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Diyarbakir E.,Ataturk University | Eyerci N.,Ataturk University | Melikoglu M.,Erzurum Training and Research Hospital | Topcu A.,Ataturk University | Pirim I.,Ataturk University
Genetic Testing and Molecular Biomarkers | Year: 2012

Human leukocyte antigen (HLA) B27 has a strong association with ankylosing spondylitis (AS) and other spondyloarthropathies. More than 70 subtypes of HLA B27 have been described. The present study investigated B27 subtype distribution among B27-positive patients with AS classified according to the modified New York criteria and healthy controls. Sequence-specific primer polymerase chain reaction technique was used for B27 subtyping of 43 unrelated patients with AS and 39 volunteer bone marrow donors. Among patients with AS, the male-female ratio was 6.2 and the mean age was 30 years. No relationship was found between the B27 subtypes and clinical and laboratory findings in patients with AS (p>0.05). Similarly, the frequencies of B27 subtypes did not significantly differ between patients and controls. In this study, B*2746, B*2749, and B*2767 subtypes were detected for the first time. Among B27 subtypes, the most common B27 alleles found in the patients and the controls were B*2702 and B*2705. In addition, B*2702 subtype was found predominantly in both patients (48.8%) and controls (46.2%). In conclusion, in addition to commonly encountered B*2702 and B*2705 HLA subtypes, a B*2749 subtype in a patient with AS and B*2746 as well as B*2767 subtypes in controls were determined for the first time. © 2012 Mary Ann Liebert, Inc. Source


Hakan N.,Dr. Sami Ulus Maternity and Children Hospital | Hakan N.,Erzurum Training and Research Hospital | Dilli D.,Dr. Sami Ulus Maternity and Children Hospital | Zenciroglu A.,Dr. Sami Ulus Maternity and Children Hospital | And 2 more authors.
European Journal of Pediatrics | Year: 2014

We aimed to determine reference values of perfusion index (PI) in healthy newborns during the early neonatal period. Preductal (right hand) and postductal (foot) PI values were assessed during the first 5 days of life by using a new generation pulse oximetry. A total of 241 newborn infants (196 [81.3 %] term and 45 [18.7 %] preterm) were enrolled to the study. On the first day, in term infants, the median (interquartile range [IQR]) preductal and postductal PI were 1.35 (1.02-1.91) and 0.88 (0.62-1.22), respectively (p=0.001). These values were 0.88 (0.60-1.26) and 0.61 (0.35-0.92) in preterm infants, with the same respect (p=0.001). From the first to third days, preductal PI remained significantly higher than the postductal PI (p<0.001, for all comparisons). Both preductal and postductal PI of term newborns were significantly higher than those of preterm infants (p<0.001, for both comparisons). These differences in PI disappeared on the fifth day of life. Conclusion: PI values which reflect peripheral perfusion seem to reach to a steady state on the fifth day of life following physiological maturation. © 2013 Springer-Verlag. Source


Ekinci M.,Kafkas University | Huseyinoglu N.,Kafkas University | Cagatay H.H.,Kafkas University | Ceylan E.,Erzurum Training and Research Hospital | And 2 more authors.
Current Eye Research | Year: 2013

Purpose: The objective of this study was to determine the central corneal thickness (CCT) measurements in patients with Sleep Apnea Syndrome (SAS) and the relationship between the severity of SAS and minimal arterial oxygen saturation (min. SpO2) with respect to CCT. Materials and methods: Two hundred and fourteen eyes of 107 patients (58 males, 49 females) who were diagnosed as SAS and 80 eyes of 40 healthy subjects (20 males, 20 females) were included in the study. The SAS patients were divided into subgroups according to their Apnea-Hypopnea Index (AHI) values as: AHI values between 5 and 15 as subgroup 1, between 15 and 30 as subgroup 2, and the values ≥30 as subgroup 3. The CCT was measured by an ultrasonic pachymetric system. Statistical analyses were an analysis of variance test and, for post-hoc analysis, the Dunnett C test. Results: Mean age was 52.5±10.96 years in the study group, and 40.7±10.14 years in the control group. There were 58 (54.2%) males and 49 (45.8%) females in the study group, and 20 (50%) males and 20 (50%) females in the control group. Mean CCT values were 526.65±25.06, 525.26±29.25, 512.93±43.20 and 539.90±17.28 in subgroup 1, subgroup 2, subgroup 3 and the control group, respectively. There were no statistically significant differences between gender and age groups with respect to CCT (p>0.05). When the mean CCT values of each subgroups were compared with the control group, the differences were statistically significant (p<0.05). There was a negative correlation between CCT and AHI values and a positive correlation between CCT and min. SpO2 values. Conclusions: CCT measurements differ significantly in patients with SAS compared with healthy control subjects. It should be taken into consideration that SAS may reduce CCT over time and that CCT should be measured in each ophthalmic examination. © 2013 Informa Healthcare USA, Inc. Source


