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Tatar A.O.,Erzurum Region Education and Research Hospital | Yoruk O.,Atatürk University | Akgun M.,Atatürk University
European Archives of Oto-Rhino-Laryngology | Year: 2014

The objective of this prospective, randomized study was to evaluate the effect of pre-emptive local infiltration of lidocaine, lidocaine plus dexamethasone, levobupivacaine and levobupivacaine plus dexamethasone on postoperative pain in Modified Radiofrequency Assisted Uvulopalatoplasty (MRAUP) cases. Sixty adult patients (44 males and 16 females) aged 32-51 years with simple snoring were divided into four groups. The anesthesia of the patients in the first group was achieved with lidocaine HCl, in the second group, with lidocaine HCl and dexamethasone sodium phosphate, in the third group, with levobupivacaine, and in the fourth group, levobupivacaine and dexamethasone sodium phosphate. All the patients were applied Modified Radiofrequency Assisted Uvulopalatoplasty technique. The pain experienced by the patients during swallowing and at rest on the 1st, 3rd, 5th, 7th, and 10th day and analgesic consumption were evaluated using standard 10 cm visual analog scales. The mean duration of operation in the group that received lidocaine HCl was 22 ± 3 min, while in the group that received levobupivacaine HCl was 27 ± 4 min. There were statistically significant differences between the groups for analgesic effects on the 1st, 3rd, 5th, and 7th day and for the amount of analgesics used, on the 1st, 3rd, and 5th day. The best results were obtained in the group that received levobupivacaine HCl and steroid (p < 0.001). Steroid and local anesthetic combinations are superior to controls in the management of postoperative pain in MRAUP surgery. © 2013 Springer-Verlag.


Albayrak A.,Erzurum Region Education and Research Hospital | Albayrak F.,Atatürk University
Hepatitis Monthly | Year: 2011

Implication for Health policy/practice/research/medical education: This editorial has been written to aware about the drawbacks of the liver granuloma and the importance of brucellosis as one of the most common zoonotic diseases. Reading this article is recommended especially to pathologists, infectious diseases specialists and gastroenterologists in the viewpoint of differential diagnosis of liver granuloma. Prevention of this infection should be considered more by authorized people in the health system. © 2011 Kowsar M.P.Co. All rights reserved.


Demir M.,Erzurum Region Education and Research Hospital
Southern Medical Journal | Year: 2010

Objectives: The Maastricht III Consensus agreed that effective treatment for Helicobacter pylori (HP) should achieve an intention-totreat (ITT) eradication rate above 80%, which is still lacking in patients with type 2 diabetes mellitus (DM). This pilot study was designed to confirm the efficacy of a 14-day sequential treatment regimen in patients with type 2 DM. Methods: This is a prospective, open-label, single-center pilot study. All patients included in this study underwent upper gastrointestinal endoscopy. HP status was evaluated in each patient by a rapid urease test and histopathologic examination. For seven days, all patients received pantoprazole 40 mg twice daily (b.i.d.) and amoxicillin 1000 mg b.i.d., followed by pantoprazole 40 mg b.i.d., metronidazole 500 mg b.i.d., and tetracycline 500 mg once each day for the remaining seven days. The study population consisted of 38 consecutive patients with type 2 DM (18 female, 20 male; mean age 48.0 ± 12.2 years), 30 of whom had non-ulcer dyspepsia, four had gastritis, one had gastric ulcer, and three had duodenal ulcer disease. Eradication was defined as the absence of HP as assessed with the 14C-urea breath test. Results: Thirty-seven of 38 patients completed the study. All side effects were observed in eight patients (21.1%). None of the patients discontinued treatment because of side effects. The eradication rate in the DM group was 22/38 (57.9%) for the ITT analysis and 22/37 (59.5%) for the per-protocol (PP) analysis. Conclusion: The results of 14-day sequential therapy for the firstline treatment of HP in patients with type 2 DM were disappointing. Further studies with new antibiotic combinations are needed to find better methods of eradicating HP in patients with type 2 DM. Copyright © 2010 by The Southern Medical Association.


