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Polat B.,Ataturk University | Suleyman H.,Recep Tayyip Erdogan University | Sener E.,Erzurum Regional Education and Research Hospital | Akcay F.,Ataturk University
Journal of Cardiovascular Pharmacology and Therapeutics | Year: 2015

Background and Purpose: To investigate the effect of thiamine and thiamine pyrophosphate on doxorubicin-induced cardiotoxicity biochemically and histopathologically and to examine whether doxorubicin cardiotoxicity is related to the conversion of thiamine into thiamine pyrophosphate and inhibition of thiamine pyrophosphokinase (TPK) enzyme. Experimental Approach: A total of 48 Albino Wistar male rats were used. Rats were divided into groups as thiamine + doxorubicin (TIA + DOX), thiamine pyrophosphate + doxorubicin (TPP + DOX), DOX, and healthy (HEA) groups. One hour after the administration of thiamine and TPP in 25 mg/kg doses, 5 mg/kg doxorubicin were injected to all groups except HEA group during 7 days. Then, the samples were collected for biochemical (glutathione [GSH], malondialdehyde [MDA], DNA damage, creatine kinase (CK), CK-MB, and troponine I [TP-I]), molecular (TPK), and histopathological examinations. Key Results: Oxidant parameters (MDA and DNA damage) decreased and antioxidant parameter (GSH) increased in TPP + DOX group. In addition, levels of CK, CK-MB, and TP-I were low in the TPP + DOX group and high in the TIA + DOX and DOX groups. Cardiac tissue was protected in TPP + DOX group, and no protective effect was observed in TIA + DOX and DOX groups. Messenger RNA expression of TPK was decreased in DOX and TIA + DOX groups. Conclusion and Implications: The cardiotoxic effect of doxorubicin originated from the inhibition of TPK enzyme resulting in insufficient production of thiamine pyrophosphate. © The Author(s) 2014. Source


Emsen I.M.,Erzurum Regional Education and Research Hospital
The Journal of craniofacial surgery | Year: 2015

PURPOSE: Nasal septal perforations (NSPs) are one of the major complications among the nose surgery that the surgeon has to solve it. There are many reasons on the etiology of septal perforation such as iatrogenic and idiopathic. All the surgical procedures are based on 2 main principles, namely repair using an intranasal flaps: mucosal, mucoperichondrial, mucoperiosteal flaps within the nasal cavity; and extranasal flaps. Operation can be carried out using either the "closed technique" or "open technique." The author presents a different or additional method, namely alar winged flaps (AWFs).PATIENTS AND METHODS: Between 2010 and 2014, a total of 13 patients with medium-large NSP were treated with this approach. Of these 13 patients, 9 were male (69%) and 4 female (31%). Average age was 40.13 years. In 13 cases, average diameter of the perforation was between 1.5 and 2.4 cm; in 1 case, it was >3 cm; in 2 cases, it was <2 cm.RESULTS: Alar winged flaps was used for better exposure in all patients. Etiology of the NSP was detected as previous septal surgery in 5 cases (38%), over septal tissue resection in 3 cases (23%), and infection at septal surgery, blunt trauma, >1 blunt trauma, nasal corticosteroid using, respectively. There was no preoperative and postoperative complication. At the early follow-up, AWF flap incision scar was cosmetically satisfactory.DISCUSSION: As can be seen from the senior authors' description, especially large NSPs are difficult problems to solve. The proposed surgical techniques are still offered the highest recurrence rates. To address this problem, the authors developed the AWF method. The operation time before using AWF was so long in our previous NSP surgeries. After AWF, the authors saved an average of 14 to 25 minutes in each operation. No visible scar is seen on the AWF donor areas at the early follow-up. The authors suggest this flap method bilaterally and/or unilaterally for the medium or large perforations. Source


Kuduban O.,Erzurum Regional Education and Research Hospital | Kuduban S.D.,Erzurum Palandoken Government Hospital
American Journal of Case Reports | Year: 2015

