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Incheon, South Korea

Enprani Co. | Date: 2014-11-06

Beauty masks; Body lotions; Cosmetic creams for skin care; Cosmetics; Dentifrices; Hair lotions; Hand lotions; Lipsticks; Make-up preparations; Make-up removing preparations; Mascara; Nail enamels; Non-medicated lip care preparations; Perfumery; Shampoos; Shower gels; Skin lotions; Soaps. Advertising, marketing and promotion services in the field of cosmetics; Distributorships in the field of cosmetics; On-line retail store services featuring cosmetics; Retail cosmetic stores; Wholesale store services featuring cosmetics.

Lam U.D.P.,Inha University | Hoang D.N.,Inha University | Lee H.-B.,Inha University | Kim B.,Enprani Co. | And 3 more authors.
Korean Journal of Chemical Engineering | Year: 2011

To develop a novel skin depigmenting agent from natural sources, the inhibition of melanogenesis by the Chinese herb, Sterculia lynchnophera (SL), was evaluated. Treatment of B16F10 melanoma cells and melan-a cells with SL exhibited a 32.9% and 68.2% inhibition of melanin synthesis without cytotoxicity at a concentration of 200 μg/ml, respectively. This herb possessed a high free radical scavenging activity with IC50=11. 02 μM. The methanol extract of SL slightly inhibited in vitro mushroom tyrosinase activity (23. 4% at a concentration of 200 μg/ml) and had a significant inhibitory effect on cellular tyrosinase activivity (48.65% and 88.56% inhibition at the concentration 200 μg/ml in B16F10 cells and C57BL/6 melan-a cells, respectively). From the western blotting results, SL inhibited the expression of tyrosinase and tyrosinase related protein 1 (TRP-1). Taken together, we suggest that SL may be a safe and effective depigmentation agent. © 2011 Korean Institute of Chemical Engineers, Seoul, Korea.

Kim B.,Enprani Co. | Kim H.,Asthma Center and Seoul Medical Research Institute | Kim J.E.,Enprani Co. | Lee S.H.,Yonsei University
Tissue Engineering and Regenerative Medicine | Year: 2013

Topical retinoids have been an important therapy used in the treatment of acne. However, retinoids often have adverse effects that range from mild to moderate local irritation. Retinyl retinoate is a member of a new generation of well-tolerated synthetic retinoids used as a topical retinoid treatment. To assess retinyl retinoate 0.05% for acne vulgaris therapy, fifteen female patients with mild to moderate facial acne prevalence were included in a double- blind, placebo-controlled, split-face trial for 8 weeks by investigators and measurement of sebum amount. In addition, retinyl retinoate was measured in anti-bacterial efficacy by an agar plate diffusion assay. Retinyl retinoate showed a significant decrease in both inflammatory and non-inflammatory lesions, and in sebum amount at 8 weeks (P < 0.05). The application of retinyl retinoate is effective and no local side effects for acne lesions. Retinyl retinoate had somewhat anti-bacterial activity against Propionibacterium acnes (P. acnes). These results indicate that retinyl retinoate can be used as treatment for mild acne or could potentiate the efficiency of an additive anti-acne agent. Retinyl retinoate is possible to be suggested as a topical anti-acne treatment with excellent tolerance.

Kim H.,Yonsei University | Kim H.,Enprani Co. | Kim M.,Samkyung Costech Co. | Quan Y.,Kyoto Pharmaceutical University | And 9 more authors.
Skin Research and Technology | Year: 2012

Background: The novel hybrid retinoid, retinyl retinoate, is a synthetic material that was designed to reduce the side effects of retinoic acid and to increase the stability of retinol. The formulation of the retinyl retinoate, however, is required to enhance skin permeation, and thus to increase the anti-wrinkle effect. Aim: To identify the efficacy of retinyl retinoate microsphere using biodegradable polymer as an anti-aging agent of cosmetics in treating females over 30 years old with periorbital wrinkles. Methods: The retinyl retinoate microsphere was prepared using the biodegradable polymer; polylactic acid (PLA). We also conducted two clinical studies with a total of 44 Korean women for 12 weeks. In the first clinical study, 20 patients completed a 12-week trial of cream A [3% PLA-retinyl retinoate (2%) microsphere] applied twice daily to the face. In the second clinical study, 24 patients completed a 12-week trial of cream B (0.06% retinyl retinoate) applied twice daily to the face. Efficacy was based on a global photodamage score, photographs, and image analysis using replicas and Visiometers every 4 weeks. Results: The PLA-retinyl retinoate microsphere was more effective for the permeation of retinyl retinoate than retinyl retinoate in itself. The cream A, which contains 3% PLA-retinyl retinoate (2%) microsphere, showed a statistically significant improvement in facial wrinkles (P<0.05) in 20 volunteers after only 4 weeks of application in a clinical trial test. The visual wrinkle improvement and the maximum roughness improvement rate (R2) for cream A was 6.05%, 8.03% higher than that of cream B which contains 0.06% retinyl retinoate, after 4 weeks. Conclusion: Retinyl retinoate has a potent anti-wrinkle activity, and the PLA-retinyl retinoate microsphere could be a useful cosmeceutical product for anti-aging purposes. © 2011 John Wiley & Sons A/S.

Kim B.,Enprani Co. | Kim J.E.,Enprani Co. | Lee S.M.,Enprani Co. | Kim H.-S.,Jungwon University
Korean Journal of Chemical Engineering | Year: 2014

Scutellaria baicalensis extract (SBE) was investigated to determine its effects on the transactivation activity of peroxisome proliferator-activated receptors (PPAR)-responsive element (PPRE) and anti-oxidant activity for improvement of skin barrier function. The treatment with SBE resulted in a significant increase in the transactivation activity of PPRE such as PPAR-α and effect in anti-oxidant and anti-microbial activity. In addition, SBE promotes the expression of protein related to cornified envelope (CE) formation such as involucrin. Therefore, these results indicate that SBE can promote keratinocyte differentiation and restore skin barrier homeostasis, and is suggested to be an appropriate skin therapeutic agent for improving epidermal permeability barrier function. © 2013 Korean Institute of Chemical Engineers, Seoul, Korea.

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