Escuela Superior de Medicina del IPN

Mexico City, Mexico

Escuela Superior de Medicina del IPN

Mexico City, Mexico

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Romero-Salinas G.,Hospital Materno Infantil Inguaran | Romero-Salinas G.,Metropolitan Autonomous University | Pulido Olivares V.H.,Escuela Superior de Medicina del IPN | Pulido Olivares V.H.,Metropolitan Autonomous University | And 7 more authors.
Clinica e Investigacion en Ginecologia y Obstetricia | Year: 2012

Objective: To determine the morphological consequences and heart rate alterations in fetuses with hypomotility. Material and method: A sample of 40 patients was divided into 2 groups. Group 1 (the problem group) consisted of 20 pregnant patients who had been diagnosed with fetal hypomotility. Group 2 (the control group) consisted of 20 patients with a normal pregnancy. Fetal heart rate (FHR) and uterine contractility were measured for 2 hours. A Corometrics cardiotocograph model 0115JAA, series 0488301 was used. Results: The baseline FHR of the two groups was compared. The mean and standard deviation (SD) were 136.91 ± 8.75 beats/min in group 1 and 135.5 ± 10.57 beats/min in group 2. The difference between the means was one beat and the t-value was 0.46. This difference was not significant. The mean and SD of the amplitude of the accelerations were calculated in both groups, obtaining values of 22.47 ± 7.76 in group 1 and 24.81 ± 7.41 in group 2. The difference between the means was two beats and the t-value was 0.97. This difference was not significant. The time interval between the mother noticing the lack of fetal movement and the consultation was recorded in hours. The mean and SD were 35.5 ± 22.70. hours. The time periods when FHR did not vary were recorded in minutes. The mean and SD were 28.94 ± 13.50. min. Conclusions: In group 1, the physical status of the newborns was evaluated using the Apgar test at 1 and 5. minutes. At 1. minute, two of the neonates were depressed (Apgar scores of 2 and 5) and 18 were vigorous (Apgar scores of 7 to 9). At 5. minutes, Apgar scores were between 7 and 9 in 19 neonates. Only one neonate continued to be depressed, scoring -2. In group 2, Apgar scores at 1. minute were between 7 and 9 in nine neonates. At 5. minutes, these scores increased to between 8 and 9. Height and weight were determined. The mean and SD for weight were 3.233 ± 0.395,92. g in group 1 was 2.960 ± 0.421,05. g in group 2. The difference between means was 273. g and the t-value was 0.03. This difference was not significant. The mean and SD for height were 50.46 ± 2.97. cm in group 1 and 49.77 ± 1.09. cm in group 2 and the t-value was 0.82. The difference between the means was not significant. © 2010 Elsevier España, S.L.

Orihuela O.,Hospital Of Especialidades | De Jesus Ventura M.,Hospital Of Especialidades | Avila-Diaz M.,Hospital Of Especialidades | Cisneros A.,Hospital General Of Zona 27 | And 9 more authors.
Peritoneal Dialysis International | Year: 2014

Introduction: Spectral analysis of heart rate variability is a noninvasive method for evaluating autonomic cardiovascular dysfunction under various clinical conditions, such as in dialysis patients, in whom an imbalance between the sympathetic and parasympathetic nervous system appears to be an important risk factor for sudden cardiovascular death and arrhythmia. Objective: We compared the effect of icodextrin-based dialysis solution, an option that allows for better metabolic and fluid overload control, with that of glucose-based dialysis fluid on sympathetic and parasympathetic activity in the heart, as assessed by heart rate variability, in diabetic patients on peritoneal dialysis (PD). Methods: This secondary analysis uses data from a randomized controlled trial in diabetic PD patients with high or high-average peritoneal transport using icodextrin-based (ICO group, n = 30) or glucose-based (GLU group, n = 29) solutions for the long dwell. All patients underwent 24-hour electrocardiographic Holter monitoring at baseline, and at 6 and 12 months of follow-up. Results: We observed no significant differences between the groups in most of the variables analyzed, although values were, in general, below reference values. In the ICO group, total power and both low- and high-frequency power in normalized units increased, but the percentage of RR intervals with variation of more than 50 ms declined over time; in the GLU group, all those values declined. Plasma catecholamine levels were higher at baseline and declined over time. Conclusions: These results indicate a partial recovery of sympathetic activity in the ICO group, probably because of better extracellular fluid control and lower exposure to glucose with the use of icodextrin-based dialysis solutions. © 2014 International Society for Peritoneal Dialysis.

