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Ekinci M.,Kafkas University | Ceylan E.,Erzurum Training and Research Hospital Ophthalmology Clinic | Cagatay H.H.,Kafkas University | Keles S.,Atatürk University | And 4 more authors.
Current Eye Research | Year: 2014

Purpose: To evaluate the toxic effects of chronic lead (Pb) exposure on retinal nerve fiber layer thickness (RNFLT), macular thickness (MT) and choroidal thickness (CT) in battery industry workers. Materials and Methods: Male factory workers (n = 50) and healthy non-employees (n = 20) participated in the study. Group 1 (n = 22) comprised lead workers; Group 2 (n = 16), box makers; Group 3 (n = 12), assistant personnel; and Group 4 (n = 20), healthy non-employees. All participants were given Best-Corrected Visual Acuity (BCVA) tests, full ophthalmologic examinations, and Spectral Domain Optical Coherence Tomography (SD-OCT) of the optic nerve head, RNFL, macula, and choroid. Blood lead levels (BLL) in venous blood samples were determined. The duration of exposure to lead varied, and is expressed in months. Results: Average (mean ± SD) ages of participants were 27.55 ± 4.00, 28.69 ± 3.48, 32.00 ± 3.38, and 29.85 ± 5.48 yrs (Groups 1-4, respectively). BLL were 46.2 ± 2.32, 29.31 ± 3.30, 16.9 ± 1.9, and 2.85 ± 0.98 μg/dL (Groups 1-4, respectively). Durations of exposure to lead were 43.86 ± 10.81, 42.81 ± 4.86, and 49.42 ± 6.14 mo (Groups 1-3, respectively). OCT averages for RNFL were 101.68 ± 5.32, 119.50 ± 13.47, 127.67 ± 8.92, and 130.9 ± 6.63 μm (Groups 1-4, respectively). Although RNFLTs of Group 1 were significantly less than those of for Groups 2-4, and, RNFLTs of Groups 2 and 3 were significantly less than that of Group 4, there were no significant differences between Group 2 and 3. MTs were 94.50 ± 6.78, 105.63 ± 5.43, 111.50 ± 6.74 and 147.95 ± 6.67 μm, (Groups 1-4, respectively). CTs were 176.41 ± 15.39, 222.19 ± 17.79, 239.17 ± 15.64, and 251.50 ± 10.98 μm (Groups 1-4, respectively). Both MTs and CTs displayed significant differences among the four groups. Conclusions: Ocular changes in individuals who are chronically exposed to lead include decrease in RNFT, MT, and CT, and thus these parameters should be evaluated during ophthalmologic examination of individuals working in lead-based industries. © 2014 Informa Healthcare USA, Inc. All rights reserved: reproduction in whole or part not permitted.

Ceylan E.,Erzurum Training and Research Hospital Ophthalmology Clinic | Ekinci M.,Kafkas University | Aksu N.,Istanbul University | Kartal B.,Erzurum Training and Research Hospital Ophthalmology Clinic | And 5 more authors.
Neuro-Ophthalmology | Year: 2014

Folic acid has a fundamental role in central nervous system (CNS) function at all ages, especially the methionine synthase-mediated conversion of homocysteine to methionine, which is essential for nucleotide synthesis and genomic and non-genomic methylation. Folic acid and vitamin B12 may have roles in the prevention of disorders of CNS development, mood disorders, and dementias, including Alzheimer disease and vascular dementia in elderly people. The authors examined the peripapillary retinal nerve fibre layer thickness (RNFLT) in patients with nutritional folic acid deficiency using optical coherence tomography (OCT). Patients were divided into two groups according to blood folic acid levels: blood folic acid <7nmol/L as Group 1 and >7nmol/L as Group 2. Peripapillary RNFL measurements were performed. There were significant positive correlations between serum folate levels and RNFLT in all quadrants (p<0.05), except for the temportal quadrant (p=0.41). © 2014 Informa Healthcare USA, Inc. All rights reserved: reproduction in whole or part not permitted.

Ekinci M.,Kafkas University | Huseyinoglu N.,Kafkas University | Huseyin Cagatay H.,Kafkas University | Keles S.,Atatürk University | And 2 more authors.
Neuro-Ophthalmology | Year: 2014

Sleep apnoea syndrome (SAS) is characterised by repetitive episodes of cessation of breathing during sleep, resulting in hypoxaemia and hypercapnia. Ophthalmological consequences such as glaucoma, non-arteritic anterior ischaemic neuropathy and papilloedema are relevant to hypoxaemia. The choroid is a vascular structure that performs several regulatory functions for the retina. Defects in this structure contribute to degenerative, inflammatory, and neovascular changes in the retina. The authors examined the choroidal thickness (CT) in sleep apnoea patients using optical coherence tomograpy (OCT). The sleep apnoea patients were divided into subgroups according to their apnoea-hypopnoea index (AHI) scores, and statistical analysis was performed using the AHI and minimal arterial oxygen saturation (min. Spo2) values. There was a medium-high negative correlation between CT and AHI (Spearman rho: r-=0.744, p-=-0.000), and a positive correlation between CT and min. Spo2 values (Pearson correlation: r-=-0.308, p-=-0.000). © 2014 Informa Healthcare USA, Inc.

