Taylor J.,Environmental and Geomatic Engineering |
Lai K.M.,Environmental and Geomatic Engineering |
Clifton D.,Polygon UK Ltd
Environment International | Year: 2011
With a changing climate and increased urbanisation, the occurrence and the impact of flooding is expected to increase significantly. Floods can bring pathogens into homes and cause lingering damp and microbial growth in buildings, with the level of growth and persistence dependent on the volume and chemical and biological content of the flood water, the properties of the contaminating microbes, and the surrounding environmental conditions, including the restoration time and methods, the heat and moisture transport properties of the envelope design, and the ability of the construction material to sustain the microbial growth. The public health risk will depend on the interaction of these complex processes and the vulnerability and susceptibility of occupants in the affected areas. After the 2007 floods in the UK, the Pitt review noted that there is lack of relevant scientific evidence and consistency with regard to the management and treatment of flooded homes, which not only put the local population at risk but also caused unnecessary delays in the restoration effort. Understanding the drying behaviour of flooded buildings in the UK building stock under different scenarios, and the ability of microbial contaminants to grow, persist, and produce toxins within these buildings can help inform recovery efforts. To contribute to future flood management, this paper proposes the use of building simulations and biological models to predict the risk of microbial contamination in typical UK buildings. We review the state of the art with regard to biological contamination following flooding, relevant building simulation, simulation-linked microbial modelling, and current practical considerations in flood remediation. Using the city of London as an example, a methodology is proposed that uses GIS as a platform to integrate drying models and microbial risk models with the local building stock and flood models. The integrated tool will help local governments, health authorities, insurance companies and residents to better understand, prepare for and manage a large-scale flood in urban environments. © 2011 Elsevier Ltd.
Bainbridge J.W.B.,University College London |
Mehat M.S.,University College London |
Sundaram V.,University College London |
Robbie S.J.,University College London |
And 30 more authors.
New England Journal of Medicine | Year: 2015
BACKGROUND: Mutations in RPE65 cause Leber's congenital amaurosis, a progressive retinal degenerative disease that severely impairs sight in children. Gene therapy can result in modest improvements in night vision, but knowledge of its efficacy in humans is limited. METHODS: We performed a phase 1-2 open-label trial involving 12 participants to evaluate the safety and efficacy of gene therapy with a recombinant adeno-associated virus 2/2 (rAAV2/2) vector carrying the RPE65 complementary DNA, and measured visual function over the course of 3 years. Four participants were administered a lower dose of the vector, and 8 were administered a higher dose. In a parallel study in dogs, we investigated the relationship among vector dose, visual function, and electroretinography (ERG) findings. RESULTS: Improvements in retinal sensitivity were evident, to varying extents, in six participants for up to 3 years, peaking at 6 to 12 months after treatment and then declining. No associated improvement in retinal function was detected by means of ERG. Three participants had intraocular inflammation, and two had clinically significant deterioration of visual acuity. The reduction in central retinal thickness varied among participants. In dogs, RPE65 gene therapy with the same vector at lower doses improved vision-guided behavior, but only higher doses resulted in improvements in retinal function that were detectable with the use of ERG. CONCLUSIONS: Gene therapy with rAAV2/2 RPE65 vector improved retinal sensitivity, albeit modestly and temporarily. Comparison with the results obtained in the dog model indicates that there is a species difference in the amount of RPE65 required to drive the visual cycle and that the demand for RPE65 in affected persons was not met to the extent required for a durable, robust effect. (Funded by the National Institute for Health Research and others; ClinicalTrials.gov number, NCT00643747.) Copyright © 2015 Massachusetts Medical Society.
Robson S.,Environmental and Geomatic Engineering |
Beraldin J.-A.,National Research Council Canada |
Brownhill A.,Environmental and Geomatic Engineering |
MacDonald L.,Environmental and Geomatic Engineering
Proceedings of SPIE - The International Society for Optical Engineering | Year: 2011
Flexible manufacturing technologies are supporting the routine production of components with freeform surfaces in a wide variety of materials and surface finishes. Such surfaces may be exploited for both aesthetic and performance criteria for a wide range of industries, for example automotive, aircraft, small consumer goods and medial components. In order to ensure conformance between manufactured part and digital design it is necessary to understand, validate and promote best practice of the available measurement technologies. Similar, but currently less quantifiable, measurement requirements also exist in heritage, museum and fine art recording where objects can be individually hand crafted to extremely fine levels of detail. Optical 3D measurement systems designed for close range applications are typified by one or more illumination sources projecting a spot, line or structured light pattern onto a surface or surfaces of interest. Reflections from the projected light are detected in one or more imaging devices and measurements made concerning the location, intensity and optionally colour of the image. Coordinates of locations on the surface may be computed either directly from an understanding of the illumination and imaging geometry or indirectly through analysis of the spatial frequencies of the projected pattern. Regardless of sensing configuration some independent means is necessary to ensure that measurement capability will meet the requirements of a given level of object recording and is consistent for variations in surface properties and structure. As technologies mature, guidelines for best practice are emerging, most prominent at the current time being the German VDI/VDE 2634 and ISO/DIS 10360-8 guidelines. This considers state of the art capabilities for independent validation of optical non-contact measurement systems suited to the close range measurement of table top sized manufactured or crafted objects. © 2011 Copyright Society of Photo-Optical Instrumentation Engineers (SPIE).
