Chatterjee C.,ESIC. PGIMSR MC MH
Research Journal of Pharmaceutical, Biological and Chemical Sciences | Year: 2015
Tea is most commonly consummated beverage in the world. Black tea is made from the dried leaves of Camellia sinensis, a shrub formerly known as Thea sinensis. We had set forward this study to examine the analgesic activities of black tea in experimental animal model. Evaluation of analgesic effects of black tea on mice. Black tea leaves were commercially obtained from P and A Arse, Rajdhani Apt. BIK-I Rg Barua Road,Ganeshguri, Guwahati, tea leaves (100 gm) were extracted with ethyl acetate using soxhlet assembly. The extract was concentrated in a rotary flash evaporator under reduced pressure to semisolid mass. black tea decoction (10% and 20%) was prepared by soaking 10 and 20 g of black tea in 100 ml boiled water separately, soaked for 2 min and thereafter filtered. This filtrate was designated as black tea decoction. Central and peripheral analgesic activities were evaluated by tail flick, tail immersion and acetic acid-induced writhing test respectively. This is an experimental study. In central analgesic model black tea decoction (10% and 20%) had shown no analgesic action at different hours as the reaction time was less than 10 seconds at all time interval. But at peripheral analgesic model black tea decoction (10% and 20%) had shown 20% and 39.81% inhibition, respectively, as compared to control group whereas Aspirin had shown around 52.81% (p<0.002) of inhibition. Taken together, our data indicate that black tea (20%) has a potential peripheral analgesic activity. Further studies involving isolation of active principles will help to pinpoint the mechanisms contributing to the analgesic activity of tea.