \tInnovation in distributed management methods for complex interconnected systems\n \tProgress in methods for the rigorous analysis and validation of systems of systems;\n \tImprovements in the management of electric grids and of large production complexes;\n \tTools for the engineering of management systems for systems of systems;\n \tIdentification of technology gaps in advanced management and coordination methods.\n\n\nThe developed coordination methods will lead to improved system stability and lower resource consumption in industrial production, and in electricpower generation and distribution. This will result in a reduction of the CO2-emissions, higher competitiveness of the European industry and lower prices for the customers. Thus, DYMASOS will contribute to the goal of a greener and more competitive Europe.


Grant
Agency: Cordis | Branch: FP7 | Program: CP-FP | Phase: NMP.2013.1.4-1 | Award Amount: 3.82M | Year: 2014

DEEPEN will develop an integrated open source multiscale simulation environment, targeted at problems common to future nanoscale electronic and photonic devices. New device simulators require an atomic-scale description of selected critical regions of a transistor or LED to capture details otherwise inaccessible. They must also resolve the considerable uncertainty in many critical parameters required for device optimisation. DEEPEN addresses both these issues, coherently combining state-of-the-art existing methods and developing new methodologies, integrated within a multiscale framework spanning from first-principles to macroscopic models. DEEPEN brings together leading groups with expertise not just in simulation, but also in its application to device design and optimization. It builds on Tyndall and ETHZ expertise in material and device properties, with experimental input from PDI also critical for validation of the multiscale models developed. Industry partners include a key multiscale modelling system provider (TiberLAB), a leading TCAD simulation provider (Synopsys) and an industrial end-user (Osram) who provide experimental validation and test the simulation environment for device design and investigation. Future code distribution will be supported through the project web site and through TiberLABs existing support environment, www.tibercad.org. The nanoscale models to be developed address the challenging problem not just of predicting quantitatively electronic bands and quantum phenomena at the nanoscale, but also of linking these critical properties to overall device behaviour. The project emphasizes aggressive dissemination of results to maximize impact, including organization of Training Schools and an International Workshop, as well as the release and support of demonstration software and the open source interfaces. Overall, the project significantly strengthens European competitiveness, with clear routes to successful exploitation of the technology.


Grant
Agency: Cordis | Branch: FP7 | Program: CP | Phase: ICT-2009.8.2 | Award Amount: 9.14M | Year: 2010

The overall objectives of the AQUTE project are\nA) To develop quantum technologies based on atomic, molecular and optical (AMO) systems for\n* scalable quantum computation;\n* entanglement-enabled technologies like metrology and sensing.\nB) To establish and exploit new interdisciplinary connections, coming from AMO physics, but also including concepts and experimental settings of solid state systems, in order to\n* reinforce interdisciplinary links at the frontiers of quantum information science, and other fields of physics or science in general;\n* conceive and realize novel hybrid systems that couple in a coherent way physically different quantum degrees of freedom.\nObj. A will be pursued along two complementary directions:\n* a bottom-up approach, where individually trapped atomic particles are combined into elementary general-purpose quantum processors including qubit interconnects;\n* a top-down approach, where many-particle atomic systems are employed to realize special-purpose quantum processors, for instance quantum simulators.\nGroundbreaking work in qualitatively new directions is also needed to lay the foundations for the future attainment of scalable fault-tolerant architectures. AQUTE will thus also\n* investigate new experimental systems that have become available in the laboratory and are of direct relevance for QIFT;\n* optimize existing and develop novel theoretical concepts for quantum processing.\nObj. B connects atomic quantum technologies for QIFT to a wider context, by\n* exploring hybrid approaches to QIFT beyond AMO physics;\n* improving connections between QIFT and science in general, following the emergence of a new quantum paradigm at the frontier of nanosciences and information sciences.\nThese research lines determine the structuring of the AQUTE workplan into four deeply interrelated Sub-Projects: Entangling gates and quantum processors, Hybrid quantum systems and interconnects, Quantum Simulators and Quantum Technologies.


Grant
Agency: Cordis | Branch: H2020 | Program: RIA | Phase: LCE-21-2015 | Award Amount: 4.00M | Year: 2016

SET-Nav will support strategic decision making in Europes energy sector, enhancing innovation towards a clean, secure and efficient energy system. Our research will enable the EC, national governments and regulators to facilitate the development of optimal technology portfolios by market actors. We will comprehensively address critical uncertainties and derive appropriate policy and market responses. Our findings will support the further development of the SET-Plan and its implementation by continuous stakeholder involvement. These contributions of the SET-Nav project rest on three pillars: The wide range of objectives and analytical challenges set out by the call for proposals can only be met by developing a broad and technically-advanced modelling portfolio. Advancing this portfolio and enabling knowledge exchange via a modelling forum is our first pillar. The EUs energy, innovation and climate challenges define the direction of a future EU energy system, but the specific technology pathways are policy sensitive and need careful comparative evaluation. This is our second pillar. Using our strengthened modelling capabilities in an integrated modelling hierarchy, we will analyse multiple dimensions of impact of future pathways: sustainability, reliability and supply security, global competitiveness and efficiency. This analysis will combine bottom-up case studies linked to the full range of SET-Plan themes with holistic transformation pathways. Stakeholder dialogue and dissemination is the third pillar of SET-Nav. We have prepared for a lively stakeholder dialogue through a series of events on critical SET-Plan themes. The active involvement of stakeholders in a two-way feedback process will provide a reality check on our modelling assumptions and approaches, and ensure high policy relevance. Our aim is to ensure policy and market actors alike can navigate effectively through the diverse options available on energy innovation and system transformation.


Grant
Agency: Cordis | Branch: FP7 | Program: CP-CSA-Infra | Phase: INFRA-2010-1.1.27 | Award Amount: 12.01M | Year: 2010

The overall aim of NERA is to achieve a measurable improvement and a long-term impact in the assessment and reduction of the vulnerability of constructions and citizens to earthquakes. NERA will integrate the key research infrastructures in Europe to monitor earthquakes and assess their hazard and risk, and will combine expertise in observational and strong-motion seismology, modeling, geotechnical and earthquake engineering to develop activities to improve the use of infrastructures and facilitate the access to data. NERA will ensure the provision of high-quality services, including access to earthquake data and parameters and to hazard and risk products and tools. NERA will coordinate with other EC projects (SHARE, SYNER-G) a comprehensive dissemination effort. NERA will contribute to the OECD GEM program and to the EPOS ESFRI infrastructure.


Grant
Agency: Cordis | Branch: FP7 | Program: CP-CSA-Infra | Phase: INFRA-2010-1.1.14 | Award Amount: 9.90M | Year: 2011

Genome sequencing initiated a new age in biology. Now, the emphasis is on the biological interpretation of the genome: zooming on the biological functioning of the gene-products, i.e. the proteins, emerging into a filed termed proteomics. Protein levels depend not only on mRNA levels, but also on translational controls & regulated degradation, making the measurement of expression at the protein level a prerequisite. The expression levels of all proteins, their modifications, localization and interactions, provide the most relevant single data set characterizing a biological system. The PRIME-XS consortium aims to provide state-of-the-art proteomics technologies to the European biological and biomedical research community. Its twelve partners, all leading in the field of proteomics, will provide access to their technology at six access facilities, distributed over Europe, will develop new technologies to better aid the research community in answering current day scientific questions, and will organize a wide range of meetings, courses and training events to disseminate their knowledge and expertise. Special emphasis will be placed on extending this knowledge to new member states of the European Union and other regions of Europe with less privileged availability of proteomics facilities. Access to the facilities will be advertised widely and will be open to all researchers in Europe, via an open, independently reviewed, online application system. Research proposals will be evaluated and, if selected, linked to an appropriate access facility. Many of the partners will be involved in research projects aiming at the development of new methods and tools to aid the access facilities and users. Results obtained will be communicated to both facility operators as well as user via publications, meetings and courses. Together with an industrial platform, users as well as other stakeholders, the consortium will also aim to provide the basis for a sustainable, Europe wide, proteomics community to maintain the high level of proteomics access and research, also beyond the duration of this project.


Grant
Agency: Cordis | Branch: FP7 | Program: MC-ITN | Phase: FP7-PEOPLE-2011-ITN | Award Amount: 2.99M | Year: 2012

Biological cells are entities with highly complex, non-linear control circuits. They can thus express intricate behavior, such as stochasticity-induced multistability, oscillations, responses at different time scales, hysteretic behavior, memory, etc. Biology is only about to start to investigate these phenomena, which all occur at single cell level and often result in phenotypic heterogeneity. It is required to experimentally probe single cells, as population-level analyses will mask most of the behaviors of individual cells. Development of single cell measurement techniques represents an area for exciting research and development, being the key enabling technique to ultimately understand important complex biological behaviors. The education of highly qualified specialists with multidisciplinary skills is a pivotal prerequisite for addressing these biological problems and, even more importantly, for transferring this knowledge into marketable products. This proposal seeks funding for a truly interdisciplinary European consortium to train researchers to develop and exploit novel technologies for single-cell analysis in the context of system-level metabolic cell behavior. The crucial importance of single cell analysis has been stressed in a recent Science News Focus and the area of metabolism was highlighted in Natures New year, new science outlook for 2011. ISOLATE represents an Initial Training Network involving eleven trainees. A range of methodologies will be included to provide unique training to fellows in single cell analyses and to investigate complex phenomena. A high degree of multidisciplinarity and the inclusion of key industrial stakeholders make ISOLATE especially suitable for a training program ranging from forefront microtechnology, bioengineering, biophysics, via analytical chemistry to biochemistry and systems biology.


Grant
Agency: Cordis | Branch: FP7 | Program: CP-IP | Phase: HEALTH-2009-2.1.2-1 | Award Amount: 15.08M | Year: 2010

MitoSys will generate a comprehensive mathematical understanding of mitotic division in human cells, a process of fundamental importance for human health. To create the critical mass and multidisciplinarity that is needed to achieve this ambitious goal, internationally leading mathematicians, biochemists/biophysicists and biologists working at twelve universities, research institutes, international organizations and companies in eight different European countries will collaborate. Mathematicians will focus on four biological modules that represent the most important aspects of the mitotic cell division process; (i) spindle assembly, (ii) the spindle assembly checkpoint and kinetochores, (iii) segregation of mitotic chromosomes and (iv) mitotic exit. Computational models of these separate modules will be integrated into a comprehensive model of mitosis that combines these steps of mitosis with regulation by protein kinases and ubiquitin ligases. To be able to achieve these tasks, the modellers will be supported by biologists and physicists who will use microscopic imaging, biochemistry, biophysics, single-molecule techniques and proteomics to generate kinetic and other quantitative data suitable for model building. To evaluate the relevance of the mathematical models for human health and disease, other biologists will subject selected key predictions from these models to rigorous in-vivo tests by using conditional knock-out mice. MitoSys will compile and disseminate its own data and models, but also datasets from public sources, in a web-database, which will serve as a systems biology resource for the scientific community. To train other scientists in systems biology, MitoSys will organize a practical workshop on mathematical modelling. Finally, MitoSys will inform the general public about systems biology of mitosis and its relevance to health and disease by organizing an exhibition, which will be displayed in several European cities.


Grant
Agency: Cordis | Branch: H2020 | Program: MSCA-ITN-ETN | Phase: MSCA-ITN-2015-ETN | Award Amount: 3.84M | Year: 2016

The development of effective novel drugs - especially for rare and neglected diseases - is one of the biggest challenges of the upcoming decades, as illustrated by the recent Ebola outbreak. Moreover, European innovation in new drug registrations is dramatically falling behind compared to the US and Asia. The principal aim of the AEGIS ITN is to implement the first comprehensive, intersectoral cross-disciplinary and structured curriculum for doctoral students in the European Research Area by establishing a unique training platform for the next generation of European researchers in early drug discovery. A significant added value is provided through networking with key European pharmaceutical companies. A key research aim of AEGIS is improving the efficiency and success of early stage drug development by combining innovative methods and techniques to tackle difficult but promising targets (i.e. protein-protein interactions), as potentially valuable drug targets are often neglected due to the high risk associated with their validation. The consortium joins leading academic and industry researchers in an open innovation environment for innovative drug development in Europe. It is supported by several additional partners and stakeholders in the field. Integrated training of the fellows takes place at the host institute and by secondments, research schools and individual training within the AEGIS network. The scientific training includes complementary skills, management, intellectual property rights, fund raising, communication and career planning. AEGIS will improve the availability of a highly skilled workforce for European industries and research, greatly enhance the employability and the career perspectives of young researchers for academia as well as for industry, and will be the seed of a sustainable development in innovative drug discovery, in particular for rare and neglected diseases.


Grant
Agency: Cordis | Branch: H2020 | Program: RIA | Phase: ICT-13-2016 | Award Amount: 6.91M | Year: 2017

The Future Media Internet (FMI) will be driven by evolving existing over-the-top (OTT) solutions towards a stronger integration with emerging programmable communication and computing infrastructures to address consumer demand for personalised, interactive, mobile and localised media experiences. Creating a trusted platform that brings together technology, creative sectors and consumers in the development of pioneering media applications and services will be crucial to drive European innovation and competitiveness. FLAME will address this goal by establishing an FMI ecosystem based on the Experimentation-as-a-Service (EaaS) paradigm that supports large-scale experimentation of novel FMI products and services using real-life adaptive experimental infrastructures encompassing not only the compute and storage facilities but also the underlying software-enabled communication infrastructure. FLAMEs ecosystem will engage both the creative industries (broadcast, gaming, etc.) and ICT industries (telcos, services) responsible for online distribution, broadcast, communication, and distribution of digital content. Through acceleration methodologies and an advanced experimentation platform (surrogate service management, adaptive service routing, experimental media service chains and experimentation toolbox), FLAME will allow industry, SMEs and entrepreneurs to conduct experiments in real-life experimental infrastructures and gain insight into the performance, acceptance and viability of solutions. FLAMEs innovation potential will be maximised by establishing FLAME Trailblazers (Bristol, Barcelona) to show the way for FLAME Replicators across Europe using a replication process based on best practice sustainability, governance, and engagement models, and infrastructure standards and specifications. A 3rd party investment strategy will create a vibrant FMI ecosystem that adds significant value to current FIRE\ efforts, and puts in place measures for long term sustainability.


Grant
Agency: Cordis | Branch: H2020 | Program: RIA | Phase: PHC-11-2015 | Award Amount: 7.42M | Year: 2016

Cancer is the second leading cause of mortality in EU member states with ~90% of all cancer deaths caused by metastatic spread. Despite its significance, measuring metastatic potential as well as potential indicators of therapy efficacy remain unmet clinical challenges. Recently, it has been demonstrated in vitro, that aggressive metastatic cells pull on their surroundings suggesting that metastatic potential could be gauged by measuring the forces exert by tumours. Furthermore, many solid tumours show a significantly increased interstitial fluid pressure (IFP) which prevents the efficient uptake of therapeutic agents. As a result, a reduction in IFP is recognized as a hallmark of therapeutic efficacy. Currently, there is no non-invasive modality that can directly image these forces in vivo. Our objective is the non-invasive measurement of both IFP within tumours as well as the forces they exert on their surrounding environment. This will be used to predict a tumours metastatic potential and importantly, changes in these forces will be used to predict the therapeutic efficacy of drug therapy. To attain this goal, the biomechanical properties of the tumour and its neighbouring tissue will be measured via MR-elastography at various measured deformation states. Resultant images will be used to reconstruct images of the internal and external forces acting on the tumour. We call this novel imaging modality Magnetic Resonance Force (MRF) imaging. We will calibrate MRF via cell cultures and pre-clinical models, and then test the method in breast, liver, and brain cancer patients. Thereby, we will investigate whether MRF data can predict metastatic spread and measure IFP in patients. We will also investigate the potential to non-invasively modulate the force environment of cancer cells via externally applied shear forces with the aim of impacting cell motility and proliferation. This can provide novel mechanism for anticancer therapeutic agents via mechanotransduction.


Grant
Agency: Cordis | Branch: H2020 | Program: MSCA-ITN-ETN | Phase: MSCA-ITN-2016 | Award Amount: 3.89M | Year: 2017

The network Collective effects and optomechanics in ultra-cold matter (ColOpt) will train early-stage researchers (ESR) in fundamental science and applications in the areas of cold atom and quantum physics, optical technologies and complexity science to promote European competiveness in emergent quantum technologies. It consists of nine academic nodes and three companies from six European countries, supported by two partners in Brazil and the USA, five further non-academic partners and one public-private partnership. Collective, nonlinear dynamics and spontaneous self-organization are abundant in nature, sciences and technology and of central importance. Building on this interdisciplinary relevance, a particular novelty of ColOpt is the integration of classical and quantum self-organization. The research program focuses on collective interactions of light with laser-cooled cold and quantum-degenerate matter. We will explore innovative control of matter through optomechanical effects, identify novel quantum phases, enhance knowledge of long-range coupled systems and advance the associated trapping, laser and optical technologies, establishing new concepts in quantum information and simulation. ColOpt combines cutting-edge science with training in complex instrumentation and methods to the highest level of technical expertise, both experimentally and theoretically, and fosters the development of transferable skills and critical judgement. Each ESR will be exposed to a broad spectrum of experimental, theoretical and industrial environments, to obtain core competence in one of them and the collaborative experience and skills to thrive in a truly international and intersectorial framework. ESRs will develop the capabilities to analyse and understand complex interactions, and will gain awareness of societal and entrepreneurial needs and opportunities. Taken together, this will enable them to excel in a variety of sectors of our diverse and rapidly changing society.


Grant
Agency: Cordis | Branch: H2020 | Program: RIA | Phase: LCE-33-2016 | Award Amount: 2.86M | Year: 2017

Despite process heat is recognized as the application with highest potential among solar heating and cooling applications, Solar Heat for Industrial Processes (SHIP) still presents a modest share of about 0.3% of total installed solar thermal capacity. As of todays technology development stage economic competitiveness restricted to low temperature applications; technology implementation requiring interference with existing heat production systems, heat distribution networks or even heat consuming processes - Solar thermal potential is mainly identified for new industrial capacity in outside Americas and Europe. In this context, INSHIP aims at the definition of a ECRIA engaging major European research institutes with recognized activities on SHIP, into an integrated structure that could successfully achieve the coordination objectives of: more effective and intense cooperation between EU research institutions; alignment of different SHIP related national research and funding programs, avoiding overlaps and duplications and identifying gaps; acceleration of knowledge transfer to the European industry, to be the reference organization to promote and coordinate the international cooperation in SHIP research from and to Europe, while developing coordinated R&D TRLs 2-5 activities with the ambition of progressing SHIP beyond the state-of-the-art through: an easier integration of low and medium temperature technologies suiting the operation, durability and reliability requirements of industrial end users; expanding the range of SHIP applications to the EI sector through the development of suitable process embedded solar concentrating technologies, overcoming the present barrier of applications only in the low and medium temperature ranges; increasing the synergies within industrial parks, through centralized heat distribution networks and exploiting the potential synergies of these networks with district heating and with the electricity grid.


Patent
Friedrich Miescher Institute for Biomedical Research and ETH Zurich | Date: 2014-02-06

The present invention provides a method for the targeted infection of cells. Said method is characterized in that it comprises the step of contacting the cell with a virus attached to a support. The present invention also encompasses a support to which a molecule binding specifically to a molecule present on the surface of a virus is attached, said molecule binding specifically to a molecule present on the surface of said virus being optionally attached to the support through a linking moiety.


Grant
Agency: Cordis | Branch: FP7 | Program: CP-IP-SICA | Phase: ENV.2011.4.1.1-1 | Award Amount: 8.67M | Year: 2011

Today, countries use a wide variety of methods to monitor the carbon cycle and it is difficult to compare data from country to country and to get a clear global picture. The current global observational and modelling capabilities allow us to produce estimates of carbon budget at different level (from local to global) but many uncertainties still remain. Decision makers need now more than ever systematic, consistent and transparent data, information and tools for an independent and reliable verification process of greenhouse gas emissions and sinks. Therefore higher quality and quantity of CO2 and CH4 data, from different domains and with an enhanced spatial and temporal resolution, need to be collected by a globally integrated observation and analysis system. This can be obtained by the coordinated Global Carbon Observation and Analysis System that this project aims at designing, addressing the climate targets of the Group on Earth Observations (GEO) toward building a Global Earth Observation System of Systems (GEOSS) for carbon. Specific objectives of the GEOCARBON project are: Provide an aggregated set of harmonized global carbon data information (integrating the land, ocean, atmosphere and human dimension) Develop improved Carbon Cycle Data Assimilation Systems (CCDAS) Define the specifications for an operational Global Carbon Observing System Provide improved regional carbon budgets of Amazon and Central Africa Provide comprehensive and synthetic information on the annual sources and sinks of CO2 for the globe and for large ocean and land regions Improve the assessment of global CH4 sources and sinks and develop the CH4 observing system component Provide an economic assessment of the value of an enhanced Global Carbon Observing System Strengthen the effectiveness of the European (and global) Carbon Community participation in the GEO system


Grant
Agency: Cordis | Branch: FP7 | Program: CSA-SA | Phase: SEC-2013.4.1-5 | Award Amount: 1.13M | Year: 2014

The main objective of POP-ALERT is to prepare societies and populations to cope with crisis and disasters in a rapid, effective and efficient way by blending traditional Crisis Preparedness & First-Reaction strategies with the use of innovative contemporary tools. POP-ALERT proposes to undertake thorough behavioural research and take traditional Crisis Management research a step further by carrying out a series of empirical studies, taking into account new issues related to targeting both local populations and visitors such as expats or tourists (cultural differences, language barriers, etc.), in order to create a framework to facilitate the assessment of the populations capacity to absorb and preparedness to make use of different Crisis Management strategies and technologies developed at the EU level. POP-ALERT will identify specific target success stories within existing and past community preparedness programmes and put together a portfolio of case studies on social networking and community self-reliance initiatives which could potentially be replicated to crisis with a European dimension and to cross-border disasters. The project will seek to study the best ways to blend contemporary tools with the existing practices identified in order to create flexible and easily deployable toolkits for preparing and alarming the European population in case of a crisis. The approach this project proposes for improving the current practices revolves around the use of messaging and cultural sharing technologies to create awareness using technologies and approaches that offer the best form of accessibility and penetration by citizens and authorities. POP-ALERT will propose a pilot project (designing criteria for selection of the area and population to be involved in the pilot, developing scenarios and objectives) in order to test the generic methodologies and to assess their effectiveness in raising an improved level of preparedness of the community.


Grant
Agency: Cordis | Branch: FP7 | Program: CP-TP | Phase: KBBE.2011.1.2-05 | Award Amount: 4.80M | Year: 2012

The overall goal of EURoot is to help farmers to face both climate change, which is expected to result in increasingly uneven rainfall, and meet the societal demand for sustainable agriculture with reduced use of water and fertilizers. EURoot objective is to enhance the cereal plant capability to acquire water and nutrients through their roots and maintain growth and performance under stress conditions. Making use of join phenotyping and modelling platforms, EURoot will conduct a suite of experiments designed to better understand and model: i. The genetic and functional bases of root traits involved in soil exploration and resource uptake, ii. The bio-geochemical properties of the soil, including beneficial association with mycorhizal fungi, influencing extraction of nutrient and water by the root system and iii. The plant signalling processes involved in soil environment sensing and responsible for adaptive root system response enhancing soil exploration and resource acquisition. The EURoot project is based on a tripod of interactive WPs addressing specific complementary questions i.e. WP1, genetics of root traits, WP2, root:soil interactions, WP3, root : shoot signalling-, and on two platforms WPs allowing to share innovative phenotyping methods relevant to field conditions and linked to crop performance (WP4) and multi scale modelling (WP5) aiming at integrating root architecture, resource dynamics in the soil and root uptake, and inner plant signalling processes, to design root ideotypes allowing enhanced resource acquisition under stress. Results will be readily translated into screening methods, models and tools (markers, biochemical signatures) to guide the challenging breeding for improved root traits allowing enhanced water and nutrient capture. It will allow the further development of novel cereal cultivars with higher resilience, tolerating erratic rainfalls and reduced fertilizer application, while achieving their yield potential.


Grant
Agency: Cordis | Branch: FP7 | Program: CPCSA | Phase: ICT-2013.9.9 | Award Amount: 72.73M | Year: 2013

Understanding the human brain is one of the greatest challenges facing 21st century science. If we can rise to the challenge, we can gain profound insights into what makes us human, develop new treatments for brain diseases and build revolutionary new computing technologies. Today, for the first time, modern ICT has brought these goals within sight. The goal of the Human Brain Project, part of the FET Flagship Programme, is to translate this vision into reality, using ICT as a catalyst for a global collaborative effort to understand the human brain and its diseases and ultimately to emulate its computational capabilities. The Human Brain Project will last ten years and will consist of a ramp-up phase (from month 1 to month 36) and subsequent operational phases.\nThis Grant Agreement covers the ramp-up phase. During this phase the strategic goals of the project will be to design, develop and deploy the first versions of six ICT platforms dedicated to Neuroinformatics, Brain Simulation, High Performance Computing, Medical Informatics, Neuromorphic Computing and Neurorobotics, and create a user community of research groups from within and outside the HBP, set up a European Institute for Theoretical Neuroscience, complete a set of pilot projects providing a first demonstration of the scientific value of the platforms and the Institute, develop the scientific and technological capabilities required by future versions of the platforms, implement a policy of Responsible Innovation, and a programme of transdisciplinary education, and develop a framework for collaboration that links the partners under strong scientific leadership and professional project management, providing a coherent European approach and ensuring effective alignment of regional, national and European research and programmes. The project work plan is organized in the form of thirteen subprojects, each dedicated to a specific area of activity.\nA significant part of the budget will be used for competitive calls to complement the collective skills of the Consortium with additional expertise.


Grant
Agency: Cordis | Branch: FP7 | Program: CP-IP | Phase: KBBE.2010.1.1-01 | Award Amount: 10.25M | Year: 2011

Fruit Breedomics has as its strategic goal to improve the efficiency of fruit breeding by bridging the gap between scientific genetics research and application in breeding. Fruit Breedomics takes a multidisciplinary approach, including genetics, genomics, ecophysiology and bioinformatics, to improve the efficiency apple and peach breeding programmes by: i) developing new and adapted tools, ii) studying a wide range of traits to enlarge the coverage of selection criteria, iii) analysing and exploiting the wide genetic diversity available, iv) making the research outputs (valuable traits, genetic markers and genes, innovative tools and methodologies, new plant material) directly applicable for the breeders, v) establishing a stakeholder network. Fruit Breedomics will provide the European fruit tree sector with cutting-edge breeding tools to improve selection efficiency as well as superior pre-breeding material to meet grower and consumer demands for healthy cultivars of high quality that can be grown in sustainable agriculture systems in the context of climate change. The project will develop tailored molecular and bioinformatics tools to extensively exploit the diversity present in European germplasm collections and breeding populations. This will lead to the selection of desired favourable genes needed for improvement of main horticultural traits. The collected data will provide precious genetic information on the pool of genitors and founders to be used in future breeding programmes. The project will focus primarily on apple and peach, two major fruits in Europe, but many tools and much knowledge gained will also be of benefit to other species of the Rosaceae family via the strong ancestral relatedness among these species.


Grant
Agency: Cordis | Branch: FP7 | Program: MC-ITN | Phase: FP7-PEOPLE-2013-ITN | Award Amount: 3.45M | Year: 2013

Protozoan parasites and helminths are the cause of some of the most devastating diseases worldwide and a major effort is needed to be able to control or eliminate these diseases. Glycoconjugates are abundant and ubiquitous on the surface of many parasites and they are frequently involved in their survival strategies by forming a protective barrier against host defences. A common feature of the parasites cell surface architecture is the presence of an elaborate and often highly decorated glycocalyx that allows it to interact and respond to the external environment. Therefore, the study of the glycobiology of these organisms offers unique opportunities to devise novel strategies to tackle parasitic-caused diseases. However, the exquisite diversity of these glycoconjugates and of their biosynthetic machineries, the difficulties related with their structural analysis and the complexity associated with their synthesis in the laboratory, poses a tremendous challenge for the scientific community. To address these challenges GlycoPar proposes to establish a European based training programme in a world-class collaborative research environment steered by some of the world leaders in the fast evolving field of parasite glycobiology, in close association with European industrial enterprises. The researchers recruited through this initiative will be exposed, both at the local and network-wide level, to a multicultural and highly multidisciplinary PhD training. This programme will acquaint them with a complete range of state-of-the-art glycobiology methodologies, alongside with valuable transferable and entrepreneurial skills. All together the aim is to create a PhD-level trained generation of young scientists capable of tackling the challenges that parasite glycobiology implies with improved career prospects and employability as well as preparing them to become future leaders in research institutions and industry.


Grant
Agency: Cordis | Branch: FP7 | Program: MC-ITN | Phase: FP7-PEOPLE-2012-ITN | Award Amount: 3.56M | Year: 2012

Soft nanotechnology is generally considered as a field that will have a major impact on technological developments in near future. However, the fundamental understanding of the wealth of new structures lacks far behind, despite supporting activity from material science. Such an understanding is indispensable for sustainable growth of this important research domain and its applications. A physics-oriented interdisciplinary education is urgently needed to guide young researchers to the point where they can tackle the relevant fundamental questions. SOMATAI is set up to provide just such training by combining two distinct scientific fields: Soft matter science is a well established interdisciplinary field for the bulk investigation of polymers, colloids, and liquid crystals with response amplitude and time to external stimuli as a function of soft matter structure being of special interest. The second highly relevant field is interface science, since nano-structured materials contain a huge area of internal interfaces which have an essential impact on material properties. The application of the soft matter approach to interfaces promises new and deeper understanding of interfacial phenomena. Interfaces of a water phase to a solid, liquid or gaseous second phase are of special interest and a focal point of SOMATAI. Such interfaces are highly relevant to products from European industry (food, cosmetics, paints) and processes (washing, coating, water purification). They have an outstanding importance from a scientific point of view due to specific interactions at such interfaces. This carefully planned teaching and research programme in a network of 10 leading academic partners, 1 large scale companies, 2 SMEs, and 4 top-level associated partners from Germany, Taiwan and the USA will ensure that young researchers are given an excellent training in a pioneering research domain of high scientific and technological relevance, where Europe can take a leading position.


Grant
Agency: Cordis | Branch: FP7 | Program: CP-IP | Phase: HEALTH.2013.1.3-1 | Award Amount: 15.99M | Year: 2013

HeCaToS aims at developing integrative in silico tools for predicting human liver and heart toxicity. The objective is to develop an integrated modeling framework, by combining advances in computational chemistry and systems toxicology, for modelling toxic perturbations in liver and heart across multiple scales. This framework will include vertical integrations of representations from drug(metabolite)-target interactions, through macromolecules/proteins, to (sub-)cellular functionalities and organ physiologies, and even the human whole-body level. In view of the importance of mitochondrial deregulations and of immunological dysfunctions associated with hepatic and cardiac drug-induced injuries, focus will be on these particular Adverse Outcome Pathways. Models will be populated with data from innovative in vitro 3D liver and heart assays challenged with prototypical hepato- or cardiotoxicants; data will be generated by advanced molecular and functional analytical techniques retrieving information on key (sub-)cellular toxic evens. For validating perturbed AOPs in vitro in appropriate human investigations, case studies on patients with liver injuries or cardiomyopathies due to adverse drug effects, will be developed, and biopsies will be subjected to similar analyses. Existing ChEMBL and diXa data infrastructures will be advanced for data gathering, storing and integrated statistical analysis. Model performance in toxicity prediction will be assessed by comparing in silico predictions with experimental results across a multitude of read-out parameters, which in turn will suggest additional experiments for further validating predictions. HeCaToS, organized as a private-public partnership, will generate major socioeconomic impact because it will develop better chemical safety tests leading to safer drugs, but also industrial chemicals, and cosmetics, thereby improving patient and consumer health, and sustaining EUs industrial competitiveness.


Grant
Agency: Cordis | Branch: FP7 | Program: MC-ITN | Phase: FP7-PEOPLE-2011-ITN | Award Amount: 4.25M | Year: 2011

RNA molecules are at the heart of life. It is now commonly admitted that nearly all the human genome is transcribed, and a wealth of new coding and non-coding RNAs have been discovered. Importantly, modern RNAs are never naked, but always exist in complex with proteins to form RNPs (Ribonucleoproteins). In the case of non-coding RNAs, these proteins are usually stably associated with the RNA and help to perform their function. In contrast, RNA binding proteins are usually transiently bound to coding RNAs, and control various aspects of their metabolism. For the next generation of scientists, a great challenge will be to understand the function and the mechanisms of action of the myriads of RNPs. The goal of this ITN (RNPnet) is first to bring together existing labs from different discipline, to join forces and tackle key questions in the field, and second, to produce highly-trained young researchers that will be sensitized to RNA and possess a multidisciplinary approach to research. The multiple expertises present in the fifteen labs of this network will be used in a highly cooperative and integrated manner. The research training will focus on studying RNPs involved in mRNA surveillance, splicing and editing. In addition, a total of fifteen meetings including two summer schools and several workshops are planed to strengthen education and interaction among participants of RNPnet. Finally, another important aspect of RNPnet is the presence of two industrial partners. Their aim is to use the enormous potential of RNA biology in therapeutic applications, either by modifying RNAs and using it as a drug, or by targeting specific RNA binding proteins with small molecules. We foresee that the presence of industrial partners will be highly beneficial for the students, and that, by exposing them to both the academic and industrial world, we will both facilitate communication between these worlds and provide to the young trainees a large panorama of their possible career.


