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Rajajinagar, India

Vaithianathan R.,ESIC MC and PGIMSR | Philipchandran,Madrs Medical College | Selvambigai G.,Chengleput Medical College | Jayaganesh P.,Tagore Medical College and Hospital
Journal of Clinical and Diagnostic Research | Year: 2013

Hepatocellular adenoma (Hca) is a rare, benign, liver cell tumour. Hca is most frequently seen in women with a history of oral contraceptive use. Hca is also reported in children with glycogen storage disorders, galactosaemia, Hurler's syndrome, severe immune deficiency states, diabetes mellitus, sex hormone disturbances, Fanconis anaemia, in those who are on androgen therapy and also in seizure disorder patients who are on carbamazepine therapy. Usually, Hca arises typically in a clinical setting of hormonal or metabolic abnormalities which stimulate hepatocyte proliferation. Though it is rare, a few cases of spontaneous Hca have been reported in children and also in adults, which were not associated with any of the known risk factors which are associated with Hca. Hca has to be differentiated from focal nodular hyperplasia, hepatocellular carcinoma and hepatoblastoma. The histological features and the assessment of cell proliferation by using immuno histochemistry, help in confirming the diagnosis of Hca. In a few cases of Hca, malignant transformations have been reported. Hence, a careful search for malignant transformations is necessary. In this report, we have documented two cases of spontaneous Hca which occurred in two normal children. Source

Jaiprakash H.,University of Kuala Lumpur | Benglorkar G.M.,ESIC MC and PGIMSR
Research Journal of Pharmaceutical, Biological and Chemical Sciences | Year: 2014

Mirabegron is an orally active β3 adrenoceptor agonist useful for the symptomatic relief of overactive bladder (OAB).Originally it was developed to treat diabetes and then its use was focused for OAB. This drug has been shown to reduce the resting intravesical pressure and contraction frequency in anesthetized rates without affecting the amplitude of micturition contraction. It has also shown to reduce the non-micturition bladder contractions in an awake rat model with bladder outlet obstruction. Mirabegron is known to be a cytochrome P450 (CYP) 2D6 inhibitor and shown a concern for pharmacokinetic interactions. It has shown a low incidence of adverse effects as compared to antimuscarinic drugs which are the first line of treatment in OAB. Hence it has been shown to be one of the most notable alternative drugs to antimuscarinic agents in the treatment of OAB. Source

Niveditha,ESIC MC and PGIMSR | Srikanth,Khaja Banda Nawaz Institute of Medical science | Singh H.,Ms Ramaiah Medical College | Srinivasa R.,Ms Ramaiah Medical College
Research Journal of Pharmacy and Technology | Year: 2013

Long term antiepileptic therapy has been associated with altered bone metabolism, and is a risk factor for development of osteoporosis. The present study was done to know the changes in biochemical markers of bone metabolism associated with antiepileptic therapy. This was a case control study conducted at a tertiary care hospital in South India in June 2010 where 80 patients and 20 controls, aged 20 to 40 years were enrolled for the study. Measurement of seven markers were done to determine the risk of fractures namely, serum calcium, serum phosphorous and 25(OH) D levels, bone formation markers - BSAP (Bone specific alkaline phosphatase) and osteocalcin, bone resorption markers - C telopeptide and urinary hydroxyproline. Statistical analysis was done using Student t test/Chi-square test. Student t test (Unpaired, two tailed) has been used to find the significance of study parameters between two groups In the present study alteration of all the biochemical markers was statistically significant in cases when compared with controls. When gender comparison was done among the biochemical markers, only bone specific alkaline phosphatase and serum phosphorus showed a statistically significant difference, whereas other parameters did not show any statistically significant difference. Statistically significant difference between serum calcium and phosphorus levels, C-telopeptide levels in the polytherapy group. Antiepileptic drugs appear to have negative influence bone health, there was a significant association between AED use and alteration in biochemical parameters, which may increase the fracture risk. Physicians should consider a monitoring schedule for patients taking antiepileptics, especially if they have other risk factors that contribute to bone disease. © RJPT All right reserved. Source

Deepthi R.,ESIC MC and PGIMSR | Ashakiran S.,Saptagiri Institute of Medical science and Research Center | Akhilesh T.V.,Sri Devaraj Urs Medical College | Reddy M.,Sri Devaraj Urs Medical College
Journal of Krishna Institute of Medical Sciences University | Year: 2015

Background: Mental health problems are more commonly seen in youth, more so in medical students. Physical activity though known to improve mental health is difficult to follow among medical students. Aims & Objectives: This study aimed to in vestigate self-reported levels of anxiety and depression and compare these with self-reported physical activity among medical students in an institution of India. Material & Methods: A Cross sectional study was done among 430 medical students and interns of a medical college of rural Karnataka, India. Hospital Anxiety and Depression Scale (HADS) and International Physical Activity Questionnaire (IP AQ) were administered to assess mental health status and physical activity levels respectively. Results: The prevalence of anxiety (65.1%), depression (39.5%) and anxiety with depression (34.4%) was high among medical students. Only 18.1% of students were highly active while 35.9% were inactive when physical activity levels were measured. Students who were highly active and minimally active in physical activity showed lower levels of depression and anxiety compared to low physical activity group. lConclusion: Mental health problems are high and physical activity levels are low among medical undergraduate students. Engagement in physical activity can be an important contributory factor in positive mental health of future doctors. © 2015 Journal of Krishna Institute of Medical Sciences University. Source

Shashikumar M.,ESIC MC and PGIMSR | Goud B.R.,St Johns Medical College | Joseph B.,St Johns Medical College | Varghese P.S.,St Johns Medical College
Indian Journal of Forensic Medicine and Toxicology | Year: 2016

Introduction: Mortuary services are integral to the compendium of services provided by a tertiary health care centre. Mortuary or Post-Mortem rooms have potential hazards and risks for the health personnel as well as attendants of the deceased. Objectives of the study: To identify existing practices and Occupational Health and Safety (OSH) measures in a Mortuary and to assess the use of Personal Protective Equipment (PPEs) among Health Care Workers. Material and Method: This is a crosssectional study set in a private tertiary care teaching hospital. An Observation Checklist was developed for the pupose of assessing hazards which was partially based on Occupational Hazard Checklist of OSHA for a Mortuary. Results: The personnel involved in transporting the body to the mortuary are exposed to the biological hazards namely the body fluids of the deceased and exposure to aerosols spills and splashes incidental to activities in the Post Mortem Room. The potential physical hazards are injuries due to slips and falls. The potential chemical hazards are contact dermatitis and allergic asthma due to exposure to formalin vapours in cases of embalming and drugs/chemicals ingested by the deceased. The workers are at risk for Pulmonary Tuberculosis, Hepatitis B and HIV. The potential ergonomic hazards are musculoskeletal diseases and Repetitive Stress Injuries at the shoulder, elbow and small joints of the hands. The PPEs use was not consistent in most areas of the mortuary. © 2015, Indian Journal of Forensic Medicine and Toxicology. All rights reserved. Source

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