Incheon, South Korea
Incheon, South Korea

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Kim H.,Yonsei University | Kim H.,Enprani Co. | Koh J.,Dermapro Co. | Baek J.,Dermapro Co. | And 6 more authors.
Skin Research and Technology | Year: 2011

Background: All-trans-retinoic acid (RA) and all-trans-retinol (ROL) are not widely used as anti-wrinkle agents due to their irritancy and photo-stability, respectively. Therefore, the safety and photo-stability in the development of RA or ROL derivatives have been an important issue. Aim: To identify the efficacy of retinyl retinoate as an anti-aging agent of cosmetics in treating females over 30 years old with periorbital wrinkles. Methods: The clinical study was a prospective, double-blind, randomized, and controlled study with a total of 11 Korean women. At every 4 weeks, the effectiveness was assessed with a global photodamage score, photographs, and image analysis using replicas and visiometers. The dermal distance and intensity was also evaluated using Dermascan C. Results: A statistically significant improvement in facial wrinkles (P<0.05) in eleven volunteers was observed in a clinical trial. The successive application of 0.06% retinyl retinoate cream for 3 months showed decreased depth and area of wrinkles in comparison with 0.075% retinol cream. The visual wrinkle improvement and the maximum roughness improvement rate (R2) for retinyl retinoate cream were 22% higher than that of retinol cream after 12 weeks. A statistically significant increase was observed after 8 and 4 weeks for dermal distance and dermal intensity, respectively (P<0.05). Conclusions: Retinyl retinoate had characteristic features of new anti-aging agents, and effectively improved facial wrinkle conditions. © 2011 John Wiley & Sons A/S.


Kim B.,Enprani Co. | Kim J.E.,Enprani Co. | Lee S.M.,Enprani Co. | Kim H.-S.,Jungwon University
Korean Journal of Chemical Engineering | Year: 2014

Scutellaria baicalensis extract (SBE) was investigated to determine its effects on the transactivation activity of peroxisome proliferator-activated receptors (PPAR)-responsive element (PPRE) and anti-oxidant activity for improvement of skin barrier function. The treatment with SBE resulted in a significant increase in the transactivation activity of PPRE such as PPAR-α and effect in anti-oxidant and anti-microbial activity. In addition, SBE promotes the expression of protein related to cornified envelope (CE) formation such as involucrin. Therefore, these results indicate that SBE can promote keratinocyte differentiation and restore skin barrier homeostasis, and is suggested to be an appropriate skin therapeutic agent for improving epidermal permeability barrier function. © 2013 Korean Institute of Chemical Engineers, Seoul, Korea.


Lam U.D.P.,Inha University | Hoang D.N.,Inha University | Lee H.-B.,Inha University | Kim B.,Enprani Co. | And 3 more authors.
Korean Journal of Chemical Engineering | Year: 2011

To develop a novel skin depigmenting agent from natural sources, the inhibition of melanogenesis by the Chinese herb, Sterculia lynchnophera (SL), was evaluated. Treatment of B16F10 melanoma cells and melan-a cells with SL exhibited a 32.9% and 68.2% inhibition of melanin synthesis without cytotoxicity at a concentration of 200 μg/ml, respectively. This herb possessed a high free radical scavenging activity with IC50=11. 02 μM. The methanol extract of SL slightly inhibited in vitro mushroom tyrosinase activity (23. 4% at a concentration of 200 μg/ml) and had a significant inhibitory effect on cellular tyrosinase activivity (48.65% and 88.56% inhibition at the concentration 200 μg/ml in B16F10 cells and C57BL/6 melan-a cells, respectively). From the western blotting results, SL inhibited the expression of tyrosinase and tyrosinase related protein 1 (TRP-1). Taken together, we suggest that SL may be a safe and effective depigmentation agent. © 2011 Korean Institute of Chemical Engineers, Seoul, Korea.


Kim B.,Enprani Co. | Kim B.,Yonsei University | Kim J.E.,Enprani Co. | Kim H.,Enprani Co. | And 3 more authors.
International Journal of Dermatology | Year: 2012

Background Retinoids have been used for the treatment of skin disorders such as acne, psoriasis, and photoaging. However, despite their beneficial effects, topical retinoids often cause severe local irritation called retinoid dermatitis. We previously developed a novel vitamin A derivative, retinyl retinoate, which induces less irritation and affords excellent tolerance. In this study, we examined whether co-treatment with topical peroxisome proliferator-activated receptor-α (PPARα) agonists (e.g. WY14643) reduce retinoid dermatitis in hairless mouse skin. Methods The effect of concomitant treatment with a PPARα agonist on retinoid dermatitis in hairless mouse epidermis was evaluated by measuring transepidermal water loss, epidermal histology, and cytokine expression. Results Retinyl retinoate induced less severe retinoid dermatitis than retinoic acid. Topical application of a PPARα agonist improved the stratum corneum structure and function, reduced mRNA expression of interleukin (IL)-1α, tumor necrosis factor-α and IL-8, and inhibited ear edema induced by retinoic acid or retinyl retinoate. Conclusions Our results indicate that PPARα agonists can potentially be used to improve retinoid dermatitis. We suggest that co-treatment with retinyl retinoate and a PPARα agonist may reduce or prevent detrimental alterations in retinoid-treated skin. © 2012 The International Society of Dermatology.


