Erenkoy Psychiatry Education and Research Hospital

Erenkoy Psychiatry Education and Research Hospital

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PubMed | Ankara Numune Education and Research Hospital, Erenkoy Psychiatry Education and Research Hospital, Suleyman Demirel University of Turkey and Istanbul Science University
Type: | Journal: International journal of bipolar disorders | Year: 2015

The aim of this study was to investigate whether childhood trauma (CT) and affective temperament have an impact on resilience in bipolar patients.One hundred cases with bipolar disorder (BD) diagnosis according to the Diagnostic and Statistical Manual of Mental Disorders, 4th Edition (DSM-IV) were evaluated consecutively in their euthymic period during outpatient follow-up interviews. Diagnostic interviews were done with SCID-I, affective temperament was evaluated with the Temperament Evaluation of Memphis, Pisa, Paris and San Diego Autoquestionnaire, and resilience was evaluated with the Resilience Scale for Adults (RSA). The presence of CT was determined and measured with the Childhood Trauma Questionnaire (CTQ).Among the bipolar patients, it was found that 35 cases (35%) were CT+. Depressive, cyclothymic, and anxious temperament scores were higher in CT+ cases. However, resilience scores were higher in CT- cases. In bipolar patients with and without childhood trauma, the relationship between temperament and resilience appears to be different. A negative relation between sexual abuse, emotional abuse, emotional neglect, and anxious temperament scores and resilience scores was shown in regression analysis.CT and affective temperament both have an impact on resilience in bipolar patients.


Kesebir S.,Erenkoy Psychiatry Education and Research Hospital | Isitmez S.,Erenkoy Psychiatry Education and Research Hospital | Gundogar D.,Suleyman Demirel University of Turkey
Journal of Affective Disorders | Year: 2012

Background: The objective of this study was to investigate the frequency of compulsive buying in bipolar disorder (BD), to compare it with healthy controls, and to search if there is a difference between bipolar cases with and without compulsive buying in terms of sociodemographic qualities, temperament, clinical characteristics and comorbid diagnoses. Methods: One-hundred outpatient cases diagnosed as BD according to DSM-IV were evaluated consecutively. Following the diagnosis interview (SCID-I and II) the subjects completed the mood disorders registry form, Compulsive Buying Scale and TEMPS-A. Results: Compulsive buying scores were higher in bipolar patients than healthy controls (p < 0.001). Cases with compulsive buying revealed higher cyclothymic and irritable temperament scores than other bipolar patients (p = 0.029 vs 0.045). Premenstrual syndrome and postpartum onset were more frequent, while psychotic symptoms were less in compulsive buyer bipolar patients (p = 0.002, 0.009 vs 0.034). Severity of episode was lower (p = 0.01), number of episodes was higher (p = 0.009). Acute onset and remission before and after maintenance treatment were more frequent in patients with compulsive buying (p = 0.011 and p = 0.011). Full remission between episodes was 100%. Cases with axis-1 and axis-2 comorbidities demonstrated higher compulsive buying scores (p = 0.025 and 0.005). Limitations: Treatment regimen differences between patients are a limitation of the study. Conclusions: This is the first study to relate compulsive buying with the clinical characteristics of BD. Our results reveal that compulsive buying in BD occurs together with mood episodes which are not very severe, but frequent and with abrupt onset. © 2011 Elsevier B.V. All rights reserved.


Kesebira S.,Erenkoy Psychiatry Education and Research Hospital | Turana C.,Erenkoy Psychiatry Education and Research Hospital | Sunera O.,Erenkoy Psychiatry Education and Research Hospital | Yaylacib E.T.,Ankara Numune Education and Research Hospital
Bipolar Disorders | Year: 2016

