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Rotterdam, Netherlands

Erasmus University Rotterdam is a renowned public university located in Rotterdam, the Netherlands, in the city that also houses the largest port in Europe. The university is named after Desiderius Erasmus Roterodamus, a 15th-century humanist and theologian. Erasmus for centuries has enjoyed popularity in academia, being a person who should always be remembered by Rotterdam.Erasmus University Rotterdam has been among the best in all kinds of world rankings. In 2007, Erasmus University Rotterdam ranked top ten of the top universities in Europe by " Financial Times ". In 2014, Erasmus University Rotterdam is ranked by Times Higher Education as 20th in Europe and 73rd in the world, with its social science as 47th, and clinical and health as 37th in the world.The university has seven faculties and focuses on four areas of expertise.Health - Faculty of Medicine and Health science/Erasmus MC and institute of Health Policy & Management Wealth - Erasmus School of Economics and Rotterdam School of Management, Erasmus UniversityGovernance - Erasmus School of Law and Faculty of Social scienceCulture - Erasmus School of History, Culture and Communication, Faculty of Social science and Faculty of PhilosophyErasmus MC is the largest and one of the foremost academic medical centers and trauma centers in the Netherlands, whereas its economics and business school, Erasmus School of Economics and Rotterdam School of Management, Erasmus University are leading economics school and business school within Europe and the world. Wikipedia.

Kayser M.,Erasmus University Rotterdam
Current Biology | Year: 2010

The human history of Oceania is unique in the way that it encompasses both the first out-of-Africa expansion of modern humans to New Guinea and Australia as well as the last regional human occupation of Polynesia. Other anthropological peculiarities of Oceania include features like the extraordinarily rich linguistic diversity especially of New Guinea with about 1,000 often very distinct languages, the independent and early development of agriculture in the highlands of New Guinea about 10,000 years ago, or the long-term isolation of the entire region from the outside world, which lasted as long as until the 1930s for most of the interior of New Guinea. This review will provide an overview on the genetic aspects of human population history of Oceania and how some of the anthropological peculiarities are reflected in human genetic data. Due to current data availability it will mostly focus on insights from sex-specifically inherited mitochondrial DNA and Y-chromosomal DNA, whereas more genome-wide autosomal DNA data are soon expected to add additional details or may correct views obtained from these two, albeit highly complex, genetic loci. © 2010 Elsevier Ltd. All rights reserved.

Background-Arrhythmogenic right ventricular dysplasia/cardiomyopathy (ARVD/C) is a cardiomyopathy characterized by ventricular arrhythmias and an abnormal right ventricle. Implantable cardioverter defibrillator (ICD) therapy may prevent sudden cardiac death in patients with ARVD/C. Currently, an overview of outcomes, appropriate and inappropriate interventions, and complications of ICD therapy in ARVD/C is lacking. Methods and Results-A literature search was performed to identify studies reporting outcome and complications in patients with ARVD/C who underwent ICD implantation. Of 641 articles screened, 24 studies on 18 cohorts were eligible for inclusion. In case of multiple publications on a cohort, the most recent publication was included in the meta-analysis. There were 610 patients (mean age, 40.4 years; 42% women), who had an ICD for primary or secondary prevention of sudden cardiac death. Risk factors for sudden cardiac death were presyncope (61%), syncope (31%), previous cardiac arrest (14%), ventricular tachycardia (58%), and ventricular fibrillation (6%). Antiarrhythmic medication consisted mostly of β-blockers (38%), amiodarone (14%), or sotalol (30%). During the 3.8-year follow-up, annualized cardiac mortality rate was 0.9%, annualized noncardiac mortality rate was 0.8%, and annualized heart transplant rate was 0.9%. The annualized appropriate and inappropriate ICD intervention rates were 9.5% and 3.7%, respectively. ICD-related complications consisted of difficult lead placement (18.4%), lead malfunction (9.8%), infection (1.4%), lead displacement (3.3%), and any complication (20.3%). Conclusions-Cardiac and noncardiac mortality rates after ICD implantation in patients with ARVD/C are low. Appropriate ICD interventions occur at a rate of 9.5%/y. Inappropriate ICD interventions and complications lead to considerable ICDrelated morbidity. © 2013 American Heart Association, Inc.