Camacho-Arroyo I.,University of the Basque Country | Gonzalez-Arenas A.,University of the Basque Country | Espinosa-Raya J.,Escuela Superior de Medicina Del I.P.N. | Pina-Medina A.G.,University of the Basque Country | Picazo O.,Escuela Superior de Medicina Del I.P.N.
Life Sciences | Year: 2011

Aims: We analyzed the effects of the short- and long-term administration of estradiol (E2) or progesterone (P4) after ovariectomy on the expression of MAP2, Tau and GFAP in prefrontal cortex and hippocampus. Main methods: Sprague Dawley rats were ovariectomized and immediately treated with E2 or P4 for 2 or 18 weeks. At the end of treatments, hippocampus and prefrontal cortex were excised, proteins were extracted and MAP2, Tau and GFAP were analyzed by Western blot. Key findings: MAP2 and Tau content was not modified by E2 in the prefrontal cortex. On the contrary, P4 decreased MAP2 content after a short-term treatment, while it increased that of MAP2 and TAU in this brain region after a long-term treatment. E2 increased MAP2 content in hippocampus. In this region, short-term administration of P4 increased that of MAP2. GFAP content was diminished after a long-term administration of P4 in hippocampus. Significance: Current data emphasize the importance of short- and long-term sex steroid treatment on neuronal and glial cytoskeletal proteins expression. © 2011 Elsevier Inc. All Rights Reserved.

Del Olmo-Turrubiarte A.,Hospital Infantil Of Mexico Federico Gomez Himfg | Del Olmo-Turrubiarte A.,Metropolitan Autonomous University | Calzada-Torres A.,Hospital Infantil Of Mexico Federico Gomez Himfg | Diaz-Rosas G.,Hospital Infantil Of Mexico Federico Gomez Himfg | And 6 more authors.
IJC Heart and Vasculature | Year: 2015

The main objective of this study was to create a postnatal model for cardiac hypertrophy (CH), in order to explain the mechanisms that are present in childhood cardiac hypertrophy. Five days after implantation, intraperitoneal (IP) isoproterenol (ISO) was injected for 7. days to pregnant female mice. The fetuses were obtained at 15, 17 and 19. dpc from both groups, also newborns (NB), neonates (7-15. days) and young adults (6. weeks of age). Histopathological exams were done on the hearts. Immunohistochemistry and western blot demonstrated GATA4 and PCNA protein expression, qPCR real time the mRNA of adrenergic receptors (α-AR and β-AR), alpha and beta myosins (α-MHC, β-MHC) and GATA4. After the administration of ISO, there was no change in the number of offsprings. We observed significant structural changes in the size of the offspring hearts. Morphometric analysis revealed an increase in the size of the left ventricular wall and interventricular septum (IVS). Histopathological analysis demonstrated loss of cellular compaction and presence of left ventricular small fibrous foci after birth. Adrenergic receptors might be responsible for changing a physiological into a pathological hypertrophy. However GATA4 seemed to be the determining factor in the pathology. A new animal model was established for the study of pathologic CH in early postnatal stages. © 2015 The Authors. Published by Elsevier Ireland Ltd.