Objectives: In patients with bipolar disorder, the rate of mortality from cardiovascular disease is twofold higher than that in other psychiatric disorders. The risk of cardiovascular disease has been found to be associated with intracellular adhesion molecule (ICAM), vascular cell adhesion molecule (VCAM), and E-selectin. The aim of the present study was to compare ICAM, VCAM, and E-selectin levels in patients with bipolar disorder at first manic episode and in healthy controls, and to investigate the presence of a relationship between adhesion molecule levels and clinical properties. Methods: Fifty patients with bipolar disorder diagnosed with mania according to DSM-IV-TR criteria, who were experiencing their first episode, were evaluated consecutively. The control group consisted of 50 healthy individuals with no history of psychiatric treatment, matched with the manic patients in terms of age, gender, and smoking status. The Young Mania Rating Scale was used for confirmation of severity of mania. Plasma ICAM, VCAM, and E-selectin levels were measured and compared between the two groups. Results: ICAM and VCAM levels were found to be higher in first-manic episode patients than in healthy individuals. A weak correlation was found between ICAM levels and YMRS scores in manic patients. Conclusions: In the present study, which is the first to look at the proinflammatory and prothrombotic state in bipolar disorder, ICAM and VCAM levels were found to be higher in first-episode mania patients than in healthy individuals. As the study group included first-episode mania cases, there was no effect seen from the long-term use of psychotropic agents. Risk of cardiovascular disease, reflected by increased ICAM and VCAM levels, is generally present in patients with bipolar disorder at the onset of the disease. © 2016 John Wiley & Sons A/S.


Kesebir S.,Erenkoy Psychiatry Education and Research Hospital | Tatlidil Yaylaci E.,Ankara Numune Education and Research Hospital | Suner O.,Erenkoy Psychiatry Education and Research Hospital | Gultekin B.K.,Erenkoy Psychiatry Education and Research Hospital
Journal of Affective Disorders | Year: 2014

Background The aim of this study was to investigate whether uric acid levels are different between patients with remission period of bipolar disorder type I (BD) and patients with remission period of major depressive disorder (MDD). Methods For this aim 41 patients diagnosed with BD and 30 patients diagnosed with recurrent MDD according to DSM-IV who were in remission period for at least 8 weeks were evaluated consecutively. The median age and gender distribution of the two groups were similar. Subjects with comorbid psychiatric diagnosis and/or severe medical illnesses were excluded. Affective temperament was evaluated with TEMPS-A (Temperament Evaluation of Memphis, Pisa, Paris and San Diego Autoquestionnaire). Plasma uric acid levels were recorded in mg/dl. Results The uric acid levels of BD patients were found higher than patients with MDD and healthy controls. Additionally uric acid levels of MDD patients were lower than patients with BD and healthy subjects (F=4.183, p=0.039). A moderate correlation between hyperthymic and irritable temperament scores and uric acid levels was detected in both patient groups and in healthy controls. A negative correlation was observed between depressive temperament and uric acid levels only in MDD group. Limitations The measurements of temperament were estimated depending on the patient's statement. The medications that patients used were not controlled. Conclusion There is a purinergic dysfunction not only in BD but also in MDD patients. High uric acid levels are associated with hyperthymic and irritable temperament scores whereas low uric acid levels are associated with depressive temperament scores. © 2014 Published by Elsevier B.V.


Gulpek D.,Ataturk Training and Research Hospital | Kelemence Kaplan F.,Ardahan State Hospital | Kesebir S.,Erenkoy Psychiatry Education and Research Hospital | Bora O.,Ataturk Training and Research Hospital
Nordic Journal of Psychiatry | Year: 2014

Background and Aims: In the recent years, it has been observed that alexithymia is not specified for the psychosomatic disorders. It is known that alexithymia is observed frequently in various psychiatric disorders especially in the somatoform disorders. The aim of this study is to evaluate alexithymia in the patients with the conversion disorder. Methods: The study was performed in the Psychiatry Outpatients Clinics of the Izmir Atatürk Training and Research Hospital and Erenköy Psychiatry Education and Research Hospital. A total of 93 cases-47 outpatients who were diagnosed with conversion disorder according to the DSM-IV criteria and 46 age, gender and educational level matched healthy controls-were included in the study. All the cases were assessed by a Structured Clinical Interview for DSM-IV and were evaluated with a questionnaire (which included demographics and clinical data), the Toronto Alexithymia Scale and the Somatosensory Amplification Scale. Results: When the two groups were compared, the Toronto Alexithymia Scale scores (except "externally oriented thinking" subscale) and the Somatosensory Amplification Scale score of the conversion disorder group were statistically significantly higher than the control group. The number of the alexithymic cases of the patient group was significantly higher than the control group's. Conclusions: The level of alexithymia in conversion disorder patients, without any other psychiatric disorder, is higher than that of the healthy controls. During the evaluation of the psychological state of patients with conversion disorder, it could be useful to keep in mind the probability of them having alexithymia to determine the type of suitable therapy. © 2014 Informa Healthcare.


