Agency: Cordis | Branch: FP7 | Program: CP-IP | Phase: SEC-2012.3.4-6 | Award Amount: 15.61M | Year: 2013
FastPass will establish and demonstrate a harmonized, modular approach for Automated Border Control (ABC) gates. FastPass brings together key players of the entire ABC value chain - system and component producers, research institutions, governmental authorities and end-users. The development of a harmonized ABC gate will be accomplished with continuous end-user involvement. The entire innovation process, from components development to the final design of the user interface, will continuously be evaluated by the two end user groups, travellers and border guards. Border control is a major challenge for security and mobility within the EU. Travellers request a minimum delay and a speedy border crossing, while Border Guards must fulfil their obligation to secure the EUs borders against illegal immigration and other threats. Fastpass will serve both demands at the same time to keep security at the highest level while increasing the speed and the comfort for all legitimate travellers at all border control points. The FastPass ABC process will be designed to address both requirements with equal emphasis. One aspect of a speedy border crossing by legitimate travellers is a harmonised user interface. This will allow frequent travellers from Europe and third country states to pass through an ABC with minimum delay, using the full potential of ID documents. Improved traveller identification technologies, such as new biometric modules will increase the security of the ABC process and minimise spoofing. A demonstration and evaluation at all types of border (air, land and sea) will be implemented in at least three different member states. Compliance with European societal values and citizens rights is central to the acceptance of the developed technologies, and will accompany the development and end-user interaction throughout the project. FastPass will develop a reference architecture for ABC gates, and will pursue a European initiative for a global standard in ABC technology.
Rheumatology (Oxford, England) | Year: 2013
To characterize a novel anti-NKG2A autoantibody detected in a patient with SLE during a severe flare, and in a cross-sectional study investigate the occurrence of such autoantibodies in patients with SLE and primary SS (pSS). Serum or IgG from patients with SLE, pSS and healthy volunteers were assayed for blocking of anti-NKG2A or HLA-E binding to peripheral blood mononuclear cells or CD94/NKG2A- and CD94/NKG2C-transfected Ba/F3 cells. The anti-NKG2A autoantibodies were evaluated for effect on NK cell degranulation in response to HLA-E-transfected K562 cells. IFN-α was determined by an immunoassay and disease activity by the SLEDAI score. Anti-NKG2A autoantibodies, which blocked binding of HLA-E tetramers to CD94/NKG2A-transfected cells and impaired NKG2A-mediated inhibition of NK cell activation, were observed in a patient with SLE. The presence of anti-NKG2A autoantibodies was associated with high SLE disease activity (SLEDAI score 14 and 16) and increased serum IFN-α. Of 94 SLE, 60 pSS and 30 healthy donor sera, only the index patient serum contained anti-NKG2A autoantibodies. The presence of autoantibodies targeting NKG2A is a rare event, but when such autoantibodies occur they may promote excessive NK cell function. This can contribute to the pathogenesis by increasing the killing of cells and the release of autoantigens. Our findings highlight the possible importance of NK cells in the SLE disease process.
Bygum A.,Entrance |
Vestergaard H.,University of Southern Denmark
International Archives of Allergy and Immunology | Year: 2013
Background: The prevalence of acquired angioedema (AAE) is hitherto unknown and, to date, less than 200 patients have been reported worldwide. AAE is associated with lymphoproliferative conditions and autoantibodies against C1 inhibitor (C1INH). Rituximab (RTX) is increasingly used in the treatment of AAE patients. Methods: A nationwide study of AAE patients was performed in Denmark. Clinical features, associated disorders, treatments and outcomes were registered. Results: Eight AAE patients were identified. The diagnostic delay was on average 1 year and 8 months. Patients were treated with C1INH concentrate or icatibant on demand. Six patients were diagnosed with a clonal B-cell disorder during follow-up, on average 2.5 years after the first swelling. Two patients had monoclonal B-cell lymphocytosis (MBL). Two patients received RTX. Conclusions: AAE is a rare condition occurring in less than 10% of patients with C1INH deficiency in Denmark. AAE is highly associated with haematologic disorders, and we recommend yearly follow-up visits with clinical examination and blood tests including flow cytometry to diagnose B-cell conditions at an early stage. We report 2 patients with AAE and associated MBL, which is a benign expansion of clonal B lymphocytes. MBL can be the precursor of chronic lymphocytic leukaemia or is associated with non-Hodgkin's lymphoma. If angioedema is poorly controlled with standard treatment regimens, we suggest treatment of the associated haematologic disorder. Based on a review of the literature and our own data, we recommend therapy with RTX, especially in patients with anti-C1INH autoantibodies. Copyright © 2013 S. Karger AG, Basel.
Lecture Notes in Computer Science (including subseries Lecture Notes in Artificial Intelligence and Lecture Notes in Bioinformatics) | Year: 2014
The aim of this paper is to provide examples illustrating the conditions for effectively functionalizing the "method of converting graphics into a form that can be perceived using senses other than sight" in the field of HCI. Specifically, it is shown that advantages that method are fully achieved with the implementation of a prototype embossed graphics output function for the statistical analysis software R. In attempting to generate automated tactile graphics from the output of any kind of graphics software, the strategy described below will be useful: a. To investigate whether the intermediate graphics format used in the relevant software consists of primitive vector format drawing commands and character printing commands that handle characters as codes, and b. If the latter conditions are fulfilled, to perform conversion to tactile graphics at the stage of graphics data expressed as that intermediate format. © 2014 Springer International Publishing.
