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Danic B.,Etablissement Francais du Sang Bretagne | Lefrere J.-J.,Sanguine | Lefrere J.-J.,Laboratoire dHematologie
Hematologie | Year: 2011

The purpose of this paper is to study, through films from different countries and from different epochs which show transfusion or blood donation, the impression which has been given to the public in the course of the 20 th century and its sociological impact. With these two components, the act of donation and the act of transfusion, the relatively short history of blood transfusion is distinguished by upheavals in both the medical and the socio-political fields of the past century.

Lefrere J.-J.,University of Paris Descartes | Danic B.,Etablissement Francais du Sang Bretagne
Hematologie | Year: 2013

A cultural field, where the representation of blood transfusion and donation of blood has never been studied, is the comic strip, which is a relatively recent art, having emerged in the nineteenth century, before becoming a mass medium during the twentieth century. We have sought, by calling on collectors and using the resources of Internet, comic books devoted, wholly or in part, to the themes of transfusion and blood donation. We present some of them here, indicating the title, country of origin, year of publication and names of authors. The theme of the superhero using transfusion to transmit his virtues or his powers is repeated in the first North-American comic strips. More recently, comic strips have been conceived from the outset with a promotional aim: they perpetuate positive images and are directed towards a young readership, wielding humor to reduce the fear of venipuncture. Few comic strips denounce the abuse of the commercialization of products derived from the human body. The image of Transfusion and blood donation given by the comic strips is not to be underestimated, because their readership is primarily children, some of whom will be, in adulthood, potential blood donors. Furthermore, if some readers are transfused during their lives, the impact of a memory more or less conscious of these childhood readings will resurface, both in terms of hopes and fears. Copyright © 2007 John Libbey Eurotext.

Lefrere J.-J.,Sanguine | Lefrere J.-J.,Laboratoire dHematologie | Danic B.,Etablissement Francais du Sang Bretagne
Hematologie | Year: 2011

This papers describes several illustrations of historical transfusions and point out common characteristics and differences over three centuries, through the major elements used by illustrators. During this pioneering epoch, the transfusion imagery, through the representation of the three actors of transfusion (recipient, donor, doctor) varied considerably over time, as did representation of the procedures of transfusion.

Danic B.,Etablissement Francais du Sang Bretagne | Lefort C.,Etablissement Francais du Sang Pays de Loire
Transfusion Clinique et Biologique | Year: 2010

The notification of serious adverse events occurring resulting from the collection of blood or blood components is a statutory requirement. The value of this set of surveillance procedures is the use of data collected. This article focuses on the organization of the French notification system, and the management of the main side effects known and reported. © 2010 Elsevier Masson SAS.

Saliou P.,French Institute of Health and Medical Research | Saliou P.,University of Western Brittany | Saliou P.,Laboratoire Dhygiene Et Of Sante Publique | Gac G.L.,French Institute of Health and Medical Research | And 24 more authors.
PLoS ONE | Year: 2013

Despite type I haemochromatosis (HC) is mainly associated with the HFE C282Y/C282Y genotype, a second genotype - C282Y/H63D-has mostly been described in other patients. Its association with HC, apart from any associated co-morbid factors, remains unclear and complex to interpret for physicians. This study assesses the weight of this genotype and the role of co-morbid factors in the occurrence of iron overload. This prospective study included the C282Y/C282Y (n =172) and C282Y/H63D (n=58) patients enrolled in a phlebotomy program between 2004 and 2007 in a blood centre of western Brittany (Brest, France), where HC is frequent. We compared prevalence of these two genotypes, as well as patients' profile regarding degree of iron overload and prevalence of co-morbid factors. First, we confirmed the obvious deficit of C282Y/H63D compound heterozygotes among patients cared by phlebotomies. This genotype was 3.0 times less frequent than the C282Y/C282Y genotype among those patients (18.9% vs. 56.0%) whereas it was 4.9 times more frequent in the general population (4.3% vs. 0.9%; p<0.0001). Despite a similar level of hyperferritinaemia, the C282Y/H63D patients who came to medical attention had a milder plasma iron overload, reflected by a lower transferrin saturation median (52.0% vs. 84.0%; p<0.0001). They also exhibited more frequently co-morbid factors, as heavy drinking (26.0% vs. 13.9%; p=0.0454), overweight (66.7% vs. 39.4%; p=0.0005) or both (21.3% vs. 2.6%; p<0.0001). Ultimately, they required a lower amount of iron removed to reach depletion (2.1 vs. 3.4 g; p<0.0001), clearly reflecting their lower tissue iron. This study confirms that H63D is a discrete genetic susceptibility factor whose expression is most visible in association with other co-factors. It highlights the importance of searching for co-morbidities in these diagnostic situations and of providing lifestyle and dietary advice. © 2013 Saliou et al.

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