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Carlsbad, CA, United States

Glickman J.F.,Rockefeller University | Lundback T.,Karolinska Institutet | Napper A.D.,Nemours Center for Childhood Cancer Research | Niles W.D.,Etaluma Inc. | And 6 more authors.
Assay and Drug Development Technologies | Year: 2014

Has the impact of irreproducibility on the discovery and development of drugs, as with global warming, metaphorically speaking, crept up on us as we slept? Or is the problem more an issue of heightened awareness? We currently find ourselves in a time when the impact of irreproducibility can easily be amplified by the combinatorial effect of our increasing reliance on advanced technologies and unrealistic expectations of how scientific truths unfold. How and why we got here is a topic that has been written on extensively1-3 and is probably as complex as any other problem, given the dependence of science today on so many external forces. Through a series of questions, we asked members of our editorial board their opinions on scientific irreproducibility. They chose to answer the same questions from different levels, indicating the depth of the problem and perhaps where they each believe change for the better needs to begin. My thanks to the participants. - Jim Inglese, PhD Editor-in-Chief Assay and Drug Development Technologies © 2014, Mary Ann Liebert, Inc. 2014. Source

Kahle J.,Etaluma Inc. | Levin R.,Etaluma Inc. | Niles W.,Etaluma Inc. | Rasnow B.,Etaluma Inc. | And 2 more authors.
JALA - Journal of the Association for Laboratory Automation | Year: 2010

Advances in laboratory instrumentation often increase the complexity, size, and cost of the device. The resulting complexity and cost, however, then reduce the accessibility of the device to many laboratories. We examine ways to use technological advances to simplify the design of laboratory devices, retaining the essential components that yield sufficient capabilities for routine uses. Inverted fluorescence microscopes, for example, have evolved into large complex instruments with exquisite imaging capability and are loaded with features requiring trained users and costing tens of thousands of dollars. This has limited their potential ubiquity within laboratories. For simple fluorescence microscopy applications, a much smaller and less expensive device with far fewer features would minimize the issues encountered with traditional inverted fluorescence microscopes. Advances in inexpensive complimentary metal-oxide semiconductor sensor technology have allowed its consideration as an alternative to the expensive charge-coupled device cameras currently used. Based on these advances, we have developed a compact, single-color, single-magnification device with a retail price an order of magnitude lower than current benchtop fluorescence microscopes. This device makes routine fluorescence microscopy applications immediately accessible to individual researchers and less well-funded laboratories. Tasks such as determining the presence of cells, their health, confluence, and fluorescent labeling or protein expression are compatible with such a simplified version. The low cost, small size, and ease of use of this device allows fluorescence microscopy to become more accessible for point-of-care medicine and at many points in the research process. © 2010 Society for Laboratory Automation and Screening. Source

Kahle J.,Etaluma Inc. | Levin R.,Etaluma Inc. | Niles W.,Etaluma Inc. | Rasnow B.,Etaluma Inc. | And 2 more authors.
American Laboratory | Year: 2011

Some of the applications of a compact and easy-to-use inverted flourescence microscope are discussed. The LumaScope™ fluorescence microscope was one of these devices that utilized improved and miniaturized universal serial bus (USB) communications, light-emitting diodes (LEDs), and complementary metal-oxide semiconductor (CMOS) for different applications. The microscope was designed to be sturdy and easy to use, and to withstand frequent use by multiple students and laboratory technicians without requiring special training. It was also intended to be used as an inverted microscope to allow the observation of many more types of cellular preparations due to its open deck design and ability to accommodate the various focal lengths required for Petri dishes, flasks, microplates, and chambered slides. The small size allowed it to fit easily within incubators, hoods, and Faraday cages, under stereoscopes, on desks, and at single laboratory bench stations. Source

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