Baris I.I.,Istanbul University | Arman Karakaya Y.,Erzurum Region Education and Research Hospital
Turk Patoloji Dergisi/Turkish Journal of Pathology | Year: 2013

Objective: Mardin is an area of low socioeconomic level with low rates of contraceptive method use. Our aim in this study was to evaluate the Effects of the contraceptive methods used in the area on epithelial cell abnormalities and vaginal flora changes. Material and Method: Cervical smear samples received at the Pathology Department between 2010 and 2012 of 526 patients who had used a contraceptive method and 112 who had never used one were included in the study. The cases were divided into 3 groups as those using hormonal contraception (107, 20.3%), those using an intrauterine device (343, 65.2%) and those using a barrier method (76, 14.4%). The evaluation was made using the Bethesda 2001 criteria for cervical epithelial abnormalities and specific cervicovaginal infections. Results: T ere was no significant difference between the groups for epithelial cell abnormalities while bacterial vaginitis (12%, p=0.03) and Trichomonas vaginalis (7.6%) were more common in the IUD users. TheActinomyces rate in RIA users was 1.3%. T ere was only 1 case of bacterial vaginitis in the barrier group and none of the other patients had a specific infection. Discussion: We did not find a significant cytopathic Effect of using a IUD or hormonal contraception in our study. T ere was a low rate of epithelial abnormality in the barrier method group. IUD was seen to increase the incidence of bacterial vaginitis, Trichomonas vaginalis and Actinomyces. We did not find a significant Effect of hormone use on the vaginal flora.


Demir M.,Erzurum Region Education and Research Hospital | Ataseven H.,Erzurum Region Education and Research Hospital
Turkish Journal of Medical Sciences | Year: 2011

Aim: There is no effective eradication regimen for Helicobacter pylori (HP) in Turkey. Recent studies have shown that sequential therapy may be superior to the standard triple therapy in terms of the eradication of HP. In this study, we aim to assess the efficacy of a 14-day sequential treatment regimen as a first-line therapy for HP eradication. Materials and methods: This is a prospective, open-label, single-centre study. The study involved 86 consecutive patients with nonulcer dyspepsia. All patients were randomly assigned into 2 study groups at a 2:1 ratio using random sampling numbers. The first group of patients were administered a sequential treatment: pantoprazole 2 × 40 mg and amoxicillin 2 × 1000 mg for the first 7 days and pantoprazole 2 × 40 mg, metronidazole 2 × 500 mg, and tetracycline 4 × 500 mg for the remaining 7 days. The second group of patients were administered pantoprazole 2 × 40 mg, amoxicillin 2 × 1000 mg, and clarithromycin 2 × 500 mg (PAC) for 14 days. Eradication was defined as the absence HP as assessed with the (14-C) urea breath test 4 weeks aft er the end of the antimicrobial therapy. Results: The eradication rate in the sequential group was 56.1% for the ITT analysis and 57.1% for the PP analysis, the eradication rate of the PAC group was 58.6% for both PP and ITT analysis. There was a statistically significant diff erence between the eradication rates of the groups for both PP and ITT analysis. There was no statistically significant difference in the adverse effects encountered in both groups (10.5% versus 13.8% P > 0.05). Conclusion: These results suggest that a 14-day sequential eradication regimen is not effective as a first-line therapy for HP eradication. © TÜBITAK.


Albayrak A.,Erzurum Region Education and Research Hospital | Ertek M.,Refik Saydam National Public Health Agency | Tasyaran M.A.,Ataturk Region Education and Research Hospital | Pirim I.,Atatürk University
Biochemical Genetics | Year: 2011

Human leukocyte antigen (HLA) alleles have been associated with the clinical outcomes of hepatitis B virus (HBV) infection, which range from spontaneous recovery to hepatocellular carcinoma. In this study involving subjects from eastern Turkey, the frequencies of HLA-B35, HLA-CW4, HLA-DQ2, and HLA-DQ8 were markedly higher in the chronic HBV group than those in the spontaneously recovered group; the frequencies of HLA-A11 and HLA-A24 in the nonresponsive HBV vaccine group were markedly higher than those in the responsive HBV vaccine group; and the frequency of HLA-CW6 in the nonresponsive HBV vaccine group was significantly lower than in the responsive group. A complete understanding of HLA types associated with the progression to chronic HBV infection and their effects within the cell at the molecular level will be an important contribution in the development of new HBV vaccines and new treatment strategies for chronic HBV infection. © 2010 Springer Science+Business Media, LLC.


