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Villanueva C.,Escuela Superior de Medicina del IPN | Kross R.D.,Kross Link Laboratories
International Journal of Molecular Sciences | Year: 2012

Antioxidants are among the most popular health-protecting products, sold worldwide without prescription. Indeed, there are many reports showing the benefits of antioxidants but only a few questioning the possible harmful effects of these "drugs". The normal balance between antioxidants and free radicals in the body is offset when either of these forces prevails. The available evidence on the harmful effects of antioxidants is analyzed in this review. In summary, a hypothesis is presented that "antioxidant-induced stress" results when antioxidants overwhelm the body's free radicals. © 2012 by the authors; licensee MDPI, Basel, Switzerland.


Del Olmo-Turrubiarte A.,Laboratorio Of Investigacion Of Biologia Del Desarrollo Y Teratogenesis Experimental | Del Olmo-Turrubiarte A.,Metropolitan Autonomous University | Calzada-Torres A.,Laboratorio Of Investigacion Of Biologia Del Desarrollo Y Teratogenesis Experimental | Diaz-Rosas G.,Laboratorio Of Investigacion Of Biologia Del Desarrollo Y Teratogenesis Experimental | And 6 more authors.
IJC Heart and Vasculature | Year: 2015

The main objective of this study was to create a postnatal model for cardiac hypertrophy (CH), in order to explain the mechanisms that are present in childhood cardiac hypertrophy. Five days after implantation, intraperitoneal (IP) isoproterenol (ISO) was injected for 7. days to pregnant female mice. The fetuses were obtained at 15, 17 and 19. dpc from both groups, also newborns (NB), neonates (7-15. days) and young adults (6. weeks of age). Histopathological exams were done on the hearts. Immunohistochemistry and western blot demonstrated GATA4 and PCNA protein expression, qPCR real time the mRNA of adrenergic receptors (α-AR and β-AR), alpha and beta myosins (α-MHC, β-MHC) and GATA4. After the administration of ISO, there was no change in the number of offsprings. We observed significant structural changes in the size of the offspring hearts. Morphometric analysis revealed an increase in the size of the left ventricular wall and interventricular septum (IVS). Histopathological analysis demonstrated loss of cellular compaction and presence of left ventricular small fibrous foci after birth. Adrenergic receptors might be responsible for changing a physiological into a pathological hypertrophy. However GATA4 seemed to be the determining factor in the pathology. A new animal model was established for the study of pathologic CH in early postnatal stages. © 2015 The Authors. Published by Elsevier Ireland Ltd.


Orihuela O.,Instituto Mexicano del Seguro Social IMSS | De Jesus Ventura M.,Instituto Mexicano del Seguro Social IMSS | Avila-Diaz M.,Instituto Mexicano del Seguro Social IMSS | Cisneros A.,Hospital General de Zona 27 | And 9 more authors.
Peritoneal Dialysis International | Year: 2014

Introduction: Spectral analysis of heart rate variability is a noninvasive method for evaluating autonomic cardiovascular dysfunction under various clinical conditions, such as in dialysis patients, in whom an imbalance between the sympathetic and parasympathetic nervous system appears to be an important risk factor for sudden cardiovascular death and arrhythmia. Objective: We compared the effect of icodextrin-based dialysis solution, an option that allows for better metabolic and fluid overload control, with that of glucose-based dialysis fluid on sympathetic and parasympathetic activity in the heart, as assessed by heart rate variability, in diabetic patients on peritoneal dialysis (PD). Methods: This secondary analysis uses data from a randomized controlled trial in diabetic PD patients with high or high-average peritoneal transport using icodextrin-based (ICO group, n = 30) or glucose-based (GLU group, n = 29) solutions for the long dwell. All patients underwent 24-hour electrocardiographic Holter monitoring at baseline, and at 6 and 12 months of follow-up. Results: We observed no significant differences between the groups in most of the variables analyzed, although values were, in general, below reference values. In the ICO group, total power and both low- and high-frequency power in normalized units increased, but the percentage of RR intervals with variation of more than 50 ms declined over time; in the GLU group, all those values declined. Plasma catecholamine levels were higher at baseline and declined over time. Conclusions: These results indicate a partial recovery of sympathetic activity in the ICO group, probably because of better extracellular fluid control and lower exposure to glucose with the use of icodextrin-based dialysis solutions. © 2014 International Society for Peritoneal Dialysis.


Meneses A.,CINVESTAV | Perez-Garcia G.,CINVESTAV | Ponce-Lopez T.,CINVESTAV | Castillo C.,Escuela Superior de Medicina del IPN
International Review of Neurobiology | Year: 2011

Growing evidence indicates that antagonists of the 5-hydroxytryptamine (serotonin) receptor6 (5-HT6) improve memory and reverse amnesia, although the mechanisms involved are poorly understood. Hence, in this paper an attempt was made to summarize recent findings. Available evidence indicates that diverse 5-HT6 receptor antagonists produce promnesic and/or antiamnesic effects in diverse conditions, including memory formation, age-related cognitive impairments, memory deficits in diseases such as schizophrenia, Parkinson, and Alzheimer's disease (AD). Notably, some 5-HT6 receptor agonists seem to have promnesic and/or antiamnesic effects. At the present, it is unclear why 5-HT6 receptor agonists and antagonists may facilitate memory or may reverse amnesia in some memory tasks. Certainly, 5-HT6 drugs modulate memory, which are accompanied with neural changes. Likewise, memory, aging, and AD modify 5-HT6 receptors and signaling cascades. Further investigation in different memory tasks, times, and amnesia models together with more complex control groups might provide further clues. Notably, human studies suggest a potential utility of 5-HT6 receptor antagonists in mild-to-moderate AD patients. Even individuals with mild cognitive impairment (MCI) offer a great opportunity to test them. © 2011 Elsevier Inc.


Bautista-Cruz A.,National Polytechnic Institute of Mexico | Arnaud-Vinas M.R.,Escuela Superior de Medicina del IPN | Martinez-Gutierrez G.A.,National Polytechnic Institute of Mexico | Sanchez-Medina P.S.,National Polytechnic Institute of Mexico | Pacheco R.P.,National Polytechnic Institute of Mexico
Journal of Medicinal Plants Research | Year: 2011

Rural and urban populations in Valles Centrales, Oaxaca, Mexico, use certain plant species for therapeutic and dietary purposes. The wild-growing plants most commonly consumed during the rainy season by those with scarce economic resources are Portulaca oleracea L., Galinsoga quadriradiata Ruiz & Pavon and Anoda cristata (L.) Schltdl. (vernacular names: verdolaga, piojito and violeta, respectively). Cnidoscolus chayamansa Mc Vaugh, a cultivated plant known as chaya, is also frequently consumed. This work aims to document the ethnobotanical and nutritional importance of these four plants. A semi-structured interview was applied to 175 middle-aged and elderly women selected by snowball technique. Chaya and violeta had both medicinal and dietary uses. Chaya was used in the treatment of diabetes, high cholesterol, renal disorders, high blood pressure, as a weight loss aid, and for inflammation of the arms and legs. Violeta was used as a cough remedy. These plants were consumed in a tea prepared from fresh plant parts. Verdolaga and piojito were only consumed as food. Chaya was the best source of ascorbic acid (350.83 mg/100 g), retinol (5.26 mg/100 g), iron (7.51 mg/100 g) and protein (8.15%). Chaya's potential as a medicinal and edible plant suggests this species ought to be cultivated commercially. © 2011 Academic Journals.

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