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Boston, MA, United States

Morris W.,Essess, Inc
Studies in Computational Intelligence | Year: 2016

A study of the development of a car-mounted system for mobile hyperspectral mapping that integrates thermal cameras, near-infrared cameras, and 3D LiDAR data. The data produced by this system is used for city scale thermal energy analysis, which allows property owners to determine the most cost effective energy efficiency improvements for their buildings. The data collection system uses ROS to record several terabytes of data during each night of operation. This case study will consider our internal best practices and lessons learned during development of a robust system running ROS for thousands of miles. © Springer International Publishing Switzerland 2016. Source


Xiao N.,University of Massachusetts Medical School | Laha S.,University of Massachusetts Medical School | Das S.P.,University of Massachusetts Medical School | Morlock K.,University of Massachusetts Medical School | And 2 more authors.
Blood | Year: 2015

Thrombopoietin (Thpo) signaling through the c-Mpl receptor promotes either quiescence or proliferation of hematopoietic stem cells (HSCs) in a concentration-dependent manner; however, in vivo Thpo serum levels are responsive to platelet mass rather than HSC demands, suggesting additional regulation exists. Ott1 (Rbm15), a spliceosomal component originally identified as a fusion partner in t(1;22)-associated acute megakaryocytic leukemia, is also essential for maintaining HSC quiescence under stress. Ott1 controls the alternative splicing of a dominant negative isoform, Mpl-TR, capable of inhibiting HSC engraftment and attenuating Thpo signaling. Ott1, which associates with Hdac3 and the histone methyltransferase, Setd1b, binds to both c-Mpl RNA and chromatin and regulates H4 acetylation and H3K4me3 marks. Histone deacetylase or histone methyltransferase inhibition also increases Mpl-TR levels, suggesting that Ott1 uses an underlying epigenetic mechanism to control alternative splicing of c-Mpl. Manipulation of Ott1-dependent alternative splicing may therefore provide a novel pharmacologic avenue for regulating HSC quiescence and proliferation in response to Thpo. © 2015 by The American Society of Hematology. Source


Konicek A.R.,U.S. National Institute of Standards and Technology | Lefman J.,U.S. National Institute of Standards and Technology | Lefman J.,Essess, Inc | Szakal C.,U.S. National Institute of Standards and Technology
Analyst | Year: 2012

We present a novel method for correlating and classifying ion-specific time-of-flight secondary ion mass spectrometry (ToF-SIMS) images within a multispectral dataset by grouping images with similar pixel intensity distributions. Binary centroid images are created by employing a k-means-based custom algorithm. Centroid images are compared to grayscale SIMS images using a newly developed correlation method that assigns the SIMS images to classes that have similar spatial (rather than spectral) patterns. Image features of both large and small spatial extent are identified without the need for image pre-processing, such as normalization or fixed-range mass-binning. A subsequent classification step tracks the class assignment of SIMS images over multiple iterations of increasing n classes per iteration, providing information about groups of images that have similar chemistry. Details are discussed while presenting data acquired with ToF-SIMS on a model sample of laser-printed inks. This approach can lead to the identification of distinct ion-specific chemistries for mass spectral imaging by ToF-SIMS, as well as matrix-assisted laser desorption ionization (MALDI), and desorption electrospray ionization (DESI). © The Royal Society of Chemistry 2012. Source


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