EnVivo Pharmaceuticals

Watertown, MA, United States

EnVivo Pharmaceuticals

Watertown, MA, United States
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Prueksaritanont T.,Sharp Corporation | Tang C.,EnVivo Pharmaceuticals
AAPS Journal | Year: 2012

Thorough characterization and in-depth understanding of absorption, distribution, metabolism, and elimination (ADME) properties of a drug candidate have been well recognized as an important element in small molecule (SM) drug discovery and development. This has been the area of focus for drug metabolism and pharmacokinetics (DMPK) scientists, whose role has been evolving over the past few decades from primarily being involved in the development space after a preclinical candidate was selected to extending their involvement into the discovery stage prior to candidate selection. This paradigm shift has ensured the entry into development of the best candidates with optimal ADME properties, and thus has greatly impacted SM drug development through significant reduction of the failure rate for pharmacokinetics related reasons. In contrast, the sciences of ADME and DMPK have not been fully integrated into the discovery and development processes for large molecule (LM) drugs. In this mini-review, we reflect on the journey of DMPK support of SM drug discovery and development and highlight the key enablers that have allowed DMPK scientists to make such impacts, with the aim to provide a perspective on relevant lessons learned from SM drugs that are applicable to DMPK support strategies for LMs. © 2012 American Association of Pharmaceutical Scientists.


Trademark
Forum Pharmaceuticals Inc. and Envivo Pharmaceuticals | Date: 2014-03-27

pharmaceuticals and biopharmaceutical preparations; diagnostic agents, preparations and substances for medical purposes.


Trademark
Forum Pharmaceuticals Inc. and Envivo Pharmaceuticals | Date: 2014-03-27

pharmaceuticals and biopharmaceutical preparations; diagnostic agents, preparations and substances for medical purposes.


Trademark
Forum Pharmaceuticals Inc. and Envivo Pharmaceuticals | Date: 2014-03-27

pharmaceuticals and biopharmaceutical preparations; diagnostic agents, preparations and substances for medical purposes.


Trademark
Forum Pharmaceuticals Inc. and Envivo Pharmaceuticals | Date: 2014-03-27

pharmaceuticals and biopharmaceutical preparations; diagnostic agents, preparations and substances for medical purposes.


Trademark
Forum Pharmaceuticals Inc. and Envivo Pharmaceuticals | Date: 2014-04-29

pharmaceuticals and biopharmaceutical preparations; diagnostic agents, preparations and substances for medical purposes. consultation and analysis services in the field of biotechnology, pharmaceutical research and development, diagnostics, and drug therapy; biological, pharmaceutical and clinical research and development services for others.


Trademark
Forum Pharmaceuticals Inc. and Envivo Pharmaceuticals | Date: 2016-02-02

Pharmaceutical preparations for human use for the treatment and prevention of central nervous system diseases and disorders.


Trademark
Forum Pharmaceuticals Inc. and Envivo Pharmaceuticals | Date: 2016-02-02

Pharmaceutical preparations for human use for the treatment and prevention of central nervous system diseases and disorders.


Trademark
Forum Pharmaceuticals Inc. and Envivo Pharmaceuticals | Date: 2016-02-02

Pharmaceutical preparations for human use for the treatment and prevention of central nervous system diseases and disorders.


Trademark
Envivo Pharmaceuticals | Date: 2014-01-24

pharmaceuticals and biopharmaceutical preparations; diagnostic agents, preparations and substances for medical purposes. consultation and analysis services in the field of biotechnology, pharmaceutical research and development, diagnostics, and drug therapy; biological, pharmaceutical and clinical research and development services for others.

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