Indore, India
Indore, India

Eternal University is the second private university of Himachal Pradesh established by an Act of the state legislature of Himachal. It functions on a "no profit-no loss" basis. It is located in the 450-acre campus popularly known as Baru Sahib- The valley of divine peace.The university offers UGC certified undergraduate and postgraduate courses ranging from Engineering and Medical to Management and Public Health. Wikipedia.

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Singh K.,Eternal University | Sharma P.K.,Kurukshetra University
International Journal of Pharmacy and Pharmaceutical Sciences | Year: 2014

Methods: The benzenesulfonamide based bipyrazole 1a-d & 2a-f have been synthesized by the reaction between 1-[1-aryl/(benzothiazol-2-yl)-5- hydroxy-3-methylpyrazol-4-yl]butane-1,3-diones 5 and 2-hydrazinobenzothiazoles or Aryl hydrazines 3. The structures of these compounds have been characterized from the rigorous analysis of their IR, 1H-NMR, HRMS and elemental analysis. These compounds were screened for their antimicrobial activity.Results: The results revealed that compounds 1a, 2b and 2f exhibited good antibacterial activity and 1b, 1c, 2a, and 2d showed moderate antibacterial activity as compared with standard drug Ofloxacin.Conclusion: This study provides the simple method for the synthesis of new benzenzenesulfonamide based bipyrazoles which plays important role in numerous bioactive compounds.Objectives: To synthesize, characterize and evaluate antimicrobial properties of some benzenesulfonamide based bipyrazole. © 2014, International Journal of Pharmacy and Pharmaceutical Sciences. All rights reserved.

Singh D.,Ranbaxy Laboratories | Kashyap A.,Ranbaxy Laboratories | Pandey R.V.,Institute For Populationsgenetik | Saini K.S.,Eternal University
Drug Discovery Today | Year: 2011

The cytochrome P450 (CYP) enzymes, involved in the metabolism of therapeutic drugs, are the major determinants of drug half-life. From a drug industry perspective, variability in drug response owing to CYP polymorphisms makes CYP profiling a commercially interesting option for diagnosis, prognosis and predicting response to drug treatment. Recent studies highlighting microRNA-mediated regulation of CYP genes represents a major advance in our understanding of variations in individual drug responses. Herein we review new perspectives on the molecular mechanisms of CYP regulation and genotyping technologies. Together, these developments present novel therapeutic opportunities and help to explain the integrated response of cells to xenobiotic drug metabolism. © 2011 Elsevier Ltd.

Kumar R.,Eternal University | Khatkar B.S.,Guru Jambheshwar University of Science and Technology
Journal of Food Science and Technology | Year: 2017

Large (A) and small (B) granules of wheat starch were separated and their morphological, thermal, structural and pasting properties were investigated. The pasting properties of starches from two wheat varieties showed significant differences. For wheat variety C-306, the unfractionated starch showed higher peak, trough, breakdown, final, and setback viscosities than the starch isolated from wheat variety WH-147. On the contrary, unfractionated starch of variety WH-147 has higher pasting temperature than the starch of the variety C-306. Differential scanning calorimetry results showed that unfractionated starch exhibited the higher gelatinization enthalpy, peak and conclusion temperatures than the isolated A- and B-starch granules from both the varieties. Scanning electron microscopy results revealed that large A-granules appeared to be smooth and displayed disk or lenticular shape having diameter 13–35 μm, while B-granules showed a spherical shape with diameter of 2–6 μm. The variations in structures and content would result in starch granules with different chemical and physical properties. © 2017 Association of Food Scientists & Technologists (India)

Verma K.C.,Eternal University | Kotnala R.K.,National Physical Laboratory India
Solid State Communications | Year: 2011

The structural, microstructural, polarization, magnetization, dielectric constant, and relaxor characteristics of 0.7BiFeO30.3BaTiO 3 (BFBT) nanocrystals have been studied. BFBT nanocrystals were prepared by a chemical route using polyvinyl alcohol as surfactant. The phase structure is confirmed by X-ray diffraction and average particle size by transmission and scanning electron microscopy. The magnetoelectric coupling is studied by polarization hysteresis loops under the influence of applied magnetic field and the phase transition anomaly. The diffuse phase transition is studied by modified CurieWeiss law and relaxor characteristics by VogelFulcher relation. © 2011 Elsevier B.V. All rights reserved.

Verma K.C.,Eternal University | Gupta V.,University of Delhi | Kaur J.,Eternal University | Kotnala R.K.,National Physical Laboratory India
Journal of Alloys and Compounds | Year: 2013

Structural, microstructural, Raman spectroscopy, photoluminescence, saturation magnetization and magnetoelectric (ME) measurement of BaTiO 3 (BFT0) and BaFe0.01Ti0.99O3 (BFT1) nanostructures have been studied. BFT0 and BFT1 were prepared by a hydrothermal method of processing temperature 180 °C/48 h. The X-ray diffraction pattern shows the coexistence of cubic/tetragonal and hexagonal phases for BFT0 and cubic/tetragonal for BFT1. The Raman spectra confirm the coexistence of tetragonal and hexagonal phases in BFT0 and cubic in BFT1. Transmission electron microscopy images show nanorods of hexagonal shaped faces for BFT0 and cubic shaped nanowires for BFT1. The resulting mechanism of the formation of these nanostructures is discussed. The experimental and theoretical results by photoluminescence are related to the degree of disorder existing in both BFT0 and BFT1 and suggest the presence of localized states existing inside of the band gap which are directly affected for degree of order-disorder. A strong ferromagnetism in BFT1 and diamagnetism in BFT0 is observed by magnetic hysteresis. As BFT1 is ferromagnetic, the value of linear coefficient, α called Magnetoelectric (ME) coefficient is calculated as ∼16 mV/Oecm at a fixed frequency of 850 Hz. This ME coefficient α corresponds to induction of polarization by a magnetic field or of magnetization by an electric field. The observed optimum dc bias field at which the maximum ME coupling occurs is ∼750 Oe. © 2013 Elsevier B.V. All rights reserved.

