Epilepsy Society Research Center

Chalfont Saint Giles, United Kingdom

Epilepsy Society Research Center

Chalfont Saint Giles, United Kingdom

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Thompson P.J.,University College London | Thompson P.J.,Epilepsy Society Research Center | Conn H.,University College London | Baxendale S.A.,University College London | And 7 more authors.
Seizure | Year: 2016

Purpose The study aimed to assess whether engagement in a memory training programme and performing internet brain training exercises improve memory function in people with temporal lobe epilepsy (TLE). Methods Seventy-seven people with TLE, complaining of memory difficulties, completed the study. Participants ranged in age from 19 to 67 years and 40 had left TLE. Participants were randomised to one of four conditions; Group 1: traditional memory training, Group 2: Lumosity, an on-line cognitive training programme, Group 3: traditional memory training and Lumosity, and Group 4: no training. Memory efficiency and mood were assessed at baseline and three months later. Results Group analyses indicated improved verbal recall after training (p < 0.001) and improved subjective ratings (p < 0.007). More participants reported a lessening of the memory burden (p < 0.007) after training; differences were significant between Groups 1 and 3 compared to Group 4. Lumosity use was not associated with changes in the memory outcome measures but there was a relationship with depression ratings and the number of memory games played (p < 0.01). Conventional memory training, IQ, and post-surgical status were associated with positive memory outcomes. Conclusions The study indicates traditional memory rehabilitation techniques can help reduce the burden of memory impairment in TLE. There was no evidence that Lumosity the on-line cognitive training programme had specific advantages. Positive change was not universal and larger studies will be required to explore factors associated with successful outcomes. © 2016 British Epilepsy Association. Published by Elsevier Ltd. All rights reserved.


PubMed | Epilepsy Society Research Center, University of Sao Paulo and University College London
Type: | Journal: Seizure | Year: 2016

The study aimed to assess whether engagement in a memory training programme and performing internet brain training exercises improve memory function in people with temporal lobe epilepsy (TLE).Seventy-seven people with TLE, complaining of memory difficulties, completed the study. Participants ranged in age from 19 to 67 years and 40 had left TLE. Participants were randomised to one of four conditions; Group 1: traditional memory training, Group 2: Lumosity, an on-line cognitive training programme, Group 3: traditional memory training and Lumosity, and Group 4: no training. Memory efficiency and mood were assessed at baseline and three months later.Group analyses indicated improved verbal recall after training (p<0.001) and improved subjective ratings (p<0.007). More participants reported a lessening of the memory burden (p<0.007) after training; differences were significant between Groups 1 and 3 compared to Group 4. Lumosity use was not associated with changes in the memory outcome measures but there was a relationship with depression ratings and the number of memory games played (p<0.01). Conventional memory training, IQ, and post-surgical status were associated with positive memory outcomes.The study indicates traditional memory rehabilitation techniques can help reduce the burden of memory impairment in TLE. There was no evidence that Lumosity the on-line cognitive training programme had specific advantages. Positive change was not universal and larger studies will be required to explore factors associated with successful outcomes.


Thompson P.J.,University College London | Thompson P.J.,Epilepsy Society Research Center | Baxendale S.A.,University College London | Baxendale S.A.,Epilepsy Society Research Center | And 4 more authors.
Seizure | Year: 2015

Purpose To examine the cognitive risks of temporal lobe surgery in patients aged 50 years and older. Methods We analysed data from 55 patients who underwent temporal lobe surgery (26 left-sided:29 right sided) from 1988 to 2012 at our centre. Pre-surgical and one year post-operative memory and naming capacity were compared to data obtained from two younger cohorts; 185 aged 18-30 and 220 aged 31-49. Results Pre-operative memory impairments were most marked for the oldest cohort and were associated with a longer duration of epilepsy. Naming capacity improved with age and better performance was associated with a later age at epilepsy onset. Post-operative declines were largest in older patients, achieving statistical significance for verbal memory, naming and subjective ratings. Left temporal lobe resections carried the greatest risk of memory and naming decline. Cognitive outcomes were unrelated to seizure outcome, VIQ or mood. Conclusion Our findings indicate the cognitive risks of TLE surgery are greater for older patients. Cognitive outcomes need to be considered when assessing the efficacy of epilepsy surgery in older cohorts and pre-operative performance levels need to be taken into account. © 2015 British Epilepsy Association. Published by Elsevier Ltd. All rights reserved.

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