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Gao C.-Z.,Kunming University of Science and Technology | Gao C.-Z.,Engineering Laboratory for Advanced Battery and Material of Yunnan Province | Zhang Y.,Kunming University of Science and Technology | Chen J.,Kunming University of Science and Technology | And 7 more authors.
Yaoxue Xuebao | Year: 2015

Platinum-based anticancer drugs have been becoming one of the most effective drugs for clinical treatment of malignant tumors for its unique mechanism of action and broad range of anticancer spectrum. But, there are still several problems such as side effects, drug resistance/cross resistance and no-specific targeting, becoming obstacles to restrict its expanding of clinical application. In recent years, supramolecular chemistry drug delivery systems have been gradually concerned for their favorable safety and low toxicity. Supramolecular macrocycles-platinum complexes increased the water solubility, stability and safety of traditional platinum drugs, and have become hot focus of developing novel platinum-based anticancer drugs because of its potential targeting of tumor tissues/organs. This article concentrates in the research progress of the new drug delivery system between platinum-based anticancer drugs with three generations of macrocycles: crown ether, cyclodextrin, cucurbituril and calixarene.


Zhang Y.,Kunming University of Science and Technology | Zhang Y.,Engineering Laboratory for Advanced Battery and Material of Yunnan Province | Gao C.,Kunming University of Science and Technology | Gao C.,Engineering Laboratory for Advanced Battery and Material of Yunnan Province | And 7 more authors.
Applied Organometallic Chemistry | Year: 2015

Seven dinuclear platinum(II) complexes with a novel chiral tetradentate ligand, (1R,1′R,2R,2′R)-N1,N1′-(1,4-phenylenebis(methylene))dicyclohexane-1,2-diamine, were designed, synthesized and spectrally characterized. All the complexes were evaluated for their in vitro cytotoxicity against human HepG-2, A549, HCT-116 and MCF-7 cancer cell lines. The results indicated that all compounds showed positive biological activity against HepG-2, A549 and HCT-116 cancer cell lines. In particular, compounds D7 and D2 showed better activity than carboplatin against HepG-2 and A549 and compound D7 also showed an activity close to that of oxaliplatin. Copyright © 2015 John Wiley & Sons, Ltd.


PubMed | Engineering Laboratory for Advanced Battery and Material of Yunnan Province and Kunming University of Science and Technology
Type: Journal Article | Journal: Mini reviews in medicinal chemistry | Year: 2016

Platinum-based (Pt-based) anticancer drugs have been recognised as one of the most effective drugs for clinical treatment of malignant tumors due to its unique mechanism of action and broad range of anticancer spectrum. But, there are still some limitations such as side effects, drug resistance/cross resistance, no-specific targeting, becoming obstacles to restrict its expanding of clinical application. Targeted drug delivery system (TDDS) is a promising strategy for the research of novel Pt-based anticancer drugs. A variety of TDDS have been explored to improve the antitumor activity of Pt-based drugs such as nanoparticle drug systems, polymer-drug systems, drugs-macrocyclic compounds systems, etc. The review concentrates on recent development of various targeted drug delivery techniques, which could provide more opportunities for the development of Pt-based drugs with better efficiency, lower toxicity and less resistance.

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