Walbridge S.,University of Waterloo |
Fernando D.,Environmental and Geomatic Engineering |
Adey B.T.,Environmental and Geomatic Engineering |
Raimbault J.,University of Waterloo
Proceedings, Annual Conference - Canadian Society for Civil Engineering | Year: 2013
In order for bridge managers to evaluate the consequences of adopting new fatigue retrofitting techniques and management strategies on the cost of maintaining their bridge infrastructure, simple predictive models are needed, which can be easily integrated with the analytical tools that are already being using to model other deterioration processes (e.g. corrosion, road surface wear). These models must be capable of predicting the effects of inspection and retrofitting events with a sufficient degree of accuracy to ensure that optimal management strategies are correctly identified. Considering the large number of fatigue-prone welds and structures that may be present in a road network, minimizing computational effort is also critical. In this paper, a simple Markov chain deterioration model, similar to those currently used in bridge management systems (BMSs) to model deterioration due to other processes, is used to determine critical cost ratios for selecting optimal fatigue management strategies for steel highway bridge welds, First, the model is briefly described. A study is then presented, wherein the long term costs associated with different management strategies are related to parameters such as the equivalent stress range, traffic volume, and intervention costs for a generic weld detail. The results of this study are used to establish critical cost ratio contour plots, which can be used for the selection of the optimal management strategy. A limited number of strategies are investigated, in order to demonstrate an application of the presented methodology. They are composed of different intervention types, including: inspection, repair, replacement, and the use of post-weld 'peening' treatments. Copyright © (2013) by the Canadian Society for Civil Engineering.
Ahmadabadian A.H.,Environmental and Geomatic Engineering |
Robson S.,Environmental and Geomatic Engineering |
Boehm J.,Environmental and Geomatic Engineering |
Shortis M.,RMIT University |
And 2 more authors.
ISPRS Journal of Photogrammetry and Remote Sensing | Year: 2013
Photogrammetric methods for dense 3D surface reconstruction are increasingly available to both professional and amateur users who have requirements that span a wide variety of applications. One of the key concerns in choosing an appropriate method is to understand the achievable accuracy and how choices made within the workflow can alter that outcome. In this paper we consider accuracy in two components: the ability to generate a correctly scaled 3D model; and the ability to automatically deliver a high quality data set that provides good agreement to a reference surface. The determination of scale information is particularly important, since a network of images usually only provides angle measurements and thus leads to unscaled geometry. A solution is the introduction of known distances in object space, such as base lines between camera stations or distances between control points. In order to avoid using known object distances, the method presented in this paper exploits a calibrated stereo camera utilizing the calibrated base line information from the camera pair as an observational based geometric constraint. The method provides distance information throughout the object volume by orbiting the object.In order to test the performance of this approach, four topical surface matching methods have been investigated to determine their ability to produce accurate, dense point clouds. The methods include two versions of Semi-Global Matching as well as MicMac and Patch-based Multi-View Stereo (PMVS). These methods are implemented on a set of stereo images captured from four carefully selected objects by using (1) an off-the-shelf low cost 3D camera and (2) a pair of Nikon D700 DSLR cameras rigidly mounted in close proximity to each other. Inter-comparisons demonstrate the subtle differences between each of these permutations. The point clouds are also compared to a dataset obtained with a Nikon MMD laser scanner. Finally, the established process of achieving accurate point clouds from images and known object space distances are compared with the presented strategies.Results from the matching demonstrate that if a good imaging network is provided, using a stereo camera and bundle adjustment with geometric constraints can effectively resolve the scale. Among the strategies for dense 3D reconstruction, using the presented method for solving the scale problem and PMVS on the images captured with two DSLR cameras resulted in a dense point cloud as accurate as the Nikon laser scanner dataset. © 2013 International Society for Photogrammetry and Remote Sensing, Inc. (ISPRS).
Schobi R.,Environmental and Geomatic Engineering. |
Chatzi E.N.,Environmental and Geomatic Engineering.