Singh K.,Eternal University
Current Organic Synthesis | Year: 2016

Indan-1,3-dione is a versatile building block in organic synthesis. This review focuses on the applications of indan-1,3-dione to generate a large variety of indeno fused heterocycles such as Indeno-pyridine, diindenopyridine, indenoquinoline and indeno-cyclopenta-pyridine, indenofuran, indeno-indoloquinones, indenopyran, indenopyrimidine, indenotriazin-5-one, Indenoimidazole, indenopyrazoles and many others. Many of these molecules exhibit promising biological activities. © 2016 Bentham Science Publishers.

Kaur J.,Eternal University | Shah J.,National Physical Laboratory India | Kotnala R.K.,National Physical Laboratory India | Verma K.C.,Eternal University
Ceramics International | Year: 2012

The pure and transition metal (Co and Fe = 3 and 5 mol%) doped SnO 2 nanoparticles have been synthesized by a chemical route using polyvinyl alcohol as surfactant. These nanoparticles were characterized by X-ray diffraction (XRD), transmission electron microscopy (TEM), Raman, Fourier transform infrared (FTIR) spectroscopy, photoluminescence (PL) and magnetic measurements. The XRD patterns show that all the samples have tetragonal rutile structure without any extra phase and the value of average particle size using FWHM lies within 12-29 nm is also confirmed by TEM. FTIR spectrum has been used to confirm the formation of SnO bond. Raman spectroscopy shows the intensity loss of classical cassiterite SnO 2 vibration lines which is an indication of significant structural modifications. From PL, an intense blue luminescence centered at a wavelength ∼530 nm is observed in the prepared SnO 2 nanoparticles, which is different from the yellow-red light emission observed in SnO 2 nanostructures prepared by other methods. The strong blue luminescence from the as-grown SnO 2 nanoparticles is attributed to oxygen-related defects that have been introduced during the growth process. These Co and Fe-doped SnO 2 nanoparticles exhibit room temperature ferromagnetism and the value of their magnetic moment and phase transition temperature are sensitive to their size and stoichiometric ratio. © 2012 Elsevier Ltd and Techna Group S.r.l. All rights reserved.

Verma K.C.,Eternal University | Kumar M.,Eternal University | Kotnala R.K.,National Physical Laboratory India
Metallurgical and Materials Transactions A: Physical Metallurgy and Materials Science | Year: 2014

The Pb0.7Sr0.3[(Fe2/3Ce 1/3)0.012Ti0.988]O3 (PSFCT) and Pb0.7Sr0.3[(Fe2/3La1/3) 0.012Ti0.988]O3 nanoparticles were prepared by chemical synthesis route using polyvinyl alcohol as surfactant. X-ray diffraction pattern has been used to analyze the phase structure and average particles size. The phase structure is also confirmed by Raman spectra. The chemical states of Pb2+, Sr2+, Fe3+; Ti 4+, Ce3+, La3+, and oxygen ions have been analyzed by X-ray photoelectron spectroscopy. The magnetoelectric coupling effect is confirmed by magnetic phase transition near ferroelectric phase-transition temperature. The magnetoelectric effect is also confirmed by measuring the value of magnetoelectric coefficient (α E) as the function of applied dc magnetizing field under the influence of ac magnetic field of 10 Oe and frequencies of 847 and 997 Hz. The higher value of α E is observed in PSFCT sample. © 2013 The Minerals, Metals & Materials Society and ASM International.

Kaur J.,Eternal University | Kotnala R.K.,National Physical Laboratory India | Verma K.C.,Eternal University
Materials Letters | Year: 2011

Multiferroic Ba(FexTi1 - x)O3 (BFT) nanorods were prepared by a chemical route using polyvinyl alcohol as surfactant. The presence of PVA in excess is responsible to convert cubic or spherical shaped nanoparticles into rodlike structure. Tetragonal phase and nano dimensions in the form of rods of BFT specimens are identified. These BFT nanorods show improvement in the coexistence of ferroelectricity and ferromagnetism of multiferroic properties than their nanoparticles. The effect of low dimensions of BFT rods to control dielectric constant with low loss up to higher frequency region has been observed. With 1% of Fe-doping BFT shows higher value of spontaneous polarization, saturation magnetization and dielectric constant than with other dopants. © 2011 Elsevier B.V. All Rights Reserved.

Rawat N.,Kansas State University | Neelam K.,Punjab Agricultural University | Tiwari V.K.,Kansas State University | Dhaliwal H.S.,Eternal University
Plant Breeding | Year: 2013

More than 60% of the world population suffers from iron deficiency, and over 30% of the global population has zinc deficiency. Micronutrient deficiency leads to compromised health and economic losses and is prevalent in populations depending on non-diversified plant-based diets. Increasing mineral content of staple food crops through biofortification is the most feasible strategy of combating micronutrient malnutrition. Additionally, it will also enhance the agronomic efficiency of crops on mineral poor soils. A multipronged strategy towards enhancing mineral content of cereal grains should involve increased uptake of minerals from soil, enhanced partitioning towards grain and improved sequestration in the edible tissues of grains. At the same time, it is essential to improve mineral absorption in vivo from cereal-based diets. Both conventional and modern breeding approaches and genetic engineering are being employed for biofortification of crop plants. With increased understanding of mineral uptake and transport mechanisms in plants, it is becoming ever more possible to engineer biofortified crop plants with the ultimate goal of overcoming hidden hunger. © 2013 Blackwell Verlag GmbH.

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