Grant
Agency: Cordis | Branch: H2020 | Program: MSCA-ITN-ETN | Phase: MSCA-ITN-2015-ETN | Award Amount: 3.91M | Year: 2016

The SUBITOP ETN is a framework for training and career development of young researchers in Geodynamics, Geophysics, Geology and Geomorphology. It has a scientific focus on the dynamics of continental margins where tectonic plates are recycled through subduction. Subduction processes have shaped and govern many aspects of the topography of Europe, and other continents, and they determine the patterns and intensity of geological hazards such as earthquakes, volcanic activity and landsliding. The Training Network will imbue 15 young scientists with the ability to address the links between the geological processes within subduction zones and the processes that impact the Earths surface above, using a comprehensive range of modelling and observation techniques and exploiting the full diversity of active and ancient subduction systems within Europe. SUBITOP fuses research and training at ten leading centres of the Earth Sciences in Europe and forges partnerships with 15 companies for its fellows, with participants in eight countries. It will train Early Stage Researchers (ESR) through a structured programme of cross-disciplinary, collaborative research, and integrated skills and outreach activities. This experience-based training is centred on PhD projects, covering a spectrum of topics from the deep mechanics of subduction zones to the erosion of their uplifted topography. Together the projects probe the functioning of the subduction system in its entirety, and they are welded together by shared techniques, study sites and data sets. Through their projects, the ESRs will acquire skills in modelling and observation of coupled processes in complex geological systems. SUBITOP will also impart essential communication, outreach and career management skills, and first-hand experience of the private sector through project-specific secondments and co-supervision by industry partners, and embed its ESRs in the active TOPO-Europe research community.


Grant
Agency: Cordis | Branch: FP7 | Program: NoE | Phase: HEALTH.2010.2.1.2-2 | Award Amount: 16.04M | Year: 2010

The EpiGeneSys Network of Excellence aims to enable European epigenetics research to enter the arena of systems biology, a new step forward with major implications for human health. Many diseases, not explained solely by gene mutation, have rather been associated with epigenetic disorders. Following the identification of key epigenetic regulators, a move towards a systems biology approach is needed to understand their dynamic functional relationships. This NoE identified 4 areas aiming at: 1) characterizing the molecular dynamics of epigenetic systems at the single molecule and cell level, 2) linking genotypes to epigenotypes, 3) investigating how environmental, developmental and metabolic signals act upon the epigenome, and 4) understanding epigenetic inheritance through replication, mitosis and meiosis. The common objective is to address fundamental epigenetic mechanisms in quantitative terms both spatially and temporally. The ultimate goal is to express the underlying dynamic events in mathematical terms in order to model and predict how the balance between maintenance and erasure of epigenetic information varies in specific developmental contexts under normal or pathological conditions. A major effort on data management and technology will provide standardised protocols for processing, normalising, and analysing each type of epigenetics data set. Common platforms, tools and resources including a key multilayer toolbox will be implemented for wide use and easy access for researchers, within the NoE and the epigenetics community at large. This NoE will function as an essential bridge between epigenetics researchers and the systems biology community. In the NoE, 22 teams will join efforts to address Epigenetics questions from a systems biology perspective. The combination of a strong training plan together with extension through open targeted calls to recruit young talent will further contribute to build a coherent new EpiGeneSys Area of European Research.


Grant
Agency: Cordis | Branch: H2020 | Program: RIA | Phase: INFRAIA-1-2014-2015 | Award Amount: 13.00M | Year: 2015

Particle physics is at the forefront of the ERA, attracting a global community of more than 10,000 scientists. With the upgrade of the LHC and the preparation of new experiments, the community will have to overcome unprecedented challenges in order to answer fundamental questions concerning the Higgs boson, neutrinos, and physics beyond the Standard Model. Major developments in detector technology are required to ensure the success of these endeavours. The AIDA-2020 project brings together the leading European infrastructures in detector development and a number of academic institutes, thus assembling the necessary expertise for the ambitious programme of work. In total, 19 countries and CERN are involved in this programme, which follows closely the priorities of the European Strategy for Particle Physics. AIDA-2020 aims to advance detector technologies beyond current limits by offering well-equipped test beam and irradiation facilities for testing detector systems under its Transnational Access programme. Common software tools, micro-electronics and data acquisition systems are also provided. This shared high-quality infrastructure will ensure optimal use and coherent development, thus increasing knowledge exchange between European groups and maximising scientific progress. The project also exploits the innovation potential of detector research by engaging with European industry for large-scale production of detector systems and by developing applications outside of particle physics, e.g. for medical imaging. AIDA-2020 will lead to enhanced coordination within the European detector community, leveraging EU and national resources. The project will explore novel detector technologies and will provide the ERA with world-class infrastructure for detector development, benefiting thousands of researchers participating in future particle physics projects, and contributing to maintaining Europes leadership of the field.


Grant
Agency: Cordis | Branch: H2020 | Program: IA | Phase: GV-3-2014 | Award Amount: 23.39M | Year: 2015

In order to realize sustainable mobility in Europe, both urban and long distance vehicles for road transport will have to be significantly more efficient by 2020\ and a considerable contribution will have to come from the energy efficiency improvement of the powertrain. Moreover, together with the progressive efficiency increase coming from the engine technology evolution, the use of Low-Carbon Alternative Fuels, such as Natural Gas, will play a fundamental role to accelerate the process of decarbonization of the transportation sector that in Europe is targeted for the 2050 time horizon. In this context, being well-known the benefits of the Natural Gas Vehicles adoption in Europe, this proposal aims to exploit the main benefits of gas-powered engines developing CNG-only, mono-fuel-engines able to comply with: post Euro 6 noxious emissions 2020\ CO2 emissions targets new homologation cycle and Real Driving conditions and simultaneously improving engine efficiency and vehicle performance also with regard to its CNG range capability. These engines, based on new combustion processes, require also dedicated technological solutions for: Innovative injection, ignition and boosting system concepts Advanced exhaust gas aftertreatment system Detecting the gas-quality and its composition The results obtained from the experimental activities on the demonstration vehicles and engines will be harmonized and analysed throughout a final overall assessment of the different approaches. The demonstrator vehicles will be assessed in terms of performance and emissions with regard to NEDC, WLTP and under real driving conditions. Moreover, the final assessment of the vehicles will be certified, as independent testing, by JRC (Joint Research Centre) which will carry out additional measurements in their own testing facilities both on chassis dyno and by means of PEMS (Portable Emissions Measurement System).


Grant
Agency: Cordis | Branch: H2020 | Program: RIA | Phase: INFRADEV-4-2014-2015 | Award Amount: 15.00M | Year: 2015

ENVRIPLUS is a cluster of research infrastructures (RIs) for Environmental and Earth System sciences, built around ESFRI roadmap and associating leading e-infrastructures and Integrating Activities together with technical specialist partners. ENVRIPLUS is driven by 3 overarching goals: 1) favoring cross-fertilization between infrastructures, 2) implementing innovative concepts and devices across RIs, and 3) facilitating research and innovation in the field of environment to an increasing number of users outside the RIs. ENVRIPLUS organizes its activities along a main strategic plan where sharing multi-disciplinary expertise will be most effective. It aims to improve Earth observation monitoring systems and strategies, including actions towards harmonization and innovation, to generate common solutions to many shared information technology and data related challenges, to harmonize policies for access and provide strategies for knowledge transfer amongst RIs. ENVRIPLUS develops guidelines to enhance trans-disciplinary use of data and data-products supported by applied use-cases involving RIs from different domains. ENVRIPLUS coordinates actions to improve communication and cooperation, addressing Environmental RIs at all levels, from management to end-users, implementing RI-staff exchange programs, generating material for RI personnel, and proposing common strategic developments and actions for enhancing services to users and evaluating the socio-economic impacts. ENVRIPLUS is expected to facilitate structuration and improve quality of services offered both within single RIs and at pan-RI level. It promotes efficient and multi-disciplinary research offering new opportunities to users, new tools to RI managers and new communication strategies for environmental RI communities. The produced solutions, services and other project results are made available to all environmental RI initiatives, thus contributing to the development of a consistent European RI ecosystem.


Grant
Agency: Cordis | Branch: H2020 | Program: IA | Phase: MG-4.1-2014 | Award Amount: 25.11M | Year: 2015

The project HERCULES-2 is targeting at a fuel-flexible large marine engine, optimally adaptive to its operating environment. The objectives of the HERCULES-2 project are associated to 4 areas of engine integrated R&D: Improving fuel flexibility for seamless switching between different fuel types, including non-conventional fuels. Formulating new materials to support high temperature component applications. Developing adaptive control methodologies to retain performance over the powerplant lifetime. Achieving near-zero emissions, via combined integrated aftertreatment of exhaust gases. The HERCULES-2 is the next phase of the R&D programme HERCULES on large engine technologies, which was initiated in 2004 as a joint vision by the two major European engine manufacturer groups MAN and WARTSILA. Three consecutive projects namely HERCULES - A, -B, -C spanned the years 2004-2014. These three projects produced exceptional results and received worldwide acclaim. The targets of HERCULES-2 build upon and surpass the targets of the previous HERCULES projects, going beyond the limits set by the regulatory authorities. By combining cutting-edge technologies, the Project overall aims at significant fuel consumption and emission reduction targets using integrated solutions, which can quickly mature into commercially available products. Focusing on the applications, the project includes several full-scale prototypes and shipboard demonstrators. The project HERCULES-2 comprises 4 R&D Work Package Groups (WPG): - WPG I: Fuel flexible engine - WPG II: New Materials (Applications in engines) - WPG III: Adaptive Powerplant for Lifetime Performance - WPG IV: Near-Zero Emissions Engine The consortium comprises 32 partners of which 30% are Industrial and 70% are Universities / Research Institutes. The Budget share is 63% Industry and 37% Universities. The HERCULES-2 proposal covers with authority and in full the Work Programme scope B1 of MG.4.1-2014.


Grant
Agency: Cordis | Branch: H2020 | Program: RIA | Phase: EINFRA-4-2014 | Award Amount: 16.42M | Year: 2015

PRACE, the Partnership for Advanced Computing, was established in May 2010 as a permanent pan-European High Performance Computing service providing world-class systems for world-class science. Six systems at the highest performance level (Tier-0) are deployed by Germany, France, Italy and Spain providing researchers with over 9 billion core hours of compute time. HPC experts from twenty-five member states - funded in part in three implementation projects - enabled users from academia and industry to ascertain leadership and remain competitive in the Global Race. Currently PRACE is preparing for PRACE 2.0, the successor of the initial five year period. The objectives of PRACE-4IP are to build on and seamlessly continue the successes of PRACE and start new innovative and collaborative activities proposed by the consortium. These include: assisting the transition to PRACE 2.0; strengthening the internationally recognised PRACE brand; continuing advanced training which so far provided more than 15.000 person-training days to over 4700 persons, preparing strategies and best practices towards exascale computing, coordinating and enhancing the operation of the multi-tier HPC systems and services, and supporting users to exploit massively parallel systems and novel architectures. The proven project structure will be used to achieve each of the objectives in six dedicated work packages. The project will continue to be managed by Jlich. The activities are designed to increase Europes research and innovation potential especially through: seamless and efficient Tier-0 services and a pan-European HPC ecosystem including national capabilities; promoting take-up by industry and special offers to SMEs; analysing new flexible business models for PRACE 2.0; proposing strategies for deployment of leadership systems; collaborating with the ETP4HPC, the coming CoEs and other European and international organisations on future architectures, training, application support and policies.


Grant
Agency: Cordis | Branch: H2020 | Program: RIA | Phase: INFRADEV-1-2014 | Award Amount: 3.09M | Year: 2015

RICHFIELDS Research Infrastructure on Consumer Health and Food Intake using E-science with Linked Data Sharing There is growing interest in consumer health as related to food, behaviour and lifestyle determinants. However, data is fragmented, key information is lacking, and the resulting knowledge gap prohibits policy makers and companies to make effective public health nutrition strategies and reformulation of food products. Making the healthy the easy choice requires knowledge on the context of personal life style choices of EU-citizens. RICHFIELDS will design a world-class infrastructure for innovative research on healthy food choice, preparation and consumption of EU-citizens, closely linked to their behaviour and lifestyle. This unique RI will bridge the gap by linking the agri-food and nutrition-health domains and account for the regional and socio-economic diversity of the EU. The RI will be instrumental to produce a scientifically reliable, technically sound and socio-legally robust evidence-base that enables scientists to efficiently collect, unlock, connect and share research data of EU-citizens. Consumers are central to the design: they harbour crucial information, as they increasingly adopt mobile apps and tech-wear, get access to e-business data and even medical information. Collectively, such real-life-time data create new opportunities for research, by e.g., monitoring of food-behaviour providing personalized feedback. For further testing, detailing and underpinning and theory-building, interfaces will be created to distributed facilities for experimental research, e.g., virtual supermarkets. Further enrichment of data is achieved via interfaces with information systems for food and health. The consumer-focus and the scientific evidence of RICHFIELDS will, via its services, be available to (a) EU-consumers and consumer platforms, (b) stakeholders along the food chain, and (c) policy actors in the agri-food and nutrition-health domain.


Grant
Agency: Cordis | Branch: H2020 | Program: RIA | Phase: NMBP-26-2016 | Award Amount: 7.49M | Year: 2017

The npSCOPE project aims at developing a new integrated instrument (the nanoparticle-scope) optimised for providing a complete physico-chemical characterisation of nanoparticles both in their pristine form or embedded in complex matrices such as biological tissues. Using sophisticated correlative data processing methodologies and algorithms based on statistical methods in conjunction with appropriate visualisation methods of the results, the npSCOPE instrument will allow rapid, accurate and reproducible measurements. The instrument will be based on the Gas Field Ion Source as a key enabling technology, which we will combine with a number of new developments in the field of electron and ion microscopy. We will progressively ramp up the TRL of the instrument and associated methodologies to reach TRL 7 by the end of the project. The new technology, and all related processes and methodologies, will be validated via round-robin studies performed independently by several partner institutions, crosschecked with conventional analysis technologies to demonstrate the advancements and capabilities of the npSCOPE technology and benchmarked in representative case studies. Given the low sample quantities needed and the strong potential of the instrument to generate high-quality physico-chemical data on nanomaterials, both ex situ and in situ, npSCOPE will allow a major step forward in defining key descriptors for read-across, grouping, in silico modelling and creating meaningful relationships with biological activity data for QSAR purposes. To reach these objectives, the project consortium will be composed of research centres internationally recognised for innovative instrument developments, well-established instrument manufacturers and experts in nanotoxicology in various fields of application to demonstrate and validate the applicability of npSCOPE for the risk assessment of nanomaterials in consumer products.


Grant
Agency: Cordis | Branch: H2020 | Program: MSCA-RISE | Phase: MSCA-RISE-2015 | Award Amount: 1.22M | Year: 2016

The main goal of the MediHealth project is to introduce a novel approach for the discovery of active agents of food plants from Mediterranean diet and other global sources to promote healthy ageing. This will be achieved through an extended and well-balanced scheme of researchers secondments between 5 universities and 4 enterprises from EU & Associated countries as well as 4 universities from Third countries. A mutual scientific project developed on the needs and interests of both sectors exploiting the existing complementary expertise will be the base of this proposal. Plants from the Mediterranean diet and food plants from TC will be rationally selected and will be subjected to an integrated, interactive and comprehensive platform including in silico, in vitro (advanced cell-based assays), in vivo (flies and mice models) & metabolism assessment. Advanced analytical techniques will embrace the pharmacological evaluation process for the efficient isolation and identification of bioactive plant constituents. Pharmacological profiling of bioactive natural products as well as identification and synthesis of their metabolites will be carried out. Finally, to carry to the stage of development innovative products in the area of nutraceuticals/dietary supplements process-optimization studies will be performed. Within this project, core scientific multidisciplinary knowledge from different research areas will be integrated creating valuable synergies. Expertise will be transferred by means of the seconded researchers training in environments with different research orientation where complimentary skills are required. Special attention will be given to dissemination activities aiming to public awareness of benefits of healthy diet(s). MediHealth aspires to comprise a successful model promoting considerably researchers competences and long-lasting collaboration between Industry and Academia generating innovation potential at the European and global levels.


Grant
Agency: Cordis | Branch: H2020 | Program: RIA | Phase: EINFRA-11-2016 | Award Amount: 16.11M | Year: 2017

PRACE, the Partnership for Advanced Computing is the permanent pan-European High Performance Computing service providing world-class systems for world-class science. Systems at the highest performance level (Tier-0) are deployed by Germany, France, Italy and Spain providing researchers with over 11 billion core hours of compute time. HPC experts from 25 member states enabled users from academia and industry to ascertain leadership and remain competitive in the Global Race. Currently PRACE is in transition to PRACE 2, the successor of the initial five year period. The objectives of PRACE-5IP are to build on and seamlessly continue the successes of PRACE and start new innovative and collaborative activities proposed by the consortium. These include: assisting the transition to PRACE 2 including an analysis of Trans National Access; strengthening the internationally recognised PRACE brand; continuing and extend advanced training which so far provided more than 18 800 persontraining days; preparing strategies and best practices towards Exascale computing; coordinating and enhancing the operation of the multi-tier HPC systems and services; and supporting users to exploit massively parallel systems and novel architectures. A high level Service Catalogue is provided. The proven project structure will be used to achieve each of the objectives in 6 dedicated work packages. The activities are designed to increase Europes research and innovation potential especially through: seamless and efficient Tier-0 services and a pan-European HPC ecosystem including national capabilities; promoting take-up by industry and new communities and special offers to SMEs; implementing a new flexible business model for PRACE 2; proposing strategies for deployment of leadership systems; collaborating with the ETP4HPC, CoEs and other European and international organisations on future architectures, training, application support and policies. This will be monitored through a set of KPIs.


Grant
Agency: Cordis | Branch: H2020 | Program: IA | Phase: LCE-03-2015 | Award Amount: 25.07M | Year: 2016

DESTRESS is aimed at creating EGS (Enhanced geothermal systems) reservoirs with sufficient permeability, fracture orientation and spacing for economic use of underground heat. The concepts are based on experience in previous projects, on scientific progress and developments in other fields, mainly the oil & gas sector. Recently developed stimulation methods will be adapted to geothermal needs, applied to new geothermal sites and prepared for the market uptake. Understanding of risks in each area (whether technological, in business processes, for particular business cases, or otherwise), risk ownership, and possible risk mitigation will be the scope of specific work packages. The DESTRESS concept takes into account the common and specific issues of different sites, representative for large parts of Europe, and will provide a generally applicable workflow for productivity enhancement measures. The main focus will be on stimulation treatments with minimized environmental hazard (soft stimulation), to enhance the reservoir in several geological settings covering granites, sandstones, and other rock types. The business cases will be shown with cost and benefit estimations based on the proven changes of the system performance, and the environmental footprint of treatments and operation of the site will be controlled. In particular, the public debate related to fracking will be addressed by applying specific concepts for the mitigation of damaging seismic effects while constructing a productive reservoir and operating a long-term sustainable system. Industrial participation is particularly pronounced in DESTRESS, including large energy suppliers as well as SMEs in the process of developing their sites. The composition of the consortium involving major knowledge institutes as well as key industry will guarantee the increase in technology performance of EGS as well as an accelerated time to market.


Grant
Agency: Cordis | Branch: H2020 | Program: RIA | Phase: ICT-24-2015 | Award Amount: 6.35M | Year: 2016

The TrimBot2020 project will research the robotics and vision technologies to prototype the first outdoor garden trimming robot. The robot will navigate over varying terrain, approach rose bushes, hedges and boxwood topiary, to trim them to an ideal shape. The robot will be based on a modified Bosch Indego robot lawnmower, which will navigate using a user-defined garden map and 3D scene analysis, and then visually servo a novel electric plant cutter. Achieving this will require a combination of robotics and 3D computer vision research and innovation activities. Original developments will be required for 3D sensing of semi-regular surfaces with physical texture (overgrown plant surfaces), coping with outdoor lighting variations, self-localising and navigating over real terrain and around obstacles, visual servoing to align the vehicle with potentially moving target plants, visual servoing to align leaf and branch cutters to a compliant surface, and innovative engineering to deliver all this on a small battery-powered consumer-grade vehicle. Development of these capabilities aligns closely with the Robotics Strategic Research Agenda and Multi-Annual Roadmap aspirations. This project falls clearly in the consumer market domain. It will develop service robotics, advanced perceptual capabilities, mobile manipulation, and flexible and reactive autonomy. As a novel robotics application, the current TRL is 1/2, but the project aims to achieve TRL 5/6. Bosch expects to exploit the projects results to extend its current automated lawnmower product. This exciting project will extend generic robotics and computer vision technologies, explore a new robot application, has an explicit route to market exploitation by an experienced manufacturer, and has a great team with experienced plant roboticists and world-leading computer vision researchers, led by an experienced EC project coordinator.


Grant
Agency: Cordis | Branch: FP7 | Program: NOE | Phase: ICT-2011.1.6 | Award Amount: 5.99M | Year: 2011

The goal of EINS is coordinating and integrating European research aimed at achieving a deeper multidisciplinary understanding of the development of the Internet as a societal and technological artefact, whose evolution is increasingly interwined with that of human societies. Its main objective is to allow an open and productive dialogue between all the disciplines which study Internet systems under any technological or humanistic perspective, and which in turn are being transformed by the continuous advances in Internet functionalities and applications. EINS will bring together research institutions focusing on network engineering, computation, complexity, security, trust, mathematics, physics, sociology, game theory, economics, political sciences, humanities, law, energy, transport, artistic expression, and any other relevant social and life sciences.\nThis multidisciplinary bridging of the different disciplines may also be seen as the starting point for a new Internet Science, the theoretical and empirical foundation for an holistic understanding of the complex techno-social interactions related to the Internet. It is supposed to inform the future technological, social, political choices concerning Internet technologies, infrastructures and policies made by the various public and private stakeholders, for example as for the far-ended possible consequences of architectural choices on social, economic, environmental or political aspects, and ultimately on quality of life at large.\nThe individual contributing disciplines will themselves benefit from a more holistic understanding of the Internet principles and in particular of the network effect. The unprecedented connectivity offered by the Internet plays a role often underappreciated in most of them; whereas the Internet provides both an operational development platform and a concrete empirical and experimental model. These multi- and inter-disciplinary investigations will improve the design of elements of Future Internet, enhance the understanding of its evolving and emerging implications at societal level, and possibly identify universal principles for understanding the Internet-based world that will be fed back to the participating disciplines. EINS will:\nCoordinate the investigation, from a multi-disciplinary perspective, of specific topics at the intersection between humanistic and technological sciences, such as privacy & identity, reputation, virtual communities, security & resilience, network neutrality\nLay the foundations for an Internet Science, based i.a. on Network Science and Web Science, aiming at understanding the impact of the network effect on human societies & organisations, as for technological, economic, social & environmental aspects\nProvide concrete incentives for academic institutions and individual researchers to conduct studies across multiple disciplines, in the form of online journals, conferences, workshops, PhD courses, schools, contests, and open calls


Grant
Agency: Cordis | Branch: H2020 | Program: RIA | Phase: NMBP-09-2016 | Award Amount: 6.23M | Year: 2017

Optogenerapy proposes a new interferon- (IFN-) drug delivery system to revolutionize Multiple Sclerosis treatment. The aim is to develop and validate a new bio-electronic cell based implant device to be implanted subcutaneously providing controlled drug release during at least 6 months. The cell confinement within a chamber sealed by a porous membrane allows the device to be easily implanted or removed. At the same time, this membrane acts to prevent immune rejection and offers long-term safety in drug release while overcoming the adverse effects of current cellular therapies. Wireless powered optogenetics light controlling the cellular response of genetically engineered cells is used to control the production of IFN-. Replacing standard intravenous IFN- delivery by subcutaneous delivery prevents short and long term side effects and efficiency-losses related to drug peaks and discontinuation, while saving non-adherence costs. It is a low-cost system enabling large scale manufacturing and reduction of time to market up to 30% compared to other cell therapies, combining: - Polymeric biomaterials with strong optical, biocompatibility and barrier requirements, to build the cell chamber and to encapsulate the optoelectronics. - Optoelectronics miniaturization, autonomy and optical performance. - Optimal cellular engineering design, enhanced by computer modelling, for stability and performance of the synthetic optogenetic gene pathway over long-term implantation. - Micro moulding enabling optoelectronics and membrane embedding for safety and minimal invasiveness. The innovation potential is so huge that a proof-of-concept was listed by Scientist Magazine as one of the 2014s big advances in science. In our top-class consortium, industrial pull meets technological push, ensuring that the preclinically validated prototype obtained at the end responds to market demands. BOSTON SCIENTIFIC, worldwide leader in neuromodulation active implants, has clear exploitation plans and high market penetration potential. 4 research intensive SMEs: TWO, GENEXPLAIN, NEOS and ULTRASION bring specific competences while increasing their own competitiveness.


Grant
Agency: Cordis | Branch: H2020 | Program: RIA | Phase: LCE-07-2016-2017 | Award Amount: 7.17M | Year: 2016

FIThydro addresses the decision support in commissioning and operating hydropower plants (HPP) by use of existing and innovative technologies. It concentrates on mitigation measures and strategies to develop cost-efficient environmental solutions and on strategies to avoid individual fish damage and enhancing population developments. Therefore HPPS all over Europe are involved as test sites. The facilities for upstream and downstream migration are evaluated, different bypass systems including their use as habitats and the influence of sediment on habitat. In addition existing tools and devices will be enhanced during the project and will be used in the experimental set-ups in the laboratories and at the test sites for e.g. detection of fish or prediction of behavior. This includes sensor fish, different solutions for migration as e.g. trash rack variations, different fish tracking systems, but also numerical models as habitat and population model or virtual fish swimming path model. Therefore a three-level-based workplan was created with preparatory desk work at the beginning to analyze shortcomings and potential in environment-friendly hydropower. Following the experimental tests will be conducted at the different test sites to demonstrate and evaluate the effects of the different options not covered by the desk-work. Thirdly, these results are fed into a risk based Decision Support System (DSS) which is developed for planning, commissioning and operating of HPPs. It is meant to enable operators to fulfill the requirements of cost-effective production and at the same time meet the environmental obligations and targets under European legislation and achieve a self-sustained fish population.


Grant
Agency: Cordis | Branch: FP7 | Program: CP-CSA | Phase: ENERGY.2013.10.1.10 | Award Amount: 21.20M | Year: 2014

Concentrating Solar Thermal Energy encompasses Solar Thermal Electricity (STE), Solar Fuels, Solar Process Heat and Solar Desalination that are called to play a major role in attaining energy sustainability in our modern societies due to their unique features: 1) Solar energy offers the highest renewable energy potential to our planet; 2) STE can provide dispatchable power in a technically and economically viable way, by means of thermal energy storage and/or hybridization, e.g. with biomass. However, significant research efforts are needed to achieve this goal. This Integrated Research Programme (IRP) engages all major European research institutes, with relevant and recognized activities on STE and related technologies, in an integrated research structure to successfully accomplish the following general objectives: a) Convert the consortium into a reference institution for concentrating solar energy research in Europe, creating a new entity with effective governance structure; b) Enhance the cooperation between EU research institutions participating in the IRP to create EU added value; c) Synchronize the different national research programs to avoid duplication and to achieve better and faster results; d) Accelerate the transfer of knowledge to industry in order to maintain and strengthen the existing European industrial leadership in STE; e) Expand joint activities among research centres by offering researchers and industry a comprehensive portfolio of research capabilities, bringing added value to innovation and industry-driven technology; f) Establish the European reference association for promoting and coordinating international cooperation in concentrating solar energy research. To that end, this IRP promotes Coordination and Support Actions (CSA) and, in parallel, performs Coordinated Projects (CP) covering the full spectrum of current concentrating solar energy research topics, selected to provide the highest EU added value and filling the gaps among national programs.


Grant
Agency: Cordis | Branch: H2020 | Program: RIA | Phase: BIOTEC-03-2016 | Award Amount: 7.48M | Year: 2017

Genetic tractability of bacterial cells allows generating synthetic microbial chassis platforms (SMCPs) with remarkable biotechnological applications but their functionality currently faces important off-genome limitations due to deficient protein-protein interactions, unfavorable protein stoichiometry or generation of toxic intermediates that ultimately compromise the industrial production processes. To solve this problem, Rafts4Biotech project will take advantage of our recent discovery, that bacteria are able to organize subcellular membrane compartments similar to the so-called lipid rafts of eukaryotic cells, to improve/protect specific cellular processes. Rafts4Biotech project will engineer bacterial cells to confine biotechnologically relevant reactions into bacterial lipid rafts to optimize their stoichiometry and protect cells from undesirable metabolic interferences. Hence, the Rafts4Biotech project will produce new generation reliable and robust SMCPs in which industrial production processes are confined in bacterial lipid rafts, released from their classical off-genome limitations and optimized for industrial production. Moreover, this concept can be applied to many prokaryotes, since lipid rafts happens to occur in many bacterial species. Based on this versatility, Raft4Biotech project will use two biotechnologically relevant biosystems, Bacillus subtilis and Escherichia coli, to engineer synthetic bacterial lipid rafts to optimize the performance of three challenging biochemical processes in the fields of pharmaceutical, cosmetics and feed industrial sectors. To achieve this, Rafts4Biotech consortium combines different expertise in synthetic biology, systems biology and mathematical modeling and it includes a number of SMEs that will actively work in this project and will translate this technology into market application. The technology developed by Rafts4Biotec will optimize multistep industrial processes and invigorate European research.


Grant
Agency: Cordis | Branch: FP7 | Program: CSA-CA | Phase: KBBE.2010.4-01 | Award Amount: 1.12M | Year: 2011

The objective is to further integrate/refine the EuroFIR Food Platform (EFP), to improve/support the ways research is undertaken into relationships between food, diets and health in Europe. Our focus is on extending application and exploitation of validated food data and tools for pan-European nutrition studies and networked usage, implementation of standards and best practice. This together forms the basis of long-term sustainability through the newly established legal entity EuroFIR AISBL). Six Work Packages are included: Quality standards & certification; Systems integration & operational support; Integration & business development; Training; Dissemination & Management. The revised consortium has 35 existing EuroFIR partners (18 as 3rd parties/EuroFIR AISBL members). The already achieved high-level institutional commitment will be further strengthened. The new General Assembly consists of executive representatives of all beneficiaries (who are also AISBL Members), thus real and durable integration is achievable. The Executive Board will work closely with EuroFIR AISBL to provide an integrated approach to joint activities and stakeholder engagements. A high-level External Advisory Board of key users/stakeholders from Europe and internationally will ensure that food data, other products and services are fine-tuned to stakeholders needs, keeping Europe at the forefront of leadership and innovation in this area. Outputs are consistent with the ETP `Food for Life and will further support Theme 2 (FP7) in food and nutrition research contributing to the structuring of the European Research Area and world-class scientific/technological excellence. Additionally, the outputs bring the EFP in alignment with the current European CEN Standard on Food Data and its application.


Grant
Agency: Cordis | Branch: FP7 | Program: MC-ITN | Phase: FP7-PEOPLE-2013-ITN | Award Amount: 3.40M | Year: 2014

The purpose of the SIMDALEE2 (Sources, Interaction with Matter, Detection and Analysis of Low Energy Electrons) network is to establish a world-class research training platform for the science and technology of nanoscale manipulation and analysis using low energy electrons. Apart from an effective and well-structured training programme, the network will pursue the following scientific goals: (1) optimizing beam size by correlating contemporary field emission (FE) theory with high resolution holographic measurements of magnetic and electric fields of FE tips with different shapes, both with and without primary electron optics; (2) putting the understanding of the contrast mechanism of electron beam techniques on a sound footing by comparing physical models with novel benchmark spectra acquired using a coincidence technique; (3) improving detection as well as understanding of emitted energy-, angular-, and spin-dependent spectra. This issue will be addressed for the common case of detectors in the a field-free environment, and for the special case when the emitted electrons encounter an electric field prior to detection; (4) Electron beam modification of nanostructured surfaces; (5) Progress in the aforementioned fields will lead to the development of an innovative prototypical methodology for nanoscale characterization with electron beams in the form of a compact desktop-type Near-Field-Emission Scanning Electron Microscope (NFESEM). Finally, (6) the economic impact and feasibility of low energy electron beam methodology will be investigated within the project. Accordingly, the ESRs and ERs will develop and acquire experience on a comprehensive methodology beneficial for any industrial or academic laboratory employing or developing electron beam techniques for natural science studies, as well as for biology and engineering. Their participation in this interdisciplinary and intersectoral network will greatly further their career opprtunities in S&T in Europe.


