Endura SpA

Ravenna, Italy

Endura SpA

Ravenna, Italy
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Patent
Endura S.p.A., Babolna Bioenvironmental Center Ltd. and AGChem Access Ltd | Date: 2017-03-15

The invention relates to a compound of Formula (I), wherein n is 0 or 1,R_(1) is H or CH_(3) and R_(2) is a linear (C_(3)-C_(6))alkyl and an insecticide composition comprising at least one insecticide active ingredient and at least one a compound of Formula (I).


Patent
Endura S.p.A., Babolna Bioenvironmental Center Ltd. and AGChem Access Ltd | Date: 2017-03-15

The present invention relates to a pesticide composition comprising at least one pesticidal active ingredient and at least one methylendioxyphenyl derivative compound of Formula (I), wherein R_(1) is a linear (C_(4)-C_(6))alkyl.


PubMed | Rothamsted Research, ApresLabs Ltd and Endura SpA
Type: Journal Article | Journal: Pest management science | Year: 2016

Derivatives of piperonyl butoxide with alkynyl side chains were tested in vitro and in vivo against pyrethroid-resistant Meligethes aeneus and imidacloprid-resistant Myzus persicae.Synergists with the alkynyl side chain were more effective inhibitors of P450 activity in vitro than piperonyl butoxide, and demonstrated high levels of synergism in vivo, with up to 290-fold synergism of imidacloprid against imidacloprid-resistant M. persicae.These second-generation synergists could overcome metabolic resistance in many pest species and possibly enable reduced rates of insecticide application in some cases. 2016 Society of Chemical Industry.


Grant
Agency: European Commission | Branch: FP7 | Program: BSG-SME | Phase: SME-2013-1 | Award Amount: 1.32M | Year: 2013

Insect pests cause significant damage to agricultural crops and transmit several important diseases of humans and animals. Chemical insecticides have been used to control insect pests for many decades and remain essential to ensure a supply of affordable food and as part of disease vector control for the foreseeable future. Unfortunately, the world-wide use of synthetic insecticides over many years has led to increased resistance to insecticides and contributed to environmental contamination. One way to reduce insecticide use without compromising control is to use a synergist in combination with an insecticide. Synergists are themselves nontoxic but act by increasing the effectiveness of the insecticides they are used with. They do this by inhibiting the metabolic systems in insects that detoxify insecticides. The goal of this project is to develop ecofriendly synergists for use in formulations with insecticides, both in agriculture and in Public Health, enabling a reduction in the amount of insecticidal active applied, and thereby reducing the adverse effects of these insecticides on beneficial insects such as bees. On the basis of in-depth experimental analyses of the interactions of the known synergist piperonyl butoxide with metabolic enzymes in pest insects, new molecular structures will be designed, synthesized and evaluated on pest and beneficial species using laboratory bioassays and field trials. In addition, the synthesis process to manufacture these synergists will be evaluated with the aim of achieving an industrially and economically feasible process. Finally strategies will be developed that use the novel synergists to enhance the control of insect pests while preserving beneficial insects. As such this research has significant scientific, economic, and social impact as part of sustainable food production and disease control and will enhance the partners competitiveness in this important industry by means of global patent and license agreements.


The invention relates to the use of a derivative compound of 1,3-benzodioxole of formula (I) wherein R is a linear or branched (C_(4)-C_(10)) alkyl substituent as a synergistic compound of insecticidal active ingredients insecticidal compositions comprising at least one compound of Formula (I) and at least one insecticidal active ingredient are also described.


