Etablissement Francais du Sang Bretagne

Rennes, France

Etablissement Francais du Sang Bretagne

Rennes, France
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Delepine-Farvacques S.,University of Rennes 2 – Upper Brittany | Terrade F.,University of Rennes 2 – Upper Brittany | Danic B.,Etablissement francais du sang Bretagne | Lebaudy J.-P.,Etablissement francais du sang Bretagne
Transfusion Clinique et Biologique | Year: 2017

The purpose of this study, based on the Theory of planned behavior, is to identify and ultimately better understand what determines the fidelity and the regularity of donors committed in plasmapheresis donation. This qualitative study is a primary stage to establish a classification of donors in a French socio-cultural context. For this reason, we have carried out a survey among 16 regular plasmapheresis donors, by way of semi-structured individual interviews at the Établissement français du sang - Brittany. The level of commitment of these regular donors is considered as a level of appropriation. If subjective norms have initially influenced their decision to donate blood, no specific motivation has been highlighted for them to donate plasma except a generally favourable attitude towards the voluntary donation process. The perception of control over their environment is a variable which played a decisive role in the donor's intention to give, with little cost associated to plasmapheresis donation and recourse to internal causal explanations. A better comprehension of the plasmapheresis donors' determinants should lead us to a more efficient awareness of new potential donors, thereby enhancing recruitment and retention. Due to the increasing need for plasma-derived products, this study's ultimate issue is closely correlated both with ethical and socio-economic aspects. Following which, after analysing the results, a certain number of recommendations will be made. © 2017 Elsevier Masson SAS.

Beurel A.,University of Rennes 2 – Upper Brittany | Terrade F.,University of Rennes 2 – Upper Brittany | Lebaudy J.-P.,Etablissement Francais du Sang Bretagne | Danic B.,Etablissement Francais du Sang Bretagne
Transfusion Clinique et Biologique | Year: 2017

The major contribution of Human Sciences in the understanding of the whole blood donation behavior has been through the study of individuals' motivations and deterrents to donate. However, if whole blood donation has been very widely studied in the last sixty years, we still know very little about plasma donation in voluntary non-remunerated environments. Yet, the need for plasma-derived products has been strongly increasing for some years, and blood collection agencies have to adapt if they want to meet this demand. This article aims to review the main motivations and deterrents to whole blood donation, and to compare them with those that we already know concerning plasma donation. Current evidence shows similarities between both behaviors, but also differences that indicate a need for further research regarding plasma donation. © 2017.

Fichou Y.,Etablissement francais du sang Bretagne | Fichou Y.,French Institute of Health and Medical Research | Ferec C.,Etablissement francais du sang Bretagne | Ferec C.,French Institute of Health and Medical Research | And 2 more authors.
Transfusion Clinique et Biologique | Year: 2017

Molecular analysis, or genotyping, of genes involved in the expression of blood group antigens has been a standard strategy used in immunohaematology laboratories routinely. For the past ten years, next-generation sequencing (NGS), or second-generation sequencing, has become the reference method in genetics. Extensive study of distinct targets, large genomic regions, and even whole genome is henceforth possible by this approach at minimal cost. Blood group genotyping has thus taken advantage of this technological advent. A few preliminary studies have open the way to NGS in this field by studying one or several genes, in a wide range of samples (donors and patients) by using several different platforms. These works have helped in the identification of both the benefits and limitations of the technology. Other recently published studies have benefited from these preliminary data to improve the methodology, specificity and accuracy of output data. In parallel novel strategies, i.e. third-generation sequencing, which can sequence long DNA regions at the single-molecule level, have emerged and shown promise for the potential resolution of complex rearrangements involving genes of the Rh and MNS blood group systems respectively. As technological and methodological hurdles have been overcome, these approaches may be used in a clinical situation in a near future. © 2017 Elsevier Masson SAS.

Gac F.,Rennes University Hospital Center | Thibert J.B.,Etablissement Francais du Sang Bretagne | Le Berre C.,Etablissement Francais du Sang Bretagne | Le Priol J.,Rennes University Hospital Center | And 6 more authors.
International Journal of Laboratory Hematology | Year: 2013

Introduction: An umbilical cord blood bank was recently opened in our institution as an alternative source of hematopoietic stem cells. Before inclusion of a cord blood in an international register, a WBC with differential is requested, among others. Currently, the reference method is the microscopic manual count, and we sought to evaluate the routine flow cytometric method (CytoDiff™) as an alternative. Methods: A total of 161 cord bloods were analyzed between November 2010 and February 2011. WBC differentials were determined for each sample, by (i) the cell counter (DxH800), (ii) a manual review, and (iii) the flow cytometry using the CytoDiff™ antibody cocktail. Results: Correlation coefficients between flow cytometry and microscopic count were satisfying for neutrophils, lymphocytes, and immature granulocytes and acceptable for eosinophils. On the other hand, we found lower correlation coefficient for basophils and monocytes. Monocytes' correlation was better when comparing flow cytometry with cell counter. Conclusion: The flow cytometric approach is suitable to realize cord blood WBC differential and allows for the identification of additional cell subsets. © 2012 Blackwell Publishing Ltd.