Grant
Agency: Cordis | Branch: FP7 | Program: CP | Phase: ENV.2013.6.1-2 | Award Amount: 11.46M | Year: 2013

Clouds are a very important, yet not well understood feedback factor in climate change and they contribute to the effective radiative forcing (ERF) from aerosol-cloud interactions (ACI). The uncertainty in ERFaci is larger than for any other forcing agent. Also, feedbacks between the terrestrial and marine biosphere and the atmosphere involving ACI are thought to play an important role in regulating climate change but their relevance remains poorly quantified. BACCHUS proposes to quantify key processes and feedbacks controlling ACI, by combining advanced measurements of cloud and aerosol properties with state-of-the-art numerical modelling. The analysis of contrasting environments will be the guiding strategy for BACCHUS. We will investigate the importance of biogenic versus anthropogenic emissions for ACI in regions that are key regulators of Earths climate (Amazonian rain forest) or are regarded as tipping elements in the climate system (Arctic). BACCHUS will generate a unique database linking long-term observations and field campaign data of aerosol, cloud condensation and ice nuclei and cloud microphysical properties; this will enable a better quantification of the natural aerosol concentrations and the anthropogenic aerosol effect. BACCHUS will advance the understanding of biosphere aerosol-cloud-climate feedbacks that occur via emission and transformation of biogenic volatile organic compounds, primary biological aerosols, secondary organic aerosols and dust. Integration of new fundamental understanding gained in BACCHUS in Earth Systems Models allows to reduce the uncertainty in future climate projections. This will have a direct impact on decision-making addressing climate change adaptation and mitigation. BACCHUS brings together a critical mass of experimentalists and modellers with the required scientific expertise to address these complex topics and a high commitment to communicate their findings in many ways in order to ensure a high-impact project.


Grant
Agency: Cordis | Branch: H2020 | Program: RIA | Phase: SFS-04-2014 | Award Amount: 5.31M | Year: 2015

LANDMARK is a pan-European multi-actor consortium of leading academic and applied research institutes, chambers of agriculture and policy makers that will develop a coherent framework for soil management aimed at sustainable food production across Europe. The LANDMARK proposal builds on the concept that soils are a finite resource that provides a range of ecosystem services known as soil functions. Functions relating to agriculture include: primary productivity, water regulation & purification, carbon-sequestration & regulation, habitat for biodiversity and nutrient provision & cycling. Trade-offs between these functions may occur: for example, management aimed at maximising primary production may inadvertently affect the water purification or habitat functions. This has led to conflicting management recommendations and policy initiatives. There is now an urgent need to develop a coherent scientific and practical framework for the sustainable management of soils. LANDMARK will uniquely respond to the breadth of this challenge by delivering (through multi-actor development): 1. LOCAL SCALE: A toolkit for farmers with cost-effective, practical measures for sustainable (and context specific) soil management. 2. REGIONAL SCALE - A blueprint for a soil monitoring scheme, using harmonised indicators: this will facilitate the assessment of soil functions for different soil types and land-uses for all major EU climatic zones. 3. EU SCALE An assessment of EU policy instruments for incentivising sustainable land management. There have been many individual research initiatives that either address the management & assessment of individual soil functions, or address multiple soil functions, but only at local scales. LANDMARK will build on these existing R&D initiatives: the consortium partners bring together a wide range of significant national and EU datasets, with the ambition of developing an interdisciplinary scientific framework for sustainable soil management.


Healthspan (the life period when one is generally healthy and free from serious disease) depends on nature (genetic make-up) and nurture (environmental influences, from the earliest stages of development throughout life). Genetic studies increasingly reveal mutations and polymorphisms that may affect healthspan. Similarly, claims abound about lifestyle modifications or treatments improving healthspan. In both cases, rigorous testing is hampered by the long lifespan of model organisms like mice (let alone humans) and the difficulty of introducing genetic changes to examine the phenotype of the altered genome. We will develop C. elegans as a healthspan model. Already validated extensively as an ageing model, this organism can be readily modified genetically, and effects of environmental manipulations on healthspan can be measured in days or weeks. Once validated as a healthspan model, it can be used for an initial assessment of preventive and therapeutic measures for humans, as well as for risk identification and the initial evaluation of potential biomarkers. It will also prove useful to study interactions between genetic and various environmental factors.


Grant
Agency: Cordis | Branch: FP7 | Program: CP | Phase: ENERGY.2013.2.4.1 | Award Amount: 13.30M | Year: 2013

The IMAGE project will develop a reliable science based exploration and assessment method to IMAGE geothermal reservoirs using an interdisciplinary approach based on three general pillars: 1 Understanding the processes and properties that control the spatial distribution of critical exploration parameters at European to local scales. The focus will be on prediction of temperatures, in-situ stresses, fracture permeability and hazards which can be deduced from field analogues, public datasets, predictive models and remote constraints. It provides rock property catalogues for 2 and 3. 2 Improving well-established exploration techniques for imaging and detection beyond the current state of the art and testing of novel geological, geophysical and geochemical methods to provide reliable information on critical subsurface exploration parameters. Methods include a) geophysical techniques such as ambient seismic noise correlation and magnetotellurics with improved noise filtering, b) fibre-optic down-hole logging tools to assess subsurface structure, temperature and physical rock properties, and c) the development of new tracers and geothermometers. 3 Demonstration of the added value of an integrated and multidisciplinary approach for site characterization and well-siting, based on conceptual advances, improved models/parameters and exploration techniques developed in 1 and 2. Further, it provides recommendations for a standardized European protocol for resource assessment and supporting models. The IMAGE consortium comprises the leading European geothermal research institutes and industry partners who will perform testing and validation of the new methods at existing geothermal sites owned by the industry partners, both in high temperature magmatic, including supercritical, and in basement/deep sedimentary systems. Application of the methods as part of exploration in newly developed fields will provide direct transfer from the research to the demonstration stage.


Grant
Agency: GTR | Branch: EPSRC | Program: | Phase: Training Grant | Award Amount: 5.00M | Year: 2014

Quantum technologies promise a transformation of measurement, communication and computation by using ideas originating from quantum physics. The UK was the birthplace of many of the seminal ideas and techniques; the technologies are now ready to translate from the laboratory into industrial applications. Since international companies are already moving in this area, there is a critical need across the UK for highly-skilled researchers who will be the future leaders in quantum technology. Our proposal is driven by the need to train this new generation of leaders. They will need to be equipped to function in a complex research and engineering landscape where quantum physics meets cryptography, complexity and information theory, devices, materials, software and hardware engineering. We propose to train a cohort of leaders to meet these challenges within the highly interdisciplinary research environment provided by UCL, its commercial and governmental laboratory partners. In their first year the students will obtain a background in devices, information and computational sciences through three concentrated modules organized around current research issues. They will complete a team project and a longer individual research project, preparing them for their choice of main research doctoral topic at the end of the year. Cross-cohort training in communication skills, technology transfer, enterprise, teamwork and career planning will continue throughout the four years. Peer to peer learning will be continually facilitated not only by organized cross-cohort activities, but also by the day to day social interaction among the members of the cohort thanks to their co-location at UCL.


Grant
Agency: Cordis | Branch: FP7 | Program: CP-FP | Phase: ENV.2011.1.3.2-2 | Award Amount: 4.19M | Year: 2011

The project will reduce future Europes vulnerability and risk to drought by innovative in-depth studies that combine drought investigations in six case study areas in water-stressed regions (river basin and national scale) with drought analyses at the pan-European scale. Knowledge transfer across these scales is paramount because vulnerability is context-specific (e.g. physical, environmental, socio-economic, cultural, legal, institutional), which requires analyses on detailed scales, whereas international policies and drought-generating climate drivers and land surface processes are operating on large scales. The project will adopt Science-Policy Interfacing at the various scales, by establishing Case Study Dialogue Fora and a pan-Europe Dialogue Forum, which will ensure that the research will be well integrated into the policy-making from the start of the project onwards. The study will foster a better understanding of past droughts (e.g. underlying processes, occurrences, environmental and socio-economic impacts, past responses), which then will contribute to the assessment of drought hazards and potential vulnerabilities in the 21th C. An innovative methodology for early drought warning at the pan-European scale will be developed, which will improve on the forecasting and a suite of interlinked physical and impact indicators. This will help to increase drought preparedness, and to indentify and implement appropriate Disaster Risk Reduction measures (along the lines of the UN/ISDR HFA). The project will lead through the combined drought studies at different scales to the identification of drought-sensitive regions and sectors across Europe and a more thorough implementation of the EU Water Framework Directive, particularly by further developing of methodologies for Drought Management Plans at different scales (incl. EU level). The work will be linked with the European Drought Centre ensuring that the outcome will be consolidated beyond the project lifetime.


Grant
Agency: Cordis | Branch: FP7 | Program: CP-TP | Phase: NMP.2012.4.0-1 | Award Amount: 4.18M | Year: 2012

Building skyscrapers, Real Estate has to constantly deal with social, economical and political issues. Nowadays market calls for a less conflictual and more profitable development niche, until now especially limited by livability and psychological constrains coming from the absence of natural light: underground architecture, including earth-sheltered and earth-covered buildings. Hypogeal spaces can tackle congestion, lack of open public space and aging infrastructures, exponentially increasing urban design opportunities to populate the volume contained by an over exploited earth surface. Underground can limit visual impact (zeroing main concerns about skyscrapers)and promote efficient land use in a noise and vibration-free environment, reducing energy costs by heat loss and daily temperature fluctuations control. Until now the discomfort caused by sky and sun deprivation consents hypogeal architecture only where protection from harsh climate conditions and natural disasters count more than above mentioned discomfort. SkyCoat, with a great leap underground, recreates the experience of natural light, obtained by complementary presence of both direct sun and diffused sky lights. Disadvantages of hypogeal architecture, like limited or no natural light and negative psychological reactions, are blown away by the possibility of reproducing the sun and the sky many meters under the earth surface, therefore opening a new and unexplored territory for real estate investors, architecture designers and buildings end-users. SkyCoat technology will also be verified in light design, testing how housing, offices, retail, industry and transport, can benefit from indoor natural light reproduction. At the same time, SkyCoat will be tested as coating material for skyscrapers: a thin layer of a nano-structured dichroic material will reflect warm sun light and scatter complementary cold sky component, allowing a tailor-made silhouette not necessarily corresponding to the building volume


Grant
Agency: Cordis | Branch: FP7 | Program: MC-ITN | Phase: FP7-PEOPLE-2010-ITN | Award Amount: 3.51M | Year: 2011

This network will bridge two very active disciplines in physics, namely the quantum electrodynamics of atoms or ions strongly interacting with light in resonators, and the emerging field of solid-state superconducting circuit quantum electrodynamics. Advanced techniques will be developed jointly with industry partners for the manipulation of a deterministic number of particles - atoms, ions or artificial atoms - with electromagnetic fields covering the microwave and the optical frequency spectrum. The interdisciplinary training of a new generation of young researchers will strengthen the European expertise in those fields, and will allow for a new discipline to emerge that combines single-atom control methods with superconductor micro-chip fabrication. The use of high-quality resonators, whether superconducting transmission lines or highly-reflecting mirrors, coupled to a controlled number of particles will open novel avenues to explore quantum dynamics via hitherto inaccessible physical mechanisms. These new control scenarii will be strengthened by the development of potentially marketable technologies of great multidisciplinary interest. The network groups 10 research centres and 3 companies representing the cutting edge of research in the quantum electrodynamics of fundamental systems in Europe. The network will train 12 ESRs and 2 ERs, with focus on (i) establishing bonds between solid-state and quantum optics physics, (ii) strengthening the communication between theory and experiment, and, (iii) concretizing links between fundamental and applied research. Prominent scientists and industry leaders will contribute to the schools and workshops. Special attention will be given on developing complementary skills, such as communication, presentation, project planning and management.


Grant
Agency: Cordis | Branch: FP7 | Program: CP-TP | Phase: KBBE.2011.1.2-07 | Award Amount: 3.80M | Year: 2012

The sustainable provision of ecosystem services (ES) in and from mountain regions is of crucial importance to an array of stakeholders and society in general, going much beyond the interests of particular landowners in the mountain regions themselves. Mountain ecosystems can only continue to provide all these services in a rapidly changing world if a wide array of ES is considered in forest management at local, landscape and regional scales (multi-functionality). The project builds on seven case study regions in major mountain ranges throughout Europe covering a wide range of forest types, socio-economic conditions and cultural contexts and seeks to develop and evaluate strategies for their multifunctional management considering risks and uncertainty due to changing climatic and socio-economic conditions. The project addresses four main ES: timber production, protection against gravitational natural hazards, the role of forests in climate change mitigation via carbon sequestration as well as bioenergy production, and nature conservation and the maintenance of biodiversity. Non-timber forest products, recreation as well as use of forested landscapes by game and livestock species will be dealt with as well. To analyse conflicts and complementarities among ES from stand to landscape scales, improved models for the assessment and projection of ecosystem services as well as novel planning and decision support tools will be developed together with SMEs and applied in the case study regions. Stakeholder panels in all study regions will inform research activities and contribute to the development of improved mountain forest management approaches. SME partners play a key role in the development of new planning tools. Ultimately, ARANGE will translate project findings on the efficient provision of multiple ES from mountain forests into decision support for policy makers and forest practitioners, so as to improve the robustness of planning tools in real-world decision making.


Grant
Agency: Cordis | Branch: FP7 | Program: CP-IP | Phase: SST.2011.1.1-3. | Award Amount: 17.02M | Year: 2012

HERCULES was conceived in 2002 as a long-term R&D Programme, to develop new technologies for marine engines. It is the outcome of a joint vision by the two major European engine manufacturer Groups MAN & WARTSILA, which together hold 90% of the worlds marine engine market. The present proposed HERCULES-C project is the Phase III of the HERCULES Programme. In order to take marine engine technology a step further towards improved sustainability in energy production and total energy economy, an extensive integration of the multitude of the new technologies developed in Phases I and II is required. HERCULES-C addresses this challenge by adopting a combinatory approach for engine thermal processes optimization, system integration, as well as engine reliability and lifetime. The first Objective of HERCULES-C is to achieve further substantial reductions in fuel consumption, while optimizing power production and usage. This will be achieved through advanced engine developments in combustion and fuel injection, as well as through the optimization of ship energy management and engine technologies supporting transport mission management. The second Objective of HERCULES-C is to achieve near-zero emissions by integrating the various technologies developed in the previous research Projects, in Phases I and II. The third Objective is to maintain the technical performance of engines throughout their operational lifetime. This requires advanced materials and tribology developments to improve efficiency and reliability, as well as sensors, monitoring and measurement technologies to improve the controllability and availability of marine power plants. The project HERCULES-C structure of RTD work comprises 47 Subprojects, grouped into 10 Work Packages and 5 Work Package Groups, spanning the complete spectrum of marine diesel engine technology. The HERCULES-C Project has duration of 36 months, a Consortium with 22 participants. and a total budget of EUR 17 million.


Grant
Agency: Cordis | Branch: FP7 | Program: CP-IP | Phase: SEC-2011.4.2-2 | Award Amount: 17.31M | Year: 2012

Recent dramatic events such as the earthquakes in Haiti and LAquila or the flooding in Pakistan have shown that local civil authorities and emergency services have difficulties with adequately managing crises. The result is that these crises lead to major disruption of the whole local society. The goal of ICARUS is to decrease the total cost (both in human lives and in ) of a major crisis. In order to realise this goal, the ICARUS project proposes to equip first responders with a comprehensive and integrated set of unmanned search and rescue tools, to increase the situational awareness of human crisis managers and to assist search and rescue teams for dealing with the difficult and dangerous, but life-saving task of finding human survivors. As every crisis is different, it is impossible to provide one solution which fits all needs. Therefore, the ICARUS project will concentrate on developing components or building blocks that can be directly used by the crisis managers when arriving on the field. The ICARUS tools consist of assistive unmanned air, ground and sea vehicles, equipped with human detection sensors. The ICARUS unmanned vehicles are intended as the first explorers of the area, as well as in-situ supporters to act as safeguards to human personnel. The unmanned vehicles collaborate as a coordinated team, communicating via ad hoc cognitive radio networking. To ensure optimal human-robot collaboration, these ICARUS tools are seamlessly integrated into the C4I equipment of the human crisis managers and a set of training and support tools is provided to the human crisis to learn to use the ICARUS system. Furthermore, the project aims to provide an integrated proof-of-concept solution, to be evaluated by a board of expert end-users that can verify that operational needs are addressed.


Grant
Agency: Cordis | Branch: FP7 | Program: CSA-CA | Phase: FP7-PEOPLE-2011-EURAXESS-II | Award Amount: 3.49M | Year: 2012

Advanced research and knowledge-based innovation are keys to develop sustainable and globally competitive high-tech industry in high-cost Europe. Early access to front-line research results demands recruitment of, and collaboration between, world-class researchers. Reduction of legal and practical barriers to transnational mobility is then imperative. Interdisciplinary, intersectorial and geographical mobility must be facilitated by providing key practical information and qualified hands-on assistance to mobile researchers within a European Research Area (ERA) open to the world in line with the Lisbon Agenda (2000), the Researchers Charter & Code (2005), Scientific VISA (2005), the ERA Green Paper (2007), the Ljubljana process (2008), the Europe 2020 Strategy (2009), the Europe 2020 Flagship Initiative Innovation Union (2010), and the process towards the new Common Strategic Framework (2011). The EURAXESS network is a pan-European initiative in 37 countries with national web portals and over 200 Service Centers (ESCs) and Local Contact Points (LoCPs) at research institutions, established to facilitate researcher mobility by providing key practical information and qualified hands-on assistance to mobile researchers. In EURAXESS TOP2, which builds from EURAXESS TOP and other related EU- projects, key people from 17 Partners and 13 Associate Partners join forces to enhance the overall performance, quality, effectiveness and coherence of the information and services delivered by the network by exchange of best practices achieved over the years, training sessions and updating of portals. The interlinked Work Packages and Tasks include Charter & Code, Social Security & Pensions, Open Recruitment, Industry/Innovation, Skills, Portals, Capacity Building, Electronic Handbook updating, Promotion, and Strategic Dialogue with key stakeholders. Expected impacts: improved services \ enhanced recruitment and mobility of researchers.


Grant
Agency: Cordis | Branch: FP7 | Program: CP | Phase: ENV.2013.6.4-4 | Award Amount: 3.98M | Year: 2013

Critical Infrastructures (CIs) provide essential goods and services for modern society; they are highly integrated and have growing mutual dependencies. Recent natural events have shown that cascading failures of CIs have the potential for multi-infrastructure collapse and widespread societal and economic consequences. Moving toward a safer and more resilient society requires improved and standardized tools for hazard and risk assessment of low probability-high consequence (LP-HC) events, and their systematic application to whole classes of CIs, targeting integrated risk mitigation strategies. Among the most important assessment tools are the stress tests, designed to test the vulnerability and resilience of individual CIs and infrastructure systems. Following the results of the stress tests recently performed by the EC for the European Nuclear Power Plants, it is urgent to carry out appropriate stress tests for all other classes of CIs. To this end, STREST will establish a common and consistent taxonomy of CIs; develop a rigorous, consistent modelling approach to hazard, vulnerability, risk and resilience assessment of LP-HC events; design a stress test framework and specific applications to address the vulnerability, resilience and interdependencies of CIs. STREST will focus on earthquakes, tsunamis, geotechnical effects and floods, and on three principal CI classes: (a) individual, single-site, high risk infrastructures, (b) distributed and/or geographically extended infrastructures with potentially high economic and environmental impact, and (c) distributed, multiple-site infrastructures with low individual impact but large collective impact or dependencies. STREST will work with key European CIs, to test and apply the developed stress test methodologies to specific CIs, chosen to typify general classes of CIs, with the final goal of enabling the implementation of European policies for the systematic implementation of stress tests.


Grant
Agency: Cordis | Branch: FP7 | Program: CP-TP | Phase: KBBE.2013.3.6-02 | Award Amount: 7.17M | Year: 2013

Peptides are among the most versatile natural products that nature provides to cater for a broad set of biotechnological applications ranging from antibiotics to personal hygiene. Their diversity comes from a broad variety of posttranslational modifications that is used to provide additional functionality beyond to what is possible with the classic proteinogenic set of 20 amino acids. In SYNPEPTIDE, we want to recruit such additional functionality for rational molecular design purposes in order to facilitate the design and the production of synthetic peptides. To this end, we intend to standardize the integration of chemical diversity in peptide design and production by the following activities: [i] translational integration of chemically suitable non-canonical amino acids for posttranslational in vivo and in vitro modification; [ii] systematic recruitment of selected highly relevant posttranslational modifications from natural peptide synthesis routes into the design process. These activities will ultimately allow to drastically expand our arsenal of functionalities in the design of novel molecules and our capacity to reliably produce them.


Grant
Agency: Cordis | Branch: FP7 | Program: CP-FP | Phase: KBBE.2011.3.6-04 | Award Amount: 3.88M | Year: 2012

There is a high societal need for a sustainable production of key chemistry, food and health care compounds. Microbial cell factories are logical production systems, but up to now they use sugars and other food derived raw materials as substrates. Sugars originating from plants demand cultivable land which is more and more needed for human nutrition. Methanol - with a worldwide production capacity of more than 46 million tons per year - is regarded as an alternative highly attractive raw material in microbial fermentation for the manufacturing of special, fine, bulk, and fuel chemicals. This is especially true for the EU market, where industrial biotechnology still is hampered by strict use and price regulations as well as import limitations for agricultural commodities, such as corn or sugar. The supply of methanol can base upon both fossil and renewable resources, rendering it a highly flexible and sustainable raw material. Our vision is a viable methanol-based European bio-economy, which we will promote by for the first time applying synthetic biology principles for cell factory development in order to harness methanol as a general feedstock for the manufacturing of special and fine chemicals. In nature, methylotrophic microorganisms can utilize methanol as their sole source of carbon and energy. The project PROMYSE will deliver an alternative route to sought-after chemicals, with a major focus on terpenoids. PROMYSE combines two frontline research topics: orthogonal modularization of methylotrophy within a Synthetic Biology concept and employing methanol as a feedstock for biotechnological production. Through the transfer of methylotrophy modules, Synthetic Biology will pave the way to capitalize on the metabolic versatility and engineered production pathways of genetically well tractable microorganisms, such as E. coli, B. subtilis and C. glutamicum for biotransformation from methanol.


Grant
Agency: Cordis | Branch: FP7 | Program: CP-IP | Phase: ENV.2009.2.1.3.1;ENV.2009.1.1.3.1 | Award Amount: 8.93M | Year: 2010

The GHG-Europe project aims to improve our understanding and capacity for predicting the European terrestrial carbon and greenhouse gas (GHG) budget by applying a systematic, comprehensive and integrative approach. GHG-Europe quantifies the annual to decadal variability of the carbon and GHG budgets of terrestrial ecosystems in EU27 plus Switzerland and in six data-rich European regions via data-model integration, diagnostic and predictive modelling. Models are calibrated by multi-site observations. Research includes CO2, CH4 and N2O in forests, croplands, grasslands, shrublands, peatlands and soils. Via an integrated approach, GHG Europe scales up consistently from local to regional and continental scale via scale dependent error propagation and systematic quantification of uncertainties, model validation at different scales and top-down verification by atmospheric inversion models. At regional and European scale lateral C transport by land use, trade and rivers are included. Variability in C and GHG budgets is attributed to natural (climate) and anthropogenic drivers (N deposition, land use, past and present management) by synthesis of past and emerging experiments, targeted observations in hot spots and hot moments and model sensitivity analyses. For this purpose, observations are extended to under-sampled regions and ecosystems with likely high importance for the European C budget: forests and land use change in Eastern Europe and Mediterranen shrublands. The future vulnerability of carbon pools and risks of positive feedbacks in the climate-carbon system are assessed by scenario analyses with biophysical models and by integrating feedbacks with socio-economic changes and EU climate and land use policies. GHG-Europe uses a bidirectional interaction with stakeholders to provide regular and timely scientific advice targeted to the emerging needs of the UNFCCC process and for implementing post-2012 climate commitments in Europe.


Grant
Agency: Cordis | Branch: H2020 | Program: RIA | Phase: SFS-12-2014 | Award Amount: 8.82M | Year: 2015

Euromix aim to develop an experimentally verified, tiered strategy for the risk assessment of mixtures of multiple chemicals derived from multiple sources across different life stages. The project takes account of the gender dimension and balances the risk of chemicals present in foods against the benefits of those foods. Important concepts for this new strategy are prioritisation criteria for chemicals based on their exposure and hazard characteristics and evaluation of the role of mode of action in grouping chemicals into cumulative assessment groups. In-silico and in-vitro tools will be developed and verified against in-vivo experiments, with focus on four selected endpoints (liver, hormones, development and immunology) to provide a full proof-of-principle. The EuroMix project will result in an innovative platform of bioassays for mixture testing and refined categorisation of chemicals in cumulative assessment groups. New hazard and exposure models will be embedded in a model toolbox, made available for stakeholders through an openly accessible web-based platform. Access to the web-based tools will be facilitated by training. Criteria will be set and guidance will be written on how to use and implement the tiered test strategy. Dissemination and harmonisation of the approach within EU, Codex Alimentarius, and WHO will be achieved by involving a.o. WHO and US-EPA in the project and by the participation of experts playing a key role in helping establish international food safety policies. It is expected that the new mechanism-based strategy, the bioassay platform, the openly accessible web-based model toolbox, and clear guidance on a tiered hazard and exposure test and risk assessment strategy will boost innovation in the public and private sector, provide a sound scientific basis for managing risks to public health from chemical mixtures, ultimately reduce the use of laboratory animals, and support the global discussion of risk assessment policies for mixtures.


Grant
Agency: Cordis | Branch: FP7 | Program: CP | Phase: SEC-2009-3.2-03 | Award Amount: 11.72M | Year: 2010

VIRTUOSO projects aims at providing European Security stakeholders with a toolkit based on an open-source-software framework and a set of advanced information processing tools. This toolkit will allow building end-user oriented applications: - Ranging from open source collection to decision support - Providing at each step actionable, rated, validated information - Integrated in an open framework in order to accept existing or future tools - Compliant with legal & ethical issues The VIRTUOSO toolkit will increase user productivity by automating time consuming activities and eliminating current bottlenecks that will be accurately identified with a large panel of users. Due to numerous application domains and the various size of the resources needed by the application of such a toolkit, this toolkit will demonstrate high level scalability, from mobile to High Power Computing systems. Cooperation of various European agencies will be addressed by proposing a standard, open and Interoperable toolkit, facilitating storage and sharing of information. Guidelines will be proposed.


Grant
Agency: Cordis | Branch: FP7 | Program: CP | Phase: ENERGY.2011.2.5-2 | Award Amount: 3.07M | Year: 2011

The CSP2 project puts forward an alternative heat transfer fluid (HTF) for concentrating solar power (CSP) plants. We propose to use dense gas-particle suspensions -DPS- (approximately 50% of solid) in tubes as HTF; these tubes set in a bundle constitute the solar absorber (receiver), placed at the top of a central receiver CSP system. This new HTF behaves like a liquid although it permits to extend working temperatures at temperature higher than 550C; moreover, it may be used as an energy storage medium because of its good thermal capacity. It is composed of any particulate mineral standing high temperature, thus deeply reducing the environmental impact and addressing the safety concern in comparison with standard HTF. Finally, it can be easily produced in high quantities without any chemical process development. Eight partners with complementary capabilities will work together in order to reach the project goals. They are 5 top-ranked public research organisations and universities and 3 private companies (including 2 SMEs), well established and specialized in electricity production from concentrated solar energy, high temperature gas-solid reactors, and solid handling, respectively. In the frame of the project, a 100-150 kWth pilot loop will be designed, constructed and tested at the focus of the CNRS solar furnace in Odeillo, The main target for the innovative solar receiver is to deliver hot DSP in the temperature range 500C-750C for solid mass flow rate varying from 1 to 2 tons/h with a 70% thermal efficiency. Finally, the global system will be analyzed and scale-up will be proposed toward industrial CSP facilities (10-50 MWe). Economic assessment will allow comparing this new technology to the molten salt one.


Grant
Agency: Cordis | Branch: H2020 | Program: IA | Phase: BIOTEC-3-2014 | Award Amount: 11.39M | Year: 2015

Oxygen functionalities are key functional groups in many of todays chemicals and materials. The efficient introduction of oxygen-functionalities into raw materials are key chemical transformations in bulk and fine chemicals. Innovative bio-catalytic oxidation routes using molecular oxygen (from air) under benign and mild (pH) conditions such as ambient temperature and pressure can greatly improve the sustainability and economics of processes, but were so far mainly been applied in the pharma segments. In this segment, the enzyme-catalyzed step often represents the highest added value and the high price of the end-product (> 1000/kg) justifies less than optimal enzyme production and limitations in its catalytic efficiency. In order to achieve the widening of industrial application of enzymatic bio-oxidation processes to also larger volume but lower price chemical markets, ROBOX will demonstrate the techno-economic viability of bio-transformations of four types of robust oxidative enzymes: P450 monooxygenases (P450s), Baeyer-Villiger MonoOxygenase (BVMOs), Alcohol DeHydrogenase (ADH) and Alcohol OXidase (AOX) for which target reactions have already been validated on lab-scale in pharma, nutrition, fine & specialty chemicals and materials applications. ROBOX will demonstrate 11 target reactions on large scale for these markets in order to prepare them for scale up to commercial-scale plants. ROBOX is industry-driven with 2 major industrial players and 6 SMEs. It will assess the potential of technologies applied to become platform technologies technologies (multi-parameter screening systems, computational methodologies, plug bug expression systems) for broad replication throughout the chemical industry. The markets addressed within ROBOX represent a joint volume of over 6.000 ktons/year. The introduction of bio-oxidation processes is expected to bring substantial reductions in cost (up to -50%), energy use (-60%), chemicals (-16%) and GHG-emissions (-50%).


Grant
Agency: Cordis | Branch: FP7 | Program: MC-ITN | Phase: FP7-PEOPLE-2010-ITN | Award Amount: 3.91M | Year: 2011

Approximately 80% of all products are or were a particle at some point in their processing lifetime. Particle and colloid technology has been described as the Growth Engine of Tomorrow with the market projected to grow from $2T to $10Tr over the next decade. Alongside with this challenge, the number of researchers active in powder technology is limited and only a few universities, public and private institutes are educating specialists in this field. PowTech ITN aims to integrate inter-sectoral and multidisciplinary research in particle and powder technology into the training of 15 highly skilled young researchers, to strengthen the competitiveness of food and pharmaceutical industry and to strengthen the European Research Area. The PowTech ITN has 20 partners (9 industry) and comprises a focused research programme and a graduate school. The Focused Research programme will use an engineering design approach applied to powder processing. The understanding and modelling of powder structure from a molecular to a macro disperse scale will be used to understand how powder properties/functionality are formed or modified during processing. This knowledge will be used to select the appropriate process for production of the structure of interest. The long-term aim is to develop innovative products and to provide tools allowing minimal pilot plant trials. The PowTech Graduate School is aligned with the research objectives of the project covering relevant S&T and personal skills courses but also an intensive and continuous training in collaboration with industry. In addition to the industrial secondments, the ESRs will have industrial training in different industries. An industrial mentor will be appointed to guide their Career development plan. The ESR will also be trained in Research Methodology through preparing a research plan for their work, and later in their project by developing a research plan, supervising a MSc student, and writing a Grant application.


Grant
Agency: Cordis | Branch: FP7 | Program: CP-CSA-Infra | Phase: INFRA-2010-1.1.8 | Award Amount: 10.93M | Year: 2010

In the past two decades spectacular insight into basic principles of life has been obtained from paradigmatic high-resolution structural investigations providing a rational basis for biological experiments. NMR is an indispensable enabling technology for determining such structures and their interactions in solution, the immobilized state and living cells. The power of NMR to link structural, dynamic, kinetic and thermodynamic information makes it an essential component of cutting edge research in medicine and biology. Bio-NMR pools pan-European resources of the most relevant bio-NMR infrastructures. Eleven partners will provide access to researchers involved in structural biology following the EU-NMR I3 project. This initiative successfully responded to the increasing demand for access since 1994. Seven other excellent partners, including the leading NMR manufacturer Bruker, are included in the new consortium. Jointly, they will develop methods aimed at pushing the frontiers of biological NMR and improving the quality of access to allow users to tackle ever more challenging goals in cellular structural biology. Finally, all nineteen partners, amongst them a company specialized in NMR technology dissemination, are involved in the networking activities. These include (1) knowledge transfer among consortium members, Bio-NMR users and other NMR researchers, (2) the demonstration to biologists of the potential of structural biology with NMR , and lowering the barriers to their becoming users, (3) interactions with industrial and medical communities, and (4) raising awareness of the impact of the results achieved through Bio-NMR among society, financing and governing bodies with the final aim of developing a business plan for self-sustainability. The overall project and its management have been conceived in coordination with INSTRUCT, which will contribute to the cultural frame and networking activities of Bio-NMR.