Patent
Endura S.P.A. | Date: 2013-07-05

Use of formulations consisting of suspo-emulsions comprising a microcapsule suspension, the microcapsules including at least one active ingredient selected from the pyrethroid and/or neonicotinoid classes, at least one synergistic agent, and an emulsion comprising at least an active ingredient of the above classes, and at least one synergistic agent, the microcapsules being formed of polyurea, obtainable by inter-facial polymerization of diphenylmethylen-4,4-diisocyanate, optionally in admixture with polymethylenpolyphenylisocyanate, the formulations having a prolonged knockdown and killing effect, even of three months, even of six months or even of nine months, the suspo-emulsions comprising: component A): microcapsules in suspension comprising inside the microcapsule at least one active ingredient, a synergistic agent, optionally a solvent, the total amount of these components being not higher than 50% by weight with respect to the weight of the suspension A), the complement to 100% by weight of component A) comprising the polymer of the micro-capsule shell, water and additives; component B): emulsion comprising an amount of at least one active ingredient and one synergistic agent, the amount of active ingredient+synergistic agent being not higher than 50% by weight of the emulsion, of component B) constituted by water, additives, optionally solvents.


A process is described for preparing enriched enantiomers of the compound 3-(benzo[1,3]dioxol-5-yl)-2-methylpropanal of formula (I) comprising the following steps: i) reacting the racemic compound 3-(benzo[1,3]dioxol-5-yl)-2-methylpropanol (2) with phthalic anhydride to give the racemic acid (3); ii) resolving the racemic acid (3) with optically active 1-aryl-1-ethanamine (4) in which Ar is an aromatic or heteroaromatic group having from 6 to 12 members optionally substituted with one or more substituents chosen from the group consisting of (C_(1)-C_(3)) alkyl, (C_(1)-C_(3)) alkoxy and halogen; iii) recovering the (S)-(2) and (R)-(2) alcohols from the resolved acids (3) of step ii) by alkaline hydrolysis; iv) converting the (S)-2 and (R)-2 alcohols into the respective (S) and (R) enantiomers of compound (I).


Patent
Endura S.P.A. and Rothamsted Research | Date: 2012-03-07

Provided are compositions comprising (i) a neonicotinoid; and (ii) a compound of formula (I) or (II), preferably wherein the composition is a pesticide composition, for example an insecticide composition. Also provided is use of a compound of formula (I) or (II) as a neonicotinoid synergist and use of a compound of formula (I) or (II) in combination with a neonicotinoid. Further provided are methods for controlling pests.


Patent
Endura S.p.a. and Rothamsted Research | Date: 2011-03-02

An alkynyl phenoxy compound of Formula (I) is described, wherein R_(1) and R_(2), similar or different, are (C_(1)-C_(4))alkyl or R_(1)O- and R_(2)O- together represent a group -O-CH_(2)-O-, -O-CH(CH_(3))-O-, -O-CH_(2)-CH_(2)-O-, -O-CH_(2)-CH_(2)-, R_(3) is (C_(1)-C_(6))alkyl, (C_(3)-C_(6))alkenyl or -B-(CH_(2)-CH_(2)-O)z-R_(6) where B is -CH_(2)-O- or -O-, z is 0, 1 or 2 and R_(6) is (C_(1)-C_(4))alkyl; R_(4) is hydrogen or methyl;R_(5) is hydrogen or methyl;x is an integer from 1 to 2; y is 0,1 or 2; with the proviso that when R_(3) is -B-(CH_(2)-CH_(2)-O)_(2)-R_(6), y is 1 and 5-(propargyloxy)-benzo[1,3]dioxole is excluded. A pesticide composition comprising the compound of the invention and a pesticidal active ingredient is also described.


Patent
Endura S.p.A. and Sipcam S.p.A. | Date: 2013-05-08

Use of formulations comprising polyurea microcapsules obtainable by interfacial polymerization of diphenylmethylen-4,4-diisocyanate (MDI), optionally in admixture with polymethylenepolyphenylisocyanate (PAPI), said formulations having a prolonged knockdown and killing effect longer than at least three months, preferably at least of 6 months, still more preferably at least of 9 months from the application, wherein the microcapsules comprise:an active principle selected from the pyrethroid and/orneonicotinoid classes,synergizing agents selected between PBO and Verbutin,the concentration of the active principle in the microcapsule as % by weight on the total of the microcapsule is comprised between 1% and 60%the average diameter of the microcapsules is comprised between 2 and 50 m.

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