Escape Therapeutics Inc.

San Jose, CA, United States

Escape Therapeutics Inc.

San Jose, CA, United States
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Patent
Escape Therapeutics Inc. | Date: 2016-08-29

Compositions of HLA-G^(+) MSC and methods of using them, including methods of transplanting compositions of HLA-G^(+) MSC into human recipients, are provided. Also provided are methods of preparing compositions of HLA-G^(+) MSC, including by treatment with DNA methylation inhibitors.


Patent
Escape Therapeutics Inc. | Date: 2014-10-16

The present invention includes new hybrid hydrogel scaffolds comprised of a polyoxyethylene-polyoxypropylene (block) copolymer (a poloxamer) and a self-assembling peptide, which maintain the mechanical and bioactive properties of its individual constituents (as compared to when the individual constituents are scaffolds or hydrogels by themselves). The hydrogels of the invention can include a combination of materials from different origins or with different properties that provides a hybrid material that meets the multiple needs of a scaffold for tissue engineering.


Methods and compositions are provided for the differentiation and characterization of mammalian fibroblast from mesenchymal stem cells. The methods of the invention provide a means to obtain mesenchymal stem cell-derived fibroblast populations, e.g., seeded on a scaffold, which may be used in wound healing.


Methods and compositions are provided for the differentiation and characterization of mammalian fibroblast from mesenchymal stem cells. The methods of the invention provide a means to obtain mesenchymal stem cell-derived fibroblast populations, e.g., seeded on a scaffold, which may be used in wound healing.


Patent
Escape Therapeutics Inc. | Date: 2015-08-06

Methods and compositions are provided for the identification and isolation of mammalian HLA-G^(+) MSC, HLA-E^(+) MSC, or HLA-G^(+)/HLA-E^(+) MSC. The methods of the invention provide a means to obtain enriched HLA-G^(+ )MSC, HLA-E^(+ )MSC, or HLA-G^(+)/HLA-E^(+) MSC populations.


Patent
Escape Therapeutics Inc. | Date: 2013-12-10

Methods and compositions are provided for the identification and isolation of mammalian HLA-G^(+) MSC, HLA-E^(+) MSC, or HLA-G^(+)/HLA-E^(+ )MSC. The methods of the invention provide a means to obtain enriched HLA-G^(+) MSC, HLA-E^(+) MSC, or HLA-G^(+)/HLA-E^(+ )MSC populations.


Patent
Escape Therapeutics Inc. | Date: 2015-01-28

Disclosed herein are genetically modified cells expressing HLA-G (e.g., cell surface HLA-G) persistently, and nucleic acid compositions useful for generating such genetically modified cells. Also disclosed are cell therapy methods that utilize genetically modified cells that express HLA-G persistently. The HLA-G genetic modifications described herein provide the cells with characteristics of reduced immunogenicity and/or improved immunosuppression, such that these cells have the promise of being universal or improved donor cells for transplants, cellular and tissue regeneration or reconstruction, and other therapies.


Patent
Escape Therapeutics Inc. | Date: 2015-07-17

Isolated populations of mesenchymal stem cells (MSCs) are provided, including mammalian mesenchymal stem cells (MSCs) characterized by the lack of CD54 (CD54^()) or low cell-surface CD54 (CD54^(low)). Methods of in vitro cell differentiation and methods of treatment using said isolated populations are also provided.


Patent
Escape Therapeutics Inc. | Date: 2014-11-26

Peptides that increase melanin synthesis are provided. These peptides include pentapeptides YSSWY, YRSRK, and their variants. The peptides may activate the enzymatic activity of tyrosinase to increase melanin synthesis. The pharmaceutical, cosmetic, and other compositions including the peptides are also provided. The methods of increasing melanin production in epidermis of a subject are provided where the methods include administering compositions comprising an amount of one or more peptides effective to increase the melanin production. The methods also include treating vitiligo or other hypopigmentation disorders with compositions including one or more peptides.


Patent
Escape Therapeutics Inc. | Date: 2012-08-23

The present invention includes new hybrid hydrogel scaffolds comprised of a polyoxyethylene-polyoxypropylene (block) copolymer (a poloxamer) and a self-assembling peptide, which maintain the mechanical and bioactive properties of its individual constituents (as compared to when the individual constituents are scaffolds or hydrogels by themselves). The hydrogels of the invention can include a combination of materials from different origins or with different properties that provides a hybrid material that meets the multiple needs of a scaffold for tissue engineering.

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