Basu A.,ESIC Hospital and ODC EZ |
Mazumdar I.,KPC Medical College |
Goswami K.,ESIC Hospital and ODC EZ
IIOAB Journal | Year: 2013
Background: Lead (Pb) exposure through contaminated environment has adverse health impacts that can affect almost every organ or system in the human body, including the bone and teeth, causing brittle bones and weakness. Pb stored in bones can re-enter the blood stream during periods of increased bone mineral recycling & can be redeposited in the soft tissues of the body causing musculoskeletal, renal, ocular, immunological, neurological, reproductive, and developmental abnormalities. Recent industrialization of developing countries have contributed to elevated levels of Pb in the urban environment, leading to emission of contaminated fumes that are deposited on vegetables during their production and transport. Prolonged consumption of such food may lead to the chronic accumulation of Pb in the system. Objective: To determine the extent of lead contamination in 10 common vegetables around Kolkata in India, and assess the implication of contamination on food safety. Methods: The present research was conducted to study Pb level concentrations in vegetables along a major highway with dense traffic. Concentration of lead after dry mineralization and organic phase extraction (APDC / MIBK) is determined using the atomic absorption spectrophotometry (AAS) in a Perkin Elmer AAS 2380 apparatus. Results: Mean ± SD of the concentration of Pb is analyzed in triplicates. Statistically significant difference is p < 0.0001. Vegetable samples obtained from roadside show 3-4 times higher lead concentration, carrot being the most Pb tolerant. Pb accumulation in the crops follows the order: carrot > radish > beet > cabbage > brinjal > cauliflower > spinach > tomato > chilly. It's concentration in various parts of plants shows: root > stems > leaves > other edible parts. Conclusion: samples analyzed were contaminated with abnormal levels of Pb sufficient enough to expose residents of Kolkata, India to adverse health effects of the metal.
Mazumdar I.,Hospital Jadavpur |
Goswami K.,ESIC Hospital and ODC EZ
Indian Journal of Clinical Biochemistry | Year: 2014
It is well known that chronic exposure of lead leads to adverse health effects. Workers for plastic industry are generally exposed to high concentration of lead as fume, dust, and additive that protect PVC. This study was done on them to find out the detrimental effects of chronic lead exposure on hepatic and hematological toxicity. Blood and 24 h urine sample was collected from 47 plastic industry workers and matched against 42 controls for various parameters. The study group shows significant increase in blood (p < 0.0001) and urinary level of lead (p < 0.0001). Hemoglobin levels were significantly decreased (p < 0.0001), and the liver enzymes like ALP, ALT, AST and y-GT were significantly increased (p < 0.0001) in all cases exposed for >10 years. Serum lipid peroxide by quantitative assay of thiobarbituric acid reactive substances was also found increased in the study group (p < 0.0001). The observations point towards the acute health risk faced by plastic industry workers, in whom chronic exposure to lead increases the absorption and accumulation, over a period of time, of this highly toxic element in their body. This increases oxidative stress, causes metabolic damage to RBC and cell membranes, and also suggests necrosis of liver cell, hepatocellular injury and presence of space occupying lesions. Considering the data immediate health and hygiene monitoring and proper rehabilitation for the suffering population seem to be of paramount need in plastic industry to minimize occupational hazards. © 2013 Association of Clinical Biochemists of India.
Paul S.,Medical College |
Paul K.K.,ESIC Hospital and ODC EZ |
Palodhi S.,Medical College |
Dutta S.,Medical College
Pharmacologyonline | Year: 2010
Cholesterol lowering ability of finely powdered seeds of Nigella sativa(NS) was evaluated in comparison to atorvastatin, the most frequently used lipid lowering agent. Hypercholesterolemia was induced to the animals with cholesterol powder (50mg/kg/day) for the study duration (16 weeks). At the end of 4 weeks, they were randomly selected and divided into 3 groups (n=6). Group II received Cholesterol + atorvastatin (10 mg/day); Group III received Cholesterol + NS(5G/kg/day) while Group I continued with cholesterol powder (to serve as control) for the rest study period. Serum cholesterol, LDL, HDL and Triglycerides (TG) were estimated using the enzymatic method at 0, 4, 8, 12, 16 weeks in all the groups. The results were tabulated and analyzed statistically using one way ANOVA test. The results indicate that both atorvastatin and Nigella sativa have a definite role in retarding the rate of weight gain as a consequence to high cholesterol diet in rabbits. Also, there is fewer rises in all the lipid parameters in both the treatment groups when compared to the control group. Though atorvastatin is definitely more effective in reducing the lipid parameters, it also significantly lowers HDL where as NS shows promising results when compared to placebo and also has a favourable effect on HDL. NS is commonly used as food additive and has a wide range of medicinal properties. It can be recommended as a dietary supplement for long term use without toxic effects in the primary prevention of hypercholesterolemia and atherosclerosis and also has therapeutic potential in patients with coronary artery disease.
PubMed | Esic Hospital And Odc Ez
Type: Journal Article | Journal: Ayu | Year: 2012
Obesity is defined as the condition in which excessive amount of fat is accumulated in the body. Classical Ayurvedic texts describe eight types of despicable designated as Nindita purusha including atisthaulya. Corpulent people are characterized by short in longevity, slow movement, difficult to indulge in sex, weak, emission of bad body odor, profuse perspiration, excessive hunger and excessive thirst. Sixty to seventy percent of cardiac patients die of obesity and contribute to develop coronary artery disease, diabetes mellitus, hypertension, hyperlipidaemia. In the present study, 66 patients of obesity were treated with Shilajatu processed with Agnimantha. After complition of therapy, 5.09 0.24 kg and 2.06 0.10 kg/m(2) reduction of body weight and body mass index, respectively were noted. The result was found to be statistically highly significant (P<0.001). No adverse effects were observed in any of the treated patients.