Tellez R.,CINVESTAV | Rocha L.,CINVESTAV | Castillo C.,Escuela Superior de Medicina del IPN | Castillo C.,Instituto Nacional Of Perinatologia Isidro Espinoza Of Los Reyes | Meneses A.,CINVESTAV
Behavioural Brain Research | Year: 2010

Serotonin transporter (SERT) has been associated with drugs of abuse like d-methamphetamine (METH). METH is well known to produce effects on the monoamine systems but it is unclear how METH affects SERT and memory. Here the effects of METH and the serotonin reuptake inhibitor fluoxetine (FLX) on autoshaping and novel object recognition (NOR) were investigated. Notably, both memory tasks recruit different behavioral, neural and cognitive demand. In autoshaping task a dose-response curve for METH was determined. METH (1.0. mg/kg) impaired short-term memory (STM; lasting less of 90. min) in NOR and impaired both STM and long-term memory (LTM; lasting 24 and 48. h) in autoshaping, indicating that METH had long-lasting effects in the latter task. A comparative autoradiography study of the relationship between the binding pattern of SERT in autoshaping new untrained vs. trained treated (METH, FLX, or both) animals was made. Considering that hemispheric dominance is important for LTM, hence right vs. left hemisphere of the brain was compared. Results showed that trained animals decreased cortical SERT binding relative to untrained ones. In untrained and trained treated animals with the amnesic dose (1.0. mg/kg) of METH SERT binding in several areas including hippocampus and cortex decreased, more remarkably in the trained animals. In contrast, FLX improved memory, increased SERT binding, prevented the METH amnesic effect and re-established the SERT binding. In general, memory and amnesia seemed to make SERT more vulnerable to drugs effects. © 2010 Elsevier B.V.

Meneses A.,CINVESTAV | Perez-Garcia G.,CINVESTAV | Ponce-Lopez T.,CINVESTAV | Castillo C.,Escuela Superior de Medicina del IPN
International Review of Neurobiology | Year: 2011

Growing evidence indicates that antagonists of the 5-hydroxytryptamine (serotonin) receptor6 (5-HT6) improve memory and reverse amnesia, although the mechanisms involved are poorly understood. Hence, in this paper an attempt was made to summarize recent findings. Available evidence indicates that diverse 5-HT6 receptor antagonists produce promnesic and/or antiamnesic effects in diverse conditions, including memory formation, age-related cognitive impairments, memory deficits in diseases such as schizophrenia, Parkinson, and Alzheimer's disease (AD). Notably, some 5-HT6 receptor agonists seem to have promnesic and/or antiamnesic effects. At the present, it is unclear why 5-HT6 receptor agonists and antagonists may facilitate memory or may reverse amnesia in some memory tasks. Certainly, 5-HT6 drugs modulate memory, which are accompanied with neural changes. Likewise, memory, aging, and AD modify 5-HT6 receptors and signaling cascades. Further investigation in different memory tasks, times, and amnesia models together with more complex control groups might provide further clues. Notably, human studies suggest a potential utility of 5-HT6 receptor antagonists in mild-to-moderate AD patients. Even individuals with mild cognitive impairment (MCI) offer a great opportunity to test them. © 2011 Elsevier Inc.

Bautista-Cruz A.,National Polytechnic Institute of Mexico | Arnaud-Vinas M.R.,Escuela Superior de Medicina del IPN | Martinez-Gutierrez G.A.,National Polytechnic Institute of Mexico | Sanchez-Medina P.S.,National Polytechnic Institute of Mexico | Pacheco R.P.,National Polytechnic Institute of Mexico
Journal of Medicinal Plants Research | Year: 2011