Grant
Agency: Cordis | Branch: FP7 | Program: CP | Phase: INFRA-2011-2.1.1. | Award Amount: 10.17M | Year: 2011

Key questions in physics can be answered only by constructing a giant underground observatory to search for rare events and study terrestrial and astrophysical neutrinos. The Astroparticle Roadmap of ApPEC/ASPERA strongly supports this, recommending that: a new large European infrastructure of 100000-500000 ton for proton decay and low-energy neutrinos be evaluated as a common design study together with the underground infrastructure and eventual detection of accelerator neutrino beams. The latest CERN roadmap also states: a range of very important non-accelerator experiments takes place at the overlap of particle and astroparticle physics exploring otherwise inaccessible phenomena; Council will seek with ApPEC a coordinated strategy in these areas of mutual interest. Reacting to this, uniting scientists across Europe with industrial support to produce a very strong collaboration, the LAGUNA FP7 design study has had a very positive effect. It enabled, via study of seven pre-selected locations (Finland, France, Italy, Poland, Romania, Spain and UK), a detailed geo-technical assessment of the giant underground cavern needed, concluding finally that no geo-technical show-stoppers to cavern construction exist. Building on this, the present design study will address two challenges vital to making a final detector and site choice: (i) to determine the full cost of construction underground, commissioning and long-term operation of the infrastructure, and (ii) to determine the full impact of including long baseline neutrino physics with beams from CERN.


Grant
Agency: Cordis | Branch: FP7 | Program: CSA-SA | Phase: SiS.2012.1.2-1 | Award Amount: 4.59M | Year: 2013

Synthetic biology (SynBio) offers huge potential for applications in energy, health and the environment. It also brings with it various challenges such as regulatory issues of biosafety, biosecurity and intellectual property rights, as well as potential environmental and socio-economic risks in developing countries. As yet, however, there is scant public knowledge about the technology. It is thus essential to establish an open dialogue between stakeholders concerning SynBios potential benefits and risks and to explore possibilities for its collaborative shaping on the basis of public participation. SYN-ENERGY will organise a wide range of mobilisation and mutual learning processes relating to these challenges. Besides a number of well-established European and international networks, the consortium encompasses and can mobilise a wide variety of stakeholders from science, industry, civil society, policy, education, art and other areas. Learning processes will contribute to a better understanding of SynBio research and innovation and to enhanced public engagement, while at the same time stimulating reflection on novel approaches to an inclusive governance framework that is capable of fostering responsible research and innovation. The processes will involve citizens and specific publics through well-established and innovative means of engagement, and will support the convergence of stakeholders and perspectives. Activities will be structured by four platforms, highlighting SynBios future, public, cultural and research & innovation perspectives. The iterative mutual learning process within SYN-ENERGY will be open to change in order to accommodate the dynamics of an emergent field. By dint of its approach, design and consortium, SYN-ENERGY will be a Science in Society activity with significant impact, raising public awareness of SynBio and yielding benefits for involved stakeholders, public discourse and European policy making in an international context.


Grant
Agency: Cordis | Branch: FP7 | Program: CP | Phase: ENV.2013.6.1-2 | Award Amount: 11.32M | Year: 2013

StratoClim will produce more reliable projections of climate change and stratospheric ozone by a better understanding and improved representation of key processes in the Upper Troposphere and Stratosphere (UTS). This will be achieved by an integrated approach bridging observations from dedicated field activities, process modelling on all scales, and global modelling with a suite of chemistry climate models (CCMs) and Earth system models (ESMs). At present, complex interactions and feedbacks are inadequately represented in global models with respect to natural and anthropogenic emissions of greenhouse gases, aerosol precursors and other important trace gases, the atmospheric dynamics affecting transport into and through the UTS, and chemical and microphysical processes governing the chemistry and the radiative properties of the UTS. StratoClim will (a) improve the understanding of the microphysical, chemical and dynamical processes that determine the composition of the UTS, such as the formation, loss and redistribution of aerosol, ozone and water vapour, and how these processes will be affected by climate change; (b) implement these processes and fully include the interactive feedback from UTS ozone and aerosol on surface climate in CCMs and ESMs. Through StratoClim new measurements will be obtained in key regions: (1) in a tropical campaign with a high altitude research aircraft carrying an innovative and comprehensive payload, (2) by a new tropical station for unprecedented ground and sonde measurements, and (3) through newly developed satellite data products. The improved climate models will be used to make more robust and accurate predictions of surface climate and stratospheric ozone, both with a view to the protection of life on Earth. Socioeconomic implications will be assessed and policy relevant information will be communicated to policy makers and the public through a dedicated office for communication, stakeholder contact and international co-operation.


Grant
Agency: Cordis | Branch: H2020 | Program: RIA | Phase: EeB-03-2014 | Award Amount: 5.99M | Year: 2015

Built2Spec brings together a new and breakthrough set of technological advances for self-inspection and quality assurance that will be put into the hands of construction stakeholders to help meeting EU energy efficiency targets, new build standards, and related policy ambitions. B2S will expand upon a cloud based construction support platform, conceived following the most advanced integrated design and delivery framework for the building sector and hosting applications that facilitate worksite activities and quality compliance by putting knowledge in hands of contractors, in the form of shared design specifications and 3D models, installation guidelines, information on regulatory frameworks, and help from construction experts on smartphones and tablets. New self-inspection technologies managed within the platform and developed in the project include: Special IR camera in smartphones coupled with new mathematical reverse models for on-the-fly analysis of existing buildings envelope thermal properties Rapid BIM modelling via instant 3D capture with smartphones, passed via the cloud to the refurbishment team back-office, allowing accurate instant energy efficiency evaluation, quality check and streamlined quotation process Portable, innovative low pressure air tightness technique allowing testing of occupied buildings Smart sensor-embedded construction elements (identification, structural performance, and building environment parameters) Portable single device for Indoor Air Quality tests offering multi-gas capabilities targeting the most harmful gas pollutants A novel lightweight portable sound source for on-site acoustic tests to regulation compliance The B2S system will be integrated into the operations of SME contractors, large construction firms, and end user clients directly within the consortium and work program activities, assuring systematic and scientific performance measures, feedback and powerful exploitation and dissemination strategies.


Grant
Agency: Cordis | Branch: FP7 | Program: CP-IP | Phase: HEALTH-2009-2.1.2-1 | Award Amount: 13.84M | Year: 2010

Tuberculosis (TB) is a re-emerging global health threat caused by Mycobacterium tuberculosis (Mtb). One third of the worlds population is infected with Mtb and new infections occur at a rate of one per second. Despite global research efforts, mechanisms underlying pathogenesis, virulence and persistence of Mtb infection remain poorly understood. Simple reductionist approaches are insufficient to understand its complex biology. The grand goal of the SysteMTb project is to establish a Systems Biology framework to understand key features of Mtb and its interactions with the host which, in turn, will provide new insights and a solid (model based) knowledge for the development of novel and cost-effective strategies to combat tuberculosis. To achieve this, SysteMTb will: i) generate and integrate quantitative data sets of Mtb (e.g. transcriptomics, proteomics, metabolomics, structural genomics, lipidomics, glycomics) alone, or in the presence of host macrophages, ii) develop computer models at different appropriate levels of system complexity with emphasis on metabolism, regulatory networks and transcription regulation, and iii) identify new possible targets for therapeutic intervention based on computer modelling. The combination of these approaches will provide a rational framework to understand mycobacterial physiology during infection and to identify essential nodes that are optimal for effective therapeutic interventions.


Grant
Agency: Cordis | Branch: FP7 | Program: CP | Phase: ICT-2011.5.2 | Award Amount: 18.10M | Year: 2013

The DementiA Research Enabled by IT project responds to the European Parliaments 2011 resolution for a European Initiative on Alzheimers disease and other dementias, and the EU Year of the Brain 2014 Initiative. It delivers the first patient-specific predictive models for early differential diagnosis of dementias and their evolution. Its mechanistic/phenomenological models of the ageing brain account simultaneously for the patient-specific multiscale biochemical, metabolic and biomechanical brain substrate, as well as for genetic, clinical, demographic and lifestyle determinants. It investigates the effect of metabolic syndrome, diabetes, diets, exercise, and pulmonary conditions on the ageing brain, as environmental factors influencing onset and evolution of dementias.\n\nAn integrated clinical decision support platform will be validated/ tested by access to a dozen databases of international cross-sectional and longitudinal studies, including exclusive access to a population study that has tracked brain ageing in more than 10,000 individuals for over 20 years (Rotterdam Study).\n\nEnabling more objective, earlier, predictive and individualised diagnosis and prognosis of dementias will support health systems worldwide to cope with the burden of 36M patients that, due to ageing societies, will increase to 115M by 2050. Worldwide costs are estimated to 450B annually. In 2012, the WHO declared dementia a global health priority.\n\nOur consortium assembles highly recognised engineering, physical, biomedical and clinical scientists, and industrial partners experienced in exploiting VPH technologies in healthcare. Co-operation with infrastructure projects like VPH-Share, related international Physiome efforts, and other dementia research consortia is assured, allowing European researchers from different disciplines to contribute to share resources, methods and generate new knowledge.


Grant
Agency: Cordis | Branch: FP7 | Program: CP | Phase: ICT-2011.1.1 | Award Amount: 3.64M | Year: 2012

Flexible optical networking is widely proposed today by major vendors and operators as the solution that offers smooth system upgradability towards Tb/s capacities and optimized use of network resources. Latest research and development efforts proposed a variety of multi-carrier signal transmission methods with significantly increased spectral efficiency, (compared to legacy WDM), allowing the transport of ultra-high capacity channels and the adaptive filling of wavelength channels according to the demands and the required performance on a link distance basis. These developments enable the flexible bandwidth utilization of the optical links but are limited to the point-to-point transport of data. The key network element required to truly enable the realization of a flexible optical networking system is a flexible switching node capable to adaptively add, drop and switch tributaries with variable bandwidth characteristics from/to ultra-high capacity wavelength channels at the lowest switching granularity.The FOX-C project aims to design, develop and evaluate the first functional system prototype of flexible add-drop multiplexers and flexible optical cross-connects, with fine switching granularity at the optical subcarrier level with the purpose to enable the end-to-end network routing of any tributary channel with flexible bandwidth down to 10Gb/s carried over wavelength superchannels, each with an aggregated capacity beyond 1Tb/s. Moreover, the project will define and evaluate the flexible transmission solutions and their exact characteristics, thus providing a holistic flexible optical networking approach applicable in next generation networks.The FOX-C project consortium consists of industrial partners with leading position in the field of optical node design and development, as well as academic partners with worldwide recognised research on flexible transmission solutions, forming together a strong research team capable of meeting the project objectives.


Grant
Agency: Cordis | Branch: FP7 | Program: MC-ITN | Phase: FP7-PEOPLE-2012-ITN | Award Amount: 3.54M | Year: 2013

SPRITE is a multi-disciplinary European training network which brings together Europes premier research institutes in technology and applications of ion beams. Those involved are already actively collaborating, for example in the recently very favourably reviewed EC Infrastructure project SPIRIT. SPRITE addresses the urgent European need - identified in a recent Foresight Review - to train the next generation of researchers in this multi- and supra- disciplinary emerging field. Through its Internship Mobility Partnerships (IMPs) SPRITE offers an innovative training package, providing the researchers with the opportunity to gain real world experience and business facing skills in the private and public sectors. In addition, ELVEs (European Laboratory Visit Exchanges) are an integral part of the training program. In combination with the IMPs, every ER and ESR will thus spend up to 30% of its time outside its host laboratory, part of this time in another EC country. Collaboration with the IAEA opens up a further dimension to SPRITE, enabling the researchers to put their research into a global context and to interact with scientists from all over the world. Despite the numerous participants SPRITE is able to offer a personalized training program. For this purpose the Action Planner, a web-based training needs analysis tool, developed at the University of Surrey will be used. This maps on to the Researcher Development Framework, currently being trialled by the European Science Foundation. Action Planner allows the training for each researcher to be tailored to their individual needs and aspirations. In addition to individualized training, SPRITE organizes network wide training events, encompassing amongst others technical training and business facing skills. In this way SPRITE researchers will leave not only as a brilliant and experienced researcher but also as a skilled manager, able to lead their own group.


Grant
Agency: Cordis | Branch: FP7 | Program: CP | Phase: ICT-2009.8.0 | Award Amount: 4.00M | Year: 2011

CADMAD aims to make a foundational breakthrough in the way computers and computer-aided design and manufacturing is employed in DNA-based research and development, making a radically new use of information technologies in biology and biotechnology.Biology and biotechnology research involves DNA programming, which is akin to computer programming. Researchers modify and combine DNA of interest in a programmatic way to uncover its function, to improve its function, or to create new functions. Whereas the composition and editing of computer programs is as easy as using a word-processor, the design, construction and editing of DNA in a programmatic fashion is still a slow, expensive, labour-intensive wet-lab process.CADMADs vision is to replace the labour-intensive DNA processing carried out today by tens of thousands of skilled wet-lab workers around the world, by high-throughput computer-aided design and manufacturing of DNA, which would be fundamentally more efficient than plain de novo DNA synthesis by effectively reusing existing DNA. Computed-aided design and manufacturing of semiconductor chips has enabled the computer revolution, the Internet revolution, and the mobile phone revolution. Computer-aided design and manufacturing of DNA may similarly enable a revolution in biology and biotechnology, in which high-throughput computer-aided and robotically executed experiments replace manual wet-lab work, resulting in accelerated progress in key areas of research and development.


Grant
Agency: Cordis | Branch: FP7 | Program: CP | Phase: ENERGY.2011.7.2-1 | Award Amount: 5.25M | Year: 2012

The growing share of electricity generation from intermittent renewable energy sources as well as increasing market-based cross border flows and related physical flows are leading to rising uncertainties in transmission network operation. In the mainland central Europe synchronous area due to large installations of renewable energy generation such as wind and photovoltaic, the difference between actual physical flows and the market exchanges can be very substantial. Remedial actions were identified by previous smart grid studies within the 6th European framework program in operational risk assessment, flow control and operational flexibility measures for this area. At the same time an efficient and sustainable electricity system requires an efficient usage of existing and future transmission capacities to provide a maximum of transportation possibilities. New interconnections and devices for load flow control will be integrated in future transmission networks and will offer new operational options. Further developments of coordinated grid security tools are one of the major challenges TSOs will face in future. The methods to be applied have to take into account all technological measures to enhance flexibility of power system operations. The zonal structure of the European energy market along with the legal responsibilities of TSOs for different system areas will continue to pose increasingly complex requirements to the system operators concerning the quality and accuracy of cooperation. The proposed UMBRELLA research and demonstration project is designed for coping with these challenging issues and boundary conditions. The toolbox to be developed will enable TSOs to ensure secure grid operation also in future electricity networks with high penetration of intermittent renewables. It enables TSOs to act in a coordinated European target system where regional strategies converge to ensure the best possible use of the European electricity infrastructure.


Grant
Agency: Cordis | Branch: FP7 | Program: CP | Phase: ICT-2011.9.9 | Award Amount: 11.78M | Year: 2013

The overarching goal of our project is to develop systems based on direct and deterministic interactions between individual quantum entities, which by involving large-scale entanglement can outperform classical systems in a series of relevant applications.\nWe plan to achieve that by improving technologies from atomic, molecular and optical physics as well as from solid-state physics, and by developing new ones, including combinations across those different domains. We will explore a wide range of experimental platforms as enabling technologies: from cold collisions or Rydberg blockade in neutral atoms to electrostatic or spin interactions in charged systems like trapped ions and quantum dots; from photon-phonon interactions in nano-mechanics to photon-photon interactions in cavity quantum electrodynamics and to spin-photon interactions in diamond color centers.\nWe will work on two deeply interconnected lines to build experimentally working implementations of quantum simulators and of quantum interfaces. This will enable us to conceive and realize applications exploiting those devices for simulating important problems in other fields of physics, as well as for carrying out protocols outperforming classical communication and measurement systems.


Grant
Agency: Cordis | Branch: FP7 | Program: CP | Phase: ENV.2012.6.1-3 | Award Amount: 5.91M | Year: 2012

Adaptation in the face of climate change is currently a major challenge, not only in the EU, but all around the world. Climate change has two distinct characters: the slower trends in climatic variables such as sea water temperatur, and the extreme weather phenomena, such as heavy precipitation. The fundamental driver for regional adaptation are regional climate scenarios. Crucial for local societies is the resilience of critical infrastructures, such as Energy and Transport, against the envisaged climate scenarios. Without proper functioning of such infrastructures, many service sectors, such as Tourism, will be negatively affected. ToPDAd developes state-of-the-art socioeconomic methods&tools for an integrated assessment supporting regional adaptation decision-making. Based on these, conjectures with respect to EU level policies for the considered sectors Energy, Transport, as well as, Tourism are made. Two time frames are specified; 2010-2050 and 2050-2100 for mid-term and long-term strategy formulations. Regional strategies and EU-level policies need to be consistent across the time frames in order to avoid maladaptation. ToPDAd will also develop the European Climate Adaptation Platform (DCLIMATE-ADAPT). The CLIMATE-ADAPT is key for continuous learning, and a repository of data and tools supporting adaptation decision-making.


Grant
Agency: Cordis | Branch: FP7 | Program: CP-IP | Phase: KBBE.2011.2.4-02 | Award Amount: 7.58M | Year: 2012

Total Diet Studies (TDS) allow getting information on real dietary exposure to food contaminants consumption (heavy metals, mycotoxins, POPs...) and estimating chronic exposure to pesticide residues in food and food additives intake. TDS consider total exposure from whole diets and are based on food contamination as consumed rather than contamination from raw commodities, thus ensuring a realistic exposure measure. TDS facilitate risk assessment (RA) and health monitoring (HM). Some EU Member States (MS) and Candidate Countries (CC) have no TDS programme or use various methods to collect data, which were not examined yet to tell whether they are comparable or not. This is of interest for EFSA or WHO-FAO. Similarly it is important to harmonise methods to assess dietary exposure risks in MS, CC and at the European level compared with other world regions. The methods proposed will aim for food sampling, standard analytical procedures, exposure assessment modelling, priority foods and selected chemical contaminants consistency across MS and CC. Various approaches and methods to identify sampling and analyses will be assessed and best practice defined. Contaminants and foods which contribute most to total exposure in European populations will be defined. Priority will be given to training and support in EU MS and CC currently without TDS. It will demonstrate best practice in creating a TDS programme using harmonised methods in regions previously lacking TDS, and ensure consistency of data collected. A database will be set up describing existing EU studies and collating harmonised exposure measures and designed to allow risk assessors and managers handling dietary exposure more accurately and more specifically. TDSEXPOSURE will spread excellence in TDS throughout stakeholders and establish a legacy of harmonised methods for sampling and analysis, and science-based recommendations for future global studies.


Grant
Agency: Cordis | Branch: H2020 | Program: RIA | Phase: FETPROACT-3-2014 | Award Amount: 4.70M | Year: 2015

Quantum Simulators provide new levels of understanding of equilibrium and out-of-equilibrium properties of many-body quantum systems, one of the most challenging problems in physics. The main objective of the RYSQ project is to use Rydberg atoms for quantum simulations, because their outstanding versatility will allow us to perform a great variety of useful quantum simulations, by exploiting different aspects of the same experimental and theoretical tools. By implementing not only one but a whole family of Rydberg Quantum Simulators, the project will address both the coherent and incoherent dissipative dynamics of many-body quantum systems, with potential applications in the understanding and design of artificial light harvesting systems, large quantum systems with controlled decoherence, and novel materials. This will be achieved by building upon a novel generic approach to quantum simulation, where Rydberg atoms allow both digital (gate) and analog (interaction) simulations. In addition to solving problems in fundamental and applied science, the project will build up core competences for quantum science and technologies in mainstream engineering, by using innovative methods for communication, dissemination and exploitation of results. In summary, RYSQ plans (A) to develop a collection of novel experimental and theoretical tools for Rydberg quantum simulators, and (B) to use them as a basis for implementing many important applications of quantum simulations. The project is structured in such a way to allow for efficient exchanges within the consortium, and to maximize the overall outcome of the work.


Grant
Agency: Cordis | Branch: H2020 | Program: RIA | Phase: MG-2.1-2014 | Award Amount: 3.92M | Year: 2015

The project provides solutions for common infrastructure problems encountered in diverse regions of Europe, e.g. deterioration and scour damage to bridges, slope instability, damage to switches and crossings and track performance. Whilst similar failure modes are seen around the EU, the triggers (precipitation, earthquake loading etc.) are regional. The DESTination RAIL project will develop management tools based on scientific principles for risk assessment using real performance measurements and other vital data stored in an Information Management System. This will allow for a step-change in the management of European rail infrastructure. The objectives will be achieved through a holistic management tool based on the FACT (Find, Analyse, Classify, Treat) principle. Find - Improved techniques for the assessment of existing assets will be developed. Analyse - Advanced probabilistic models fed by performance statistics and using databases controlled by an information management system. Classify - The performance models will allow a step-change in risk assessment, moving from the current subjective (qualitative) basis to become fundamentally based on quantifiable data. Treat - The impact of proposed remediation or reconstruction will be assessed using the a probabilistic whole life cycle model which includes financial and environmental costs and the impact of work on traffic flow. The FACT principles will be implemented in a holistic decision support tool for infrastructure managers. DESTination RAIL will result significant impact in relation to the objectives of the work programme. It will reduce the cost of investment by using the IMS to manage the network, (ii) Monitoring and real-times analyses will prevent unnecessary line restrictions and closures. (iii) Lower maintenance costs by optimisimg interventions in the life cycle of the asset and (iv) optimise traffic flow in the network.


Grant
Agency: Cordis | Branch: FP7 | Program: CP-CSA | Phase: Fission-2013-3.4.1 | Award Amount: 5.53M | Year: 2013

COMET will strengthen the pan-European research initiative on the impact of radiation on man and the environment by facilitating the integration of radioecological research. COMET will build upon the foundations laid by the European Radioecology Alliance (ALLIANCE) and the on-going FP7 STAR Network of Excellence in radioecology. By collaborating with the European platforms on nuclear and radiological emergency response (NERIS) and low dose risk research (MELODI), COMET will significantly aid preparation for the implementation of the Horizon 2020 umbrella structure for Radiation Protection. In close association with STAR and the ALLIANCE, COMET will take forward the development of a Strategic Research Agenda as the basis for developing innovative mechanisms for joint programming and implementation (JPI) of radioecological research. To facilitate and foster future integration under a common federating structure, research activities developed within COMET will be targeted at radioecological research needs that will help achieve priorities of the NERIS and MELODI platforms. These research activities will be initiated in collaboration with researchers from countries where major nuclear accidents have occurred. Flexible funds, unallocated to specific tasks at project initiation, have been included within the COMET budget to facilitate RTD activities identified through the JPI mechanisms developed that are of joint interest to the ALLIANCE, NERIS and MELODI. It will also strengthen the bridge with the non-radiation community. Furthermore, COMET will develop strong mechanisms for knowledge exchange, dissemination and training to enhance and maintain European capacity, competence and skills in radioecology. The COMET consortium has 13 partners, expanding from the organisations within the FP7 STAR project. In particular, COMET partners from countries which have experienced major nuclear accidents (i.e. Ukraine and Japan) and/or who hold Observatory sites.


Grant
Agency: Cordis | Branch: FP7 | Program: MC-ITN | Phase: FP7-PEOPLE-2013-ITN | Award Amount: 3.93M | Year: 2014

TEMPO addresses the needs of European companies and society for embedded control technology, through training on cutting edge research in the rapidly emerging inter-disciplinary field of embedded predictive control and optimization. The key objectives are: - to expand the scientific and technical knowledge platform for Embedded Predictive Control and Optimization in Europe; - to exploit this platform to train a new generation of world class researchers and professionals that are highly attractive for employment by the European industry; - to establish structures for long-term cooperation and strengthen the relations among the leading universities and industry in Europe in this field, to continuously develop the research training platform that European industry relies on. To achieve the objectives listed above, the main tasks of TEMPO are: - to attract and train 14 Early Stage Researchers in embedded MPC and optimization via a joint academic/industrial program of cutting edge training-by-research, high quality supervision, complementary and transferable skills training, inter-network secondments, and workshops; - to create a closely connected group of leading European scientists that are highly sought after by European industry, and ready to push forward embedded MPC and optimization into new innovative products, industries and services; - to build a solid foundation for long-term European excellence in this field by disseminating the research and training outcomes and best practice of TEMPO into the doctoral schools of the partners, and by fostering long-term partnerships and collaboration mechanisms that will outlast the ITN; - to disseminate the know-how of the participants to each other and to external groups via networking activities, inter-sectoral exposure, secondments, workshops, demonstrations, sharing of learning material, public engagement and outreach activities, and open source public domain software outcomes.


Grant
Agency: Cordis | Branch: H2020 | Program: RIA | Phase: FETPROACT-1-2014 | Award Amount: 4.21M | Year: 2015

We propose visionary research to develop modeling, computational, and ICT tools needed to predict and influence disease spread and other contagion phenomena in complex social systems. To achieve non-incremental advances we will combine large scale, realistic, data-driven models with participatory data-collection and advanced methods for Big Data analysis. In particular we will go beyond the one-dimensional focus of current approaches tackling one aspect of the problem at a time. We will interconnect contagion progression (e.g. epidemics) with social adaptation, the economic impact and other systemic aspects that will finally allow a complete analysis of the inherent systemic risk. We will develop models dealing with multiple time and length scales simultaneously, leading to the definition of new, layered computational approaches. Towards policy impact and social response we will work to close the loop between models, data, behavior and perception and develop new concepts for the explanation, visualization and interaction with data and models both on individual and on collective level. We will cast the fundamental advances into an integrated system building on widely accepted open ICT technologies that will be used and useful beyond the project. As a tangible ICT outcome directed at facilitating the uptake and impact of the project, we will implement Interactive Social Exploratories defined as interactive environments which act as a front-end to a set of parameterizable and adjustable models, data analysis techniques, visualization methods and data collection frameworks. In summary, we aim to (1) produce fundamental theoretical, methodological and technological advances (2) mold them into a broadly usable ICT platform that will be a catalyst for producing, delivering, and embedding scientific evidence into the policy and societal processes and (3) evaluate the system empirically with policy makers and citizens focusing on the concrete problem of epidemic spreading.


Grant
Agency: Cordis | Branch: FP7 | Program: CSA-CA | Phase: HEALTH.2010.2.1.1-2 | Award Amount: 2.20M | Year: 2011

Over the last few years the field of proteomics has evolved into a prolific data producer. As a result, various databases that collect and redistribute the acquired data have been established. While data format standards for quantitative proteomics have now been defined and implemented with significant contribution from the recently completed EU ProDaC grant, standards for quantitative proteomics are still lacking. This simultaneous creation of multiple repositories and databases, and lack of standards for quantitative proteomics result in a fragmentation of data, and cause confusion for data submitters and users alike. Based on consortium expertise in the operation of large scale proteomics repositories (PRIDE, PeptideAtlas, Tranche, Peptidome) we aim to implement the next step, regular data exchange between major international proteomics resources. In parallel, we will further develop standards (mzQuantML) for the dynamic field of quantitative mass spectrometry. The main objectives of ProteomExchange are user-oriented: (i) to provide a single point of data submission to the user; (ii) to ensure data availability in all of the different member databases; (iii) to use community standard formats to represent the data, so it becomes accessible to all regardless of data origin; (iv) to provide added value through different views on the same data, from repositories to derived search tools. With an international consortium and support from large scale data producers (ISAS (Germany), U. Cambridge (UK), Karolinska Institute (Sweden)), industry (Pfizer, Philips, Waters), and journals (Nature Biotechnology, MCP, JPR), we here propose a Coordination Action project to solidify an emerging informal collaboration between major repositories into a production-quality data deposition and dissemination consortium on par with the systems so successfully employed by three-dimensional structure databases and nucleotide sequence databases, amongst others.


Grant
Agency: Cordis | Branch: FP7 | Program: CPCSA | Phase: INFRA-2010-1.2.1 | Award Amount: 70.14M | Year: 2010

Scientific research is no longer conducted within national boundaries and is becoming increasing dependent on the large-scale analysis of data, generated from instruments or computer simulations housed in trans-national facilities, by using e Infrastructure (distributed computing and storage resources linked by high-performance networks).\nThe 48 month EGI-InSPIRE project will continue the transition to a sustainable pan-European e-Infrastructure started in EGEE-III. It will sustain support for Grids of high-performance and high-throughput computing resources, while seeking to integrate new Distributed Computing Infrastructures (DCIs), i.e. Clouds, SuperComputing, Desktop Grids, etc., as they are required by the European user community. It will establish a central coordinating organisation, EGI.eu, and support the staff throughout Europe necessary to integrate and interoperate individual national grid infrastructures. EGI.eu will provide a coordinating hub for European DCIs, working to bring existing technologies into a single integrated persistent production infrastructure for researchers within the European Research Area.\nEGI-InSPIRE will collect requirements and provide user-support for the current and new (e.g. ESFRI) users. Support will also be given for the current heavy users as they move their critical services and tools from a central support model to ones driven by their own individual communities. The project will define, verify and integrate within the Unified Middleware Distribution, the middleware from external providers needed to access the e-Infrastructure. The operational tools will be extended by the project to support a national operational deployment model, include new DCI technologies in the production infrastructure and the associated accounting information to help define EGIs future revenue model.


Grant
Agency: Cordis | Branch: H2020 | Program: RIA | Phase: PHC-06-2014 | Award Amount: 3.38M | Year: 2015

Despite the fact that iodine deficiency (ID) can easily be prevented by iodine fortification of table salt, industrial salt and cattle food, Europe belongs to the worst regions in terms of access to iodized salt and is seriously ID, resulting in the perpetuation of the single most important, preventable cause of brain damage. European ID is due to significant heterogeneity in prevention and monitoring programs, leading to inappropriate interventions, increased disease burden, health inequities and increased health care costs. Up to 360 Million European citizens are exposed to ID disorders. An effective European monitoring program is a crucial step towards eradication of ID disorders with significant benefits for European citizens and the sustainability of health care systems. The effects of ID in total cause tremendous, preventable costs in health care systems of affected regions. The overall aim of EUthyroid is to evaluate ID prevention and monitoring programs in 24 European countries, to initiate capacity building for harmonized European ID prevention and monitoring programs, and to disseminate project outcomes for supporting measures on national and EU level in order to eradicate ID disorders in Europe. The project will position itself as international hub of current national initiatives in the attempt to coordinate and support existing national activities. EUthyroid will generate the first harmonized data set of ID resulting in the first valid map of iodine status in Europe. With a dedicated dissemination program about the unfavorable health outcomes of ID, EUthyroid will pave the way for a harmonized EU-wide regulation of iodination, a common approach to iodine and outcome monitoring and establish recommendations for scientists on how to monitor IDD prevention programs. The project aims to make Europe a benchmark for ID disorder prevention worldwide.


Grant
Agency: Cordis | Branch: FP7 | Program: CPCSA | Phase: INFRA-2011-2.3.5. | Award Amount: 35.18M | Year: 2011

PRACE-2IP supports the accelerated implementation of the pan-European HPC Research Infrastructure created in April 2010 as the result of the preparatory phase PRACE project. It complements and extends the work of the PRACE-1IP project that was started in July 2010.\nPRACE-2IP addresses the computational and simulation needs of European scientific communities to keep them at the forefront of discovery. Our vision is the formation of an integrated HPC ecosystem of facilities and services enabling researchers to realise the full potential of computational science within the supportive environment of the European Research Area.\nBuilding on the implementation work of the preceding PRACE and DEISA projects, PRACE-2IP will enable seamless access to HPC systems and services at the Tier-0 and Tier-1 level to users, regardless of their country of work. This provides the means and motivation to undertake ambitious, ground-breaking computational science. In particular, DEISA-like services will be integrated into the ecosystem.\nApplications enabling expertise will support researchers in code development, optimisation and petascaling to help them make effective use of the Tier-0 and Tier-1 systems. Training and dissemination activities will ensure that European scientists have the knowledge and the skills enabling them to take full advantage of the facilities on offer. Through collaboration with technology providers and vendors, novel architectures, systems and technologies will be evaluated to ensure that Europe remains at the forefront of HPC and that the future needs of the research community are understood and met. Targeted research activities will investigate possible solutions to challenges in programmability and scalability of future multi-petaflop systems.\nPRACE-2IP will considerably strengthen and deepen the co-operation between HPC centres, funding bodies and research communities in a mutually beneficial partnership to enhance European scientific competitiveness.