Aydin Kurna S.,Fatih Sultan Mehmet Education and Research Hospital | Acikgoz S.,Fatih Sultan Mehmet Education and Research Hospital | Altun A.,Fatih Sultan Mehmet Education and Research Hospital | Ozbay N.,Fatih Sultan Mehmet Education and Research Hospital | And 2 more authors.
Journal of Ophthalmology | Year: 2014

Purpose. The aim was to compare the effects of antiglaucoma eye drops on the tear functions and ocular surface. Method. Eighty-five eyes of 43 patients with glaucoma were included into this randomized prospective study. Timolol without preservative (1), timolol with benzododecinium bromide (2), latanoprost (3), bimatoprost (4), travoprost with benzalkonium chloride (5), and brimonidine with purite (6) were given to 6 groups. Schirmer I, tear film breakup time (TBUT), staining scores, and impression cytology samples were evaluated before and during 12-month-follow-up period. Results. At the end of 12 months, there was no detected change in Schirmer I and TBUT tests indicating dry eye. Corneal staining scores were higher in groups 1 and 2, while conjunctival staining scores were higher in group 6. Goblet cell count decreased in groups 1 and 5 in superior and inferior, group 2 in superior, and groups 3 and 6 in inferior conjunctiva. Squamous metaplasia grades showed a significant increase in groups 1 and 2 at 3rd, 6th, and 12th month controls (P < 0.05). Conclusion. We observed nonserious impact on tear functions and ocular surface with antiglaucoma monotherapy. Beta blockers induced more damage on the ocular surface suggesting the role of the dosing and active substances beside preservatives. © 2014 Sevda Aydin Kurna et al.


Kivanc S.,Oltu Public Hospital | Olcaysu O.,Erzurum Region Education and Research Hospital | Gelincik I.,Erzurum Region Education and Research Hospital
Indian Journal of Ophthalmology | Year: 2014

A 49-year-old woman developed a dark brown nodular mass in the lower eyelid. The lesion had grown fast for 2 months and then had remained stable in size. Excisional biopsy was performed. Histopathological examination of an excisional biopsy specimen pointed to proliferative vessels lined by increased endothelial cells without nuclear atypism. The nodular mass evaluated as a capillary hemangioma.


Gen R.,Erzurum Region Education and Research Hospital | Demir M.,Erzurum Region Education and Research Hospital | Ataseven H.,Erzurum Region Education and Research Hospital
Southern Medical Journal | Year: 2010

Background/Aim: Many studies have revealed a close relationship between Helicobacter pylori (HP) infection and insulin resistance. The aim of this study was to investigate the effects of HP eradication on insulin resistance, serum lipids and low-grade inflammation. Materials and Methods: This was a prospective, open-label, single-center study which consisted of 159 patients. The patients with HP infection received a 14-day sequential regimen. A HOMA-IR (homeostasis model assessment of insulin resistance) level was used to assess insulin resistance. Results: Eighty-eight patients with HP infection and seventy-one patients without HP infection were studied. HOMA-IR, total cholesterol (TC), triglyceride (TG), LDL cholesterol (LDL-C) and C reactive protein (CRP) levels were significantly higher and HDL-cholesterol (HDL-C) levels were significantly lower in patients with HP infection compared to the patients without HP infection (P < 0.05). The HP eradication rates with a sequential regimen in dyspeptic patients were 53.4%. Six weeks after the end of eradication therapy, the mean fasting insulin, HOMA-IR, TC, TG, LDL-C, and CRP levels in patients with successful eradication were significantly decreased from the pretreatment levels (P < 0.05) and HDL-C level was significantly increased from the pretreatment levels (P < 0.05). The mean fasting insulin, HOMA-IR, TC, TG, LDL-C, CRP levels and HDL-C levels in patients with unsuccessful eradication were not significantly changed from pretreatment levels (P < 0.05). Conclusion: This study showed beneficial effects of HP eradication on insulin resistance, atherogenic lipid abnormalities and low-grade inflammation. The results suggest that HP eradication may prevent coronary artery disease and metabolic syndrome. Copyright © 2010 by The Southern Medical Association.


Albayrak Y.,Erzurum Region Education and Research Hospital
Wounds | Year: 2011

Ranunculus arvensis is a wild growing plant, used traditionally for the treatment of various diseases. Very few chemical burn cases resulting from R arvensis are reported in the literature. We present a patient who applied the plant R arvensis externally to his left leg attempting to alleviate leg pain, and suffered chemical burns as a consequence. Treatment was started with paraffin-impregnated gauze dressings containing chlorhexidine. The patient's lesions began to recover in 4-5 days, and resolved within 14 days.

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