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Murviel-lès-Montpellier, France

Xiao P.,Northwestern University | Dudal Y.,Envolure | Corvini P.F.-X.,Northwestern University | Corvini P.F.-X.,Nanjing University | And 2 more authors.
Reactive and Functional Polymers | Year: 2012

Molecularly imprinted polymeric nanoparticles have been prepared by means of the precipitation polymerization method using a fluoroquinolone, levofloxacin, as a template, methacrylic acid as a functional monomer and 2-ethyl-2-(hydroxymethyl)propane-l,3-diol as a crosslinker. The synthesized polymers have been characterized using scanning electron microscopy that revealed that the produced systems are sub-micrometer-sized particles with a diameter ranging from 50 to 100 nm. The study of the interactions of these polymers with selected fluoroquinolones (levofloxacin, ofloxacin, and ciprofloxacin), acetaminophen, diclofenac, aspirin, and sulfamethoxazole has been carried out in acetonitrile and water. It is demonstrated that the amounts of levofloxacin and its structural analogues (ofloxacin and ciprofloxacin) bound to the molecularly imprinted polymeric nanoparticles are higher than those bound to the non-imprinted nanoparticles both in acetonitrile and in water; the binding of acetaminophen, diclofenac, aspirin and sulfamethoxazole onto both the imprinted and non-imprinted nanoparticles are shown to be significantly lower. In water, it has been shown that even if decreased, the imprinted nanoparticles retain a relevant selectivity for the studied fluoroquinolones, and the binding of other studied pharmaceuticals are not enhanced significantly (e.g. acetaminophen) or even suppressed (e.g. diclofenac sodium, aspirin and sulfamethoxazole) by the molecular imprinting. © 2012 Elsevier Ltd. All rights reserved. Source


Xiao P.,Northwestern University | Dudal Y.,Envolure | Corvini P.F.-X.,Northwestern University | Corvini P.F.-X.,Nanjing University | And 2 more authors.
Polymer Chemistry | Year: 2011

A series of highly cross-linked water insoluble polyurethanes have been produced using β-cyclodextrin and/or 2,2-bis(hydroxymethyl)propionic acid as monomers and toluene-2,4-diisocyanate or hexamethylene diisocyanate as cross-linkers. It is demonstrated that the binding specificities of the produced polymers for selected active pharmaceutical ingredients (APIs) are considerably different; the introduction of H-bond donor and acceptor systems and the chemical nature of the cross-linker are shown to influence the binding capabilities of the produced polymers for the studied APIs. © 2011 The Royal Society of Chemistry. Source


Patent
Envolure | Date: 2013-02-26

A device is provided for carrying out optical measurements such as fluorescence and absorbance measurements on samples distributed at measurement sites on a support, including first and second illumination apparatus, an optical detector, first and second optical fibres with an end facing the measurement sites at first and second faces of the support, respectively, which device further includes optical configuration apparatus configurable so as to allow the following configurations: (i) optical coupling of the first illumination apparatus with the first optical fibres and of the optical detector with the second optical fibres, (ii) optical coupling of the second illumination apparatus and the optical detector with the second optical fibres, and/or (iii) optical coupling of the second illumination apparatus and the optical detector with the first optical fibres. A corresponding method implemented in this device is also provided.


A method for measuring the biodegradability of organic substrates by the fluorescent and/or colorimetric detection of the microbial activity generated by the addition of organic substrates to a mixture of microorganisms.


This study presents the advantages of using the Envital® kit, marketed by Evolure, for rapid Methane Potential determination. The kit was assessed while monitoring two industrial digesters belonging to the company Bionerval, a Saria Group subsidiary, during a one-month sampling campaign. While the excessively long conventional measurement of BMP could not have been used for this digester monitoring experiment, the Envital® kit was able to determine the Biological Methane Potential of digester inputs and sludge outputs in less than 30h. Validated on the basis of methane productions observed at both sites, Envital® showed itself to be beneficial for digester monitoring and control. Its on-site use informs the operator, in less than 48h, of the biodegradability potential of inputs via inoculation of its own digester. Source

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