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Mexico City, Mexico

Alcocer L.,Instituto Mexicano Of Salud Cardiovascular | Meaney E.,Escuela Superior de Medicina | Hernandez-Hernandez H.,Clinica de Prevencion Del Riesgo Cardiovascular
Therapeutic Advances in Cardiovascular Disease | Year: 2015

Recent research has focused on the development of evidence-based guidelines that are intended to regulate the conduct of physicians in the diagnosis and control of hypertension, with the goal of achieving greater effectiveness and equity at the lowest possible cost. In Latin America, guidelines are available for the management of hypertension at three levels: national, regional and international. The national and regional Latin American and Caribbean (LAC) guidelines are in fact adaptations of the international guidelines. The potential benefit of applying guidelines developed in other regions to local healthcare decision making is that it will enable decision makers to take advantage of existing analyses and transfer or adapt them to their local contexts. However, this adaptation precludes the assessment of their generalizability and potential transferability. In addition, this region is characterized by wide socioeconomic differences between its inhabitants, both among and within nations. Therefore, new guidelines for the LAC region must include recommendations that are common to all hypertensive patients in the region. Moreover, we advocate the inclusion of a specific section that makes comprehensive recommendations and provides strategies for implementation according to the socioeconomic conditions of particular groups. In addition to developing guidelines that are truly applicable to the LAC region, it seems sensible to consider information that is specific to this region. Furthermore, developing evidence-based guidelines is not enough to affect positively the burden of disease caused by hypertension. Therefore, professional programs are required for the implementation of such guidelines as well as the auditing of their results. Achieving these ambitious goals will require collaborative efforts by many groups including policymakers, international organizations, healthcare providers, universities and society. © SAGE Publications.

Bustamante-Garcia R.,National Autonomous University of Mexico | Lira-Rocha A.S.,National Autonomous University of Mexico | Espejo-Gonzalez O.,National Autonomous University of Mexico | Gomez-Martinez A.E.,National Autonomous University of Mexico | Picazo O.,Escuela Superior de Medicina
Progress in Neuro-Psychopharmacology and Biological Psychiatry | Year: 2014

In spite of the wide variety of drugs available for treating anxiety, this disorder continues to represent a worldwide health problem that is classified within the first 10 causes of disability. Therefore, the search continues for new antianxiety agents, particularly those not related to benzodiazepines. Even though melatonin has been prescribed as an anxiolytic drug, its use is currently limited due to its short half-life and photo-sensitivity, among other disadvantages. The present study explores the antianxiety properties of a new 1-N substituted melatonin analog, M3C, in pinealectomized rats submitted to two behavioral tests (the cumulative burying behavior paradigm and the elevated plus-maze). Results from both tests show that M3C is effective as an anxiolytic-like agent, at doses lower than any other melatonin analog previously reported. The blocking of these actions by luzindole together with the available data suggests that the anxiolytic properties of M3C are mediated by MT1 and MT2 receptors. © 2014 Elsevier Inc.

Herrera-Gonzalez N.E.,Escuela Superior de Medicina | Robles-Perez V.,Hospital Regional | Velasco-Rodriguez J.C.,Hospital Regional | Tapia-Conyer R.,Instituto Carso | Sarti E.,Secretaria de Salud
International Journal of Biological Markers | Year: 2010

Background: Data suggest that estrogen-metabolizing genes may be involved in breast cancer carcinogenesis. Objective: The aim of this study was to determine the association of CYP1A1 and COMT polymorphisms with this disease. Material and methods: A pilot case-control study was conducted with Mexican women. Ninety-one breast cancer patients and 94 healthy controls were selected. Epidemiological and clinical questionnaires were answered by all participants, and genotyping data were obtained. CYP1A1 3801 T>C (rs4646903), CYP1A1 4889 A>G (rs1048943) and COMT 1947 G>A (rs4680) polymorphisms were analyzed by PCR-RFLP. Results: The results showed a high risk of breast cancer in women carrying the CYP1A1 (3801 T>C) m2/m2 genotype (OR=2.52; 95%CI=1.04-6.08). The risk was higher in postmenopausal women (OR=3.38; 95%CI=1.05-10.87). No association between COMT 1947 G>A (rs4680) or CYP1A1 4889 A>G (rs1048943) and breast cancer was found. Conclusions: This study suggests that the CYP1A1 (3801 T>C) m2/m2 genotype may contribute to breast cancer susceptibility in Mexican women. © 2010 Wichtig Editore.

Sanchez-Aleman E.,Autonomous University of Aguascalientes | Quintanar-Stephano A.,Autonomous University of Aguascalientes | Escobedo G.,Hospital General de Mexico | Campos-Esparza M.D.R.,Autonomous University of Aguascalientes | And 2 more authors.
NeuroImmunoModulation | Year: 2014

Background: The parasympathetic nervous system modulates the immune response in the abdominal-pelvic gut through the vagus nerve, which releases acetylcholine. This endogenous ligand acts on α7 nicotinic receptors expressed on immune cells. Objective: To study the mechanism of the production and regulation of cytokines in parasympathectomized and control hamsters during the development of amoebic liver abscesses (ALA) caused by Entamoeba histolytica.Methodology: Six- to 8-week-old male hamsters with and without vagotomy were used in a model of ALA. The animals were infected with trophozoites (350,000; HM1:IMSS strain) via the intrahepatic route and sacrificed at 6, 12, and 24 h and at 2, 4, and 7 days postinfection. Immune parameters were recorded at each time point using morphometric techniques including immunofluorescence and immunohistochemistry assays. These parameters included signal transducer and activator of transcription 3 (STAT3) levels, pro- and anti-inflammatory cytokine levels, and nuclear factor-κB (NFκB) activation in neutrophils and macrophages. Results: Compared to the control groups, the vagotomized (VAG) hamsters showed a significant increase in NFκB activation in neutrophils and macrophages, and higher levels of interleukin (IL)-1β, IL-6, interferon-γ, and tumor necrosis factor-α. VAG hamsters showed an increase in the expression of IL-8 and phosphorylated STAT3 during the first 24 h postinfection as well as slightly increased levels of transforming growth factor-β on days 2-7 postinfection. No significant differences were demonstrated in the levels of IL-10. Conclusions: These results suggest that the vagus nerve plays an important role in the regulation of inflammation during ALA formation. © 2014 S. Karger AG, Basel.

Villanueva C.,Escuela Superior de Medicina
Acta ortopédica mexicana | Year: 2010

Pain is a symptom associated with alterations of the musculoskeletal system and frequently needs to be treated by the orthopedist. The purpose of this review is to analyze the mechanisms involved in the pain sensation and the various treatments that have been applied in orthopedics to control pain. Since it is known that the analgesic response is not the same in all patients, aspects that affect the pain sensation were assessed, such as the placebo effect, patients sex and genomic factors. The treatment varieties analyzed included drug therapy, considering the drugs, their pharmaceutical presentations and the route of administration most frequently used in orthopedics; and acupuncture, which has proven to be effective in special cases.

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