Escuela Superior de Medicina del IPN

Mexico City, Mexico

Escuela Superior de Medicina del IPN

Mexico City, Mexico
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Gonzalez-Hernandez M.D.L.,Seccion de Estudios de Posgrado e Investigacion | Godinez-Hernandez D.,Universidad Michoacana de San Nicolás de Hidalgo | Bobadilla-Lugo R.A.,Escuela Superior de Medicina Del IPN | Lopez-Sanchez P.,Seccion de Estudios de Posgrado e Investigacion
Autonomic and Autacoid Pharmacology | Year: 2010

1 Pregnancy courses with low response to angiotensin II and adrenergic agonists. In preeclampsia, both effects are reverted. It is known that angiotensin II regulates adrenergic system. It is not known, however, the interaction between both systems receptors. 2 Our aim was to study if AT 1R and α1D adrenoceptor heterodimerize in preeclampsia. 3 We used subrenal aorctic coarctation in pregnant rats. Aortic tissues were prepared for confocal imaging and coimmunoprecipitated for α1D and AT1 receptors. 4 We found that AT1R and α1D adrenoceptor heterodimerize in both, healthy and preeclamptic groups. In healthy pregnant rats, heterodimer is barely detected. In preeclamptic rats however, we found higher heterodimerization. 5 These results suggest that AT1R and α1D-adrenoceptor may form heterodimers, and may play a role in preeclampsia. © 2010 Blackwell Publishing Ltd.


Valencia-Hernandez I.,Escuela Superior de Medicina Del IPN | Reyes-Ramirez J.A.,Escuela Superior de Medicina Del IPN | Urquiza-Marin H.,Universidad Michoacana de San Nicolás de Hidalgo | Nateras-Marin B.,Universidad Michoacana de San Nicolás de Hidalgo | And 2 more authors.
Pharmacology | Year: 2012

The present study investigated the hypothesis that the duration of ovarian hormone deprivation before reintroduction of oestrogen affects the role of oestrogen as a mediator of the contractile function of α1- adrenergic receptors. Rats underwent ovariectomy (OVX) or were sham-operated, and the OVX rats were treated with vehicle (corn oil) or 17β-oestradiol (E2) for 5 days either 10, 28 or 60 days after OVX. The OVX increased phenylephrine- and Ca2+-induced contractions. Interestingly, the phenylephrine-induced contractions were increased at each of the three time points, whereas the Ca2+-induced contractions were only increased in the 60-day group. E2 had biphasic effects on phenylephrine- and Ca2+-induced contractility. Indeed, E2 increased contractions in the 10-day group and diminished contractions in the other groups (the increased contractions were avoided by verapamil). These results indicate that E2 controls α1-adrenergic receptor-mediated contractility through effects on L-type Ca2+ channels in a way that depends on the timing in which the treatment with E2 is initiated. Copyright © 2012 S. Karger AG, Basel.


Meneses A.,CINVESTAV | Perez-Garcia G.,CINVESTAV | Ponce-Lopez T.,CINVESTAV | Tellez R.,CINVESTAV | Castillo C.,Escuela Superior de Medicina Del IPN
Neuropharmacology | Year: 2011

The serotonin transporter (SERT) has been associated to diverse functions and diseases, though seldom to memory. Therefore, we made an attempt to summarize and discuss the available publications implicating the involvement of the SERT in memory, amnesia and anti-amnesic effects. Evidence indicates that Alzheimer's disease and drugs of abuse like d-methamphetamine (METH) and (+/-)3,4-methylenedioxymethamphetamine (MDMA, "ecstasy") have been associated to decrements in the SERT expression and memory deficits. Several reports have indicated that memory formation and amnesia affected the SERT expression. The SERT expression seems to be a reliable neural marker related to memory mechanisms, its alterations and potential treatment. The pharmacological, neural and molecular mechanisms associated to these changes are of great importance for investigation. © 2011 Elsevier Ltd. All rights reserved.