Lecture Notes in Computer Science (including subseries Lecture Notes in Artificial Intelligence and Lecture Notes in Bioinformatics) | Year: 2012
From the perspective of assistive Technology, the hierarchical document tree structure is particularly relevant to represent a document's logical structure. This research proposes a way of realizing advantages attainable from making use of the logical structure of documents by developing a method of presenting the tree structure information of a document on a braille display. The document browser software developed for this research operates as a DAISY player. Experimentation found that using a user interface of that document browser software improves the efficiency of understanding the document's general structure and finding headings when compared to the user interface of a conventional DAISY player with numeric keypad cursor navigation. Not just the DAISY contents, the proposed user interface can be used for general-purpose applications. © 2012 Springer-Verlag.
Fertility and Sterility | Year: 2012
Low-dose hCG supplementation after GnRH agonist trigger may normalize reproductive outcome while minimizing the occurrence of OHSS in high risk IVF patients. © 2012 American Society for Reproductive Medicine, Published by Elsevier Inc.
Journal of Geochemical Exploration | Year: 2010
Sixty-one still bottled water samples, representing 41 locations, were collected from Hellas for the purpose of studying the geochemistry of ground water. Since, the dominating lithology comprises limestone, dolomitic limestone, marble, and mafic-ultramafic rocks (ophiolites), the dominant major ions in Hellenic bottled waters are Ca2+, Mg2+, CO32- and HCO3-, and are, thus, classified in the Ca2+-Mg2+-HCO3- hydrochemical facies. The source aquifers of Hellenic bottled water are apparently continuously replenished by fresh water. Comparison of values of Ca, Mg, K, Na, Cl-, HCO3-, NO3-, SO42-, pH and electrical conductivity, displayed on bottle labels with those of this study, has shown that there is a fairly good correlation between the two data sets, suggesting that the geochemistry of source aquifers is relatively stable over time, at least from 1998 to 2008. © 2010.
Journal of Public Health Policy | Year: 2014
Health and dis-ease by their etymological origins refer to an evaluative, not objective, state. Health is an adaptive state, constantly reestablishing itself through interactions between the many biological, social, emotional, and cognitive factors in a person's life. Such adaptive processes define health as an emergent state. Outcomes of emergent phenomena are not precisely predictable and reside in a phase space that contains all possible states ranging from perfect to poor health states, the latter reflecting dis-ease. However, we have seen a migration of meaning from the subjective, dis-ease, to the objective, disease, referring to uniquely identifiable biomedical change. Clinical reality though teaches us that many experiences of dis-ease are not associated with any objective abnormality, an insight with important implications for clinical care and health policy. © 2014 Macmillan Publishers Ltd.
Entrance | Date: 2012-06-20
The invention relates to a bay loading safety device including:- an articulated platform (14), whose level can be altered to adapt to the differences in height between a lorry trailer (10) and a loading bay (12),- a door (15) for shutting off access from (13) a building (11) opening onto the bay (12),- a set of buffers (16a, 16b) fixed on either side of the platform (14) to provide protection for the bay (12) when the lorry trailer (10) comes alongside the said bay (12),characterised in that it comprises,- a sensor (31) able to monitor a zone (34), called the crush zone,- a sensor (36) able to determine the distance of the lorry (10) from the bay (12),- an obstacle (35) that can be retracted during the travel of a lorry (10), so as to prevent it from coming alongside the bay (12) depending on whether the whole or part of a fixed or mobile object (17) situated in that zone (34) is present and on the distance of the lorry (10) from the bay (12).
News Article | November 15, 2016
— Entrance Consulting announced that it has begun offering specialized software consulting services to not for profit (NFP) organizations. Already an industry leader in delivering top-shelf software expertise to a wide range of industries, the firm will leverage its extensive experience to work with emerging and established NFPs in the community. NFPs frequently encounter enormous challenges in obtaining proper support for their operational needs. With the help of Entrance Consulting's suite of solutions that help organizations integrate software to optimize their overall results, NFPs will be able to benefit from best in class guidance to maximize their computing potential. Entrance Consulting's selection of services can help these organizations flourish thanks to their highly-trained and certified consulting personnel. From customized application guidance and development to assistance with data analytics, Entrance has the solutions to help propel organizations forward. With a wide variety of guidance and analysis available for companies and NFPs to harness, Entrance Consulting leads the way with their tailored offerings. Leading experts on helping organizations configure and implement both Sharepoint and Office 365, Entrance provides a roadmap to achieving both document control and workflow success. Application management consulting services provide key guidance on both custom app development and integrating off the shelf software into a computing infrastructure. Big data analytics and management support services provide organizations with the tools to interpret and integrate data to more effectively make sense of their inbound information. Entrance Consulting helps companies and organizations navigate their way through software development and integration challenges. From Sharepoint and Microsoft Office 365 solutions to providing tailored application management and development services, Entrance Consulting excels at delivering unique solutions with the goal of helping companies improve their computing operations. Their expertise spans a wide variety of industries including oil & gas, manufacturing, engineering, construction and health care. For more information, please visit http://www.entranceconsulting.com/