Kesebir S.,Erenkoy Psychiatry Education and Research Hospital | Suner O.,Erenkoy Psychiatry Education and Research Hospital | Yaylaci E.T.,Erenkoy Psychiatry Education and Research Hospital | Bayrak A.,Erenkoy Psychiatry Education and Research Hospital | Turan C.,Erenkoy Psychiatry Education and Research Hospital
Journal of Biological Regulators and Homeostatic Agents | Year: 2013

The aim of the present study was to compare uric acid levels between disease and remisson episodes of bipolar disorder (BD) and healthy individuals and to investigate whether uric acid levels were related with clinical properties and the course. Uric acid levels were compared in 43 BD patients with manic episode, 20 BD patients with depressive episode, 41 BD patients in remission and 43 healthy individuals. Informations regarding disorder was recorded using SKIP-TURK, the severity of episode was measured with Young Mania Rating Scale (YMRS) and Hamilton Depression Rating Scale (HDRS). Uric acid levels were found higher in manic, depressive and euthymic bipolar patients than those in healthy individuals. In cases in remission period, a moderate relation was present between uric acid levels and the age of onset. A moderate relation was found in manic episode between first and second week YMRS scores and uric acid levels, and a strong relation was found in depressive episode between first and second week HDRS scores and uric acid levels. While decrease in uric acid levels in manic episode was found to be associated with the decrease in YMRS scores, no such relation was shown in depressive episode. Our findings stress the impairment in purinergic functions in all episodes of BD. This impairment seems to be associated with clinical properties of BD. Copyright © by BIOLIFE, s.a.s.


PubMed | Erenkoy Psychiatry Education and Research Hospital
Type: Journal Article | Journal: Journal of affective disorders | Year: 2012

The objective of this study was to investigate the frequency of compulsive buying in bipolar disorder (BD), to compare it with healthy controls, and to search if there is a difference between bipolar cases with and without compulsive buying in terms of sociodemographic qualities, temperament, clinical characteristics and comorbid diagnoses.One-hundred outpatient cases diagnosed as BD according to DSM-IV were evaluated consecutively. Following the diagnosis interview (SCID-I and II) the subjects completed the mood disorders registry form, Compulsive Buying Scale and TEMPS-A.Compulsive buying scores were higher in bipolar patients than healthy controls (p<0.001). Cases with compulsive buying revealed higher cyclothymic and irritable temperament scores than other bipolar patients (p=0.029 vs 0.045). Premenstrual syndrome and postpartum onset were more frequent, while psychotic symptoms were less in compulsive buyer bipolar patients (p=0.002, 0.009 vs 0.034). Severity of episode was lower (p=0.01), number of episodes was higher (p=0.009). Acute onset and remission before and after maintenance treatment were more frequent in patients with compulsive buying (p=0.011 and p=0.011). Full remission between episodes was 100%. Cases with axis-1 and axis-2 comorbidities demonstrated higher compulsive buying scores (p=0.025 and 0.005).Treatment regimen differences between patients are a limitation of the study.This is the first study to relate compulsive buying with the clinical characteristics of BD. Our results reveal that compulsive buying in BD occurs together with mood episodes which are not very severe, but frequent and with abrupt onset.