Kim B.,Enprani Co. | Kim J.E.,Enprani Co. | Lee S.M.,Enprani Co. | Lee S.-H.,Yonsei University | And 6 more authors.
Experimental Dermatology | Year: 2011

We synthesized a novel derivative of a well-known skin-lightening compound niacinamide, N-nicotinoyl dopamine (NND). NND did not show inhibitory effects of tyrosinase and melanin synthesis in B16F10 mouse melanoma cells. However, NND retains high antioxidant activity without affecting viability of cells. In a reconstructed skin model, topical applications of 0.05% and 0.1% NND induced skin lightening and decreased melanin production without affecting the viability and morphology of melanocytes and overall tissue histology. Moreover, no evidence for skin irritation or sensitization was observed when 0.1% NND emulsion was applied onto the skin of 52 volunteers. The effect of NND on skin lightening was further revealed by pigmented spot analyses of human clinical trial. Overall, NND treatment may be a useful trial for skin lightening and treating pigmentary disorders. © 2011 John Wiley & Sons A/S.


Kim B.,Ellead Co. | Kim J.E.,Enprani Co. | Choi B.-K.,SN Biotech Co. | Kim H.-S.,Jungwon University
Biomolecules and Therapeutics | Year: 2015

Water chestnut (Trapa japonica Flerov.) is an annual aquatic plant. In the present study, we showed that the treatment of water chestnut extracted with boiling water resulted in a significant increase 2,2-diphenyl-1-picrylhydrazyl (DPPH) radical-scavenging activity and decrease the intracellular H2O2-induced accumulation of reactive oxygen species. In addition, water chestnut extract (WCE) inhibited lipopolysaccharide (LPS)-induced nitric oxide production and suppressed mRNA and protein expression of the inducible nitric oxide synthase gene. The cytokine array results showed that WCE inhibited inflammatory cytokine secretion. Also, WCE reduced tumor necrosis factor-α- and interleukin-6-induced nuclear factor-κB activity. Furthermore, during sodium lauryl sulfate (SLS)-induced irritation of human skin, WCE reduced SLS-induced skin erythema and improved barrier regeneration. These results indicate that WCE may be a promising topical anti-inflammatory agent. © 2015 The Korean Society of Applied Pharmacology.


Kim H.,Yonsei University | Kim H.,ENPRANI Co. | Kim N.,Ellead Skin Evaluation Center | Jung S.,Ellead Skin Evaluation Center | And 10 more authors.
British Journal of Dermatology | Year: 2010

Background Photoaged skin can be treated with retinoids, which are natural and synthetic vitamin A derivatives. However, these are photounstable and can cause skin irritation, which is a major limitation in their use in general cosmetics. Retinyl retinoate, which is an ester of all-trans retinoic acid (RA) and all-trans retinol, has reduced toxicity due to blocking of the carboxyl end group of RA and higher skin regeneration activity than retinol. Objectives To assess the efficacy of a photostable retinyl retinoate in treating women over 30 years old with periorbital wrinkles. Methods We conducted two clinical studies with a total of 46 Korean women with periorbital wrinkles, who were not pregnant, nursing or undergoing any concurrent therapy. In the first clinical study, the efficacy of retinyl retinoate was compared with placebo. Twenty-four patients completed a 12-week trial of 0·06% retinyl retinoate applied twice daily to one side of the face and a placebo applied to the other side. In the second clinical study, the efficacy of retinyl retinoate was compared with retinol. Twenty-two patients completed an 8-week trial of 0·06% retinyl retinoate applied twice daily to one side of the face and 0·075% retinol applied to the other side. Efficacy was based on a global photodamage score, photographs, and image analysis using replicas and visiometer analysis (Skin-Visiometer SV 600; Courage & Khazaka, Cologne, Germany) every 4 weeks. The standard wrinkle and roughness parameters used in assessing skin by visiometer were calculated and statistically analysed. Results The retinyl retinoate-treated wrinkles improved compared with wrinkles treated with placebo or retinol, as assessed by both the investigators and the subjects. Also, skin replica analysis indicated significant improvements in retinyl retinoate-treated skin in both studies, especially in average roughness. Conclusions Retinyl retinoate applied twice daily was significantly more effective than a placebo or retinol in treating periorbital wrinkles. Importantly, no severe side-effects were observed. © 2009 British Association of Dermatologists.


Trademark
Enprani Co. | Date: 2014-11-06

Beauty masks; Body lotions; Cosmetic creams for skin care; Cosmetics; Dentifrices; Hair lotions; Hand lotions; Lipsticks; Make-up preparations; Make-up removing preparations; Mascara; Nail enamels; Non-medicated lip care preparations; Perfumery; Shampoos; Shower gels; Skin lotions; Soaps. Advertising, marketing and promotion services in the field of cosmetics; Distributorships in the field of cosmetics; On-line retail store services featuring cosmetics; Retail cosmetic stores; Wholesale store services featuring cosmetics.


Trademark
Enprani Co. | Date: 2016-11-30

Cosmetics; Lipsticks; Make-up preparations; Body lotions; Skin lotions; Make-up removing preparations; Shower gels; Hair lotions; Mask pack for cosmetic purposes; Mascara; Hand lotions; Nail enamel; Perfumery; Beauty masks; Shampoos; Beauty soap; Dentifrices.


PubMed | Enprani Co.
Type: Journal Article | Journal: Biomolecules & therapeutics | Year: 2013

We investigated the inhibitory effects of hesperidin on melanogenesis. To find melanosome transport inhibitor from natural products, we collected the structural information of natural products from Korea Food and Drug Administration (KFDA) and performed pharmacophore-based in silico screening for Rab27A and melanophilin (MLPH). Hesperidin did not inhibit melanin production in B16F10 murine melanoma cells stimulated with -melanocyte stimulating hormone (-MSH), and also did not affect the catalytic activity of tyrosinase. But, hesperidin inhibited melanosome transport in melanocyte and showed skin lightening effect in pigmented reconstructed epidermis model. Therefore, we suggest that hesperidin is a useful inhibitor of melanosome transport and it might be applied to whitening agent.

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