Escola Superior de Saude Jean Piaget Nordeste

Saude, Portugal

Escola Superior de Saude Jean Piaget Nordeste

Saude, Portugal
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Ines L.,Servico Of Reumatologia Dos Hospitais Universitarios Of Coimbra | Couto M.,Servico Of Reumatologia Dos Hospitais Universitarios Of Coimbra | Santos C.,Escola Superior de Saude Jean Piaget Nordeste | Magalhaes M.,Polytechnic Institute of Coimbra | Silva J.A.P.D.,Servico Of Reumatologia Dos Hospitais Universitarios Of Coimbra
Cellular Immunology | Year: 2010

To compare frequency and functional activity of peripheral blood (PB) Th(c)17, Th(c)1 and Treg cells and the amount of type 2 cytokines mRNA we recruited SLE patients in active (n= 15) and inactive disease (n= 19) and healthy age- and gender-matched controls (n= 15). The study of Th(c)17, Th(c)1 and Treg cells was done by flow cytometry and cytokine mRNA by real-time PCR. Compared to NC, SLE patients present an increased proportion of Th(c)17 cells, but with lower amounts of IL-17 per cell and also a decreased frequency of Treg, but with increased production of TGF-β and FoxP3 mRNA. In active compared to inactive SLE, there is a marked decreased in frequency of Th(c)1 cells, an increased production of type 2 cytokines mRNA and a distinct functional profile of Th(c)17 cells. Our findings suggest a functional disequilibrium of T-cell subsets in SLE which may contribute to the inflammatory process and disease pathogenesis. © 2010 Elsevier Inc.

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