Ekinci M.,Kafkas University | Cagatay H.H.,Kafkas University | Gokce G.,Sarikamis Military Hospital | Ceylan E.,Erzurum Training and Research Hospital | And 4 more authors.
Clinical Ophthalmology | Year: 2014

Background: The aim of this study was to compare the effect of W-shaped skin (WS) and linear skin (LS) incisions on cutaneous scar tissue formation in patients who have undergone bilateral external dacryocystorhinostomy. Methods: Sixteen patients (14 females and two males) with acquired bilateral nasolacrimal duct obstruction were included in this prospective, interventional comparative study. LS incision was applied to one side and WS skin incision to the other side. The skin incisions were assessed 6 months after each procedure by the patients themselves and by two ophthalmologists who were unaware of the skin incision shape and side. Scar tissue that was not recognized under the same light conditions and in the same room from a 100 cm distance was recorded as grade 1. Minimally visible scar tissue was assessed as grade 2, moderately visible scar tissue as grade 3, and easily visible scar tissue as grade 4. Results: The mean scar assessment scores recorded by the first ophthalmologist were 2.50±0.82 for the LS group and 1.25±0.45 for the WS group (P,0.001). The second ophthalmologist's assessment scores were 2.25±0.86 for the LS group and 1.25±0.45 for the WS group (P,0.001). The mean patient self-assessment score for the incision scars was 2.44±1.03 for the LS group and 1.56±0.73 for the WS group (P,0.001). Conclusion: Compared with LS incision, WS incision resulted in less cutaneous scar tissue formation in patients who have undergone bilateral external dacryocystorhinostomy. © 2014 Ekinci et al. Source


Binici D.N.,Erzurum Training and Research Hospital | Karaman A.,Erzurum Nenehatun Obstetrics and Gynecology Hospital | Coskun M.,Erzurum Training and Research Hospital | Uyanik Oglu A.,Erzurum Training and Research Hospital | Ucar F.,Mustafa Kemal University
Genetic Counseling | Year: 2013

DNA damage seems to play a role in the pathogenesis of type-2 diabetes mellitus (DM2) and its complications. Several in vitro assays have been used to measure the DNA damage. In the present study, we aimed to investigate the frequency of sister chromatid exchange (SCE) and micronuclei (MN) in DM2 patients compared with healthy controls. SCE and MN tests were carried out with the blood-cell cultures from 50 DM2 patients and 30 healthy, age- and sex-matched control subjects. The mean age of the DM2 patients was 58.12 ± 13.39 years, with a mean duration of the diabetes of 5.40 ± 4.32 years. The mean level of HbA1c of the DM2 patients was 8.93 ± 2.56. Patients with DM2 showed a higher frequency of SCE compared with controls (7.11 ± 1.14 and 4.96 ± 0.92, p<0.001). Furthermore, the SCE frequency was positively correlated with the plasma HbA1c level (p<0.05), but there was no significant correlation between the duration of diabetes and SCE. On the other hand, our result showed a MN frequency significant increase in DM2 patients (3.45 ± 1.01 per 1000 cells) relative to that of the control group (1.79 ± 0.67 per 1000 cells) (p<0.001), but there was no significant correlation between the duration of diabetes, HbA1c and MN. In conclusion, these results suggest that DM2 is a condition with genomic instability characterized by an increased level of SCE and MN. Hyperglycemia-induced oxidative stress may be the underlying factor of the increased SCE and MN frequency. Source

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