Grant
Agency: Cordis | Branch: FP7 | Program: CPCSA | Phase: INFRA-2012-2.3.1. | Award Amount: 26.57M | Year: 2012

PRACE-3IP supports the accelerated implementation of the pan-European HPC Research Infrastructure (RI) created in April 2010. It continues, complements, and extends the work of the PRACE-1IP and -2IP projects.\nPRACE-3IP addresses the computational and simulation needs of European scientific communities and of industry to keep them at the forefront of discovery. Our vision is the formation of an integrated HPC ecosystem of facilities and services enabling researchers to realise the full potential of computational science within the supportive environment of the ERA.\nThe project will undertake a joint pre-commercial procurement (PCP) pilot to obtain a solution for a Whole System Design for Energy Efficient HPC. This pilot is the first of its kind on a Europe-wide level and the lessons learned will be invaluable for PRACE in its future procurement strategy and for Europe as a whole in using PCP as a driver for innovation.\nPRACE-3IP will deliver a broad set of services suitable for use by industry and commerce. The PRACE RI will be open for use by SMEs and large European businesses, offering Tier-0 and Tier-1 access, training, and applications support.\nApplications support and enabling will have a bias towards addressing major socio-economic challenges. New tools will be made available under Open Source. Best practises will be identified, documented and made available to the European HPC community in academia and industry.\nPRACE-3IP will have a broad training and outreach activity designed to engage more user communities, including industry, in the use of HPC. The next generation of students and researchers will be introduced to the benefits of HPC and the technologies and knowledge required applying it successfully in their discipline.\nPRACE-3IP will considerably strengthen and deepen the co-operation between HPC centres, funding bodies and research communities in a mutually beneficial partnership to enhance European scientific and industrial competitiveness.


Grant
Agency: Cordis | Branch: FP7 | Program: CPCSA | Phase: INFRA-2010-2.3.1 | Award Amount: 27.74M | Year: 2010

Large scale simulations are the third pillar of science today alongside theory and experiment. They produce scientific insights, technological advances, and solve problems in many fields of society. Their tools are high-end computers and effective software. PRACE, the Partnership for Advanced Computing, has been created as a not for profit association in May 2010 as a permanent pan-European High Performance Computing service providing world-class systems for world-class science. Up to six systems at the highest performance level (Tier-0) will be deployed the first one being the already installed BlueGene/P in Germany. Funding for the next three systems has been committed by France, Italy, and Spain. Twenty European states are members of the PRACE Research Infrastructure (RI). Access to the PRACE resources will be through a single peer review process. The Scientific Steering Committee represents the user communities and guides the strategic directions. PRACE works closely with national, regional, and topical centres to shape the European HPC ecosystem.\nThe PRACE-1IP project is designed to support the accelerated implementation of the RI. The project supports the evolution of the RI by refining and extending the administrative, legal and financial framework with focus on the specific requirements of industry. To enable world-class science on novel systems the project assists users in porting, optimising and petascaling applications to the different architectures and deploys consistent services across the RI. The tools and techniques will be selected to have broad applicability across many disciplines. This is accompanied by advanced training in modern programming methods and paradigms, establishing a permanent distributed training infrastructure. The PRACE brand is already well established in the international HPC scene; extensive dissemination and outreach will be continued. The project advises PRACE on procurements of the next generation of systems. Finally, promising technologies, especially with respect to energy efficiency, will be evaluated with the ultimate goal to collaborate with industrial partners to develop products exploiting STRATOS, PRACE advisory group for Strategic Technologies created in the PRACE Preparatory Phase project.


Grant
Agency: Cordis | Branch: FP7 | Program: MC-ITN | Phase: FP7-PEOPLE-2010-ITN | Award Amount: 3.50M | Year: 2011

In the understanding of the initiation and development of several diseases revolutionary changes are currently taking place. Cancer and brain diseases are examples of medical fields where new technologies are finding their way into research and applications, radically altering the way the diseases are being diagnosed and treated. Especially methods that yield information on molecular and cellular mechanisms open up the way for novel effective therapies for disease prevention and disease curing. The aim of this ITN is to conduct training and research in the field of novel bio-analytical methods and tools for cell based diseases, in specific for severe cancers and brain diseases. These methods and tools should allow faster and more reliable diagnosis, but are also of great importance for therapy research leading to novel treatment methods. This ITN combines disciplines such as engineering, biotechnology, medicine, and chip-technology and the consortium covers universities, hospitals and industry. The functionality of the devices is determined by the type of measurements that need to be performed, therefore we will focus on a few specific diseases: our cancer research will be aimed at skin cancer (melanoma) and blood cancer (leukaemia), and the part on brain diseases will focus on schizophrenia. Although we will direct our activities towards these three diseases in particular, we expect that the research (methods, devices, and technology) will also have impact on the understanding of other cancer types and other brain diseases.


Grant
Agency: Cordis | Branch: FP7 | Program: MC-ITN | Phase: FP7-PEOPLE-2011-ITN | Award Amount: 4.00M | Year: 2012

This network brings together an exceptionally strong group of world leading experts in nano-science and technology in order to achieve breakthroughs in understanding and successful utilisation of nanoscale systems in future devices. The focus of the consortium is on few spin nano-systems in solid-state materials including III-V semiconductors and Carbon-based structures: carbon nano-tubes, graphene and diamonds. Such wide material base emphasizes the truly intersectoral character of this collaboration opening opportunities for crossing the boundaries between several areas of solid-state physics and technology. In order to ensure the highest impact of this collaboration in the emerging supra-disciplinary field of physics and applications of spin nano-systems, we bring together the expertise of the world top class research institutions and industry from 4 European countries. The network will deliver top international level multidisciplinary training to 11 early stage researchers and 5 experienced researchers, offering them, in particular, an extended program of multinational exchanges and secondments. The research and development under this network will undertake a broad scope of tasks important for implementation of spin nano-systems in future devices, such as non-volatile ultra-compact memories, nano-magnetometers, spin qubits for quantum information, and high-efficiency single photon sources. The objectives of the network include: (1) Realization and optical control of coherent single spins in nanostructures; (2) Spin-orbit interaction and spin-orbit qubits in nanostructures; (3) Advanced techniques for manipulation of nuclear spins on the nanoscale; (4) Generation of long-distance entanglement between single spins.


Grant
Agency: Cordis | Branch: FP7 | Program: CP | Phase: ICT-2011.3.5 | Award Amount: 12.57M | Year: 2012

The mid-infrared (MIR) region is emerging as the favourite wavelength band for a number of applications, including high sensitivity trace detection, chemical emission monitoring, process control, and biological sensing applications. An efficient way to get precise and reliable information is to rely on spectroscopic analysis and, among the existing technologies, Tunable Diode Laser Spectroscopy (TDLS) has been identified to be the most attractive solution due to the unique adsorption spectrum of chemicals, allowing their unambiguous detection. In the MIR region, the availability of Quantum Cascade Lasers (QCL) covering a broad portion of the spectral range (MIR, 3-12 m), where many chemicals of interest for Safety & Security have their strongest absorption lines, has recently pushed forward the commercialisation of TDLS-based detection units.\nFurther technology advancements are still needed in the TDLS and QCL domains, the crucial bottlenecks being the range of tuneability, the footprint, power consumption & wallplug efficiency. Besides high cost and poor versatility, these limitations set a barrier for the realisation of powerful versatile detection units. To address these issues, MIRIFISENS will bring major technological advancements in the field of miniaturisation, process development, heterogeneous integration and co-integration of MOEMS functionalities.\nThe project will exploit state-of-the-art micro and nano-fabrication techniques. The major technologic achievements proposed will address the issues of sensitivity & selectivity, multi-gas capabilities, compactness, efficiency and cost effectiveness as specified by a number of selected Safety & Security applications. These achievements will be tested and validated for these applications. MIRIFISENS will deliver a new class of sensors with superior tuneability, better portability and extended detection capabilities, changing radically the current landscape of MIR chemical sensing spectroscopy.


Grant
Agency: Cordis | Branch: FP7 | Program: MC-ITN | Phase: FP7-PEOPLE-2010-ITN | Award Amount: 3.34M | Year: 2011

The drive across the world towards energy efficiency and reduction of CO2 emissions is leading to new industrial processes and new ways of operating existing processes. In particular, the control and operation of processes, rotating machinery and electrical equipment is becoming radically more integrated giving new opportunities for energy saving through equipment management, automation, and optimization. In the light of these challenges, there is a need for new training and research action to address technology gaps at the interfaces between the process, mechanical and electrical domains, and to realize energy savings from integrated operation. The ENERGY-SMARTOPS consortium has detailed plans for cross-disciplinary training of a cohort of Early Stage engineering researchers through personalized programmes which will provide experience of research as an exciting and rewarding career, in-depth training in research projects at the host site and on intersectorial secondments, local and network-wide courses on technical topics, complementary skills training, and participation in workshops and symposia. The research programme is organized into three themes: (i) Equipment and process monitoring integrating multiple measurements from the process, mechanical and electrical sub-systems, (ii) Integrated automation capturing information from all three subsystems, and devising new algorithms that explicitly manage the interfaces and interactions between them, (iii) Optimization to provide energy savings by better integration of operations across the process-mechanical-electrical interfaces. The consortium involves universities and the R and D groups of end-user companies and an industrial technology supplier. Its investigators are experts in electrical machinery and power electronics, compressors and pumps, modeling and optimization, instrumentation, signal analysis, equipment condition monitoring, and automation of oil and gas, steel and chemical processes.


Grant
Agency: Cordis | Branch: FP7 | Program: CP | Phase: ICT-2013.9.7 | Award Amount: 8.27M | Year: 2013

The DIADEMS project aims at exploiting the unique physical properties of NV color centres in ultrapure single-crystal CVD-grown diamond to develop innovative devices with unprecedented performances for ICT applications. By exploiting the atom-like structure of the NV that exhibits spin dependent optical transitions, DIADEMS will make optics-based magnetometry possible.\nThe objectives of DIADEMS are to develop\n- Wide field magnetic imagers with 1 nT sensivities,\n- Scanning probe magnetometer with sensitivity 10 nT and spatial resolution 10 nm,\n- Sensor heads with resolution 1 pT.\n\nTo reach such performances, DIADEMS will:\n- Use new theoretical protocols for sensing,\n- Develop ultrahigh purity diamond material with controlled single nitrogen implantation with a precision better than 5 nm,\n- Process scanning probe tips with diametre in the 20 nm range,\n- Transfer them to AFM cantilever, improve the emission properties of NV by coupling them with photonic cavities and photonic waveguides.\n\nDIADEMS outputs will demonstrate new ICT functionalities that will boost applications with high impact on society:\n- Calibration and optimization of write/read magnetic heads for future high capacity (3 Tbit per square inch) storage disk required for intense computing,\n- Imaging of electron-spin in graphene and carbon nanotubes for next generation of electronic components based on spintronics,\n- Non-invasive investigation of living neuronal networks to understand brain function,\n- Demonstration of magnetic resonance imaging of single spins allowing single protein imaging for medical research.\n\nDIADEMS aims at integrating the efforts of the European Community on NV centres to push further the limits of this promising technology and to keep Europes prominent position.


Grant
Agency: Cordis | Branch: FP7 | Program: MC-ITN | Phase: FP7-PEOPLE-2012-ITN | Award Amount: 3.74M | Year: 2014

The main goal of the project is to provide excellent initial training to young researchers in the field of high energy particle physics, paving the road for new discoveries about the fundamental nature of the Universe at a time when new discoveries are expected, and when the new Standard Model of Particle Physics is going to be forged. The research goal of HiggsTools is the investigation of electroweak symmetry breaking. This question lies at the very frontier of knowledge of theoretical particle physics and phenomenology and, in fact, the primary goal of the Large Hadron Collider (LHC) at CERN is to unveil the mechanism of electroweak symmetry breaking. During the period of the network it is certain that the mechanism of electroweak symmetry breaking will be further decoded and that the theoretical ideas that date back to 1964 will either be confirmed or supplemented through the discovery of new additional particles that contribute to it. The experiments at the LHC have already made an impressive step forward in answering this question, by discovering a particle that is looking more and more like a Higgs boson. It remains an open question, however, whether this is the Higgs boson of the Standard Model of particle physics, or possibly the lightest of several bosons predicted in some theories that go beyond the Standard Model. Finding the answer to this question will take time. The outcome of the Higgs studies at the LHC will either carve our present understanding of electroweak interactions in stone or will be the beginning of a theoretical revolution. We will therefore create a cohort of 21 early-stage researchers (ESR) who will all be in the network for the same 36 month period and therefore be able to obtain the full benefit from the training provided by the network. We request 500 person-months for early-stage researchers (ESR) in accordance with the rules of the People FP7 Programme. The remaining 256 person-months will be funded from local sources.


Grant
Agency: Cordis | Branch: FP7 | Program: CP | Phase: ICT-2013.2.1 | Award Amount: 11.09M | Year: 2013

Using a proven-in-practice user-centric design methodology, TRADR develops novel S&T for human-robot teams to assist in disaster response efforts, over multiple missions: The novel S&T makes experience persistent. Various kinds of robots collaborate with human team members to explore the environment, and gather physical samples. Throughout this collaborative effort, TRADR enables the team to gradually develop its understanding of the disaster area over, multiple possibly asynchronous missions (persistent environment models), to improve team members understanding of how to work in the area (persistent multi-robot action models), and to improve team-work (persistent human-robot teaming).


Grant
Agency: Cordis | Branch: FP7 | Program: CP | Phase: FI.ICT-2011.1.8 | Award Amount: 20.32M | Year: 2013

The FI-CONTENT 2 project aims at establishing the foundation of a European infrastructure for promoting and testing novel uses of audio-visual content on connected devices. The partners will develop and deploy advanced platforms for Social Connected TV, Mobile Smart City services, and Gaming/ Virtual worlds. To assess the approach and improve these platforms, user communities in 6 European locations will be activated for living lab and field trials. The project is strongly supported by local stakeholders (regional authorities, associations, educational organizations, user groups) who will participate in the project via User Advisory Boards. The technical capabilities of the platforms will be validated and improved by integrating new - content usage driven - partners recruited via the open call planned early in the project.\nIn FI-CONTENT (FI-PPP Phase 1), we demonstrated that challenging and bold assertions around next generation Internet content and technology needs are best assessed with radical yet practical demonstrators, use cases, APIs and field research. FI-CONTENT 2 builds on our work in Phase 1, refining the findings where appropriate.\nThe project has good relationships with the other projects of the FI-PPP program. Contacts have been taken for coordination and potentially joint experiments with other FI-PPP projects. The proposal shows how to work with FI-WARE and existing EU infrastructure projects where suitable, and demonstrates how best to create and define new domain specific technologies, mostly cloud based.\nThe FI-CONTENT 2 partnership is a balanced group of large industrial, Content and Media companies, technology suppliers, Telecommunications/Internet access operators, Living labs and Academic institutions. FI-CONTENT-2 harnesses the power and excitement of content on the new Internet to drive European innovation, content creation and distribution to enrich the lives of all Europeans.


Grant
Agency: Cordis | Branch: FP7 | Program: CP | Phase: ICT-2011.1.6 | Award Amount: 7.23M | Year: 2011

Experimentally-driven research is key to success in exploring the possible futures of the Internet. An open, general-purpose, shared experimental facility, both large-scale and sustainable, is essential for European industry and academia to innovate today and assess the performance of their solutions. OpenLab brings together the essential ingredients for such a facility. We extend early prototypes of testbeds, middleware, and measurement tools so as to provide more efficient and flexible support for a diverse set of experimental applications and protocols. The prototypes include a set of demonstrably successful testbeds: PlanetLab Europe, with its 153 partner/user institutions across Europe; the NITOS and w-iLab.t wireless testbeds; two IMS (IP Multimedia Subsystem) telco testbeds for exploring merged media distribution; a green networking testbed; the ETOMIC high precision network measurement testbed; and the HEN emulation testbed. Associated with these testbeds are similarly successful control- and experimental-plane software. OpenLab advances these prototypes with key enhancements in the areas of mobility, wireless, monitoring, domain interconnections, and the integration of new technologies such as OpenFlow. These enhancements will be transparent to existing users of each testbed, while opening up a diversity of new experiments that users can perform, extending from wired and wireless media distribution to distributed and autonomous management of new social interactions and localized services, going far beyond what can be tested on the current Internet. OpenLab results will advance the goal of a unified Future Internet Research and Experimentation (FIRE) facility. In addition, OpenLab can provide models for the Future Internet Public Private Partnership (FI-PPP). Finally, OpenLab will issue open calls to users in industry and academia to submit proposals for innovative experiments using the OpenLabs technologies and testbeds, and will devote one million euros to funding the best of these proposals.


Grant
Agency: Cordis | Branch: FP7 | Program: MC-IRSES | Phase: FP7-PEOPLE-2012-IRSES | Award Amount: 814.80K | Year: 2012

Pervasive Healthcare is focused on working out how to cope with the next generation challenges in healthcare. Addressing these challenges will require expertise and knowledge exchange with countries beyond European borders as well as training of the next generation of researchers in order to gain the expertise necessary to be able to address the upcoming challenges. Moreover, research on Pervasive Healthcare has been conducted in several areas, ranging from assisting independent living at home, supporting hospital staff, promotion healthy habits, or providing care to for people with special needs. Each of the members of the consortium has worked in one or more of these areas and they will bring this expertise to the Consortium in terms of multi-disciplinary, methodological and technical approaches. The UBI-HEALTH program will create a stimulating research exchange foundation that will equip students from different continents with expertise in Pervasive Healthcare. The knowledge of requirements and available technologies for healthcare will be shared and become complementary between students, researchers and host institutions from Europe and the associated third countries including Mexico, Chile, China and USA (this last not funded by EU). This will allow students to put this knowledge in use in their own context, improving healthcare provisioning and impacting on both preventative medicine and alternative means of treatment. In summary, the main focus of the exchange program is in one hand to consolidate the Pervasive Health domain by interaction of Experienced Researchers in identification of challenges, setting of roadmaps and production of relevant didactic materials such as a course syllabus and textbook in the topic and to enable new generation of researchers to adapt novel technologies in different healthcare contexts and establish a network of knowledge dissemination between Europe and third countries.


Grant
Agency: Cordis | Branch: FP7 | Program: CP-IP | Phase: NMP.2010.2.3-1 | Award Amount: 14.80M | Year: 2012

The development of functional materials for tissue regeneration is today mostly based on perceived and limited design criteria often using a single point approach with lengthy animal trials. The outcome after in-vitro and in-vivo evaluation is often disappointing resulting in a tedious iteration process. The main objective of this project is to achieve radical innovations in state-of-the-art biomaterials and to design highly performing bioinspired materials learning from natural processes. By this outcome driven project comprising first class academic and industrial participants the project will create scientific and technical excellence and through links with these SMEs will strengthen the technological capacity and their ability to operate competitively on an international market. BIODESIGN will (i) perform a careful retrospective-analysis of previous outcomes from clinical studies performed with humans through animal modelling in a reverse engineering approach applied to an in-vitro to the molecular design level, (ii) develop new strategies for a more rational design of ECM mimetic materials serving both as gels and load carrying scaffolds, (iii) link novel designs to adequate and more predictive in-vitro methods allowing significant reduction in development time and use of animals and (iv) evaluate these concepts for musculoskeletal and cardiac regeneration. By the development of safe, ethically and regulatory acceptable, and clinically applicable materials this project will promote harmonization while at the same time creating awareness in society of the benefits of these innovations as one of the key points is to improve health and quality of life of the patients. BIODESIGN will stimulate technological innovation, utilization of research results, transfer of knowledge and technologies and creation of technology based business in Europe. It will also support the development of world-class human resources, making Europe a more attractive to top researchers.


Grant
Agency: Cordis | Branch: H2020 | Program: MSCA-ITN-ETN | Phase: MSCA-ITN-2015-ETN | Award Amount: 3.97M | Year: 2016

This network brings together world-leading experts in nano-science and technology from 6 European countries in order to achieve breakthroughs in understanding and successful utilization of nanoscale solid-state spin systems in emerging quantum technologies. The proposed innovative science in the supra-disciplinary field of physics and applications of spin nano-systems will underpin breakthrough developments in quantum computing, quantum communications and networks, and nano-imaging. Important innovative step consolidating the joint effort of the whole consortium is the focus on crystalline solids where magnetic interactions of electron spins with lattice nuclei are negligible and well-controlled. We will develop electrically-controlled spin-quantum-bits (qubits) in Si-Ge quantum dots and nanowires; will optically manipulate spin impurities in diamond in applications for quantum computing and networks and in nano-magnetometry; will achieve new understanding of quantum phenomena due to the spin-valley coupling in atomically thin 2D semiconductors, an emerging class of materials with a promise for quantum technologies. Research training to 15 early stage researchers will be delivered by 14 academic and 7 industrial groups. Network-wide training course in transferable skills will be specially developed and delivered by the Think Ahead (Sheffield), an award winning initiative at the University of Sheffield (award by the Times Higher Education, 2014). Current proposal is designed to advance this multi-disciplinary research field significantly beyond the state-of-the-art, and train a new cohort of researchers capable of developing spin-based solid-state quantum technologies towards real-life applications in the next 5 to 10 years.


Grant
Agency: Cordis | Branch: H2020 | Program: RIA | Phase: NMBP-26-2016 | Award Amount: 10.76M | Year: 2016

An increasing number of nanomaterials (NMs) are entering the market in every day products spanning from health care and leisure to electronics, cosmetics and foodstuff. Nanotechnology is a truly enabling technology, with unlimited potential for innovation. However, the novelty in properties and forms of NMs makes the development of a well-founded and robust legislative framework to ensure safe development of nano-enabled products particularly challenging. At the heart of the challenge lies the difficulty in the reliable and reproducible characterisation of NMs given their extreme diversity and dynamic nature, particularly in complex environments, such as within different biological, environmental and technological compartments. Two key steps can resolve this: 1) the development of a holistic framework for reproducible NM characterisation, spanning from initial needs assessment through method selection to data interpretation and storage; and 2) the embedding of this framework in an operational, linked-up ontological regime to allow identification of causal relationships between NMs properties, be they intrinsic, extrinsic or calculated, and biological, (eco)toxicological and health impacts fully embedded in a mechanistic risk assessment framework. ACEnano was conceived in response to the NMBP 26 call with the aim to comprehensively address these two steps. More specifically ACEnano will introduce confidence, adaptability and clarity into NM risk assessment by developing a widely implementable and robust tiered approach to NM physico-chemical characterisation that will simplify and facilitate contextual (hazard or exposure) description and its transcription into a reliable NMs grouping framework. This will be achieved by the creation of a conceptual toolbox that will facilitate decision-making in choice of techniques and SOPs, linked to a characterisation ontology framework for grouping and risk assessment and a supporting data management system.


Grant
Agency: Cordis | Branch: FP7 | Program: MC-ITN | Phase: FP7-PEOPLE-2010-ITN | Award Amount: 5.00M | Year: 2011

Context awareness has the potential to revolutionise the way people interact with information technology. Whereas conventional computers merely interpret explicit user input, context-aware systems analyse and automatically respond upon users behaviour and situation he/she is in. This enables electronic systems to assist users in situations in which the use of conventional computers and mobile devices is out of question. A particularly relevant field are healthcare, wellness, and assisted living (HWA) applications, which is at the focus of the proposed network. Research on context awareness has continued to intensify in the last decade due to the availability of cheap sensing technologies and mobile systems. Still, building reliable context-aware systems that can deal with complex real-life situations and environments remains an open research challenge and requires a multi-disciplinary effort. iCareNet will make a decisive contribution towards solutions, leveraged through an interdisciplinary perspective ranging from sensing and sensor integration, to human-computer interaction and social factors involved in the deployment of context-aware applications. Robust and scalable system architectures and design methodologies are the principal objective of all iCareNet efforts. iCareNet unites efforts of an interdisciplinary network of leading European research groups and a strong industrial participation. Researchers will receive comprehensive inter-domain training through a series of network-wide training events on topics including signal processing, behaviour inference techniques, privacy and security, and social aspects. A number of measures including the establishment ERASUMS partnerships, formal recognition of lectures, and the design of long-term joint Ph.D. programs will ensure that the network leads to long-lasting collaborations and benefits for the involved institutions.


Grant
Agency: Cordis | Branch: FP7 | Program: CP | Phase: ICT-2011.2.1 | Award Amount: 5.91M | Year: 2013

The goal of this project is to realize an exoskeletal robot that improves the balance performance of humans, targeted at users facing balance-challenging conditions or suffering from a lack of ability to walk or maintain balance during walking. The proposed exoskeleton will know the difference between the onset of a fall and an intentional change of walking pattern, such as a turn, or a step/stair and only when necessary will it act to maintain postural balance. Available exoskeletons lack the ability to correct or assist postural balance and due to size, weight and controls; they often impede balance.The proposed exoskeleton is human-cooperative in the sense that the control of the exoskeleton is complementary to the remaining human control. Depending on application it can either assist only in difficult conditions or in case of erroneous behaviour of the user, or can assist the user maximally. Supported tasks are functional standing and walking, in a clinical, real-life or work environment, including specific actions like turning or stepping on or off an elevation.The basic concept is to understand how human postural control is structured, how and why it functions and is robust in healthy humans, and to use this knowledge to mimic and enhance the postural control through the exoskeleton in a minimally obtrusive manner. BALANCE will study and implement both anticipatory and reactive balancing mechanisms, and implement a sense of balance and sense of human motion intentions through sensor fusion techniques and data analysis. The ultimate goal is to have the exoskeleton seamlessly cooperate with the human, both for healthy and neurologically impaired subjects.A consortium of specialists in exoskeleton hardware development, human motor control, exoskeleton control, adaptive robot control, gait mechanics, biomechanical sensing and balance assessment technology has gathered in BALANCE to achieve these objectives. The exploitation of the results will focus on applications in neurorehabilitation and worker support.


Grant
Agency: Cordis | Branch: FP7 | Program: MC-ITN | Phase: FP7-PEOPLE-2012-ITN | Award Amount: 3.88M | Year: 2012

Scanning probe microscopy(SPM) has now evolved to the point where not only is imaging and manipulation with single atom resolution achievable but the state of the art in the field involves sub-molecular and sub-atomic resolution: individual chemical bonds can be resolved, their properties measured, and their spatial symmetry exploited. SPM is, however, increasingly a victim of its own success. The wide availability of commercial instruments means that the technique is now very commonly seen as a routine imaging and characterisation tool. This unfortunately engenders a mindset amongst young researchers where they see an SPM as a black box and typically have a superficial understanding of the operating principles, theoretical principles, and current (or ultimate) limits of the technique. In turn, this black box mentality has severe implications for the health and competitiveness of the SPM - and, by extension nanoscience and nanotechnology - sectors in the ERA which rely fundamentally on creative innovation. ACRITAS directly counters this decline in the skills base and creativity of young researchers by providing an exciting and challenging environment for SPM training, spanning the public and private sectors and redefining the state of the art. A defining aspect of the network is its integration of scanning probe groups whose research is carried out under what might be termed `extreme conditions (ultrahigh vacuum, cryogenic temperatures) with teams of scientists who focus on interactions and control in biologically relevant environments. Although both communities use the same types of experimental techniques, there has traditionally been rather little communication between the two, largely because of different disciplinary biases. ACRITAS will act as a new and important bridge between the physical- and life sciences in advanced SPM and will thus be unique in the training it provides in a field which underpins a vast amount of 21st century science


Grant
Agency: Cordis | Branch: FP7 | Program: CP-IP | Phase: FoF.NMP.2011-5 | Award Amount: 10.32M | Year: 2011

Today, Europes leading position in manufacturing of high-precision metal parts is being threatened by developed non-EU countries that catch up quickly on product quality at low cost. If no further action is taken, loss of jobs and GDP are at risk. To face global competition, a breakthrough is needed in tackling the following 4 challenges: 1) High number of defects 2) Many costly, energy consuming finishing operations are needed. 3) Continuous trend for higher quality, smaller features, lower costs, at simultaneous demand for customised products. 4) Six-Sigma methodology reaches its limits for these complex processes (multi step / customised). MEGaFiT will realise this essential breakthrough. The primary goal of MEGaFiT is to develop and integrate all necessary technologies which create the basis to reduce the number of defects in manufacturing of complex high-precision metal parts. This will be achieved by developing and integrating in-depth process knowledge, in-line measurement and real-time adaptive process control. Proof will be given on pilot production lines in industrial settings. MEGaFiT will do this with a consortium of partners best-in-class in these fields. The methodology that will be used to come to efficient realisation is the following: (1) Define and describe the process (2) Measure actual process performance (3) Identify potential adaptive control solutions (4) Design adaptive control solutions and (5) Verify the adaptive control solution. This methodology will result in reduction of: defects from 5-15% to <1%; cost by >20%; material and energy consumption by >20%; and number of finishing operations by >35%. The knowledge-based MEGaFiT results are also applicable in different sectors, leading to low defects, despite customization trends. MEGaFiT will therefore help in assuring a competitive and sustainable European manufacturing industry.


Grant
Agency: Cordis | Branch: H2020 | Program: RIA | Phase: FETPROACT-01-2016 | Award Amount: 7.98M | Year: 2017

A novel concept for a photo-electro-catalytic (PEC) cell able to directly convert water and CO2 into fuels and chemicals (CO2 reduction) and oxygen (water oxidation) using exclusively solar energy will be designed, built, validated, and optimized. The cell will be constructed from cheap multifunction photo-electrodes able to transform sun irradiation into an electrochemical potential difference (expected efficiency > 12%); ultra-thin layers and nanoparticles of metal or metal oxide catalysts for both half-cell reactions (expected efficiency > 90%); and stateof- the-art membrane technology for gas/liquid/products separation to match a theoretical target solar to fuels efficiency above 10%. All parts will be assembled to maximize performance in pH > 7 solution and moderate temperatures (50-80 C) as to take advantage of the high stability and favorable kinetics of constituent materials in these conditions. Achieving this goal we will improve the state-of-the-art of all components for the sake of cell integration: 1) Surface sciences: metal and metal oxide catalysts (crystals or nanostructures grown on metals or silicon) will be characterized for water oxidation and CO2 reduction through atomically resolved experiments (scanning probe microscopy) and spatially-averaged surface techniques including surface analysis before, after and in operando electrochemical reactions. Activity and performance will be correlated to composition, thickness, structure and support as to determine the optimum parameters for device integration. 2) Photoelectrodes: This unique surface knowledge will be transferred to the processing of catalytic nanostructures deposited on semiconductors through different methods to match the surface chemistry results through viable up-scaling processes. Multiple thermodynamic and kinetic techniques will be used to characterize and optimize the performance of the interfaces with spectroscopy and photo-electrochemistry tools to identify best matching between light absorbers and chemical catalysts along optimum working conditions (pH, temperature, pressure). 3) Modeling: Materials, catalysts and processes will be modeled with computational methods as a pivotal tool to understand and to bring photo-catalytic-electrodes to their theoretical limits in terms of performance. The selected optimum materials and environmental conditions as defined from these parallel studies will be integrated into a PEC cell prototype. This design will include ion exchange membranes and gas diffusion electrodes for product separation. Performance will be validated in real working conditions under sun irradiation to assess the technological and industrial relevance of our A-LEAF cell.