Rural and urban populations in Valles Centrales, Oaxaca, Mexico, use certain plant species for therapeutic and dietary purposes. The wild-growing plants most commonly consumed during the rainy season by those with scarce economic resources are Portulaca oleracea L., Galinsoga quadriradiata Ruiz & Pavon and Anoda cristata (L.) Schltdl. (vernacular names: verdolaga, piojito and violeta, respectively). Cnidoscolus chayamansa Mc Vaugh, a cultivated plant known as chaya, is also frequently consumed. This work aims to document the ethnobotanical and nutritional importance of these four plants. A semi-structured interview was applied to 175 middle-aged and elderly women selected by snowball technique. Chaya and violeta had both medicinal and dietary uses. Chaya was used in the treatment of diabetes, high cholesterol, renal disorders, high blood pressure, as a weight loss aid, and for inflammation of the arms and legs. Violeta was used as a cough remedy. These plants were consumed in a tea prepared from fresh plant parts. Verdolaga and piojito were only consumed as food. Chaya was the best source of ascorbic acid (350.83 mg/100 g), retinol (5.26 mg/100 g), iron (7.51 mg/100 g) and protein (8.15%). Chaya's potential as a medicinal and edible plant suggests this species ought to be cultivated commercially. © 2011 Academic Journals.

Munoz-Islas E.,CINVESTAV | Gonzalez-Hernandez A.,CINVESTAV | Gonzalez-Hernandez A.,National Autonomous University of Mexico | Lozano-Cuenca J.,CINVESTAV | And 6 more authors.
Cephalalgia | Year: 2015

Background During migraine, capsaicin-sensitive trigeminal sensory nerves release calcitonin gene-related peptide (CGRP), resulting in cranial vasodilatation and central nociception. Moreover, 5-HT is involved in the pathophysiology of migraine and depression. Interestingly, some limited lines of evidence suggest that fluoxetine may be effective in migraine prophylaxis, but the underlying mechanisms are uncertain. Hence, this study investigated the canine external carotid vasodilator responses to capsaicin, α-CGRP and acetylcholine before and after acute and chronic oral treatment with fluoxetine. Methods Forty-eight vagosympathectomised male mongrel dogs were prepared to measure blood pressure, heart rate and external carotid blood flow. The thyroid artery was cannulated for infusions of agonists. In 16 of these dogs, a spinal cannula was inserted (C1-C3) for infusions of 5-HT. Results The external carotid vasodilator responses to capsaicin, α-CGRP and acetylcholine remained unaffected after intracarotid or i.v. fluoxetine. In contrast, the vasodilator responses to capsaicin, but not those to α-CGRP or acetylcholine, were inhibited after chronic oral treatment with fluoxetine (300 μg/kg; for 90 days) or intrathecal 5-HT. Conclusions Chronic oral fluoxetine inhibited capsaicin-induced external carotid vasodilatation, and this inhibition could partly explain its potential prophylactic antimigraine action. © International Headache Society 2015.

Villanueva C.,Escuela Superior de Medicina del IPN | Kross R.D.,Kross Link Laboratories
International Journal of Molecular Sciences | Year: 2012

Antioxidants are among the most popular health-protecting products, sold worldwide without prescription. Indeed, there are many reports showing the benefits of antioxidants but only a few questioning the possible harmful effects of these "drugs". The normal balance between antioxidants and free radicals in the body is offset when either of these forces prevails. The available evidence on the harmful effects of antioxidants is analyzed in this review. In summary, a hypothesis is presented that "antioxidant-induced stress" results when antioxidants overwhelm the body's free radicals. © 2012 by the authors; licensee MDPI, Basel, Switzerland.

PubMed | Escuela Superior de Medicina del IPN
Type: Journal Article | Journal: International journal of molecular sciences | Year: 2012

Antioxidants are among the most popular health-protecting products, sold worldwide without prescription. Indeed, there are many reports showing the benefits of antioxidants but only a few questioning the possible harmful effects of these drugs. The normal balance between antioxidants and free radicals in the body is offset when either of these forces prevails. The available evidence on the harmful effects of antioxidants is analyzed in this review. In summary, a hypothesis is presented that antioxidant-induced stress results when antioxidants overwhelm the bodys free radicals.

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