Zwaan R.A.,Erasmus University Rotterdam
Trends in Cognitive Sciences | Year: 2014

The debate on whether language comprehension involves the manipulation of abstract symbols or is grounded in perception and action has reached an impasse, with authors from different theoretical persuasions unable to agree on the diagnostic value of empirical findings. To escape this impasse, I propose a pluralist view of cognition that encompasses abstract and grounded symbols. The contributions of these symbol types to language comprehension vary as a function of the degree to which language use is embedded in the environment. I distinguish five levels of embeddedness: demonstration, instruction, projection, displacement, and abstraction. Only through a closer analysis of context will we make significant progress toward understanding language comprehension and cognition in general. © 2014 Elsevier Ltd.

Bonifati V.,Erasmus University Rotterdam
Parkinsonism and Related Disorders | Year: 2014

In the past 15 years there has been substantial progress in our understanding of the genetics of Parkinson's disease (PD). Highly-penetrant mutations in different genes (. SNCA, LRRK2, VPS35, Parkin, PINK1, and DJ-1) are known to cause rare monogenic forms of the disease. Furthermore, different variants with incomplete penetrance in the LRRK2 and the GBA gene are strong risk factors for PD, and are especially prevalent in some populations. Last, common variants of small effect size, modulating the risk for PD, have been identified by genome-wide association studies in more than 20 chromosomal loci.Here, I first outline the evolution of the research strategies to find PD-related genes, and then focus on recent advances in the field of the monogenic forms, including VPS35 mutations in autosomal dominant PD, and DNAJC6 and SYNJ1 mutations in recessive forms of juvenile parkinsonism. Additional genetic determinants of PD likely remain to be identified, as the currently known mutations and variants only explain a minor fraction of the disease burden. There is great expectation that the new DNA sequencing technologies (exome and whole-genome sequencing) will bring us closer to the full resolution of the genetic landscape of PD. © 2013 Elsevier Ltd.

Caudri D.,Erasmus University Rotterdam
Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology | Year: 2013

A novel data-driven approach was used to identify wheezing phenotypes in pre-schoolchildren aged 0-8 years, in the Prevention and Incidence of Asthma and Mite Allergy (PIAMA) birth cohort. Five phenotypes were identified: never/infrequent wheeze, transient early wheeze, intermediate onset wheeze, persistent wheeze and late onset wheeze. It is unknown which perinatal risk factors drive development of these phenotypes. The objective of the study was to assess associations of perinatal factors with wheezing phenotypes and to identify possible targets for prevention. In the PIAMA study (n = 3963), perinatal factors were collected at 3 months, and wheezing was assessed annually until the age of 8 years. Associations between perinatal risk factors and the five wheezing phenotypes were assessed using weighted multinomial logistic regression models. Odds ratios were adjusted for confounding variables and calculated with 'never/infrequent wheeze' as reference category. Complete data were available for 2728 children. Risk factors for transient early wheeze (n = 455) were male gender, maternal and paternal allergy, low maternal age, high maternal body mass index, short pregnancy duration, smoking during pregnancy, presence of older siblings and day-care attendance. Risk factors for persistent wheeze (n = 83) were male gender, maternal and paternal allergy, and not receiving breastfeeding for at least 12 weeks. Intermediate onset wheeze (n = 98) was associated with a lower birth weight and late onset wheeze (n = 45) with maternal allergy. We identified different risk factors for specific childhood wheezing phenotypes. Some of these are modifiable, such as maternal age and body mass index, smoking, day-care attendance and breastfeeding, and may be important targets for prevention programmes. © 2013 John Wiley & Sons Ltd.

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