Grant
Agency: Cordis | Branch: H2020 | Program: RIA | Phase: SC5-06-2016-2017 | Award Amount: 6.35M | Year: 2016

The Paris Agreement substantially increased the need for countries and regions to understand the full economic, social and environmental implications of the deep decarbonisation to which the global community is now committed. The EU has long had decarbonisation ambitions, but there remains considerable uncertainty as to precisely how these ambitions will be achieved, or what the impacts of such achievement will be on the EU economy and society more generally. INNOPATHS will resolve this uncertainty to the extent possible, will characterise and provide a quantification of the uncertainty which remains, and will describe in great detail a number of possible low-carbon pathways for the EU, together with the economic, social and environmental impacts to which they are likely to lead. These pathways will be co-designed with the aid of 23 stakeholders from different sectors who have already provided letters of support to INNOPATHS. INNOPATHS will suggest through this analysis how the benefits of these pathways, such as new industries, jobs and competitiveness, may be maximized, and how any negative impacts, such as those on low-income households, or on carbon-intensive sectors, may be mitigated. INNOPATHS will communicate its insights through the normal scientific channels, and make substantial contributions to the scientific literature, but will go well beyond this in terms of interactions with stakeholders, building on the co-design processes in the project to reach out to stakeholder networks of businesses, NGOs, local and national policy makers. INNOPATHS will create four innovative online tools to explain its pathways, technological transitions and policies, to different constituencies. Through these tools and other dissemination and communication mechanisms, INNOPATHS will have a substantial impact on the climate and energy policy debates up to and beyond 2020, increasing the probability that decisions in this area will be taken in an informed and cost-effective way


Grant
Agency: GTR | Branch: EPSRC | Program: | Phase: Training Grant | Award Amount: 4.26M | Year: 2014

The Oxford-Warwick Statistics Programme will train a new cohort of at least 50 graduates in the theory, methods and applications of Statistical Science for 21st Century data-intensive environments and large-scale models. This is joint project lead by the Statistics Departments of Oxford and Warwick. These two departments, ranked first and second for world leading research in the last UK research assessment exercise, can provide a wonderful stimulating training environment for doctoral students in statistics. The Centres pool of supervisors are known for significant international research contributions in modern computational statistics and related fields, contributions recognised by over 20 major National and International Awards since 2008. Oxford and Warwick attract students with competitively won international scholarships. The programme leaders expect to expand the cohort to 11 or 12 per year by bringing these students into the CDT, and raising their funding up to CDT-level using £188K in support from industry and £150K support from donors. The need to engage in large-scale highly structured statistical models has been recognized for some time within areas like genomics and brain-imaging technologies. However, the UKs leading industries and sciences are now also increasingly aware of the enormous potential that data-driven analysis holds. These industries include the engineering, manufacturing, pharmaceutical, financial, e-commerce, life-science and entertainment sectors. The analysis bottleneck has moved from being able to collect and record relevant data to being able to interpret and exploit vast data collections. These and other businesses are critically dependent on the availability of future leaders in Statistics, able to design and develop statistical approaches that are scalable to massive data. The UK can take a world lead in this field, being a recognized international leader in Statistics; and OxWaSP is ideally placed to realize the potential this opportunity. The Centre is focused on a new type of training for a new type of graduate statistician in statistical methodology and computation that is scalable to big data. We will bring a new focus on training for research, by teaching directly from the scientific literature. Students will be thrown straight into reading and summarizing journal papers. Lecture-format contact is used sparingly with peer-to-peer learning central to the training approach. This is teaching and learning for research by doing research. Cohort learning will be enhanced via group visits to companies, small groups reproducing results from key papers, student-orientated paper discussions, annual workshops and a three-day off-site retreat. From the second year the students will join their chosen supervisors in Warwick and Oxford, five in each Centre coming together regularly for research group meetings that overlap Oxford and Warwick, for workshops and retreats, and teaching and mentoring of students in earlier years. The Centre is timely and ambitious, designed to attract and nurture the brightest graduate statisticians, broadening their skills to meet the new challenge and allowing them to flourish in a focused, communal, research-training environment. The strategic vision is to train the next generation of statisticians who will enable the new data-intensive sciences and industries. The Centre will offer a vehicle to bring together industrial partners from across the two departments to share ideas and provide an important perspective to our students on the research challenges and opportunities within commercial and social enterprises. Students training will be considerably enhanced through the Centres visits, lectures, internships and co-supervision from global partners including Amazon, Google, GlaxoSmithKline, MAN and Novartis, as well as smaller entrepreneurial start-ups Deepmind and Optimor.


Grant
Agency: Cordis | Branch: FP7 | Program: MC-ITN | Phase: FP7-PEOPLE-2010-ITN | Award Amount: 3.79M | Year: 2011

TOPOMOD is a training project designed for a team of early-stage and experienced researchers to investigate and model the origin and evolution of topography of the continents over a wide range of spatial and temporal scales and using a multi-disciplinary approach, coupling geophysics, geochemistry, tectonics and structural geology with advanced geodynamic modeling. TOPOMOD involves 8 European research teams internationally recognized for their excellence in complementary fields of Earth Sciences, to which are associated 1 research institution, 3 high-technology enterprises, and 1-2 large multinational oil and gas companies. This unique network places emphasis in experience-based training through 15 cross-disciplinary research projects that combine case studies in well-chosen target areas from the Mediterranean, the Middle and Far East, west Africa, and South America, with new developments in tectonics, mineral physics, petrology, geochemistry, seismology, structural geology and geodynamic modeling from the deep mantle to the surface. These multidisciplinary projects altogether aim to answer a key question in earth Sciences: how deep and surface processes interact to shape and control the evolution of topography in our planet. Topography influences society, not only as a result of slow landscape changes but also in terms of geo-hazard and environmental risks. TOPOMOD will provide to 13 early-stage researchers (ESRs) and 2 experienced researchers (ERs): i) state-of-the-art concepts and leading-edge research techniques that are essential to study the behavior of complex natural systems, ii) a strong career management skills with practical courses and activities; iii) solid professional connections with industry; iv) a socially-oriented skill on environmental risks management. TOPOMOD network will create an internationally recognized leading European platform on advanced geodynamic modeling.


Grant
Agency: Cordis | Branch: H2020 | Program: MSCA-RISE | Phase: MSCA-RISE-2016 | Award Amount: 1.75M | Year: 2017

Cancer is considered as the second leading cause of death worldwide. It is important to develop methodologies that improve understanding of the disease condition and progression. Over the past few years, single cell biology has been performed using micro/nano robotics for exploration of the nanomechanical and electrophysiological properties of cells. However, most of the research so far has been empirical and the understanding of the mechanisms and thus possible for cancer therapy are limited. Therefore, a systematic approach to address this challenge using advanced micro/robotics techniques is timely and important to a wide range of the technologies where micro/nano manipulation and measurement are in demand. The proposed Micro/nano robotics for single cancer cells (MNR4SCell) project focuses on the staff exchange between the 8 world recognised institutions of EU and China, and the share of knowledge and ideas, and further the development of the leading edge technologies for the design, modelling, and control of micro/nano robotics and their applications in single cancer cell measurement, characterisation, manipulation, and surgery. This project meets the objectives and requirements of the Marie Skodowska-Curie Actions: Research and Innovation Staff Exchange (RISE). The ultimate goal of MNR4SCell is to establish long-term international and multidisciplinary research collaboration between Europe and China in the challenging field of micro/nano robotics for single cancer cells in the characterisation, diagnosis and targeted therapy. The synergistic approach and knowledge established by MNR4SCell will serve as the building blocks of the micro/nano robotics and biomedical applications, and thus keep the consortiums leading position in the world for potential major scientific and technological breakthroughs in nanotechnology and cancer therapy.


Grant
Agency: Cordis | Branch: H2020 | Program: RIA | Phase: PHC-02-2015 | Award Amount: 5.70M | Year: 2016

Despite of their great promise, high-throughput technologies in cancer research have often failed to translate to major therapeutic advances in the clinic. One challenge has been tumour heterogeneity, where multiple competing subclones coexist within a single tumour. Genomic heterogeneity renders it difficult to identify all driving molecular alterations, and thus results in therapies that only target subsets of aggressive tumour cells. Another challenge lies in the integration of multiple types of molecular data into mathematical disease models that can make actionable clinical statements. We aim to develop predictive computational technology that can exploit molecular and clinical data to improve our understanding of disease mechanisms and to inform clinicians about optimized strategies for therapeutic intervention. We propose to focus on prostate cancer, a leading cause of cancer death amongst men in Europe, but also prone to over-treatment. Our approach combines the exploitation of genomic, transcriptomic, proteomic, and clinical data in primary and metastatic tumours, prospective cohorts of well characterized prostate cancer patients, drug screenings in cell lines, and the use of the Watson technology, a last generation cognitive computer developed at IBM. The translational objective of this study is to develop technology for identifying disease mechanisms and produce treatment recommendations for individual patients based on a therapeutic biomarker panel. The proposed software framework will be accessible through a graphical interface that will facilitate its dissemination and use by researchers, clinicians, and biomedical industries. The framework will provide intuitive tools to deposit, share, analyze, and visualize molecular and clinical data; as well as to infer prognosis, elucidate implicated mechanisms and recommend therapy accordingly. This software framework will serve as a proof of concept for future development by industrial partners in Europe.


Grant
Agency: Cordis | Branch: FP7 | Program: MC-ITN | Phase: FP7-PEOPLE-2011-ITN | Award Amount: 3.95M | Year: 2012

Brain disorders impose an increasing economical and social burden in the member states of the European Union (EU). For most neurodegenerative diseases and many neuropsychiatric disorders no efficient treatment is available and no cure exists. In the next coming years the number of particularly elderly people suffering from brain disorders will tremendously increase. Predictions from the turn of the century about the exponential increase of dementia patients turned out to be correct and Alzheimers disease alone is underway to become the most expensive and most pressing health problem in the EU. The complexity of these diseases requires a more integrative view of the multiple interactions between genes and environment, synaptic processes and neuronal cicuitry. This is, however, not only achieved by training more young scientists in the relevant disciplines. The plastic properties of the brain can only be exploited by scientists that are trained to deal with this complexity and that are familiar with state of the art technology as well as with the principles at different levels of analysis. In consequence it is advisable for a training network to study more than one disease and to train scientists with a wide range of skills and background knowledge. The NPlast consortium consists of four partners from the private and seven partners from the public sector and will provide a research training program for fifteen young scientists. The program covers a broad spectrum of disorders and interventions ranging from synaptopathies and trafficking deficiencies to Alzheimers disease, and from altering gene expression programs to manipulations of the extracellular matrix of the brain to preserve or restore synaptic function. The key objective of the NPlast training network is to investigate neuroplastic principles that can preserve or restore function and that can be used to rejuvenitate the brain in the elderly as well as to treat neuropsychiatric conditions in adults.


PLASMOfab aims to address the ever increasing needs for low energy, small size, high complexity and high performance mass manufactured PICs by developing a revolutionary yet CMOS-compatible fabrication platform for seamless co-integration of active plasmonics with photonic and supporting electronic. The CMOS-compatible metals Aluminum, Titanium Nitride and Copper, will be thoroughly investigated towards establishing a pool of meaningful elementary plasmonic waveguides on co-planar photonic (Si, SiO2 and SiN) platforms along with the associated photonic-plasmonic interfaces. The functional advantages of PLASMOfab technology will be practically demonstrated by developing two novel functional prototypes with outstanding performances: 1) a compact, plasmonic bio-sensor for label-free inflammation markers detection with multichannel capabilities and record-high sensitivity by combining plasmonic sensors with electrical contacts, Si3N4 photonics, high-speed biofunctionalization techniques and microfluidics 2) a 100 Gb/s NRZ transmitter for datacom applications by consolidating low energy and low footprint plasmonic modulator and ultra high-speed SiGe driving electronics in a single monolithic chip. The new integration technology will be verified through wafer-scale fabrication of the prototypes at commercial CMOS fabs, demonstrating volume manufacturing and cost reduction capabilities. PLASMOfab technology will be supported by an EDA software design kit library paving the way for a standardized, fabless plasmonic/photonic IC eco-system.


Grant
Agency: Cordis | Branch: H2020 | Program: RIA | Phase: ICT-10-2015 | Award Amount: 2.36M | Year: 2016

Political consumerism is a bottom up, grass root engagement of concerned citizens. By uniting their individual selves to a collective, the feeling of individual insignificance is transformed into a non-negligible player on the economic market. The diversification of political interests, the intransparent product interrelationships, however, far too often lead to an evaporation of the collective motion, of the rising up of individually aware citizens. The ASSET project develops and tests a pilot solution to pioneer on a new form of political consumerism aiming at empowering the individual to facilitate and to reinforce sustainable consumerism, through better decision-making and networking effects. Leveraging on the innovative combinations of interests by distilling individual and amplifying collective interests and forming collective political consumerism, it serves as an empowerment for the citizen. This crowd-sourced political consumerism builds upon open data, open source, distributed social networking and open hardware. Seizing the full potential of existing mobile communication, it creates collective awareness for political concerns amongst citizens, via integrating network and online collaboration, and collective awareness on economical demands for producers, visualizing mutual interest for sustainable consumption. The pilot solution includes an individually designed product rating system which is seamlessly integrated into the shopping routines. The pilot solution is developed by a multidisciplinary consortium including retail industry, consumer organization, social sciences and ICT centers, and is tested in fields studies with existing communities of people.


Grant
Agency: Cordis | Branch: FP7 | Program: NoE | Phase: HEALTH.2010.2.1.2-2 | Award Amount: 15.96M | Year: 2011

Biological processes occur in space and time, but current experimental methods for systems biology are limited in their ability to resolve this spatiotemporal complexity of life. In addition, traditional omics methods often suffer from limited sensitivity and need to average over populations of cells at the expense of cell to cell variation. Next-generation systems biology therefore requires methods that can capture data and build models in four dimensions, three-dimensional space and time, and needs to address dynamic events in single living cells. In fact, recent advances in automated fluorescence microscopy, cell microarray platforms, highly specific probes, quantitative image analysis and data mining provide a powerful emerging technology platform to enable systems biology of the living cell. These imaging technologies, here referred to as Systems microscopy, will be a cornerstone for next-generation systems biology to elucidate and understand complex and dynamic molecular, sub-cellular and cellular networks. As a paradigm to enable systems biology at the cellular scale of biological organization, this NoE will have as its core biological theme two basic but complex cellular processes that are highly relevant to human cancer: cell division and cell migration. Methods, strategies and tools established here will be applicable to many disease-associated processes and will be instrumental for obtaining a systems level understanding of the molecular mechanisms underlying human diseases as manifested at the living cell level. Through close multidisciplinary collaborations in our programme of joint activities this NoE will develop a powerful enabling platform for next-generation systems biology and will apply these tools to understand cellular systems underlying human cancer. This provides a unique opportunity for Europe to acquire a global lead in systems microscopy.


Grant
Agency: Cordis | Branch: FP7 | Program: CP-FP | Phase: HEALTH.2012.2.1.2-1 | Award Amount: 3.88M | Year: 2012

Therapeutic antibodies are the largest and fastest growing class of pharmaceutical biotechnology products, with annual sales above 30 billion US$. In some cases, antibody products have revolutionized the management of patients, e.g. TNF-blocking antibodies in Arthritis or Rituxan in lymphoma. However, for most antibody therapies, only a subset of patients benefit from treatment. Thus, there is an urgent need to develop more potent therapeutic antibodies and to understand the molecular basis for the differential responses of patients to treatment. This consortium consists of European centres of excellence being pioneers in the field of therapeutic antibody development and (pre-) clinical studies and will tackle both of these challenges: Innovative immunocytokines L19-IL2 and F8-IL10 are developed by Philogen for the treatment of metastatic melanoma and rheumatoid arthritis respectively at multiple clinical centres including Graz and Tbingen. Building on the strong background in proteomics biomarker discovery of ETH Zurich and Philochem, an innovative methodology (HLA-peptidome analysis) will be utilized for gaining information on the immune response in animal models and patients which receive antibody treatments. This method is based on the observation that HLA molecules in complex with peptides can be detected in the patient blood and that hundreds of HLA-associated peptides can be sequenced by mass spectrometry. The technology will be used for the profiling of responses following antibody treatment for patients with cancer and rheumatoid arthritis, as well as animal models of transplant rejection. This systems biology approach has the potential to revolutionize patient stratification in very short time. Finally, patient selection strategies will be investigated using the clinical-grade immunocytokine (F8-IL10) as an example, monitoring antibody uptake at the site of disease by immuno-PET imaging methodologies at VUMC Amsterdam in collaboration with Philogen.


Grant
Agency: Cordis | Branch: FP7 | Program: CP-FP | Phase: HEALTH.2011.2.4.3-2 | Award Amount: 9.96M | Year: 2011

The DIABAT project will employ knowledge of the function, dysfunction and physiological regulation of brown adipocytes to develop innovative therapeutic and preventive strategies for type 2 diabetes. Brown adipose tissue (BAT) is currently a worldwide recognized target to combat obesity and diabetes due to last years re-discovery of functional BAT in adult humans by several of the members of the DIABAT network (van Marken LIchtenbelt et al., N. Engl. J. Med. 360, 1500, 2009; Virtanen, Enerbck & Nuutila, N. Engl. J. Med. 360, 1518, 2009) along with sharp rise in insight in cellular, genetic, and regulatory mechanisms from animal studies. Therefore, the DIABAT project aims at recruiting and re-activating endogenous energy-dissipating BAT as a preventive and/or remedial measure for weight and blood sugar control in obesity-related type 2 diabetes (diabesity), thereby halting or preventing destruction and facilitating recovery of pancreatic beta-cells under diabetic conditions.


Grant
Agency: Cordis | Branch: FP7 | Program: CP | Phase: ICT-2013.3.1 | Award Amount: 6.22M | Year: 2013

E2SWITCH focuses on Tunnel FET (TFETs) as most promising energy efficient device candidates able to reduce the voltage supply of integrated circuits (ICs) below 0.25V and make them significantly more energy efficient by exploiting strained SiGe/Ge and III-V platforms, with CMOS technological compatibility. A full optimization and DC/AC benchmarking for complementary n- and p-type TFETs, integrated on the same fabrication platform, is proposed. Compact models are developed and implemented in Verilog A, for portability, to support the design of low power ICs with CMOS architectural compatibility for: (i) digital and (ii) analog/RF. The device scalability, operational reliability and the operation from room to high temperature, as required by ITRS metrics, are priorities of our investigations. In order to push even more the III-V and SiGe/Ge TFET performance we propose to study, optimize and experimentally validate new device concepts such as a Density-Of-State (DOS) switch exploiting the effect of dimensionality. The DOS switch will deliver deep subthermal switching (subthreshold swing less than 10mV/decade, for at least four decades of current).An advanced TCAD simulation platform is developed for the selected material systems, able to capture quantum effects and to accurately predict the influence of dimensionality. TCAD will also support the optimization of TFETs on the two proposed material platforms, with emphasis on the role of strain and on the alignment between the tunneling path and the electric field.A full set of characterization techniques including DC, AC, low frequency noise, RF measurements (S-parameters) and large range of temperature is foreseen to support the device optimization, parameter extraction and the calibration of the compact models.We will deliver very first full digital and analog circuit demonstrators and will benchmark their operational performance, reliability and robustness compared to equivalent CMOS technology nodes.


Grant
Agency: Cordis | Branch: FP7 | Program: BSG-SME | Phase: SME-2012-1 | Award Amount: 1.51M | Year: 2013

Chocolate quality is highly dependent on a stage of the manufacturing process known as tempering. Tempering is critical for reducing processing failures and ensuring a quality end product. Incorrect tempering makes the chocolate become dull, susceptible to fat bloom, soft in texture and warm in the mouth, as well as difficult to demould with a greater probability of mould marks on the surface. Tempering is a highly complex process, affected by many raw material and processing factors, whereby the specific tempering conditions required will depend on the cocoa butter used, the type of product being made and the subsequent processing. Few solutions exist for controlling the tempering process of chocolate. Solid Fat Content (SFC), the generally accepted analysis of fats and oils in the food industry, is crucial to the texture of chocolate. As SFC may change during manufacturing and storage, it is important to be able to measure this parameter to control the ingredients and manufacturing conditions for achieving optimum product quality. Traditional methods of SFC determination are slow, irreproducible, require additional chemicals and are based on sampling. An in-line sensor capable of measuring the SFC in the chocolate melt would allow automated control of the tempering process and would be of great value to manufacturers. Ultrasonics is a popular technique for understanding phase transitions as the acoustic properties of solids and liquids are so different that changes are easy to measure. Two possible methods for controlling the tempering process will be explored based on the use of ultrasound: a novel technology to control the crystal size distribution during tempering, and development of an in-line sensor capable of measuring the SFC, crystal size distribution and polymorph distribution in the melt. The combination of two methods in a system that is readily integrated in chocolate tempering machines will represent a breakthrough for the EU chocolate industry.


Grant
Agency: Cordis | Branch: FP7 | Program: CPCSA | Phase: INFRA-2011-1.2.1. | Award Amount: 4.34M | Year: 2011

SCI-BUS will create a generic-purpose gateway technology as a toolset to provide seamless access to major computing, data and networking infrastructures and services in Europe including clusters, supercomputers, grids, desktop grids, academic and commercial clouds. SCI-BUS will elaborate an application-specific gateway building technology and customisation methodology based on which user communities can easily develop their own customised gateways. SCI-BUS will use the gateway technology and customization methodology to create 11 application-specific gateways customized for various types of user communities (represented in the project) and to provide gateway services for these communities including astrophysics, seismology, helio-physics, bio-science, computational chemistry, biomedical communities, PireGrid SMEs. community, Blender community, citizens. web-2 community, DCI application developer community, business process modeling community. SCI-BUS will establish production gateway services for the represented user communities and will attract further user communities by training and by other forms of disseminations activities. SCI-BUS will use the established production customized gateways as best-practice case studies based on which other communities can build their own customized gateway. SCI-BUS will provide gateway development, operation and maintenance support for the new communities to build and operate their own customized gateways. SCI-BUS will provide user support for application developers and end-users to develop and run new DCI applications based on the developed gateways. SCI-BUS will develop business models to enable the commercial exploitation of the developed technologies and to guarantee the sustainability of the gateway services developed in the project.


Grant
Agency: Cordis | Branch: H2020 | Program: RIA | Phase: EINFRA-5-2015 | Award Amount: 4.07M | Year: 2015

Materials are crucial to scientific and technological advances and industrial competitiveness, and to tackle key societal challenges - from energy and environment to health care, information and communications, manufacturing, safety and transportation. The current accuracy and predictive power of materials simulations allow a paradigm shift for computational design and discovery, in which massive computing efforts can be launched to identify novel materials with improved properties and performance; behaviour of ever-increasing complexity can be addressed; sharing of data and work-flows accelerates synergies and empowers the science of big-data; and services can be provided in the form of data, codes, expertise, turnkey solutions, and a liquid market of computational resources. Europe has the human resources, track record and infrastructure to be worldwide leader in this field, and we want to create a CoE in materials modelling, simulations, and design to endow our researchers and innovators with powerful new instruments to address the key scientific, industrial and societal challenges that require novel materials. This CoE will be a user-focused, thematic effort supporting the needs and the vision of all our core communities: domain scientists, software scientists and vendors, end-users in industry and in academic research, and high-performance computing centres. The proposal is structured along two core actions: (1) Community codes, their capabilities and reliability; provenance, preservation and sharing of data and work-flows; the ecosystem that integrates capabilities; and hardware support and transition to exascale architectures. (2) Integrating, training, and providing services to our core communities, while developing and implementing a model for sustainability, with the core benefit of propelling materials simulations in the practice of scientific research and industrial innovation.


Grant
Agency: Cordis | Branch: FP7 | Program: CP-IP | Phase: ENV.2010.1.1.2-1 | Award Amount: 9.81M | Year: 2011

The Pan-European Gas-AeroSOls-climate interaction Study (PEGASOS) European large scale integrating project brings together most of the leading European research groups, with state-of the-art observational and modeling facilities to: (1) Quantify the magnitude of regional to global feedbacks between atmospheric chemistry and a changing climate and to reduce the corresponding uncertainty of the major ones. (2) Identify mitigation strategies and policies to improve air quality while limiting their impact on climate change. The project is organized into four scientific Themes designed to optimize the integration of methodologies, scales, and ultimately our understanding of air quality and climate interactions: (I) Anthropogenic and biogenic emissions and their response to climate and socio-economy (II) Atmospheric interactions among chemical and physical processes (III) Regional and global links between atmospheric chemistry and climate change (IV) Air quality in a changing climate: Integration with policy PEGASOS will bridge the spatial and temporal scales that connect local surface-air pollutant exchanges, air quality and weather with global atmospheric chemistry and climate. Our major focus for air quality will be Europe including effects of changes in pollutant emissions elsewhere and the time horizon for the study will be the next 50 years. During the project we will provide improved process understanding in areas of major uncertainty for better quantification of feedbacks between air quality and a changing climate. We will present, for the first time, a fully integrated analysis of dynamically changing emissions and deposition, their link to tropospheric chemical reactions and interactions with climate, and emerging feedbacks between chemistry-climate and surface processes. We will target both local and regional scales, taking into account chemistry and climate feedbacks on the global scale.


Grant
Agency: Cordis | Branch: FP7 | Program: CP | Phase: ENERGY-2007-8.1-02 | Award Amount: 7.70M | Year: 2011

BEEM-UP will demonstrate the economic, social and technical feasibility of retrofitting initiatives, drastically reducing the energy consumption in existing buildings, and lay the ground for massive market uptake. BEEM-UP involves the building owners at 3 sites in France, Sweden and the Netherlands to implement an innovative approach to go beyond a 75% reduction in space heat energy consumption, in addition to reducing the total energy consumption. Ambitious energy reduction will be demonstrated as the economically most attractive alternative for retrofitting. In integrated design the building owners, industry, designers and energy experts collaborate around the building to reach a higher performance and be more adapted to the tenant needs than if just plugging in separate solutions are used. New concepts will be identified that can be replicated in further retrofit projects. An ambitious monitoring programme to demonstrate the reduction in energy consumption will accompany the whole process, including a period of at least two years after the retrofit. This technical monitoring will be complemented with a social monitoring, focusing on the acceptance of the occupant. A whole programme is designated to involve the occupants in the retrofit. ICT systems (smart metering and building control) will encourage and support energy savings. The main challenge is to turn energy reduction in existing buildings into standard option on the market. Going beyond pure demonstration, BEEM-UP will be develop and exploitation plan based on green value, actively disseminate across Europe, and interact with stakeholders, to create a solid demand for energy reductions by building owners, and make BEEM-UP a model for future retrofits. Before 2020, all retrofit projects in Europe will target ambitious energy reductions: not because it is compulsory and good, but because it is the most attractive alternative.


Grant
Agency: Cordis | Branch: FP7 | Program: CP | Phase: ICT-2011.2.1 | Award Amount: 11.27M | Year: 2013

The goal of SHERPA is to develop a mixed ground and aerial robotic platform to support search and rescue activities in a real-world hostile environment like the alpine scenario. The technological platform and the alpine rescuing scenario are the occasion to address a number of research topics about cognition and control pertinent to the call.\nWhat makes the project potentially very rich from a scientific viewpoint is the heterogeneity and the capabilities to be owned by the different actors of the SHERPA system: the human rescuer is the busy genius, working in team with the ground vehicle, as the intelligent donkey, and with the aerial platforms, i.e. the trained wasps and patrolling hawks. Indeed, the research activity focuses on how the busy genius and the SHERPA animals interact and collaborate with each other, with their own features and capabilities, toward the achievement of a common goal.\nA mix of advanced control and cognitive capabilities characterize the SHERPA system, aiming to support the rescuer by improving his awareness of the rescue scene even in tough environments and with the genius often busy in the rescuing activity (and thus unable to supervise the platform). Thus emphasis is placed on robust autonomy of the platform, acquisition of cognitive capabilities, collaboration strategies, natural and implicit interaction between the genius and the SHERPA animals, which motivate the research activity.\nFive benchmarks, inspired by real-world scenarios, drive the research and motivate demonstration activities on realistic testing sites planned during the project.\nSeven top academic groups, two SMEs, and the Italian Association of Alpine Rescuers with the role of end-user and evaluator of the project outcomes for the specific application of search and rescuing in the alpine scenario compose the consortium.


Grant
Agency: Cordis | Branch: FP7 | Program: CP-IP | Phase: NMP.2013.1.4-2 | Award Amount: 8.62M | Year: 2014

Intrinsic (or residual) stresses, resulting from manufacturing or processing steps, mostly define the performance and limit the lifetime of nanostructured materials, thin films, coatings and MEMS devices. The established techniques for micron-scale measurement of residual stress still have strong limitations, e.g. in terms of spatial resolution, lack of depth sensing, their applicability on non-crystalline materials or accessibility to industry. In this project, a European consortium is established to develop an innovative, highly reproducible and automated measurement protocol for the analysis of residual stress on a sub-micron scale, based on incremental focused ion beam (FIB) milling, along with high-resolution in situ Scanning Electron Microscopy (SEM) imaging and full field strain analysis by digital image correlation (DIC). The activities will focus on the implementation and pre-standardisation of automated FIB-SEM, DIC and inverse stress calculation procedures, under official project liaisons with both CEN and VAMAS, together with the analysis and modelling of FIB induced artefacts and stress-structure-properties relationship for the selected materials and devices. The final aim of the project will be the development of innovative design rules, implemented into simulation and optimization tools under coordination of industry partners, for the production of residual stress-controlled nanostructured materials, with specific focus on (i) multi-layered nano-coatings, (ii) micro/nano-crystalline and amorphous materials, (iii) MEMS and 3D metal interconnects. The project is expected to realize a breakthrough in measurement, standardization and modelling ability of the residual stress distribution at the sub-micron scale. The measurement techniques and the simulation tools will provide SMEs in particular with enabling technologies for the design and efficient production of innovative micro-devices with improved performance and substantially reduce development costs.


Grant
Agency: Cordis | Branch: H2020 | Program: RIA | Phase: BIOTEC-1-2014 | Award Amount: 6.84M | Year: 2015

We aim to engineer the lifestyle of Pseudomonas putida to generate a tailored, re-factored chassis with highly attractive new-to-nature properties, thereby opening the door to the production of thus far non-accessible compounds. This industrially driven project capitalises on the outstanding metabolic endowment and stress tolerance capabilities of this versatile bacterium for the production of specialty and bulk chemicals. Specifically, we will build streamlined P. putida strains with improved ATP availability utilizing this power on demand, decoupled from growth. The well-characterized, streamlined and re-factored strain platform will offer easy-to-use plug-in opportunities for novel, DNA-encoded functions under the control of orthogonal regulatory systems. To this end, we will deploy a concerted approach of genome refactoring, model-driven circuit design, implementation of ATP control loops, structured modelling and metabolic engineering. By drawing on a starkly improved, growth-uncoupled ATP-biosynthetic machinery, empowered P. putida strains will be able to produce a) n-butanol and isobutanol and their challenging gaseous derivatives 1-butene (BE) and (iso-)butadiene (BDE) using a novel, new-to-nature route starting from glucose, as well as b) new active ingredients for crop protection, such as tabtoxin, a high-value, -lactam-based secondary metabolite with a huge potential as a new herbicide. The game-changing innovations brought in in particular the uncoupling of ATP-synthesis and production from growth - will provide strong versatility, enhanced efficiency and efficacy to the production processes, thereby overcoming current bottlenecks, matching market needs and fostering high-level research growth and development.


Grant
Agency: Cordis | Branch: FP7 | Program: CP-FP | Phase: KBBE.2010.1.4-04 | Award Amount: 3.15M | Year: 2011

RESEARCH OBJECTIVES The overall objective of this project is to identify effective and efficient approaches for the support of successful LINSA (Learning and Innovation Networks for Sustainable Agriculture) as drivers of transition towards Agricultural Innovation Systems for sustainable agriculture and rural development. In order to achieve this objective the project will: Explore LINSAs empirically as bottom-up drivers of transition Improve understanding of barriers to complex learning processes and developing recommendations on how to avoid / remove them Create open learning spaces for actors outside the project by sharing and disseminating project findings Identify institutional determinants that enable or constrain existing AKS in supporting effective LINSA in the context of changing knowledge and innovation policies Develop a conceptual framework for innovation for sustainable agriculture and rural development. TOPICS The study will be carried out in 3 fields: a) consumer oriented networks ( b) non-food oriented networks and c) purely agricultural networks or networks for sustainable land use Strategic objectives Contributing to more effective research-practice linkages in the complex innovation and value chains. Contributing to a policy framework for innovation in agriculture


Grant
Agency: Cordis | Branch: FP7 | Program: MC-ITN | Phase: FP7-PEOPLE-2011-ITN | Award Amount: 4.32M | Year: 2012

Landslides and debris flows are serious geo-hazards common to countries with mountainous terrains. The high speed and the enormity of debris mass make debris flows one of the most dangerous natural hazards. Debris flows are often triggered by landslides partially or completely mobilizing into debris flows. Globally, landslides cause billions of dollars in damage and thousands of deaths and injuries each year. The numerous devastating events worldwide have made us aware of the complexity of landslides and debris flows and our insufficient knowledge to make reliable predictions. Traditional tools for prediction and design are based on limit equilibrium analysis for landslides and shallow water model with Finite Difference solver for debris flows. Usually soil and debris are modelled as single phase materials with constant material properties. That the simple models are unable to account for the complex behaviour of landslides and debris flows, which can be best described as multiphase and multiscale, is well known to researchers and stakeholders. Obviously there is an urgent need for better understanding of the triggering mechanisms, for reliable prediction of runout dynamics, deposition pattern and impact forces and for rational design of stabilization and protection structures. The last decade saw rapid developments in advanced constitutive models, experimental techniques in laboratory and in-situ, mechanics of multiphase media, localized deformation analysis, Discrete Element Method (DEM), advanced Finite Element Method (FEM) and Computational Fluid Dynamics (CFD). Training in these subjects has been rather sporadic and scattered in various disciplines. By integrating these advances into a coherent research network we expect to achieve the breakthrough in the research on landslides and debris flows, i.e. a consistent physical model with robust numerical scheme to provide reliable prediction and rational design of protection measures for landslides and debris flows.