Kesebir S.,Erenkoy Psychiatry Education and Research Hospital | Gundogar D.,Suleyman Demirel University of Turkey | Kucuksubasi Y.,Erenkoy Psychiatry Education and Research Hospital | Tatlidil Yaylaci E.,Erenkoy Psychiatry Education and Research Hospital
Journal of Affective Disorders | Year: 2013

Background: The aim of this study was to investigate the presence of a relationship between affective temperament and resilience in patients with major depressive disorder (MDD) diagnosis, and to examine whether this relationship, if present, differs from healthy individuals. Methods: In line with this purpose, 100 cases with major depressive disorder diagnosis who were in their remission period were evaluated consecutively in their regular outpatient control interviews. The control group consisted of 100 healthy individuals without any history of psychiatric admission and treatment, matched with the depressive group in terms of age and sex. Diagnostic interviews were conducted with SCID-I, affective temperament and resilience were evaluated with TEMPS-A (Evaluation of Temperament Memphis, Pisa, Paris and San Diego-Auto questionnaire) and The Resilience Scale for Adults (RSA) - Turkish version, respectively. Results: We observed a strong relationship between resilience and hyperthymic temperament both in depressive and healthy individuals. There was an inverse relation between psychological resilience and irritable and anxious temperament in both groups. A negative correlation was observed between irritable temperament and family cohesion in depressive disorder group, while in healthy individuals a strong correlation was observed between family cohesion and depressive and anxious temperament, and a weak correlation between family cohesion and hyperthymic temperament. Limitations: The measurements of temperament and resilience were estimated depending on the patient's statement. Conclusion: There is a strong relationship between hyperthymic temperament and psychological resilience in MDD. The relationship between the type of affective temperament and the family cohesion sub-dimension of psychological resilience differs from that of healthy individuals. © 2013 Elsevier B.V.


PubMed | Erenkoy Psychiatry Education and Research Hospital
Type: Journal Article | Journal: Journal of affective disorders | Year: 2013

The aim of this study was to investigate the presence of a relationship between affective temperament and resilience in patients with major depressive disorder (MDD) diagnosis, and to examine whether this relationship, if present, differs from healthy individuals.In line with this purpose, 100 cases with major depressive disorder diagnosis who were in their remission period were evaluated consecutively in their regular outpatient control interviews. The control group consisted of 100 healthy individuals without any history of psychiatric admission and treatment, matched with the depressive group in terms of age and sex. Diagnostic interviews were conducted with SCID-I, affective temperament and resilience were evaluated with TEMPS-A (Evaluation of Temperament Memphis, Pisa, Paris and San Diego-Auto questionnaire) and The Resilience Scale for Adults (RSA)-Turkish version, respectively.We observed a strong relationship between resilience and hyperthymic temperament both in depressive and healthy individuals. There was an inverse relation between psychological resilience and irritable and anxious temperament in both groups. A negative correlation was observed between irritable temperament and family cohesion in depressive disorder group, while in healthy individuals a strong correlation was observed between family cohesion and depressive and anxious temperament, and a weak correlation between family cohesion and hyperthymic temperament.The measurements of temperament and resilience were estimated depending on the patients statement.There is a strong relationship between hyperthymic temperament and psychological resilience in MDD. The relationship between the type of affective temperament and the family cohesion sub-dimension of psychological resilience differs from that of healthy individuals.


PubMed | Erenkoy Psychiatry Education and Research Hospital
Type: Journal Article | Journal: Journal of biological regulators and homeostatic agents | Year: 2014

The aim of the present study was to compare uric acid levels between disease and remisson episodes of bipolar disorder (BD) and healthy individuals and to investigate whether uric acid levels were related with clinical properties and the course. Uric acid levels were compared in 43 BD patients with manic episode, 20 BD patients with depressive episode, 41 BD patients in remission and 43 healthy individuals. Informations regarding disorder was recorded using SKIP-TURK, the severity of episode was measured with Young Mania Rating Scale (YMRS) and Hamilton Depression Rating Scale (HDRS). Uric acid levels were found higher in manic, depressive and euthymic bipolar patients than those in healthy individuals. In cases in remission period, a moderate relation was present between uric acid levels and the age of onset. A moderate relation was found in manic episode between first and second week YMRS scores and uric acid levels, and a strong relation was found in depressive episode between first and second week HDRS scores and uric acid levels. While decrease in uric acid levels in manic episode was found to be associated with the decrease in YMRS scores, no such relation was shown in depressive episode. Our findings stress the impairment in purinergic functions in all episodes of BD. This impairment seems to be associated with clinical properties of BD.

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