EntreChem SL Edificio Cientifico Tecnologico Campus El Cristo 33006 Oviedo Spain

Spain

EntreChem SL Edificio Cientifico Tecnologico Campus El Cristo 33006 Oviedo Spain

Spain
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Rios-Lombardia N.,EntreChem SL Edificio Cientifico Tecnologico Campus El Cristo 33006 Oviedo Spain | Vidal C.,University of Oviedo | Liardo E.,EntreChem SL Edificio Cientifico Tecnologico Campus El Cristo 33006 Oviedo Spain | Moris F.,EntreChem SL Edificio Cientifico Tecnologico Campus El Cristo 33006 Oviedo Spain | And 2 more authors.
Angewandte Chemie - International Edition | Year: 2016

The ruthenium-catalyzed redox isomerization of allylic alcohols was successfully coupled with the enantioselective enzymatic ketone reduction (mediated by KREDs) in a concurrent process in aqueous medium. The overall transformation, formally the asymmetric reduction of allylic alcohols, took place with excellent conversions and enantioselectivities, under mild reaction conditions, employing commercially and readily available catalytic systems, and without external coenzymes or cofactors. Optimization resulted in a multistep approach and a genuine cascade reaction where the metal catalyst and biocatalyst coexist from the beginning. © 2016 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.

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