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News Article | December 12, 2016
Site: www.prnewswire.com

BIRMINGHAM, Ala., Dec. 12, 2016 /PRNewswire/ -- EPL, Inc., (EPL) a leading software development company serving credit unions nationwide, today announced a new partnership with MX, one of the world's fastest-growing fintech providers, to bring unified financial data and intuitive money...


Johnson G.A.,Duke University | Calabrese E.,Duke University | Little P.B.,EPL Inc. | Hedlund L.,Duke University | And 2 more authors.
NeuroToxicology | Year: 2014

The growing exposure to chemicals in our environment and the increasing concern over their impact on health have elevated the need for new methods for surveying the detrimental effects of these compounds. Today's gold standard for assessing the effects of toxicants on the brain is based on hematoxylin and eosin (H&E)-stained histology, sometimes accompanied by special stains or immunohistochemistry for neural processes and myelin. This approach is time-consuming and is usually limited to a fraction of the total brain volume. We demonstrate that magnetic resonance histology (MRH) can be used for quantitatively assessing the effects of central nervous system toxicants in rat models. We show that subtle and sparse changes to brain structure can be detected using magnetic resonance histology, and correspond to some of the locations in which lesions are found by traditional pathological examination. We report for the first time diffusion tensor image-based detection of changes in white matter regions, including fimbria and corpus callosum, in the brains of rats exposed to 8. mg/kg and 12. mg/kg trimethyltin. Besides detecting brain-wide changes, magnetic resonance histology provides a quantitative assessment of dose-dependent effects. These effects can be found in different magnetic resonance contrast mechanisms, providing multivariate biomarkers for the same spatial location. In this study, deformation-based morphometry detected areas where previous studies have detected cell loss, while voxel-wise analyses of diffusion tensor parameters revealed microstructural changes due to such things as cellular swelling, apoptosis, and inflammation. Magnetic resonance histology brings a valuable addition to pathology with the ability to generate brain-wide quantitative parametric maps for markers of toxic insults in the rodent brain. © 2014.


Kolenda-Roberts H.M.,EPL Inc. | Harris N.,EPL Inc. | Singletary E.,EPL Inc. | Hardisty J.F.,EPL Inc.
Toxicologic Pathology | Year: 2013

Twenty-eight spontaneously occurring glial tumors (previously diagnosed as astrocytomas, oligodendrogliomas, and gliomas) and eleven granular cell tumors (GCTs) were selected for evaluation using a panel of immunohistochemistry (IHC) stains (Ricinus communis agglutinin type 1 [RCA-1], ionized calcium-binding adapter molecule 1 [Iba-1], OX-6/major immunohistocompatibility complex class II, oligodendrocytes transcription factor 2 [Olig2], glial fibrillary acidic protein [GFAP], S100 beta, glutamine synthetase, neurofilament, proliferating cell nuclear antigen). In addition, nine brain tumors from a 2-year drinking water study for acrylonitrile were obtained from the Acrylonitrile Group, Inc. Based on IHC staining characteristics, Olig2+ oligodendrogliomas were the most commonly diagnosed spontaneous tumor in these animals. Many of the spontaneous tumors previously diagnosed as astrocytomas were RCA-1+, Iba-1+ and negative for GFAP, S100beta, and glutamine synthetase; the diagnosis of malignant microglial tumor is proposed for these neoplasms. Three mixed tumors were identified with Olig2+ (oligodendrocytes) and Iba-1+ (macrophage/microglia) cell populations. The term mixed glioma is not recommended for these tumors, as it is generally used to refer to oligoastrocytomas, which were not observed in this study. GCT were positive for RCA-1 and Iba-1. All acrylonitrile tumors were identified as malignant microglial tumors. These results may indicate that oligodendrogliomas are more common as spontaneous tumors, while acrylonitrile-induced neoplasms are microglial/histiocytic in origin. No astrocytomas (GFAP, S100 beta, and/or glutamine synthetase-positive neoplasms) were observed. © 2013 by The Author(s).


Trademark
EPL Inc. | Date: 2016-05-12

computer software, namely, online and mobile banking software that allows a credit union to promote products and services, provide credit-union-specific links, member-specific notations/alerts, member profiles, stop payment, online check ordering, e-statements, check images, online loan applications, and more.


Trademark
EPL Inc. | Date: 2016-04-26

computer software, namely, online and mobile banking software that allows a credit union to promote products and services, provide credit-union-specific links, member-specific notations/alerts, member profiles, stop payment, online check ordering, e-statements, check images, online loan applications, and more.


Trademark
EPL Inc. | Date: 2016-04-26

computer software, namely, an online intranet/extranet web service for credit unions to communicate with staff and their board of directors with policy, procedural manuals, calendared events, and board packets of information.


Trademark
EPL Inc. | Date: 2016-04-26

computer software that mediates and integrates a core processor and disparate applications, systems, or networks allowing for any participate (application, system, network, or core processor) to be substituted for an alternative solution.


Trademark
EPL Inc. | Date: 2016-04-27

computer software for credit unions that enables credit unions to store, upload, and attach digital information to a member or account, that archives information with electronic signatures within the workflow of opening a new account or new loan, and that enables credit-union staff to easily load and retrieve digital information.


Trademark
EPL Inc. | Date: 2012-11-11

Computer software for credit unions and financial institutions, namely, on-line document storage and access.


Trademark
EPL Inc. | Date: 2012-11-11

Computer software for credit unions and financial institutions for use in enabling customers to engage in online banking, transfer cash, pay bills, and view online account statements and view images of checks.

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