Structure and Infrastructure Engineering | Year: 2015
The signs of deterioration in worldwide infrastructure and the associated socio-economic and environmental losses call for sustainable resource management and policy-making. To this end, this work presents an enhanced variant of partially observable Markov decision processes (POMDPs) for the life cycle assessment and maintenance planning of infrastructure. POMDPs comprise a method, commonly employed in the field of robotics, for decision-making on the basis of uncertain observations. In the work presented herein, a continuous-state POMDP formulation is presented which is adapted to the problem of decision-making for optimal management of civil structures. The aforementioned problem may comprise non-linear and non-deterministic action and observation models. The continuous-state POMDP is herein coupled with a normalised unscented transform (NUT) in order to deliver a framework able to tackle non-linearities that likely characterise action models. The capabilities of this enhanced framework and its applicability to the maintenance planning problem are presented via two applications. In a first illustrative example, the use of the NUT is demonstrated within the framework of the value iteration algorithm. Next, the proposed continuous-state framework is compared against a discrete-state formulation for implementation on a life cycle assessment problem. © 2015 Taylor & Francis
Ali Hosseininaveh A.,Environmental and Geomatic Engineering |
Sargeant B.,Environmental and Geomatic Engineering |
Erfani T.,Environmental and Geomatic Engineering |
Robson S.,Environmental and Geomatic Engineering |
And 3 more authors.
Robotics and Autonomous Systems | Year: 2014
This paper describes a novel system for accurate 3D digitization of complex objects. Its main novelties can be seen in the new approach, which brings together different systems and tools in a unique platform capable of automatically generating an accurate and complete model for an object of interest. This is performed through generating an approximate model of the object, designing a stereo imaging network for the object with this model and capturing the images at the designed postures through exploiting an inverse kinematics method for a non-standard six degree of freedom robot. The images are then used for accurate and dense 3D reconstruction using photogrammetric multi-view stereo method in two modes, including resolving scale with baseline and with control points. The results confirm the feasibility of using Particle Swarm Optimization in solving inverse kinematics for this non-standard robot. The system provides this opportunity to test the effect of incidence angle on imaging network design and shows that the matching algorithms work effectively for incidence angle of 10°. The accuracy of the final point cloud generated with the system was tested in two modes through a comparison with a dataset generated with a close range 3D colour laser scanner. © 2014 Elsevier B.V. All rights reserved.
James M.R.,Lancaster University |
Robson S.,Environmental and Geomatic Engineering
Journal of Geophysical Research: Earth Surface | Year: 2012
Topographic measurements for detailed studies of processes such as erosion or mass movement are usually acquired by expensive laser scanners or rigorous photogrammetry. Here, we test and use an alternative technique based on freely available computer vision software which allows general geoscientists to easily create accurate 3D models from field photographs taken with a consumer-grade camera. The approach integrates structure-from-motion (SfM) and multiview-stereo (MVS) algorithms and, in contrast to traditional photogrammetry techniques, it requires little expertise and few control measurements, and processing is automated. To assess the precision of the results, we compare SfM-MVS models spanning spatial scales of centimeters (a hand sample) to kilometers (the summit craters of Piton de la Fournaise volcano) with data acquired from laser scanning and formal close-range photogrammetry. The relative precision ratio achieved by SfM-MVS (measurement precision: observation distance) is limited by the straightforward camera calibration model used in the software, but generally exceeds 1:1000 (i.e., centimeter-level precision over measurement distances of 10s of meters). We apply SfM-MVS at an intermediate scale, to determine erosion rates along a ∼50-m-long coastal cliff. Seven surveys carried out over a year indicate an average retreat rate of 0.70 0.05m a-1. Sequential erosion maps (at ∼0.05m grid resolution) highlight the spatiotemporal variability in the retreat, with semivariogram analysis indicating a correlation between volume loss and length scale. Compared with a laser scanner survey of the same site, SfM-MVS produced comparable data and reduced data collection time by ∼80%. © 2012. American Geophysical Union. All Rights Reserved.
Sharif Ahmadian A.,Hormozgan University |
Simons R.R.,Environmental and Geomatic Engineering
Neural Computing and Applications | Year: 2016
The functional design of submerged breakwaters is still developing, particularly with respect to modelling of the nearshore wave field behind the structure. This paper describes a method for predicting the wave transmission coefficients behind submerged breakwaters using machine learning algorithms. An artificial neural network using the radial-basis function approach has been designed and trained using laboratory experimental data expressed in terms of non-dimensional parameters. A wave transmission coefficient calculator is presented, based on the proposed radial-basis function model. Predictions obtained by the radial-basis function model were verified by experimental measurements for a two dimensional breakwater. Comparisons reveal good agreement with the experimental results and encouraging performance from the proposed model. Applying the proposed neural network model for predictions, guidance is given to appropriately calculate wave transmission coefficient behind two dimensional submerged breakwaters. It is concluded that the proposed predictive model offers potential as a design tool to predict wave transmission coefficients behind submerged breakwaters. A step-by-step procedure for practical applications is outlined in a user-friendly form with the intention of providing a simplified tool for preliminary design purposes. Results demonstrate the model’s potential to be extended to three dimensional, rough, permeable structures. © 2016 The Natural Computing Applications Forum