Grant
Agency: Cordis | Branch: H2020 | Program: RIA | Phase: LCE-15-2014 | Award Amount: 10.03M | Year: 2015

The European cement industry has committed itself to contributing to climate protection measures and therefore to curbing its CO2 emissions. CO2 capture technologies, although an essential part of all CO2 reduction scenarios, are not yet ready for large-scale deployment in the cement industry. Hence, the primary objective of CEMCAP is To prepare the ground for large-scale implementation of CO2 capture in the European cement industry To achieve this objective, CEMCAP will - Leverage to TRL 6 for cement plants the oxyfuel capture technology and three fundamentally different post combustion capture technologies, all of them with a targeted capture rate of 90%. - Identify the CO2 capture technologies with the greatest potential to be retrofitted to existing cement plants in a cost- and resource-effective manner, maintaining product quality and environmental compatibility. - Formulate a techno-economic decision-basis for CO2 capture implementation in the cement industry, where the current uncertainty regarding CO2 capture cost is reduced by at least 50%. For successful large-scale deployment of CO2 capture in the cement industry, technologies must be developed beyond the current state of the art. In order to bring the most high-potential retrofittable CO2 capture technologies to a higher TRL level and closer to implementation, CEMCAP will - Describe the routes for the development required to close technology gaps for CO2 capture from cement and assist technology suppliers along the related innovation chains. - Identify and follow up minimum five potential innovations springing from CEMCAP research. Technologies suitable for CO2 capture retrofit are focused on in CEMCAP, because cement plants typically have a lifetime of as long as 30-50 years. However, the results from CEMCAP will enable looking beyond this horizon. Therefore, CEMCAP will - Create pathways for the low to near-zero CO2 emission cement production of the future.


Grant
Agency: Cordis | Branch: FP7 | Program: MC-ITN | Phase: FP7-PEOPLE-2010-ITN | Award Amount: 4.02M | Year: 2011

Q-NET will provide initial training in the general field of Quantum Nano-Electronics, in particular spintronics, molecular electronics, single-electronics, quantum dots and nanowires, nano-cooling. The recruited researchers will be trained to state-of-the-art technologies of nanofabrication, near-field microscopies, transport measurement under extreme conditions (low temperatures, magnetic field, radio-frequency irradiation) and theoretical calculations. Ultimate detectors, innovative local probes, new metrological standards, on chip micro-coolers will be developed. 25 key scientists from 8 different institutions will interact as a consistent training staff monitored by the supervisory board by reference to a 8-task detailed program. The 16 trained young researchers will be at the ESR level for 93%. The training will be implemented through systematic secondments of young researchers from one partner to several academic and private partners. The project website will be set-up to support the training strategy and the tracing of results and IPR. It will be animated by the recruited researchers under the supervision of the coordinator. Q-NET will organize sessions of the European School On Nanosciences and Nanotechnologies (ESONN) devoted to Quantum Nano-Electronics, combining both theoretical and practical training. Annual special training sessions will be organized, covering seven complementary domains such as ethics, project management, IPR, communication skills ... The consortium involves most of the leading groups in the domain which contributed these last ten years to the European leadership in Quantum Nano-Electronics. Q-NET will significantly contribute to meet the needs of the industry in terms of highly-skilled and open-minded scientists for leading the competition in Beyond C-MOS Nano-Electronics.


Grant
Agency: Cordis | Branch: FP7 | Program: CP-IP | Phase: HEALTH.2010.2.3.2-1 | Award Amount: 16.70M | Year: 2011

The More Medicines for Tuberculosis (MM4TB) consortium evolved from the highly successful FP6 project, New Medicines for TB (NM4TB), that delivered a candidate drug for clinical development two years ahead of schedule. Building on these firm foundations and exploiting its proprietary pharmacophores, MM4TB will continue to develop new drugs for TB treatment. An integrated approach will be implemented by a multidisciplinary team that combines some of Europes leading academic TB researchers with two major pharmaceutical companies and four SMEs, all strongly committed to the discovery of anti-infective agents. MM4TB will use a tripartite screening strategy to discover new hits in libraries of natural products and synthetic compounds, while concentrating on both classical and innovative targets that have been pharmacologically validated. Whole cell screens will be conducted against Mycobacterium tuberculosis using in vitro and ex vivo models for active growth, latency and intracellular infection. Hits that are positive in two or more of these models will then be used for target identification using functional genomics technologies including whole genome sequencing and genetic complementation of resistant mutants, yeast three hybrid, click chemistry and proteomics. Targets thus selected will enter assay development, structure determination, fragment-based and rational drug design programs; functionally related targets will be found using metabolic pathway reconstruction. Innovative techniques, based on microfluidics and array platforms, will be used for hit ranking, determining rates of cidality and confirming mechanism of action. Medicinal chemistry will convert leads to molecules with drug-like properties for evaluation of efficacy in different animal models and late preclinical testing.


Grant
Agency: Cordis | Branch: FP7 | Program: CP-IP | Phase: NMP.2013.1.1-1 | Award Amount: 9.30M | Year: 2013

The present project is aimed to the development of a multi-step process for the production of second-generation biofuels from lignocellulosic biomass in a cost-efficient way through the use of tailored nanostructured catalysts. The proposed process is based on the cascade combination of three catalytic transformations: catalytic pyrolysis, intermediate deoxygenation and hydrodeoxygenation. The sequential coupling of catalytic steps will be an essential factor for achieving a progressive and controlled biomass deoxygenation, which is expected to lead to liquid biofuels with a chemical composition and properties similar to those of oil-derived fuels. According to this strategy, the best nanocatalytic system in each step will be selected to deal with the remarkable chemical complexity of lignocellulose pyrolysis products, as well as to optimize the bio-oil yield and properties. Since hydrodeoxygenation (HDO) is outlined in this scheme as the ultimate deoxygenation treatment, the overall hydrogen consumption should be strongly minimized, resulting in a significant improvement of the process economic profitability. The use of nanostructured catalysts will be the key tool for obtaining in each chemical step of the cascade process, the optimum deoxygenation degree, as well as high efficiency, in terms both of matter and energy, minimizing at the same time the possible environmental impacts. The project will involve experiments at laboratory, bench and pilot plant scales, as well as a viability study of its possible commercial application. Thereby, the integrated process will be assessed according to technical, economic, social, safety, toxicological and environmental criteria. The consortium will be formed by 17 partners, including 4 research institutions, 6 universities, 5 large industries and 2 SME.


Grant
Agency: Cordis | Branch: FP7 | Program: MC-ITN | Phase: FP7-PEOPLE-2013-ITN | Award Amount: 3.47M | Year: 2013

VitriMetTech aims at educating a group of young researchers to implement methods for cutting edge research on new metallic glasses (e.g. Fe, Mg, Al, Ti-based), also in bulk form, and their amorphous/crystalline composites, for functional, bio-mechanical, chemical and structural micro-part applications. Transfer of results to industrial companies will boost innovation in a part of the Metal sector of the European manufacturing industry. This interdisciplinary proposal by ten of the best European academic research teams with six private sector companies will both improve the availability of materials and technologies in fields were metallic glasses are already in the production line (e. g. magnetic devices), and open up new fields of application in chemistry (e. g. in catalysis and spectroscopy) and electrical and electronic engineering (e. g. motor components and MEMS). VitriMetTech comprises five Research Projects which are designed to achieve the following objectives: 1) Soft magnets with low or zero-magnetostriction for use in inductors and toroid-shaped or flat transformers. 2) Highly magnetostrictive alloys to exploit magneto-mechanical coupling for energy harvesting and cantilever devices. 3) Bio-corrodable Mg-based bulk vitrified metals for implants free of toxic elements and with low elastic modulus. 4) Nano-porous metals made from metallic glass precursors for electro- and heterogeneous catalysis, enhanced Raman spectroscopy, flexible electrodes and actuators. 5) Improving the mechanical properties of vitrified metals for the above applications: suppression of shear banding and attain ductility as a function of sample size, composition, and temperature. The training programme overcomes barriers among traditional disciplines providing top level tuition to 16 fellows (10 ESRs and 6 ERs) on topics spanning from laboratory work for the synthesis and property characterization, to processing and device fabrication, and on a full set of complementary skills.


Grant
Agency: Cordis | Branch: FP7 | Program: ERC-AG | Phase: ERC-AG-PE2 | Award Amount: 1.94M | Year: 2014

The recent discovery of a Higgs-boson like resonance at the Large Hadron Collider (LHC) at CERN is a major landmark in the quest to understand the fundamental nature of the Universe. Precise measurements of the properties of the new boson are now mandatory and must be reflected in a similar quest for higher precision from the theory side. We aim to meet this challenge by developing a theoretical framework together with suitable high-precision tools that will guarantee the continued success of the LHC programme. The aim of this proposal is therefore to develop and establish a new standard of theoretical precision in the description of physical observables at the LHC and other particle collider experiments, thereby leading to a more precise extraction of fundamental physics parameters, such as the couplings of the Higgs boson to other fundamental particles. The necessary theoretical precision will be achieved by systematically including the next-to-next-to leading order (NNLO) corrections in the perturbative expansion in the relevant simulation tools, focusing on crucial experimental benchmark processes. The techniques and frameworks we will develop will be applicable to other processes and in particular, will be very relevant to searches for physics beyond the Standard Model, and in the further interpretation of any signals that would indicate such a discovery. To achieve this ambitious goal, the PI will work very closely with a team of carefully chosen scientists with relevant overlapping and complementary expertise in precision calculations and event simulation: Professor Dr Thomas Gehrmann (University of Zrich), Professor Dr Aude Gehrmann-De Ridder (ETH Zrich) and Dr Frank Krauss (Durham University).


Grant
Agency: Cordis | Branch: FP7 | Program: CP-FP | Phase: NMP.2011.3.2-1 | Award Amount: 5.58M | Year: 2012

In response to world-wide changes in the chemical/biopharmaceutical industry, new market requirements for specific end-use product properties as well as to stricter energy, safety and environmental constraints a revolutionary approach is needed regarding equipment design, plant operation and new production paradigms that will result in better products and processes. Process intensification (PI) is the key technological pathway to drastically improve the sustainability of the chemical and biopharmaceutical processes by replacing the existing, inefficient plant equipment with new, intensified operations. PI comprises the development of novel equipment and production methods that can bring dramatic improvements in manufacturing and processing and lead to safer, cleaner, smaller and cheaper production routes. PI is expected to open up the way for the production of new products, unblock the potential for plant operation under less stable conditions and reform entire business models to foster just-in-time or distributed production. In a series of recent publications and roadmaps, PI has been identified as the path for sustainable development. The OPTICO project aims at overcoming the present limitations on implementing PI by establishing a new methodological design approach for sustainable, intensified chemical/biopharmaceutical plant design and operation through a flexible, integrated multi-scale modeling framework coupled with advanced process analytics tools and modern optimization/control techniques. It is envisaged that, within a 3 year time frame, the proposed work will enable the innovative process design and promote a substantial improvement in chemical/biopharmaceutical plant efficiency by reducing energy consumption, operating costs, handled volumes and generated wastes as well as by improving the process efficiency and safety.


Grant
Agency: Cordis | Branch: FP7 | Program: CP | Phase: ICT-2011.9.9 | Award Amount: 5.94M | Year: 2013

The ScaleQIT vision is to develop a conceptual platform for potentially disruptive technologies, advance their scope and breadth and speed up the process of bringing them from the lab to the real world. ScaleQIT will address the engineering side of quantum information processing (QIP), analyzing and implementing realistic scenarios for scaling-up superconducting hybrid systems for quantum computing and quantum simulation. The work will be based on proven, well-functioning circuits and components that show great promise for integration into useful QIP systems. ScaleQIT will develop a quantum processor based on microwave resonators and waveguides coupling a small (5-10) number of superconducting qubits of the transmon type. It will achieve most of the functionalities required by DiVincenzos criteria, and will meet many of the challenges defined by the European Quantum Information and Processing Roadmap. For the development of a useful scalable platform, the ScaleQIT project will address a wide range of challenging issues, and take them far beyond the state of the art for multi-qubit platforms, addressing several central issues: feed-back and feed-forward control; error correction; quantum memory; quantum interfaces; algorithms and protocols for computing and simulation; design of scalable architectures for high performance quantum computing.ScaleQIT aims for groundbreaking applications to quantum simulation of physical systems. If successful, it may already in the short term have a disruptive effect on the development of quantum information science. In the longer term, it can be expected to have a disruptive effect on the science of computation: combining functional processor units with, say, 10 qubits, into larger distributed systems will eventually have simulation power that rivals that of powerful digital computers. By really building and testing larger quantum-engineering systems, ScaleQIT will be a path-finder on the road to developing solid-state fault-tolerant quantum architectures.


Grant
Agency: Cordis | Branch: FP7 | Program: CP | Phase: ENERGY.2011.5.1-1 | Award Amount: 3.26M | Year: 2011

A new technology towards breakthrough innovation in solvent based post-combustion CO2 capture for enhanced energy efficiency, improved cost effectiveness and increased process sustainability and environmental benefits is developed. Advances in the identification of highly performing solvents and solvent blends in CO2 absorption, the design of innovative separation equipment internals, and the development of optimal process configurations enable a cost of approximately 16 euros per ton of CO2 captured. Such achievement can have a tremendous impact in several industrial applications such as gas-fired, coal-fired, and lignite-fired power plants as well as quick-lime production plants where solvent based post-combustion CO2 absorption can become a viable solution. The current project adopts a holistic approach towards the fulfillment of the outlined goals accomplished through research and development at multiple levels within an integrated framework. At the molecular level, the use of computer aided molecular design tools supported by accurate and adequately validated thermodynamic models enables the exhaustive investigation of the performance of multiple solvents and solvent blends in post-combustion CO2 absorption processes. The solvent blends are systematically assessed and rank-ordered against their performance towards the satisfaction of relevant process, economic, operability and sustainability criteria. The optimal solvents and solvent blends are expected to exhibit significantly better characteristics than currently used solvents in terms of energy requirements and overall environmental impact. At the unit operations level, the design of innovative process configurations and column internals that are specifically tailored for the employed solvents enhance the efficiency of the absorption based separation. Advanced modeling and optimization tools in conjunction with thorough experimental procedures ensure the achievement of high mass transfer rates and optimal flow patterns. At the plant level, the comprehensive analysis of the interactions among an existing power plant and the added solvent based post-combustion CO2 capture unit enables the optimal allocation of resources for improved energy savings and the efficient integration of the new CO2 capture process components. Pilot plant testing of the newly developed technology under operating condition encountered in practical applications ensures process stability and consistency. Several industrial applications in power production and chemicals manufacture are scheduled for comprehensive study, analysis, and evaluation thus resolving all related technical and engineering issues.


Grant
Agency: Cordis | Branch: FP7 | Program: CP-IP | Phase: ENV.2011.1.3.1-1 | Award Amount: 10.11M | Year: 2011

Earthquakes are a serious threat for many European countries, particularly those around the Mediterranean Sea. In many cities exposed to high earthquake hazard, a substantial proportion of the population still lives in buildings that do not meet modern earthquake-resistant standards. Preventive actions, such as retrofitting of structures, are essential, but they are not sufficient and cannot be applied easily on a large scale. Real-time actions focussing on decreasing the physical vulnerability and exposure of populations are a viable way to reduce earthquake risk. The primary objective of REAKT is to improve the efficiency of real-time earthquake risk mitigation methods and their capability of protecting structures, infrastructures and populations. REAKT aims to develop methodologies that will enhance the quality of information provided by earthquake forecasting, early warning and real-time vulnerability systems, as well as establishing best practices for how to use all of this information in a unified manner. In order to be used effectively, such information needs to be combined into a fully probabilistic framework, including realistic estimates of the uncertainties involved, that is suitable for decision making in real time. The REAKT consortium draws together most of the main European institutes and research groups, in addition to major non-European institutes, that are working on different aspects of earthquake early warning and probabilistic models of operational forecasting. The project is divided into 7 scientific work packages that constitute a logical sequence from, at one end, the processes involved in earthquake generation and the physics of short-term seismic changes, to the other, the threatened people. through operational earthquake forecasting, early warning and rapid assessment of damage and vulnerability, decision making and capacity building, and the application of the developed methodologies to 12 strategic test cases.


Grant
Agency: Cordis | Branch: FP7 | Program: CP | Phase: ENERGY.2013.7.3.1 | Award Amount: 7.50M | Year: 2013

The anticipated mass roll-out of electric vehicles (EVs) in Europe and the continuously increasing number of distributed energy resources (DER) are posing major challenges to Europes Distribution System Operators (DSOs) with regard to ensuring a secure and reliable energy supply and network operation. Despite ongoing research and demonstration activities in this field, particularly the development of new and the revision of existing planning rules and operational principles of DSOs still require extensive R&D efforts. The overall objective of PlanGridEV is therefore to develop new network planning tools and methods for European DSOs for an optimized large-scale roll-out of electromobility in Europe whilst at the same time maximizing the potential of DER integration. The project will also identify gaps in current network operation procedures and update tools and methods to address local load and congestion issues, leveraging on the possibilities of managing EV as controllable loads. For the validation activities the project will rely on existing infrastructures of the four involved DSOs. Taking into account improved methods for network operation, regulatory frameworks and business models, PlanGridEV will bring about an evolution of current grid planning rules and investment strategies. The comprehensive approach takes into account requirements and constraints of all relevant stakeholders, particularly through an effective cooperation between Original Equipment Manufacturers (OEMs) and DSOs accompanied by leading scientific and technological research partners in the consortium. The project will have considerable impact on the environmental, economic, scientific and societal level by enabling a more cost-effective network planning and increasing the overall hosting capacity of European distribution networks. PlanGridEV will leverage on previous research results, coordinate with on-going initiatives and ensure a successful market uptake of the developed solutions.


Grant
Agency: Cordis | Branch: FP7 | Program: CP-IP | Phase: ENV.2010.1.1.3-1 | Award Amount: 9.56M | Year: 2011

CARBOCHANGE will provide the best possible process-based quantification of net ocean carbon uptake under changing climate conditions using past and present ocean carbon cycle changes for a better prediction of future ocean carbon uptake. We will improve the quantitative understanding of key biogeochemical and physical processes through a combination of observations and models. We will upscale new process understanding to large-scale integrative feedbacks of the ocean carbon cycle to climate change and rising carbon dioxide concentrations. We will quantify the vulnerability of the ocean carbon sources and sinks in a probabilistic sense using cutting edge coupled Earth system models under a spectrum of emission scenarios including climate stabilisation scenarios as required for the 5th IPCC assessment report. The drivers for the vulnerabilities will be identified. The most actual observations of the changing ocean carbon sink will be systematically integrated with the newest ocean carbon models, a coupled land-ocean model, an Earth system model of intermediate complexity, and fully fledged Earth system models through a spectrum of data assimilation methods as well as advanced performance assessment tools. Results will be optimal process descriptions and most realistic error margins for future ocean carbon uptake quantifications with models under the presently available observational evidence. The project will deliver calibrated future evolutions of ocean pH and carbonate saturation as required by the research community on ocean acidification in the EU project EPOCA and further projects in this field. The time history of atmosphere-ocean carbon fluxes past, present, and future will be synthesised globally as well as regionally for the transcontinental RECCAP project. Observations and model results will merge into GEOSS/GEO through links with the European coordination action COCOS and will prepare the marine branch of the European Research Infrastructure ICOS.


Grant
Agency: Cordis | Branch: FP7 | Program: CP | Phase: ENV.2013.6.1-3 | Award Amount: 11.25M | Year: 2013

IMPRESSIONS will provide empirically-grounded, transformative science that quantifies and explains the consequences of high-end climate scenarios for both decision-makers and society. IMPRESSIONS will develop and apply a novel participatory methodology that explicitly deals with uncertainties and strong non-linear changes focussing on high-end climate change, but also including intermediate warming levels. This new methodology will build on the representative concentration pathways (RCPs) and shared socio-economic pathways (SSPs) to create a coherent set of high-end climate and socio-economic scenarios covering multiple scales. These scenarios will be applied to a range of impact, adaptation and vulnerability models that build on theories of complex systems and address tipping elements as key characteristics of such systems. The models will be embedded within an innovative multi-scale integrated assessment approach to improve analysis of cross-scale interactions and cross-sectoral benefits, conflicts and trade-offs. Model results will inform the development of time- and path-dependent transition pathways. These will include mechanisms to foster synergies between adaptation and mitigation and will aim to build resilience in the face of uncertainty. Methods will be applied within five linked multi-sectoral case studies at global, European and regional/local scales. Stakeholders within these case studies will be fully engaged in the research process through a series of in-depth professionally facilitated workshops which maximise their active participation in defining high-end scenarios and adaptation and mitigation pathways, and in analysing the inherent risks and opportunities of new policy strategies. This will build the capacity of stakeholders to understand the risks, opportunities, costs and benefits associated with different adaptation and mitigation pathways under high-end scenarios, and how they might be effectively embedded within decision-making processes.


Grant
Agency: Cordis | Branch: H2020 | Program: RIA | Phase: ICT-32-2014 | Award Amount: 6.47M | Year: 2015

The current trend for data placement shows a steady shift towards the cloud. The advent of cloud storage and computation services however comes at the expense of data security and user privacy. To remedy this, customers nowadays call for end-to-end security whereby only end-users and authorized parties have access to their data and no-one else. This is especially true after the outbreak of data breaches and global surveillance programs last year. In the TREDISEC project, we address this problem and we develop systems and techniques which make the cloud a secure and efficient heaven to store data. We plan to step away from a myriad of disconnected security protocols or cryptographic algorithms, and to converge on a single framework where all objectives are met. More specifically, TREDISEC addresses the confidentiality and integrity of outsourced data in the presence of a powerful attacker who controls the entire network. In addition, our proposed security primitives support data compression and data deduplication, while providing the necessary means for cloud providers to efficiently search and process encrypted data. By doing so, TREDISEC aims at creating technology that will impact existing businesses and will generate new profitable business opportunities long after the project is concluded.


Organized Crime and Terrorist Networks (OC/TN) are a major challenge for the European Union and many different stakeholder groups are involved in creating awareness, preventing, identifying and intervene in case of risk or threat. But in order to develop better strategies and instruments, we still need a deeper understanding of these phenomena. TAKEDOWN therefore aims at generating such novel insights on OC/TN. In order to meet this challenge and to investigate this complex field of research a multidimensional modelling approach is used. The resulting, proprietary TAKEDOWN Model describes social, psychological, economic aspects as well as further dimensions, activities and response approaches. A comprehensive empirical research combined with European and international expert knowledge ensures a valid and intuitive model. The TAKEDOWN Open Information Hub targets first-line-practitioners and provides modular solutions and inductive materials. The public web platform helps individuals to navigate to the right third party reporting and help lines including an innovative crowd reporting application to report digital OC/TN cases. The TAKEDOWN OC/TN Professional Solution Platform consists of various modules for law enforcement and homeland security departments. Designed with a flexible Platform as a Service (PaaS) architecture it combines knowledge materials and digital security solutions. Via the TAKEDOWN Security Dashboard information streams of native and third party applications are combined in an identification and issue management cockpit. The TAKEDOWN Professional Advisor supports experts on the selection of relevant approaches and security solutions to tackle OC/TN. With this multi-level approach, TAKEDOWN will force a better understanding of OC/TN, develop modern approaches and solutions, and will finally lead to a more efficient and effective response on OC/TN and strengthen social cohesion at pan-European level.


Grant
Agency: Cordis | Branch: H2020 | Program: MSCA-ITN-EID | Phase: MSCA-ITN-2016 | Award Amount: 2.62M | Year: 2016

In PlantHUB will capture the academic, industrial and regulatory expertise from 5 world-class universities, 1 public research organisation, 1 governmental organization, 8 enterprises including 5 SMEs to train 10 ESRs in skills and competencies necessary to apply responsible research and innovation (RRI) in the area of plant breeding and production. We wish to address the demand of RRI leadership in plant science related research and diffusion of innovation. The individual research projects are demand-driven, responding to the needs of companies - particular SMEs - to increase R&I capacities. The outcomes are new molecular tools for plant breeding, new forage, cereal and oil crop varieties, non-invasive imaging and phenotyping technologies, intelligent lighting systems for plant growth, new software and services for complex genomic analyses, and plant product quality. PlantHUB industrial doctoral programme is ground-breaking in a number of respects: (i) doctoral training is placed into an entrepreneurial environment of leading public and private organisations (ii) it combines practical hands-on R&D and technology transfer in plant breeding and production with RRI training and practise. On completion of the training, graduates will have deep interdisciplinary knowledge of plant breeding, crop improvement, high-throughput technologies, isotope and big data analysis. In combination with a portfolio of transferable skills they will be able to take a lead in stakeholder & public engagement, innovation management, technology transfer and entrepreneurship. Our programme will become a flagship example at the forefront of intersectoral research, underpinned with a carefully created training curriculum to foster awareness, know-how, expertise and competence in RRI.


Grant
Agency: Cordis | Branch: FP7 | Program: CP-FP | Phase: NMP-2009-1.1-1 | Award Amount: 2.62M | Year: 2011

Nanoscience and nanotechnology are currently revolutionizing sectors such as medicine, information technologies, environmental or materials sciences, and creating new opportunities for our societies. In this context, magnetic nanoparticles (MNP) are key components to the development of novel nano- and biotechnologies. Magnetosomes are unique hybrid magnetic MNP produced by magnetotactic bacteria (MB). They are employed in applications ranging from extraction of DNA to the development of immunoassays and uses in spintronics are envisaged. However, only a very limited amount of MNP (few mg per day) can be formed by MB, and the formation principles remain to be tackled. Biomimetics, i.e. combining biological principles with chemistry, will pave the way to understand biomineralization of tailored MNP and to find out high-value high-yield synthetic routes to solve scientific and technological challenges. Specifically, we aspire at bridging the gap between different fields of science. For the first time, we will blend biological and genetic approaches with chemical and physical knowledge to understand the key parameters controlling the size, shape, composition and assembly of hybrid MNP in vivo and in vitro. We will combine nanoscience and nanotechnology to modify these properties and develop an ensemble of magnetic nanomaterials of higher values. This approach will lead to original contributions of innovative nature based on the combined skills of the partners to manufacture and characterize the biological, chemical, structural and magnetic properties of the MNP. The industrial partner will have key importance in managing and assessing the applicability of the MNP in Magnetic Resonance Imaging (MRI). Finally, our cell biologist partner will test the biocompatibility of the designed systems. In 3 years, we aim at being able to synthesize hybrid MNP with tailored magnetic and size properties by low-cost high-yield synthesis for applications in MRI.


Grant
Agency: Cordis | Branch: FP7 | Program: CSA-CA | Phase: SST.2010.1.3-1. | Award Amount: 2.98M | Year: 2011

The objective of the project is to upgrade and further develop the current TRANSTOOLS model, here referred to as TT2, to a new and improved European transport demand and network model (TT3). The project will improve the methodological basis of TRANSTOOLS, improve and validate its data foundation, deal with known deficiencies of the existing model, make the software faster and more efficient, and focus on the user needs, model documentation and model validation. The model will be updated to the 2010 base year based upon ETISplus data. The level of detail with regard to the rail, maritime and air transport modules will be increased. The aim here is to better analyse issues of cost, capacity and externalities of transport. The impact assessment model will be improved. Cross cutting activities will focus on methodological improvements of the model, updating and validating the data, re-estimating and re-calibrating the model, and performing an overall validation of the entire framework. Special focus will be on making the model more efficient with regard to calculation time, yet without compromising on the scientific validity with regard to causal relationships and described transport behaviour. The TT3 will deliver a validated, well documented and user friendly model that will provide policy makers with a tool for assessing and developing better transport policies. TT3 will continue the tool-box approach from prior versions of the model, which ensures that it can address the needs of many different types of user, for example analyses of EU-wise transport policies, analyses of TEN-projects and links to interregional and national project appraisals. The final model of TT3 will be IPR free and more open than the present model. The consortium ensures links back to TT1, TT2, a number of other relevant Framework projects, and ensures a strong University research base including several of the leading European Universities. This guarantees a clolink to recent research.


Grant
Agency: Cordis | Branch: H2020 | Program: RIA | Phase: LCE-11-2015 | Award Amount: 6.15M | Year: 2016

Liquid hydrocarbon fuels are ideal energy carriers for the transportation sector due to their exceptionally high energy density and most convenient handling, without requiring changes in the existing global infrastructure. Currently, virtually all renewable hydrocarbon fuels originate from biomass. Their feasibility to meet the global fuel demand and their environmental impact are controversial. In contrast, SUN-to-LIQUID has the potential to cover future fuel consumption as it establishes a radically different non-biomass non-fossil path to synthesize renewable liquid hydrocarbon fuels from abundant feedstocks of H2O, CO2 and solar energy. Concentrated solar radiation drives a thermochemical redox cycle, which inherently operates at high temperatures and utilizes the full solar spectrum. Thereby, it provides a thermodynamically favourable path to solar fuel production with high energy conversion efficiency and, consequently, economic competitiveness. Recently, the first-ever production of solar jet fuel has been experimentally demonstrated at laboratory scale using a solar reactor containing a ceria-based reticulated porous structure undergoing the redox cyclic process. SUN-to-LIQUID aims at advancing this solar fuel technology from the laboratory to the next field phase: expected key innovations include an advanced high-flux ultra-modular solar heliostat field, a 50 kW solar reactor, and optimized redox materials to produce synthesis gas that is subsequently processed to liquid hydrocarbon fuels. The complete integrated fuel production chain will be experimentally validated at a pre-commercial scale and with record high energy conversion efficiency. The ambition of SUN-to-LIQUID is to advance solar fuels well beyond the state of the art and to guide the further scale-up towards a reliable basis for competitive industrial exploitation. Large-scale solar fuel production is expected to have a major impact on a sustainable future transportation sector.


Grant
Agency: Cordis | Branch: H2020 | Program: RIA | Phase: FETOPEN-1-2014 | Award Amount: 3.80M | Year: 2015

The terahertz (THz) spectral region, located between the infrared and the microwave regions, is known as the THz gap because of the lack of compact semiconductor devices. This spectral domain is currently intensively explored in view of its potential for medical diagnostics, security screening, trace molecule sensing, astronomical detection, space-borne imaging, non-invasive quality control or wireless communications. A prerequisite for public-domain applications to emerge in the strategic THz frequency range is the availability of compact size semiconductor sources operating at room temperature, which is out of range of the current technology based on GaAs quantum cascade lasers. ZOTERAC proposes a disruptive approach based on ZnO-based nano-engineered semiconductors in order to realize THz emitters operating at room-temperature with milliWatt output power capability as well as THz quantum detectors with unprecedented large operating temperatures. These devices are based on the quantum cascade concept and take benefit of the large optical phonon energy of ZnO (twice that of GaAs) for achieving high temperature operation. Establishing a new state-of-the-art for the design, growth and processing of ZnO/ZnMgO heterostructures, and developing an advanced know-how on oxide-based devices are major challenges of the project. The consortium regroups worldclass academic experts on ZnO technologies, quantum cascade lasers and detectors as well as THz optoelectronics. The strategies have been chosen based on a careful assessment of the risk attached to all tasks and achievement of targeted objectives at each stage of the project. This project which implies a strong expertize in basic physics, chemistry and engineering, is expected to generate high impacts in terms of scientific and technological achievements.


Grant
Agency: Cordis | Branch: FP7 | Program: MC-IAPP | Phase: FP7-PEOPLE-2013-IAPP | Award Amount: 1.75M | Year: 2013

The Scalable management Of LArge Scale cloud computing environments using enhanced software-defined networking technologies (SOLAS) IAPP will initiate a long term research partnership between three academic research organisations (TSSG, KTH and ETH Zrich) and two commercial sector organisations (EISI and Amadeus SAS). Consortium partners have complementary expertise and long term interests in the scientific and technology domains underpinning the data centre IT systems that realise cloud computing environments. The proposed programme of inter-sectoral secondments and targeted recruitment will, on the one hand, provide academic researchers with in-depth knowledge of the latest technologies offered by vendors like EISI and of how these are applied by operators, like Amadeus SAS, of large scale data centres like Amadeus SAS, whilst, on the other hand, providing industry researchers and engineers with knowledge of how to design, implement and deploy distributed algorithms for scalable management of data centre environments. Working in close cooperation, the consortium partners will make significant contributions to the state-of-the-art in the increasingly important area of resource management for cloud computing. Specifically, they will develop important novel enhancements to the nascent Software-Defined Networking technology paradigm and will demonstrate how data centre platforms based on this technology can be managed in a more flexible and efficient manner and can provide cloud-hosted applications with much improved analytics and data management techniques. In performing and evaluating this research programme, they will train a cohort of academic and industrial researchers that can continue to make significant contributions beyond the lifetime of SOLAS.


Grant
Agency: Cordis | Branch: FP7 | Program: CP-FP | Phase: SSH.2012.5.2-1 | Award Amount: 2.99M | Year: 2013

The big bang enlargement of the European Union (EU) has nurtured vivid debates among both academics and practitioners about the consequences of an ever larger Union for the EUs integration capacity. The research project MAXCAP will start with a critical analysis of the effects of the 2004- 2007 enlargement on stability, democracy and prosperity of candidate countries, on the one hand, and the EUs institutions, on the other. We will then investigate how the EU can maximize its integration capacity for current and future enlargements. Adopting an inter-disciplinary and mixed methods approach that combines desk research, in-depth interviews and Q-methodology, MAXCAP will a) explain the effects of the EUs integration modes and strategies on democracy and socio-economic development in the new members, candidates and neighbourhood countries; b) inquire into the relationship between the widening and deepening of the EU by establishing conditions for effective decision-making and implementation in an enlarged EU; c) identify the social limits to the EUs integration capacity related to citizens perceptions of the last and future enlargements; d) study the EUs current and past negotiation strategies in the context of enlargement and investigate to what extent they need to be adjusted to changing conditions in the EU and the candidate countries; e) examine how the EU employs different modes of integrating countries with highly diverse economic powers, democratic qualities of governance, and institutional capacities and f) assess whether alternative models, such as the European Neighbourhood Policy, can be successful in bringing countries closer to the EU. MAXCAP which features a nine-partner consortium of academic, policy, dissemination and management excellence will create new and strengthen existing links within and between the academic and the policy world on matters relating to the current and future enlargement of the EU.


