Entity

Time filter

Source Type


Minooee S.,Reproductive Endocrinology Research Center | Ramezani T.F.,Reproductive Endocrinology Research Center | Mirmiran P.,Nutrition and Endocrine Research Center | Azizi F.,Shahid Beheshti University of Medical Sciences
Iranian Journal of Endocrinology and Metabolism | Year: 2015

Introduction: Polycystic ovary syndrome (PCOS) is the most prevalent endocrinopathy in reproductive aged women. The association of early-life factors such as fetal adipose tissue and birth weight with adulthood outcomes like obesity, body fat mass (BFM) and body lean mass (BLM) is not clearly understood. We aimed to compare the association between birth weight and body composition in women with PCOS and normal controls. Materials and Methods: For this study we enrolled a total of 70 reproductive aged women with PCOS diagnosis, referring to the Reproductive Endocrinology Research Center and the same number of healthy women without polycystic ovaries by ultrasonography or hirsutism and/or anyovulatory other dysfunction were enrolled. Their birth weights were documented and their body composition was assessed, using standard measuring devices. Results: Cases were younger than the controls (29.7±4.9 versus 30.8±5.9 years) and had the same BMI (24.6±2.4 versus 24.8±4.5 kg/m2). Our study demonstrated that BFM and BLM are increased in adult PCOS women born underweight, compared to their normal counterparts (16± 4.7 versus 12.2± 4.1, P= 0.06 and 46.4±5.8 versus 41.1±5.8, P=0.07). Conclusion: The impact of fetal adipose tissue and birth weight on the occurrence adulthood obesity, BFM and BLM vary between women with and without PCOS. © 2015, Endocrine Research Center. All rights reserved. Source


Kazemijaliseh H.,Reproductive Endocrinology Research Center | Ramezani Tehrani F.,Reproductive Endocrinology Research Center | Behboudi-Gandevani S.,Reproductive Endocrinology Research Center | Khalili D.,Prevention of Metabolic Disorders Research Center | And 2 more authors.
Iranian Journal of Endocrinology and Metabolism | Year: 2015

Introduction: Normal menstruation is one of important indicators of the general health of reproductive-aged women. We aimed to investigate the prevalence of menstrual disorders and its related factors. Materials and Method: This cross-sectional study was conducted among women participants of the Tehran Lipid and Glucose Study, a population-based study aimed identify the prevalence of noncommunicable diseases from March 2013 to 2014. A total of 1393 women, aged 15-49 yr were included and all pregnant, breastfeeding and menopausal women were excluded. Socio-demographic characteristics and menstruation patterns were assessed by a standardized ad-hoc questionnaire. Menstruation was categorized based on last FIGO definitions. Data analyzed using SPSS version 11.0 (SPSS-Inc., Chicago-IL), 0.05 was set as significant level. Results: Mean age of participants was 37.7 (11) y. The results showed that 64.1% of subjects had normal menstruation and 35.8% experienced different forms of menstrual disorders. Heavy menstrual bleeding was one of the most prevalent disorders (17.2%). Prevalence of menstrual disorders was statistically higher in women <20 yr (47.7%) and >40yr (45.5%) than women between the 20-40 yr age range (P=0.001). Irregular menstrual bleeding in >20 yr, heavy menstrual bleeding in 20-40 yr and > 40yr were the most common menstrual disorders. The results remain unchanged for age and BMI after adjustment for potential confounders (OR: 1.08, CI 95%: 1.07-3.97; P<0.03), (OR: 1.05, CI 95%: 1.02-5.04; P<0.04), respectively. Conclusion: Our findings showed that menstrual disorders are prevalent as one-third of reproductive aged women suffer from one or more menstrual disorders. Understanding the prevalence of menstrual disorders could help health care providers to identify some serious diseases, and prioritize strategies to promote these women’s quality of life. © 2015, Endocrine Research Center. All rights reserved. Source


Tehrani F.R.,Reproductive Endocrinology Research Center | Noroozzadeh M.,Reproductive Endocrinology Research Center | Zahediasl S.,Research Institute for Endocrine science | Piryaei A.,Shahid Beheshti University of Medical Sciences | Azizi F.,Shahid Beheshti University of Medical Sciences
Experimental Physiology | Year: 2014

New Findings: What is the central question of this study? Would it be possible to produce a rat model of polycystic ovary syndrome (PCOS), in which the fetuses are exposed to testosterone for a short time and exhibit both endocrine and ovarian disturbances similar to PCOS, while maintaining normal reproductive system morphology in adulthood? What is the main finding and its importance? Prenatal exposure to a single dose of testosterone during the critical period of fetal development facilitates the production of a functional rat model of PCOS with minimal morphological disorders in adulthood. Production of a functional rat model that resembles many features of PCOS may contribute to a better understanding of this syndrome. Polycystic ovary syndrome (PCOS) is one of the most common endocrine disorders in women, with a prevalence of 8-12% during the reproductive years. In the present study, using prenatal exposure to a single dose of testosterone during the critical period of fetal development, we aimed to introduce an enhanced rat model that would exhibit both endocrine and ovarian disturbances similar to PCOS, while maintaining normal reproductive system morphology in adulthood. Ten pregnant rats were injected s.c. with 5 mg free testosterone on gestational day 20, while control rats received only solvent. The development and function of the reproductive system in female offspring were examined in adulthood. Prenatally androgenized offspring had irregular oestrous cycles compared with control animals, and their anogenital and anovaginal distances were increased compared with control rats (P < 0.001). No significant differences were observed in the lengths of the vagina and clitoris or the number of nipples between the two groups. Levels of testosterone and luteinizing hormone and the luteinizing hormone/follicle-stimulating hormone ratio were increased in prenatally androgenized offspring compared with control animals (P < 0.05). The numbers of preantral and antral follicles in the ovaries of prenatally androgenized offspring were also increased compared with control rats (P = 0.07 and P < 0.01, respectively). The number of corpora lutea was decreased in prenatally androgenized offspring compared with control rats. Cystic follicles were observed in the ovaries of prenatally androgenized offspring. Prenatal exposure to a single dose of testosterone during the critical period of fetal development could facilitate the development a functional rat model of PCOS in adulthood, with minimal morphological disorders in the reproductive system. © 2014 The Physiological Society. Source

Discover hidden collaborations