PubMed | Hoffmann-La Roche, Etablissement francais du sang Bretagne and Etablissement francais du sang
Type: Journal Article | Journal: Transfusion clinique et biologique : journal de la Societe francaise de transfusion sanguine | Year: 2015

To achieve blood supply, EFS organizes mobile blood collection sessions (80% of whole blood supply), close to target blood donors. Mobile sessions planning is usually developed in partnership with organizations of voluntary blood donors, based on the experience of previous sessions. However, population moving to urban areas and lifestyles changing force to focus on objective demographic analysis to determine a prospective vision of potentialities to ensure blood supply.For blood supply management, EFS recently implemented innovative methods of mapping, through Geographic Information System software (GIS) that allow a spatial representation of different indicators. Geomatics engineering gathers and processes spatially referenced information about blood collections and blood donors, combining data from EFS and data from IGN or INSEE.The authors present some examples of geomatics applied to blood supply and a feedback on the implementation of these tools in a French region. These innovative tools enhance expertise and increase the mastery of analysis for blood supply strategies.

PubMed | Sanguine, Etablissement francais du sang Bretagne and Transfusion interregionale
Type: Journal Article | Journal: Transfusion clinique et biologique : journal de la Societe francaise de transfusion sanguine | Year: 2016

Ethics is on the cross road of off values that are present along the ways of transfusion medicine. This is an important tool to afford opinions as well as debates that always emerge when discussing transfusion medicine. The wording is particularly important; this was one among several others that characterized the soul of Jean-Jacques Lefrre when he opened the doors of the ethical issues of transfusion medicine.

Lefrere J.-J.,Sanguine | Lefrere J.-J.,Laboratoire dHematologie | Danic B.,Etablissement Francais du Sang Bretagne
Hematologie | Year: 2011

This papers describes several illustrations of historical transfusions and point out common characteristics and differences over three centuries, through the major elements used by illustrators. During this pioneering epoch, the transfusion imagery, through the representation of the three actors of transfusion (recipient, donor, doctor) varied considerably over time, as did representation of the procedures of transfusion.

Danic B.,Etablissement francais du sang Bretagne | Lefort C.,Etablissement francais du sang Pays de Loire
Transfusion Clinique et Biologique | Year: 2010

The notification of serious adverse events occurring resulting from the collection of blood or blood components is a statutory requirement. The value of this set of surveillance procedures is the use of data collected. This article focuses on the organization of the French notification system, and the management of the main side effects known and reported. © 2010 Elsevier Masson SAS.

PubMed | University of Lausanne, Etablissement francais du sang Pays de la Loire and Etablissement francais du sang Bretagne
Type: Journal Article | Journal: Presse medicale (Paris, France : 1983) | Year: 2015

Over the years, transfusion medicine has been faced to many different problems, notably those related to transmission of pathogens. Major progresses have been accomplished in terms of security. However, nowadays, the discipline is confronted to the day-to-day variability and availability of blood products. More and more donors are excluded from blood donation due to various reasons, and the donor selection criteria have increased over the years, influencing the number of donors able to give blood. This paradox represents one of the constraints that transfusion medicine should resolve in the future. This paper presents some aspects either common or different between France and Switzerland.

Lefrere J.-J.,University of Paris Descartes | Danic B.,Etablissement francais du sang Bretagne
Hematologie | Year: 2013

A cultural field, where the representation of blood transfusion and donation of blood has never been studied, is the comic strip, which is a relatively recent art, having emerged in the nineteenth century, before becoming a mass medium during the twentieth century. We have sought, by calling on collectors and using the resources of Internet, comic books devoted, wholly or in part, to the themes of transfusion and blood donation. We present some of them here, indicating the title, country of origin, year of publication and names of authors. The theme of the superhero using transfusion to transmit his virtues or his powers is repeated in the first North-American comic strips. More recently, comic strips have been conceived from the outset with a promotional aim: they perpetuate positive images and are directed towards a young readership, wielding humor to reduce the fear of venipuncture. Few comic strips denounce the abuse of the commercialization of products derived from the human body. The image of Transfusion and blood donation given by the comic strips is not to be underestimated, because their readership is primarily children, some of whom will be, in adulthood, potential blood donors. Furthermore, if some readers are transfused during their lives, the impact of a memory more or less conscious of these childhood readings will resurface, both in terms of hopes and fears. Copyright © 2007 John Libbey Eurotext.

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