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Gac F.,Rennes University Hospital Center | Thibert J.B.,Etablissement Francais du Sang Bretagne | Le Berre C.,Etablissement Francais du Sang Bretagne | Le Priol J.,Rennes University Hospital Center | And 6 more authors.
International Journal of Laboratory Hematology | Year: 2013

Introduction: An umbilical cord blood bank was recently opened in our institution as an alternative source of hematopoietic stem cells. Before inclusion of a cord blood in an international register, a WBC with differential is requested, among others. Currently, the reference method is the microscopic manual count, and we sought to evaluate the routine flow cytometric method (CytoDiff™) as an alternative. Methods: A total of 161 cord bloods were analyzed between November 2010 and February 2011. WBC differentials were determined for each sample, by (i) the cell counter (DxH800), (ii) a manual review, and (iii) the flow cytometry using the CytoDiff™ antibody cocktail. Results: Correlation coefficients between flow cytometry and microscopic count were satisfying for neutrophils, lymphocytes, and immature granulocytes and acceptable for eosinophils. On the other hand, we found lower correlation coefficient for basophils and monocytes. Monocytes' correlation was better when comparing flow cytometry with cell counter. Conclusion: The flow cytometric approach is suitable to realize cord blood WBC differential and allows for the identification of additional cell subsets. © 2012 Blackwell Publishing Ltd.


PubMed | Etablissement francais du sang Bretagne, Roche Holding AG and Etablissement francais du sang
Type: Journal Article | Journal: Transfusion clinique et biologique : journal de la Societe francaise de transfusion sanguine | Year: 2015

To achieve blood supply, EFS organizes mobile blood collection sessions (80% of whole blood supply), close to target blood donors. Mobile sessions planning is usually developed in partnership with organizations of voluntary blood donors, based on the experience of previous sessions. However, population moving to urban areas and lifestyles changing force to focus on objective demographic analysis to determine a prospective vision of potentialities to ensure blood supply.For blood supply management, EFS recently implemented innovative methods of mapping, through Geographic Information System software (GIS) that allow a spatial representation of different indicators. Geomatics engineering gathers and processes spatially referenced information about blood collections and blood donors, combining data from EFS and data from IGN or INSEE.The authors present some examples of geomatics applied to blood supply and a feedback on the implementation of these tools in a French region. These innovative tools enhance expertise and increase the mastery of analysis for blood supply strategies.


PubMed | Sanguine, Etablissement francais du sang Bretagne and Transfusion interregionale
Type: Journal Article | Journal: Transfusion clinique et biologique : journal de la Societe francaise de transfusion sanguine | Year: 2016

Ethics is on the cross road of off values that are present along the ways of transfusion medicine. This is an important tool to afford opinions as well as debates that always emerge when discussing transfusion medicine. The wording is particularly important; this was one among several others that characterized the soul of Jean-Jacques Lefrre when he opened the doors of the ethical issues of transfusion medicine.


Danic B.,Etablissement Francais du Sang Bretagne | Lefrere J.-J.,Sanguine | Lefrere J.-J.,Laboratoire dHematologie
Hematologie | Year: 2011

The purpose of this paper is to study, through films from different countries and from different epochs which show transfusion or blood donation, the impression which has been given to the public in the course of the 20 th century and its sociological impact. With these two components, the act of donation and the act of transfusion, the relatively short history of blood transfusion is distinguished by upheavals in both the medical and the socio-political fields of the past century.


Lefrere J.-J.,Sanguine | Lefrere J.-J.,Laboratoire dHematologie | Danic B.,Etablissement Francais du Sang Bretagne
Hematologie | Year: 2011

This papers describes several illustrations of historical transfusions and point out common characteristics and differences over three centuries, through the major elements used by illustrators. During this pioneering epoch, the transfusion imagery, through the representation of the three actors of transfusion (recipient, donor, doctor) varied considerably over time, as did representation of the procedures of transfusion.


Danic B.,Etablissement francais du sang Bretagne | Lefort C.,Etablissement francais du sang Pays de Loire
Transfusion Clinique et Biologique | Year: 2010

The notification of serious adverse events occurring resulting from the collection of blood or blood components is a statutory requirement. The value of this set of surveillance procedures is the use of data collected. This article focuses on the organization of the French notification system, and the management of the main side effects known and reported. © 2010 Elsevier Masson SAS.