Meneses A.,CINVESTAV | Ponce-Lopez T.,CINVESTAV | Tellez R.,CINVESTAV | Gonzalez R.,CINVESTAV | And 2 more authors.
Behavioural Brain Research | Year: 2011

Diverse studies indicate that the attention deficit hyperactivity disorder (ADHD) is associated with alterations in encoding processes, including working or short-term memory. Some ADHD dysfunctional domains are reflected in the spontaneously hypertensive rat (SHR). Here SHR-saline group showed significantly poor STM and LTM relative to SD and WKY saline rats. SD and WKY rats treated with d-amphetamine displayed better STM and LTM, compared to SD-vehicle, WKY-vehicle or SHR-d-amphetamine groups. © 2010 Elsevier B.V.


Camacho-Arroyo I.,University of the Basque Country | Gonzalez-Arenas A.,University of the Basque Country | Espinosa-Raya J.,Escuela Superior de Medicina Del I.P.N. | Pina-Medina A.G.,University of the Basque Country | Picazo O.,Escuela Superior de Medicina Del I.P.N.
Life Sciences | Year: 2011

Aims: We analyzed the effects of the short- and long-term administration of estradiol (E2) or progesterone (P4) after ovariectomy on the expression of MAP2, Tau and GFAP in prefrontal cortex and hippocampus. Main methods: Sprague Dawley rats were ovariectomized and immediately treated with E2 or P4 for 2 or 18 weeks. At the end of treatments, hippocampus and prefrontal cortex were excised, proteins were extracted and MAP2, Tau and GFAP were analyzed by Western blot. Key findings: MAP2 and Tau content was not modified by E2 in the prefrontal cortex. On the contrary, P4 decreased MAP2 content after a short-term treatment, while it increased that of MAP2 and TAU in this brain region after a long-term treatment. E2 increased MAP2 content in hippocampus. In this region, short-term administration of P4 increased that of MAP2. GFAP content was diminished after a long-term administration of P4 in hippocampus. Significance: Current data emphasize the importance of short- and long-term sex steroid treatment on neuronal and glial cytoskeletal proteins expression. © 2011 Elsevier Inc. All Rights Reserved.


Tellez R.,CINVESTAV | Rocha L.,CINVESTAV | Castillo C.,Escuela Superior de Medicina del IPN | Castillo C.,Instituto Nacional Of Perinatologia Isidro Espinoza Of Los Reyes | Meneses A.,CINVESTAV
Behavioural Brain Research | Year: 2010

Serotonin transporter (SERT) has been associated with drugs of abuse like d-methamphetamine (METH). METH is well known to produce effects on the monoamine systems but it is unclear how METH affects SERT and memory. Here the effects of METH and the serotonin reuptake inhibitor fluoxetine (FLX) on autoshaping and novel object recognition (NOR) were investigated. Notably, both memory tasks recruit different behavioral, neural and cognitive demand. In autoshaping task a dose-response curve for METH was determined. METH (1.0. mg/kg) impaired short-term memory (STM; lasting less of 90. min) in NOR and impaired both STM and long-term memory (LTM; lasting 24 and 48. h) in autoshaping, indicating that METH had long-lasting effects in the latter task. A comparative autoradiography study of the relationship between the binding pattern of SERT in autoshaping new untrained vs. trained treated (METH, FLX, or both) animals was made. Considering that hemispheric dominance is important for LTM, hence right vs. left hemisphere of the brain was compared. Results showed that trained animals decreased cortical SERT binding relative to untrained ones. In untrained and trained treated animals with the amnesic dose (1.0. mg/kg) of METH SERT binding in several areas including hippocampus and cortex decreased, more remarkably in the trained animals. In contrast, FLX improved memory, increased SERT binding, prevented the METH amnesic effect and re-established the SERT binding. In general, memory and amnesia seemed to make SERT more vulnerable to drugs effects. © 2010 Elsevier B.V.