Ekinci M.,Kafkas University | Cagatay H.H.,Kafkas University | Huseyinoglu N.,Kafkas University | Ceylan E.,Erzurum Training and Research Hospital Ophthalmology Clinic | Gokce G.,Sarikamis Military Hospital Ophthalmolgy Clinic
Neuro-Ophthalmology | Year: 2014

Bacillus anthracis, the agent of anthrax, is a nonmotile, aerobic gram-positive rod that can form very resistant spores in economically poor environments. Anthrax can manifest as cutaneous, gastrointestinal, or inhalational form. Cutaneous anthrax, caused by direct skin contact, presents with eschar, lymphadenopathy, and a febrile illness. The face and eyelids are most commonly involved in cutaneous anthrax. A 45-year-old man was admitted to our clinic with high fever and swelling of the right eyelid. One day later on re-examination, formation of ulcerous lesions in the right medial canthal region was observed, with general oedema in the upper and lower eyelids. The patient was evaluated as having cutaneous anthrax and medical treatment was continued until the 28th day; he was discharged from the hospital with no loss of vision. He returned for a follow-up examination after 2 months, with decreased visual acuity (

Ekinci M.,Kafkas University | Ceylan E.,Erzurum Training and Research Hospital Ophthalmology Clinic | Cakici O.,Muǧla University | Tanyildiz B.,Istanbul University | And 2 more authors.
Expert Review of Ophthalmology | Year: 2014

Aim: To compare the effects of the anti-VEGF treatments bevacizumab and ranibizumab on visual acuity and foveal thickness in macular edema due to diabetic retinopathy. Materials and methods: 50 patients received intravitreal bevacizumab (Avastin; Group 1) and 50 received intravitreal ranibizumab (Group 2). Patients were assessed before and every month for 12 months after injection. Foveal thickness values and best corrected visual acuity were obtained at each assessment. Patients were assessed at 12-month follow-up on BCVA and foveal thickness. Results: BCVA averages for both groups showed a significant increase in visual acuity from pretreatment to 12 month follow-up. The decrease in foveal thickness was also significantly different for both groups from pretreatment to 12 month follow-up. At 12 months, there were no significant between-group differences with respect to a decrease in foveal thickness or an increase in visual acuity. Conclusions: Bevacizumab, compared to ranibizumab, was effective with fewer injections. © 2014 Informa UK Ltd.

Huseyin Cagatay H.,Kafkas University | Gokce G.,Sarkamis Military Hospital | Ekinci M.,Kafkas University | Koban Y.,Kafkas University | And 2 more authors.
Postgraduate Medicine | Year: 2014

Purpose: Pterygium is a common clinical entity that usually causes visual impairment, astigmatism and cosmetic problems. Although many surgical techniques to treat pterygium have been proposed, no single method, with minimal patient complications, has yet been accepted and established. Excision combined with conjunctival autograft is the most often used procedure for the treatment of primary pterygium, and the technique is associated with minimized recurrence rates in patients. The purpose of our study was to compare visual and refractive outcomes, complications, and recurrence rates with the use of fibrin glue versus 8.0 vicryl suture in pterygium surgery performed with conjunctival autograft. Materials and Methods: Our retrospective, comparative study included 106 eyes of 106 patients operated on for primary pterygium, between the years 2011 and 2012, and followed for ≥ 12 months. Patients were divided into 2 treatment groups: Group 1, vicryl suture use (n = 53), and Group 2, fibrin tissue glue (n = 53). Patient follow-up periods were 21.15 ± 5.3 months for Group 1 and 22.06 ± 5.2 months for Group 2. Results: Demographics and preoperative/follow-up clinical characteristics of patients revealed no significant differences between the 2 patient groups. Additionally, no significant differences were found between the patient groups in visual acuity level changes and refractive values. Although the rates of recurrence (7.5% in Group 1 and 1.9% in Group 2; P = 0.36) and graft dehiscence (Group 1, 7.5% compared with Group 2, 3.8%; P = 0.67) were slightly higher for patients in the suture group, differences did not reach significance. Conclusions: Our study results suggest that conjunctival autografting with fibrin glue has favorable visual and refractive results for patients, and is associated with lower complication rates, compared with use of the traditional 8.0 vicryl suturing technique. We suggest that fibrin tissue glue provides adequate adhesion and that graft loss will not be a problem if protective shields are used in patients postoperatively. The appropriate surgery technique should be selected by considering the advantages and disadvantages of each procedure. © Postgraduate Medicine

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