Halappanavar S.,Environmental Health Science and Research Bureau Health Canada Ottawa Canada |
Vogel U.,National Research Center for the Working Environment Copenhagen Denmark |
Wallin H.,National Research Center for the Working Environment Copenhagen Denmark |
Yauk C.L.,Environmental Health Science and Research Bureau Health Canada Ottawa Canada
Wiley Interdisciplinary Reviews: Nanomedicine and Nanobiotechnology | Year: 2017
In the 1966s visionary film 'Fantastic Voyage' a submarine crew was shrunk to 100nm in size and injected into the body of an injured scientist to repair his damaged brain. The movie (written by Harry Kleiner; directed by Richard Fleischer; novel by Isaac Asimov) drew attention to the potential power of engineered nanoscale structures and devices to construct, monitor, control, treat, and repair individual cells. Even more interesting was the fact that the film elegantly noted that the structure had to be miniaturized to a size that is not detected by the body's immune surveillance system, and highlighted the many physiological barriers that are encountered on the submarine's long journey to the target. Although the concept of miniaturizing humans remains an element of science fiction, targeted drug delivery through nanobots to treat diseases such as cancer is now a reality. The ability of nanobots to evade immune surveillance is one of the most attractive features of nanoscale materials that are exploited in the field of medicine for molecular diagnostics, targeted drug delivery, and therapy of diseases. This article will provide a concise opinion on the state-of-the-art, the challenges, and the use of systems biology-another equally revolutionary field of science-to assess the unique health hazards of nanomaterial exposures. © 2017 Wiley Periodicals, Inc.