Meneses A.,CINVESTAV | Perez-Garcia G.,CINVESTAV | Ponce-Lopez T.,CINVESTAV | Castillo C.,Escuela Superior de Medicina del IPN
International Review of Neurobiology | Year: 2011

Growing evidence indicates that antagonists of the 5-hydroxytryptamine (serotonin) receptor6 (5-HT6) improve memory and reverse amnesia, although the mechanisms involved are poorly understood. Hence, in this paper an attempt was made to summarize recent findings. Available evidence indicates that diverse 5-HT6 receptor antagonists produce promnesic and/or antiamnesic effects in diverse conditions, including memory formation, age-related cognitive impairments, memory deficits in diseases such as schizophrenia, Parkinson, and Alzheimer's disease (AD). Notably, some 5-HT6 receptor agonists seem to have promnesic and/or antiamnesic effects. At the present, it is unclear why 5-HT6 receptor agonists and antagonists may facilitate memory or may reverse amnesia in some memory tasks. Certainly, 5-HT6 drugs modulate memory, which are accompanied with neural changes. Likewise, memory, aging, and AD modify 5-HT6 receptors and signaling cascades. Further investigation in different memory tasks, times, and amnesia models together with more complex control groups might provide further clues. Notably, human studies suggest a potential utility of 5-HT6 receptor antagonists in mild-to-moderate AD patients. Even individuals with mild cognitive impairment (MCI) offer a great opportunity to test them. © 2011 Elsevier Inc.


Bautista-Cruz A.,National Polytechnic Institute of Mexico | Arnaud-Vinas M.R.,Escuela Superior de Medicina del IPN | Martinez-Gutierrez G.A.,National Polytechnic Institute of Mexico | Sanchez-Medina P.S.,National Polytechnic Institute of Mexico | Pacheco R.P.,National Polytechnic Institute of Mexico
Journal of Medicinal Plants Research | Year: 2011

Rural and urban populations in Valles Centrales, Oaxaca, Mexico, use certain plant species for therapeutic and dietary purposes. The wild-growing plants most commonly consumed during the rainy season by those with scarce economic resources are Portulaca oleracea L., Galinsoga quadriradiata Ruiz & Pavon and Anoda cristata (L.) Schltdl. (vernacular names: verdolaga, piojito and violeta, respectively). Cnidoscolus chayamansa Mc Vaugh, a cultivated plant known as chaya, is also frequently consumed. This work aims to document the ethnobotanical and nutritional importance of these four plants. A semi-structured interview was applied to 175 middle-aged and elderly women selected by snowball technique. Chaya and violeta had both medicinal and dietary uses. Chaya was used in the treatment of diabetes, high cholesterol, renal disorders, high blood pressure, as a weight loss aid, and for inflammation of the arms and legs. Violeta was used as a cough remedy. These plants were consumed in a tea prepared from fresh plant parts. Verdolaga and piojito were only consumed as food. Chaya was the best source of ascorbic acid (350.83 mg/100 g), retinol (5.26 mg/100 g), iron (7.51 mg/100 g) and protein (8.15%). Chaya's potential as a medicinal and edible plant suggests this species ought to be cultivated commercially. © 2011 Academic Journals.


Villanueva C.,Escuela Superior de Medicina del IPN | Kross R.D.,Kross Link Laboratories
International Journal of Molecular Sciences | Year: 2012

Antioxidants are among the most popular health-protecting products, sold worldwide without prescription. Indeed, there are many reports showing the benefits of antioxidants but only a few questioning the possible harmful effects of these "drugs". The normal balance between antioxidants and free radicals in the body is offset when either of these forces prevails. The available evidence on the harmful effects of antioxidants is analyzed in this review. In summary, a hypothesis is presented that "antioxidant-induced stress" results when antioxidants overwhelm the body's free radicals. © 2012 by the authors; licensee MDPI, Basel, Switzerland.


PubMed | Escuela Superior de Medicina del IPN
Type: Journal Article | Journal: International journal of molecular sciences | Year: 2012

Antioxidants are among the most popular health-protecting products, sold worldwide without prescription. Indeed, there are many reports showing the benefits of antioxidants but only a few questioning the possible harmful effects of these drugs. The normal balance between antioxidants and free radicals in the body is offset when either of these forces prevails. The available evidence on the harmful effects of antioxidants is analyzed in this review. In summary, a hypothesis is presented that antioxidant-induced stress results when antioxidants overwhelm the bodys free radicals.

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