Weber W.,Albert Ludwigs University of Freiburg | Fussenegger M.,ETH Zurich | Fussenegger M.,University of Basel
Nature Reviews Genetics | Year: 2012

Synthetic biology aims to create functional devices, systems and organisms with novel and useful functions on the basis of catalogued and standardized biological building blocks. Although they were initially constructed to elucidate the dynamics of simple processes, designed devices now contribute to the understanding of disease mechanisms, provide novel diagnostic tools, enable economic production of therapeutics and allow the design of novel strategies for the treatment of cancer, immune diseases and metabolic disorders, such as diabetes and gout, as well as a range of infectious diseases. In this Review, we cover the impact and potential of synthetic biology for biomedical applications. © 2011 Macmillan Publishers Limited. All rights reserved.


Grant
Agency: Cordis | Branch: FP7 | Program: CP | Phase: ICT-2011.6.6 | Award Amount: 4.08M | Year: 2011

The demand for mobility of people and goods in urban environments steadily increases raising long-term sustainability, quality of life and environmental concerns. While ICTs have established the ground for developing intelligent transport services and applications, their effective use for supporting cleaner urban mobility still represents a major research challenge.\neCOMPASS introduces new mobility concepts and establishes a methodological framework for route planning optimization following a holistic approach in addressing the environmental impact of urban mobility. eCOMPASS aims at delivering a comprehensive set of tools and services for end users to enable eco-awareness in urban multi-modal transportations. eCOMPASS involves a generic architecture that will consider all types and scenarios of human and goods mobility in urban environments minimizing their corresponding environmental impact. Firstly, the project will focus on the design and development of intelligent on-board and centralized vehicles fleet management systems; the fundamental objective of eco-awareness will be addressed through employing intelligent traffic prediction and traffic balancing methods, while also taking into account driving behaviour and considering the option of car drivers transferred to means of public transportation at suitable locations. Secondly, eCOMPASS will develop web and mobile services providing multi-modal public transportation route planning, taking into account contextual information (such as location and time) as well as various restrictions and/or user constraints. Recommended routes will be optimized mainly in terms of the transports environmental footprint, although additional objectives will also be considered. An important objective of eCOMPASS is to develop novel algorithmic solutions and deliver the respective services to familiar end-user mobile devices.


Grant
Agency: Cordis | Branch: H2020 | Program: ERC-POC | Phase: ERC-PoC-2015 | Award Amount: 149.88K | Year: 2016

InInVi originates from augmented reality (AR) research within the ERC project VarCity. Our findings from VarCity of highly robust plane tracking combined with state-of-the-art object recognition enables very robust and qualitatively very high augmentations. In this PoC project, we transfer these findings into commercial applications in the live TV production business. Here, mechanical, inflexible solutions dominate to create overlays or AR animations, for instance step sensors to measure the field of view of a camera. As the purely visually operating proof-of-concept technology allows to overcome many of their limitations, e.g. high set-up costs or the assumption of a fixed camera location, it provides new opportunities in video-on-demand, live TV and live streaming.


Grant
Agency: Cordis | Branch: FP7 | Program: CP-FP | Phase: AAT.2010.6.3-3. | Award Amount: 4.50M | Year: 2011

Considering the prevailing congestion problems with ground-based transportation and the anticipated growth of traffic in the coming decades, a major challenge is to find solutions that combine the best of ground-based and air-based transportation. The optimal solution would consist in creating a personal air transport system (PATS) that can overcome the problems associated with all of our current methods of transportation. We propose an integrated approach to enable the first viable PATS based on Personal Aerial Vehicles (PAVs) envisioned for travelling between homes and working places, and for flying at low altitude in urban environments. Such PAVs should be fully or partially autonomous without requiring ground-based air traffic control. Furthermore, they should operate outside controlled airspace while current air traffic remains unchanged, and should later easily be integrated into the next generation of controlled airspace. The myCopter project aims to pave the way for PAVs to be used by the general public within the context of such a transport system. Our consortium consists of experts on socio-technological evaluation to assess the impact of the envisioned PATS on society, and of partners that can make the technology advancements necessary for a viable PATS. To this end, test models of handling dynamics for potential PAVs will be designed and implemented on unmanned aerial vehicles, motion simulators, and a manned helicopter. In addition, an investigation into the human capability of flying a PAV will be conducted, resulting in a user-centred design of a suitable human-machine interface (HMI). Furthermore, the project will introduce new automation technologies for obstacle avoidance, path planning and formation flying, which also have excellent potential for other aerospace applications. This project is a unique integration of social investigations and technological advancements that are necessary to move public transportation into the third dimension.


Grant
Agency: Cordis | Branch: FP7 | Program: CP | Phase: ICT-2011.5.1 | Award Amount: 3.50M | Year: 2011

People with Parkinsons disease (PD) suffer from motor and cognitive impairments that severely impact mobility, fall risk, and multiple key aspects of functional independence. Until recently, treatment goals focused almost exclusively on symptom relief, but exciting recent work by CuPiD partners and others has demonstrated that motor learning and rehabilitation principles can be effective even in the presence of PD.\nIt is critical to make these rehab-like therapies accessible to patients in their home-setting since they need continoues training, as PD is a cronic neurodegenerative disease. Optimal rehabilitation of a neurodegenerative disease like PD requires personalized training paradigms that patients can integrate into their everyday routine in their own homes and use for many years. Ongoing, long-term treatment in a clinical setting is not feasible, cost effective, or likely something that patients can comply with year after year.\nCuPiD is designed to meet this challenge. We will develop an ICT-enabled solution to the rehabilitation of patients with PD in their home setting, tailoring the solution to target mobility, cognitive function and debilitating PD symptoms such as freezing of gait. Key components of the CuPiD solution are: 1) a home-based rehabilitation system (based on unobtrusive wearable sensors, on-board intelligence for real-time biofeedback, virtual reality, and modular, multi-modal restitution interfaces); and 2) an intelligent telemedicine infrastructure for remote monitoring and supervision of the rehabilitation program by a clinician.\nThe integrated, easy-to-use system will have a huge, beneficial impact on the therapeutic treatment of PD, empowering patients to improve their health-related quality of life in the comforts of their own home. At the same time, we envision that the ultimate costs of treatment will be reduced and the health-care burden dramatically lowered when the unique CuPiD system becomes available.


Grant
Agency: Cordis | Branch: FP7 | Program: CP-IP | Phase: NMP.2012.2.2-1 | Award Amount: 18.29M | Year: 2013

Articulating joint replacements represent a medical market exceeding 14 billion p.a. that is expected to rise as demographics reflect an ageing population. However, faster growth has been seen in the revision market, where prosthetic joints are replaced, than in primary interventions. The major cause of these revisions is that all joint replacements are prone to wear leading to loss of implant function. Further, it has been demonstrated that adverse or extreme loading has a detrimental effect on implant performance. Thus, device failure still occurs too frequently leading to the conclusion that their longevity and reliability must be improved. The premise of this proposal is to realise that wear and corrosion are an inevitable consequence of all implant interfaces within contemporary total joint replacements. To overcome this problem our novel approach is to use silicon nitride coatings in which the combined high wear resistance of this material and solubility of any silicon nitride wear particles released, reduce the overall potential for adverse tissue reactions. In this work a variety of silicon nitride based coatings will be applied to different tribological scenarios related to total hip arthroplasty. The coatings suitability in each scenario will be assessed against target profiles. In particular, it is important to consider coating performance within each of these applications under adverse conditions as well as those outlined in internationally utilised standards. To accomplish this, cutting-edge adverse simulation techniques, in vitro assays and animal models will be developed together with a suite of computational assessments to significantly enhance device testing in terms of predicting clinical performance. Data will inform new standards development and enhance current testing scenarios, and will provide 5 European enterprises with a significant market advantage, whilst providing data for a regulatory submission which is aligned with Dir 93/42/EEC.


Grant
Agency: Cordis | Branch: FP7 | Program: CP | Phase: ICT-2011.9.8 | Award Amount: 2.96M | Year: 2012

The EXA2GREEN project aims at developing a radically new energy aware computing paradigm and programming methodology for exascale computing. The key aspect of the proposed approach is that the issue of energy consumption and the resulting trade-off with the performance and the accuracy of the overall simulation process will be taken into account in all simulation levels: from the kernel, numerical/combinatorial building blocks to the application level by means of the considered mathematical models. The proposed approach of Energy-Aware Numerics goes beyond the standard hardware level or operating software stack usually considered for energy issues and puts the application in the centre of the scene for all aspects related to energy efficiency.\n\nThe EXA2GREEN project takes up this multidisciplinary challenge by bringing together HPC experts, computer scientists, mathematicians, physicists and engineers. The project team is part of an emerging, multidisciplinary European research community and covers all essential fields of expertise, which allow opening absolutely new perspectives in the area of energy-aware numerics in the exascale era.\n\nThe overall goal of this project is to develop unconventional ideas in order to cope with the issue of power consumption.\n\nReducing the power requirement by a factor of at least 100 is the challenge which needs to be addressed in order to be able to use this technology in a meaningful way. This is one of the reason why making the transition to exascale computing requests radical transformation in the current perception of numerical simulation in high performance computing.\n\nThe viability of the proposed approach will be investigated considering a proof of concept where the energy footprint of a large and operational meteorological model for atmospheric and aerosol simulation (COSMO-ART) will be analysed.


Grant
Agency: Cordis | Branch: FP7 | Program: CP | Phase: ICT-2011.3.5 | Award Amount: 3.51M | Year: 2011

For the Next Generation Access Network (NGAN) wavelength division multiplexed passive optical networks (WDM PON) appear a promising and suitable solution offering almost unlimited bandwidth similarly to point-to-point links, while allowing the advantages of fibre sharing.\nIt is widely recognized that WDM PON deployment requires colourless Optical Network Unit (ONU) transmitters, so that each user has the same transmitter. Up to now these characteristics has been unsatisfactorily obtained either with a costly tunable transmitter or by exploiting external seeding sources.\nERMES proposes a disruptive approach to the ONU transmitter. The breakthrough idea is to use a significant portion of the network to implement an embedded self-tuning modulable laser cavity.\nThis idea is based on establishing a very long cavity laser, which can be directly intensity modulated. The goal is achieved by using a dedicated multifunction active chip (MFAC), which acts as the gain medium of the cavity including: the array waveguide grating (AWG) and a reflector at the remote node (RN), and the distribution fibre connecting the ONU to the RN. After cavity set up, the active chip is directly modulated enabling up-stream up to 10 Gb/s data-rate per user. The development of a MFAC suitable for this application is mandatory to bring ERMES approach from the proof-of-principle stage closer to industrial exploitation.\nThis solution is a potential highly effective alternative to the existing approaches in terms of cost reduction as it is colourless and gets rid of the need for external seeding sources. It is also appealing in terms of achievable performance, as it is not impaired by Rayleigh back-scattering, allowing for longer bridged distances.\nERMES success will enforce European industrial leadership in the access arena, whose development in terms of capillarity and bandwidth has major social and economical fallouts. Therefore it addresses the objective of ICT-2011.3.5b.


Grant
Agency: Cordis | Branch: FP7 | Program: CP | Phase: ICT-2011.3.1 | Award Amount: 4.41M | Year: 2012

The microelectronics industry will face major challenges related to power dissipation and energy consumption in the next years. Both static and dynamic consumption will soon start to limit microprocessor performance growth. The goal of the spOt project is to modify the memory hierarchy by the integration of non-volatility (NV) as a new feature of memory cache, which would immediately minimize static power as well as paving the way towards normally-off/instant-on computing.\nTo accomplish this aggressive goal, limitations of present NV memories in terms of speed and endurance must be overcome and new architectures taking full benefit of these new functionalities must be developed. The consortium will base its research on a recent discovery achieved jointly by SPINTEC and ICN, called Spin Orbit Torque (SOT). This disruptive technology, which can be viewed as the ultimate evolution of Spin Transfer Torque, offers the same non-volatility and compliance with technological nodes below 22nm, with the addition of lower power consumption, cache-compatible high speed, and truly infinite endurance.\nTo demonstrate its viability for cache, a number of identified technology roadblocks are addressed by the spOt project through its 5 work-packages and 4 intermediate goals: i) the realization of a fast write, low power, high read signal single memory cell ii) the development of a single cell architecture (standard cell) with minimal footprint iii) A stand-alone memory test chip with full functionality iv) The full chip simulation of a low-power/normally-off multicore processor.\nThe final objective of the project is twofold: The fabrication of a SOT memory test chip, which would be benchmarked against existing and forecasted solutions in order to demonstrate the integrability and manufacturability of this new technology; The design and full chip simulation of a novel multicore processor integrating embedded SOT memory, in order to demonstrate the systemability of such approach.


Grant
Agency: Cordis | Branch: H2020 | Program: CSA | Phase: SC5-10b-2014 | Award Amount: 2.81M | Year: 2015

The aim of INSPIRATION is to adopt a funder and end-user demand-driven approach to establish and promote the adoption of the knowledge creation, transfer and implementation agenda for land use, land-use changes and soil management in the light of current and future societal challenges. Main objectives are: Formulate, consult on and revise an end-user oriented strategic research agenda (SRA), Scope out models of implementing the SRA, Prepare a network of public and private funding institutions willing to commonly fund the execution of the SRA. INSPIRATIONs mission is to improve the supply and effectiveness of science/knowledge take-up by those who really need it. The proposed methodology is based on a multi-stakeholder, multi-national and interdisciplinary approach that covers the variety of stakeholders (public bodies, business, science, citizens and society) and the variety of relevant. The vehicle to engage with all relevant stakeholders across the Member States is a National Focal Point (NFP) in 16 countries. The NFPs will organize workshops with national stakeholders of funders, end users and researchers across the various soil and land management disciplines. The results will be taken up, structured along four integrative themes and merging into thematic knowledge needs to satisfy the as yet unmet societal challenges and to ensure that knowledge contributes primarily to enable meeting these challenges. Based on these results a cross country and cross discipline dialogue will subsequently be organized among the relevant user communities, funding bodies and scientific communities in Europe in order to reach a trans-national, prioritized SRA as well as a model for execution of this SRA. Thus to achieve an SRA of which national funders believe that for any Euro they spend, they will get a multitude of Euros worth of knowledge in return. Knowledge welcomed to face their national, societal challenges.


Global trends in population growth and rising economic prosperity will increase the demand for energy, food and water, with more severe impact in fast-growing economies, such as in several African countries. The constraints on water, energy, and food could well hamper economic development, lead to social and geopolitical tensions, and cause lasting environmental damage. DAFNE advocates an integrated and adaptive water resources planning and management approach that explicitly addresses the water-energy-food (WEF) nexus from a novel participatory and multidisciplinary perspective. This includes social, economic, and ecologic dimensions, involves both public and private actors and is socially inclusive, enhances resource efficiency and prevents the loss of ecosystem services in regions where large infrastructures exist or are being built and intensive agriculture is expanding. A decision-analytic-framework (DAF) will be developed to quantitatively assess the social, economic, and environmental impact of expanding energy and food production in complex physical and political contexts, where natural and social processes are strongly interconnected and the institutional setting involves multiple stakeholders and decision-makers. The DAFNE approach will be demonstrated by analysing two cross-boundary case studies, the Zambezi and the Omo river basins. The WEF nexus will be quantified and analysed as the trade-off between conflicting objectives such as hydropower production vs irrigation, land exploitation vs conservation, etc. The nexus will be translated in economic values and impact on growth, ecosystems and ecosystem services. DAFNE will allow a better understanding of the WEF nexus, and generate and explore alternative planning and management solutions based on the cooperation of public and private stakeholders, which foster the profitable but equitable use of resources without transgressing environmental limits or creating societal and/or stakeholder conflicts.


Grant
Agency: Cordis | Branch: FP7 | Program: CP | Phase: FoF-ICT-2013.7.1 | Award Amount: 22.24M | Year: 2014

The European manufacturing industry needs competitive solutions to keep global leadership in products and services. Exploiting synergies across application experts, technology suppliers, system integrators and service providers will speed up the process of bringing innovative technologies from research labs to industrial end-users. As an enabler in this context, the EuRoC initiative proposes to launch three industry-relevant challenges: 1) Reconfigurable Interactive Manufacturing Cell, 2) Shop Floor Logistics and Manipulation, 3) Plant Servicing and Inspection. It aims at sharpening the focus of European manufacturing through a number of application experiments, while adopting an innovative approach which ensures comparative performance evaluation. Each challenge is launched via an open call and is structured in 3 stages. 45 Contestants are selected using a challenge in a simulation environment: the low barrier of entry allows new players to compete with established robotics teams. Matching up the best Contestants with industrial end users, 15 Challenger teams are admitted to the second stage, where the typical team is formed by research experts, technology suppliers, system integrators, plus end users. Teams are required to benchmark use cases on standard robotic platforms empowered by this consortium. After a mid-term evaluation with public competition, the teams advance to showcasing the use case in a realistic environment. After an open judging process, 6 Challenge Finalists are admitted to run pilot experiments in a real environment at end-user sites to determine the final EuRoC Winner. A number of challenge advisors and independent experts decide about access to the subsequent stages. A challenge-based approach with multiple stages of increasing complexity and financial support for competing teams will level the playing field for new contestants, attract new developers and new end users toward customisable robot applications, and provide sustainable solutions to carry out future challenges.


Grant
Agency: Cordis | Branch: FP7 | Program: CP-TP | Phase: KBBE.2012.3.2-01 | Award Amount: 8.15M | Year: 2012

Marine organisms, in particular sponges and their associated microorganisms, are an inexhaustible source of novel bioactive (lead) compounds for biomedical application. Industrial exploitation of this natural resource using traditional approaches is, however, hampered, with a few exceptions, by unsolvable supply problems - despite of numerous efforts in the past. Therefore, there is, very likely, only one way: to start from the genes encoding the bioproducts, or their biosynthetic pathways, to sustainably obtain the active molecules in sufficient amounts. The aim of the presented industry-driven integrating project is to combine the knowledge in marine genomics, chemogenetics and advanced chemistry to produce recombinantly prepared novel secondary metabolite (lead) compounds and analogous from them, as well as pharmacologically active peptides, and to bring them up to the pre-clinical, and hopefully also to the clinical studies. This ambitious approach is based on breakthrough discoveries and the results of previous successful EU projects of members of the applying consortium, including European leaders (or worldwide leaders) in marine (sponge) genomics, metagenomics (polyketide synthase clusters), combinatorial biosynthesis and marine natural product chemistry/structure elucidation. This multidisciplinary project, driven by high-tech genomics-based SMEs with dedicated interest in bringing marine-biotechnology-derived products to the market, will also involve the discovery and sustainable production of bioactive molecules from hitherto unexploited extreme environments, such as hydrothermal vents and deep-sea sources, and the expression/scale-up of unique enzymes/proteins of biomedical and biotechnological interest. The molecular-biology-based strategies developed in this project for a sustainable exploitation of aquatic molecular biodiversity will further strengthen the international position and effectiveness of European (SME-based) blue biotechnology industry.


Grant
Agency: Cordis | Branch: FP7 | Program: CP | Phase: ENERGY.2012.10.2.1 | Award Amount: 3.10M | Year: 2012

The HRC POWER project proposes a radically new approach combining novel advanced materials and an innovative hybridization technology to make breakthroughs at materials and concept levels: very high temperature operation up to 1300C with high Carnot efficiency, round-the-clock operation for 95% ACF, high flexibility / dispatchability, low water consumption. Novel materials will consist of advanced absorber metamaterials based on self organized structure and advanced infrared selective emitter refractory crystals. Novel technology / concept will consist of specific micro-combustor operating at very high temperature. This concept is a radically new path for renewable energy hybridization in a solid state device able to provide high quality thermal energy from solar and H2 or Biogas sources to thermal / electrical solid state converters. The main objectives of the HRC POWER project are to develop novel functional materials for advanced building blocks (solar, combustion and hybrid modes), novel high temperature joining technologies (integration of the building blocks) and to realize the proof of concept of this fully new technology, going from the architecture design to the performance assessment.


Grant
Agency: Cordis | Branch: H2020 | Program: RIA | Phase: ICT-23-2014 | Award Amount: 4.78M | Year: 2015

To feed a growing world population with the given amount of available farmland, we must develop new methods of sustainable farming that increase yield while reducing reliance on herbicides and pesticides. Precision agricultural techniques seek to address this challenge by monitoring key indicators of crop health and targeting treatment only to plants that need it. This is a time consuming and expensive activity and while there has been great progress on autonomous farm robots, most systems have been developed to solve only specialized tasks. This lack of flexibility poses a high risk of no return on investment for farmers. The goal of the Flourish project is to bridge the gap between the current and desired capabilities of agricultural robots by developing an adaptable robotic solution for precision farming. By combining the aerial survey capabilities of a small autonomous multi-copter Unmanned Aerial Vehicle (UAV) with a multi-purpose agricultural Unmanned Ground Vehicle, the system will be able to survey a field from the air, perform targeted intervention on the ground, and provide detailed information for decision support, all with minimal user intervention. The system can be adapted to a wide range of crops by choosing different sensors and ground treatment packages. This development requires improvements in technological abilities for safe accurate navigation within farms, coordinated multi-robot mission planning that enables large field survey even with short UAV flight times, multispectral three-dimensional mapping with high temporal and spatial resolution, ground intervention tools and techniques, data analysis tools for crop monitoring and weed detection and user interface design to support agricultural decision making. As these aspects are addressed in Flourish, the project will unlock new prospects for commercial agricultural robotics in the near future.


Grant
Agency: Cordis | Branch: H2020 | Program: MSCA-ITN-ETN | Phase: MSCA-ITN-2015-ETN | Award Amount: 3.46M | Year: 2016

Deictic communication is fundamental to understanding communication in both typical and atypical populations, and forms the key connection between language and objects/locations in the world. It is therefore critical to understanding human-human interaction, and human-system interaction in a range of technology applications from mobile phones to cognitive robotics and to the enhancement of clinical and educational interventions with typical and atypical populations. This ETN will train the next generation of scientists in the full range of multidisciplinary and cross-sectorial methods necessary to make significant progress in understanding deictic communication, with direct synergies between basic research and application. Training is structured around two interdisciplinary research themes Understanding Deictic Communication and Deictic Communication in Application both involving extensive and systematic co-supervision and collaboration across sites with key interplay between academic and nonacademic beneficiaries and partners. In turn we expect that a range of applications will be enhanced with increased usability, with associated societal and economic benefit. The training of the cohort of ESR fellows is based on innovative PhD training approaches, providing not only training in interdisciplinary methods, but also employing peer-assisted methods and the latest in educational innovation. This will produce a cohort of highly skilled researchers who will be highly employable given the potential contribution they will make to future research and innovation in the public and private sectors.


Grant
Agency: Cordis | Branch: H2020 | Program: RIA | Phase: ICT-23-2014 | Award Amount: 5.91M | Year: 2015

With aging infrastructure in developing-and-developed countries, and with the gradual expansion of distributed installations, the costs of inspection and repair tasks have been growing vastly and incessantly. To address this reality, a major paradigm shift is required, in order to procure the highly automated, efficient, and reliable solutions that will not only reduce costs, but will also minimize risks to personnel and asset safety. AEROWORKS envisions a novel aerial robotic team that possesses the capability to autonomously conduct infrastructure inspection and maintenance tasks, while additionally providing intuitive and user-friendly interfaces to human-operators. The AEROWORKS robotic team will consist of multiple heterogeneous collaborative Aerial Robotic Workers, a new class of Unmanned Aerial Vehicles equipped with dexterous manipulators, novel physical interaction and co-manipulation control strategies, perception systems, and planning intelligence. This new generation of worker-robots will be capable of autonomously executing infrastructure inspection and maintenance works. The AEROWORKS multi-robot team will operate in a decentralized fashion, and will be characterized by unprecedented levels of reconfigurability, mission dependability, mapping fidelity, and manipulation dexterity, integrated in robust and reliable systems that are rapidly deployable and ready-to-use as an integral part of infrastructure service operations. As the project aims for direct exploitation in the infrastructure services market, its results will be demonstrated and evaluated in realistic and real infrastructure environments, with a clear focus on increased Technology Readiness Levels. The accomplishment of the envisaged scenarios will boost the European infrastructure sector, contribute to the goal of retaining Europes competitiveness, and particularly impact our service and industrial robotics sector, drastically changing the landscape of how robots are utilized.


Grant
Agency: Cordis | Branch: H2020 | Program: CSA | Phase: INT-01-2015 | Award Amount: 2.42M | Year: 2016

The EU and the USA have highly-productive, immensely-innovative and excellence-driven research and innovation systems. Acknowledging the particular strengths of each landscape, a balanced transatlantic STI partnership of equals bears great potential and contributes to the ultimate goal of tackling societal challenges and boost economic competitiveness. International cooperation between power nodes results in a constant knowledge exchange and more efficient use of STI investment. BILAT USA 4.0s targeted transatlantic activities work towards: i) Strategic priority setting for EU-US cooperation through identifying emerging STI fields with a high benefit and added value from cooperation, thus providing evidence-based input for policy decision-making ii) Stronger interaction between EU and US researchers through thematic events promoting funding opportunities on both sides and thus strengthening the quality and quantity of partnerships between STI actors in EU MS/AC and the USA iii) Establishing optimal framework conditions through proposing concrete solutions for eliminating cooperation obstacles deriving from researchers and innovators feedback, thus, creating an environment that favors joint solutions for global challenges iv) Enhanced coordination and synergies between different policies through analyzing EU, MS/AC and US programmes and detection of duplications, thus, contributing to a greater coherence, joint ownership and resource efficiency v) Ensuring close synergies with calls launched in H2020 and their int. dimension through screening of US-targeted actions in H2020 and liaising with relevant (ERA) projects to guarantee a consistent information exchange Ensuring sustainability, project activities build on former and liaise with existing initiatives. Relevance and exploitation of project actions will be assured by a close coordination with the EC. The project will pursue a targeted communication connecting the diverse range of EU-US STI stakeholders.


Grant
Agency: Cordis | Branch: H2020 | Program: IA | Phase: WASTE-1-2014 | Award Amount: 9.67M | Year: 2015

The RESLAG project proposal is aligned with the challenges outlined in the call WASTE-1-2014: Moving towards a circular economy through industrial symbiosis. In 2010, the European steel industry generated, as waste, about 21.8 Mt of steel slag. The 76 % of the slag was recycled in applications such as aggregates for construction or road materials, but these sectors were unable to absorb the total amount of produced slag. The remaining 24 % was landfilled (2.9 Mt) or self-stored (2.3 Mt). The landfilled slag represents a severe environmental problem. The main aim of RESLAG is to prove that there are industrial sectors able to make an effective use of the 2.9 Mt/y of landfilled slag, if properly supported by the right technologies. In making this prof, the RESLAG project will also prove that there are other very important environmental benefits coming from an active use of the slag in industrial processes, as CO2 saving (up to 970 kt/y from CSP applications, at least 71 kg/ton of produced steel from heat recovery applications), and elimination of negative impacts associated with mining (from the recovery of valuable metals and from the production of ceramic materials). To achieve this ambitious goal four large-scale demonstrations to recycle steel slag are considered: Extraction of non-ferrous high added metals; TES for heat recovery applications; TES to increase dispatchability of the CSP plant electricity; Production of innovative refractory ceramic compounds. Overall, the RESLAG project aims at an innovative organizational steel by-products management model able to reach high levels of resource and energy efficiency, which considers a cascade of upgrading processes and a life cycle perspective. All these demonstrations will be lead by the industries involved in the RESLAG consortium. The RESLAG project is supported by the main organizations representing energy-intensive industries, CSP sector, energy platforms, governments, etc.


Grant
Agency: Cordis | Branch: H2020 | Program: RIA | Phase: EURO-1-2014 | Award Amount: 2.29M | Year: 2015

The Eurozone crisis corroborated the warnings of economists that weak economic policy coordination and loose fiscal oversight would be insufficient to stabilise the monetary union. To prevent a recurrence of the crisis, economists, political actors and the Blueprint of the European Commission are asking for the construction of a deep and genuine economic and monetary union with reinforced governance architecture beyond the recently adopted mechanisms. Many models of a fiscal union have been proposed and discussed. What is missing are not ideas and economic analysis, but the political consensus among member states governments for a specific integration path. Therefore, this political science project analyses the politics of economic and fiscal integration, that is, the conflict structure among member states. To this end, we aim to study the preferences of member states governments for different models of a fiscal union. Our theoretical framework builds on the comparative political economy literature and liberal intergovernmentalism and argues that domestic economic, fiscal and political factors are the main determinants of member states preferences. To empirically study the extent to which governments preferences are shaped by these factors, we propose to conduct 165 semi-structured interviews with decision makers in all member states. The interview data will be analysed with a mixed-method strategy including quantitative analysis as well as case studies. We fully expect that the findings of the project will provide guidance for the successful implementation of a feasible reform of the governance architecture of the EU to the effective stabilisation of the economy. In addition to the political feasibility analysis, we aim to study the legal context of potential integration scenarios. The consortium conducting this research covers all regions of the EU and consists of 8 distinguished political scientists and one legal scholar.


Grant
Agency: Cordis | Branch: H2020 | Program: RIA | Phase: SC5-01-2014 | Award Amount: 15.00M | Year: 2015

CRESCENDO brings together seven Earth System Modelling (ESM) groups with three Integrated Assessment Modelling teams, as well as experts in ESM evaluation, ESM projection and feedback analysis, climate impacts and science communication to address the following goals; (i) improve the process-realism and simulation-quality of European ESMs in order to increase the reliability of future Earth system projections; (ii) develop and apply a community ESM evaluation tool allowing routine ESM performance benchmarking, process-based ESM evaluation and the analysis of Earth system projections. The resulting tool will be installed and made openly-available on the Earth System Grid Federation (ESGF); (iii) further develop the discipline of emergent constraints in order to better constrain the representation of key biogeochemical and aerosol feedbacks in ESMs and thereby reduce overall uncertainty in Earth system projections; (iv) quantify the effective radiative forcing of key biogeochemical and aerosol feedbacks in ESM projections; (v) contribute to the development of a new set of combined socio-economic and climate emission scenarios that more explicitly link future socio-economic development pathways with global radiative forcing; (vi) apply the project ESMs to these new scenario data to generate an ensemble of Earth system projections for the coming century and, in combination with the underlying socio-economic scenarios, use these projections to assess joint risks and co-benefits related to climate change, climate impacts, adaptation and mitigation; (vii) ensure data produced by CRESCENDO is available to the international community through timely archival on the ESGF and work closely with climate impact assessment and regional downscaling teams to ensure maximum uptake and use of these data in such complementary areas of science; (viii) actively disseminate knowledge generated in CRESCENDO to fellow scientists, policymakers and the general public.


Grant
Agency: Cordis | Branch: H2020 | Program: RIA | Phase: FETHPC-1-2014 | Award Amount: 3.12M | Year: 2015

Energy-efficient heterogeneous supercomputing architectures need to be coupled with a radically new software stack capable of exploiting the benefits offered by the heterogeneity at all the different levels (supercomputer, job, node) to meet the scalability and energy efficiency required by Exascale supercomputers. ANTAREX will solve these challenging problems by proposing a disruptive holistic approach spanning all the decision layers composing the supercomputer software stack and exploiting effectively the full system capabilities (including heterogeneity and energy management). The main goal of the ANTAREX project is to provide a breakthrough approach to express application self-adaptivity at design-time and to runtime manage and autotune applications for green and heterogenous High Performance Computing (HPC) systems up to the Exascale level.


Grant
Agency: Cordis | Branch: H2020 | Program: RIA | Phase: INFRADEV-3-2015 | Award Amount: 3.25M | Year: 2015

ECCSEL aims at gaining recognition as a world-class research infrastructure based within leading European Carbon Capture and Storage (CCS) institutions and knowledge centres. It will be due for registration in 2015, forming a legal entity allocating efforts and resources to selected scientific and technological aspects of the CCS chain. ECCSEL will enable high-ranking researchers and scientists from all regions of Europe (and from third countries) to access state-of-the-art research facilities to conduct advanced technological research actions relevant to CCS. The proposed project aims to: implement ECCSEL as a not-for-profit organisation consistent with the European Research Infrastructure Consortium legal framework; initiate operations of ECCSEL as a world-class CCS research infrastructure in accordance with the principles developed during the preparatory phase; develop the research infrastructure to an upgraded common standard in terms of quality of services, management and access provision.

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