Zhou M.,Engineering Research Center for the Development and Application of Ethnic Medicine and TCM |
Zhou M.,Guizhou University |
Zhang R.-H.,Guizhou University |
Wang M.,Engineering Research Center for the Development and Application of Ethnic Medicine and TCM |
And 4 more authors.
European Journal of Medicinal Chemistry | Year: 2017
Triterpenoids are structurally diverse organic compounds that exist widely as natural products. Triterpenoids and their derivatives possess a wide range of biological effects including hepatoprotective, hypoglycemic, immunomodulatory, anti-inflammatory, anti-oxidant, and antitumor activities. In particular, the lupane-, oleanane-, and ursane-type triterpenes have been reported to exhibit pharmacological effects without prominent toxicity even at higher concentrations. Whereas, the poor drug-like properties (e.g., low solubility and selectivity, poor bioavailability, and short half-life) severely limit their applications. This review summarized the advances in prodrug strategies for improving the drug-like properties of different types of triterpenoids, and the information indicated in the review will surely stimulate further efforts toward the development of these compounds for potential clinical uses. © 2017 Elsevier Masson SAS
PubMed | Guizhou University, Guiyang Medical University and Engineering Research Center for the Development and Application of Ethnic Medicine and TCM
Type: Journal Article | Journal: Chinese journal of natural medicines | Year: 2016
The present study isolated 17 compounds from the tubers of Bletilla striata (Orchidaceae), using various chromatographic techniques. Their structures were identified based on their physical-chemical properties and spectroscopic analyses. Among them, two new 2-isobutylmalates, named bletimalates A (1) and B (2), together with other fifteen known compounds (3-17), were isolated and identified. Additionally, compounds 3, 4, and 8 were isolated from this plant for the first time.