Gouezec H.,University of Rennes 2 – Upper Brittany | Ferre N.,University of Rennes 2 – Upper Brittany | Herve F.,Etablissement francais du sang Bretagne | Lapart C.,Etablissement francais du sang Bretagne | And 4 more authors.
Transfusion Clinique et Biologique | Year: 2015

We assessed the benefit of predeposite autologous blood donation (PAD) before bone marrow (BM) donation on transfusion requirements, haemoglobin concentrations (Hb) and the occurrence of adverse events (AE). We collected data retrospectively from 50 donors of BM with PAD from 2010 to 2014. An autologous transfusion (AT) was given to 50% of the donors (group 1). In the group 2, the products from PAD were not used. The total volume median of marrow harvested was 17.7 mL/k (range 12.3-21.4) in the group 1 and 13.3 mL/k (8.6-22.6) in the group 2. The female ratio was higher in the group 1 (60%) than in the group 2 (16%). Bone marrow harvest led to a decline in Hb (from PAD to first day after BM donation) by 2.9 g/dL (1.5-5.5) in the group 1 and by 3.5 g/dL (1.2-5) in the group 2. The post-harvest Hb (D+1) median was identical in the two groups: 10.9 g/dL (7.6-13.5) in the group 1 versus 11.5 g/dL (9.3-13.4) in the group 2. Six AE were reported in each group. In the group with AE, the median weight was lower: 58 k (50-71) versus 75 k (52-110); and the median total volume of marrow harvested was higher: 20.1 mL/k (9.9-21.4) versus 14.3 mL/k (8.6-22.6). All post-harvest Hb were ≥ 7.6 g/dL. This study shows the high loss of Hb after BM donation but not enough to prove a blood transfusion in BM donors with median age of 36 years (16-62) and without comorbidity. The occurrence of AE (25% of BM donors) justifies a careful surveillance after the BM donation. The PAD should not be routinely offered to bone marrow donors. © 2015 Elsevier Masson SAS.


PubMed | University of Lausanne, Etablissement francais du sang Pays de la Loire and Etablissement francais du sang Bretagne
Type: Journal Article | Journal: Presse medicale (Paris, France : 1983) | Year: 2015

Over the years, transfusion medicine has been faced to many different problems, notably those related to transmission of pathogens. Major progresses have been accomplished in terms of security. However, nowadays, the discipline is confronted to the day-to-day variability and availability of blood products. More and more donors are excluded from blood donation due to various reasons, and the donor selection criteria have increased over the years, influencing the number of donors able to give blood. This paradox represents one of the constraints that transfusion medicine should resolve in the future. This paper presents some aspects either common or different between France and Switzerland.


Lefrere J.-J.,University of Paris Descartes | Danic B.,Etablissement francais du sang Bretagne
Hematologie | Year: 2013

A cultural field, where the representation of blood transfusion and donation of blood has never been studied, is the comic strip, which is a relatively recent art, having emerged in the nineteenth century, before becoming a mass medium during the twentieth century. We have sought, by calling on collectors and using the resources of Internet, comic books devoted, wholly or in part, to the themes of transfusion and blood donation. We present some of them here, indicating the title, country of origin, year of publication and names of authors. The theme of the superhero using transfusion to transmit his virtues or his powers is repeated in the first North-American comic strips. More recently, comic strips have been conceived from the outset with a promotional aim: they perpetuate positive images and are directed towards a young readership, wielding humor to reduce the fear of venipuncture. Few comic strips denounce the abuse of the commercialization of products derived from the human body. The image of Transfusion and blood donation given by the comic strips is not to be underestimated, because their readership is primarily children, some of whom will be, in adulthood, potential blood donors. Furthermore, if some readers are transfused during their lives, the impact of a memory more or less conscious of these childhood readings will resurface, both in terms of hopes and fears. Copyright © 2007 John Libbey Eurotext.


PubMed | Etablissement Francais du Sang Bretagne
Type: Journal Article | Journal: Transfusion clinique et biologique : journal de la Societe francaise de transfusion sanguine | Year: 2010

The notification of serious adverse events occurring resulting from the collection of blood or blood components is a statutory requirement. The value of this set of surveillance procedures is the use of data collected. This article focuses on the organization of the French notification system, and the management of the main side effects known and reported.

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