Objective: Unusual clinical course Background: Septorhinoplasty is a frequent surgical procedure used for both cosmetic and functional purposes. The technique varies from surgeon to surgeon and according to which suture material is used. While some surgeons prefer non-absorbable sutures, others prefer sutures with delayed absorption. These materials sometimes protrude from the skin and they may cause skin reactions. While these reactions are common in the late period, a skin reaction in the early period because of polydioxanone suture is extremely rare and to the best of our knowledge, this is the first such reported case in the literature. Case Report: A 25-year-old male patient underwent endonasal septorhinoplasty procedure with endo-tracheal general anesthesia. We hereby present the skin reaction because of frequently used polydioxanone suture on the 24th postoperative day and the management of this patient. We cut the suture at skin level and prescribed antibiotherapy, and we scheduled a follow-up for 10 days afterwards. The patient had no complaint and the control examination result was normal. Conclusions: When performing septorhinoplasty operations, very rare complications of the procedure shouldn’t be ignored and an informed consent must be obtained after explaining possible complications before the operation. This approach is important for increasing the patient compliance and proper follow-up for the patient. This way, especially post-operative early complications as our case will be able to be solved with close follow-up and intervention, before causing permanent damage. The relationship between patient who underwent rhinoplasty and the physician also has an important role on these follow-up visits. © Am J Case Rep, 2015. Source


Okanli A.,Ataturk University | Karakas S.A.,Erzurum Regional Education and Research Hospital | Ozkan H.,Ataturk University
HealthMED | Year: 2011

Objective: The study was conducted in order to detect the relationship between being exposed to mobbing and levels of assertiveness. Methods: The study was conducted as a descriptive study. It was conducted in Erzurum Regional Education and Research Hospital and Atatürk University Faculty of Medicine Yakutiye Research Hospital between the dates of 15 February 2010 and 30 April 2010. 218 nurses who accepted to be involved in the study were got into contact. In the collection of data, survey form which determines socio-demographic features; Rathus Inventory of Self-assertive (RAE) and Mobbing Scale which we have developed for nurses were used. Percentage distribution, averages, Pearson correlation analysis, cronbach alpha coefficient were used in the evaluation of data. Results: 17.4% of those who have participated in the research and got above 204 score are detected to have been exposed to mobbing according to mobbing scale. 54.1% of them were detected to be passive according to Rathus Assertiveness Inventory. There is a negative relationship between Mobbing scale and assertiveness inventory (p<0.01). As the assertiveness level increase the rate of being exposed to mobbing decrease. Conclusions: As a result, it was found out that the possibility of nurses being exposed to mobbing is high and the real reason for their being exposed to mobbing is their passive behavior. It is suggested that institutional awareness should be raised; the problem experienced in the institution should be revealed and nurses should be given education about assertiveness and communication skills. Source


Gen R.,Erzurum Regional Education and Research Hospital | Akbay E.,Mersin University | Sezer K.,Mersin University
Endocrinologist | Year: 2010

INTRODUCTION:: The aim of this study was to investigate insulin resistance in patients with mild and severe subclinical hypothyroidism (SH), and to explore the relationship between insulin resistance and cardiovascular risk factors. MATERIAL AND METHODS:: The study group consisted of 27 women with severe SH (body mass index [BMI], 28.35/3.92 kg/m), 25 women with mild SH (BMI, 27.13/3.16 kg/m), and 22 healthy women (BMI, 27.365/2.92 kg/m). The mean systolic blood pressure, diastolic blood pressure, fasting insulin, homeostasis model assessment of insulin resistance (HOMA-IR), total cholesterol, LDL-cholesterol (LDL-C), triglyceride, thyroid-stimulating hormone (TSH), and high-sensitive CRP (hs-CRP) levels were higher in patients with severe SH than patients with mild SH and control subjects. The mean fasting insulin level, TSH level, LDL-C, and hs-CRP was higher in patients with mild SH than the control group. However, systolic blood pressure, diastolic blood pressure, and HOMA-IR were similar between patients with mild SH and those in the control group. In patients with severe SH, HOMA-IR was positively associated with TSH, total cholesterol, LDL-C, triglyceride, hs-CRP, and diastolic blood pressure but negatively associated with HDL-C. There was no correlation between HOMA-IR and waist circumference, W/H ratio, fT3, fT4, and systolic blood pressure in patients with severe SH. In patients with mild SH, HOMA-IR was positively correlated with TSH and hs-CRP, but there was no correlation between HOMA-IR and other parameters. CONCLUSION:: We conclude that severe SH was associated with increased insulin resistance and increased cardiovascular risk factors such as lipid abnormalities, hypertension, and hs-CRP. Our data also suggest that insulin resistance may play a role in mediating the effects of severe SH on diastolic blood pressure, lipid abnormalities, and low-grade inflammation. Mild SH is associated only with early insulin resistance, LDL-C, and low-grade inflammation. © 2010 by Lippincott Williams & Wilkins. Source

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