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PubMed | Adnan Menderes University, Erenkoy Mental Health Research and Training Hospital and Ataturk State Hospital
Type: | Journal: Journal of child and adolescent psychopharmacology | Year: 2016

Attention-deficit/hyperactivity disorder (ADHD) is a common comorbid disease in children with pediatric autoimmune neuropsychiatric disorders associated with streptococcal infections (PANDAS), in which tic-like involuntary movements are frequently seen clinical conditions. In contrast to psychostimulants, atomoxetine is considered as having minimal effects on tics. Here we report two cases with ADHD and PANDAS who were treated with atomoxetine for their ADHD and comorbid tics.


Simsek G.G.,Yozgat State Hospital | Zincir S.,Erenkoy Mental Health Research and Training Hospital | Gulec H.,Erenkoy Mental Health Research and Training Hospital | Eksioglu S.,Siverek State Hospital | And 2 more authors.
Nordic Journal of Psychiatry | Year: 2015

Objective: The aim of this study is to investigate the relationship between features of electroencephalography (EEG), including seizure time, energy threshold level and post-ictal suppression time, and clinical variables, including treatment outcomes and side-effects, among schizophrenia inpatients undergoing electroconvulsive therapy (ECT). Method: This is a naturalistic follow-up study on schizophrenia patients, diagnosed using DSM-IV-TR criteria, treated by a psychosis inpatient service. All participants completed the Brief Psychiatric Rating Scale (BPRS), the Global Assessment of Functioning (GAF) scale, the Frontal Assessment Battery (FAB) and a Data Collection Form. Assessments were made before treatment, during ECT and after treatment. Findings: Statistically significant improvements in both clinical and cognitive outcome were noted after ECT in all patients. Predictors of improvement were sought by evaluating electrophysiological variables measured at three time points (after the third, fifth and seventh ECT sessions). Logistic regression analysis showed that clinical outcome/improvement did not differ by seizure duration, threshold energy level or post-ictal suppression time. Discussion and conclusion: We found that ictal EEG parameters measured at several ECT sessions did not predict clinical recovery/outcomes. This may be because our centre defensively engages in "very specific patient selection" when ECT is contemplated. ECT does not cause short-term cognitive functional impairment and indeed improves cognition, because symptoms of the schizophrenic episode are alleviated. © 2015 Informa Healthcare.


Zincir S.,Golcuk Military Hospital | Zincir S.B.,Erenkoy Mental Health Research and Training Hospital | Doruk A.,Gulhane Military Medical Academy | Erdem M.,Gulhane Military Medical Academy | And 5 more authors.
Psychiatry Research | Year: 2014

Nitric oxide (NO) is thought to be involved in the pathogenesis of schizophrenia as well as many neuropsychiatric disease. Asymmetric dimethylarginine (ADMA) reduces the level of NO by inhibiting nitric oxide synthase (NOS) enzyme. In this study it is aimed to be investigated ADMA in patients with first-episode schizophrenia. In this study, according to DSM-IV diagnostic criteria for schizophrenia-like psychotic disorder, 49 male first-episode schizophrenia patients-whose mean age was 23.4±3.5 year-and age and education matched 30 healthy male subjects were included for comparison. ADMA levels of the patients were measured before and after 2 months of therapy. In order to rule out the conditions that may affect the levels of ADMA, people whose physical examination and laboratory findings were within normal range were included in the study. In this study plasma ADMA levels of first-episode schizophrenia patients and control group were 3.6±1.5. μmol/L and 1.02±1.02 respectively. After 2 months of antipsychotic treatment plasma ADMA levels of the schizophrenia patients decreased compared to baseline. There was no relationship between the ADMA levels and the clinical severity of the disease. It is considered to be the role of ADMA in the etiopathogenesis of schizophrenia. © 2014 Elsevier Ireland Ltd.


Objective: The aim of this study was to evaluate the relationship between attention deficit and hyperactivity disorder sub-dimensions and the course of Bipolar Disorder, disability and quality of life. Method: In this study 150 euthymic patients attending the Erenköy Research Hospital of Psychiatric and Neurological Diseases for routine follow-ups, who had a diagnosis of bipolar disorder according to the DSM-IV criteria, were evaluated. Considering that they were euthymic patients, the Young-Mania Scale and the Hamilton Depression Rating Scale were applied, respectively. The Adult Attention Deficit and Hyperactivity Rating Scale was applied to evaluate the attention deficit and hyperactivity disorder subdimensions. The patients were divided into four groups in terms of the scale scores, sub-dimensions of attention-deficit hyperactivity disorder, attention deficit (AD), hyperactivity (HD), attention deficit and hyperactivity (ADHD) and the accompanying form of non-pure BD patients. Three groups were compared, because the number of patients with HD was limited. The General Assessment of Functioning Scale was applied to determine their level of disability in patients subduction - IGDO (Global Assessment Schedule - VAS) and the World Health Organization Quality of Life Scale was applied to assess quality of life (WHOQOL). Results: In our study, 20% of BD patients in a euthymic period had symptoms of attention deficit and hyperactivity. Hyperactivity is not component, where only the size of the group of patients is the lack of attention, 21.3% of BD subgroup had sole attention deficit subdimension without hyperactivity component. Relatively, the age of onset and the number of episodes were lower and the number of hospitalizations was higher in the ADHD subgroup. IGDO scores were relatively higher in the BD subgroup while the GAS scores were the highest in the pure BD subgroup and the quality of life variables were more impaired than others in the ADHD subgroup. Conclusion: In bipolar disorder, collocating attention deficit and hyperactivity dimensions increase disability and impair quality of life.

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