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Pouyamanesh Z.,Islamic Azad University at Tehran | Amoli M.M.,Endocrinology and Metabolism Clinical science Institute | Yaghmaei P.,Islamic Azad University at Tehran | Ebrahim-Habibi A.,Tehran University of Medical Sciences
Tropical Journal of Pharmaceutical Research | Year: 2016

Purpose: To evaluate the preventive and therapeutic effects of inulin supplementation in Naval Medical Research Institute (NMRI) male mice fed with high fat diet. Methods: NMRI male mice (n = 36) were divided into three groups. Control (C1), obese (O1) and experimental mice (E1) were fed during 8 weeks as follows: C1 with normal rodent pellet, O1 with high fat diet, and E1 with high fat diet plus 20% inulin. C2, O2, and E2 were fed as follows: C2 with normal rodent pellets for 12 weeks; O2 with high fat diet during 8 weeks and switched to normal rodent pellet during next 4 weeks; and E2 with high fat diet over a period of 8 weeks and switched to normal rodent pellet plus 20% inulin for 4 weeks. Body weight, serum glucose, triglycerides, total cholesterol, high density lipoprotein (HDL), low density lipoprotein (LDL), and hepatic α-amylase gene expression were measured. Results: Groups receiving high fat diet showed higher weight (30.71 ± 0.66 g in O2, p < 0.001), nonfasting blood glucose levels (257.69 ± 5.10 mg/dl in O2, p < 0.001), TG (282.15 ± 1.83 mg/dl in O2, (p < 0.001)), and cholesterol levels (335.72 ± 2.23 mg/dl in O2, (p < 0.001)), compared with control. In C2 group, mean body weight was 25.71 ± 0.54 g, non-fasting blood level 161.54 ± 4.48 mg/dl, TG level 214.29 ± 5.54 mg/dl, and cholesterol level 164.29 ±4.57 mg/dl. Compared to obese group, mice receiving inulin showed lower blood glucose levels (223.10 ± 8.7 mg/dl in E2, p < 0.001), body weight (27.86 ± 0.57 g in E2, p < 0.001), TG (232.14 ± 4.02 mg/dl in E2, p < 0.001) and cholesterol (249.97 ± 2.28 in E2, p < 0.001). A slight decrease in hepatic α-amylase gene expression was observed only in E1. Conclusion: Besides its sweetening properties, inulin may also find use as a potential anti-obesity compound. © Pharmacotherapy Group, Faculty of Pharmacy, University of Benin, Benin City, 300001 Nigeria. All rights reserved. Source


As'adi K.,Tehran University of Medical Sciences | Salehi S.H.,Tehran University of Medical Sciences | Shoar S.,Shariati Hospital | Hashemian S.J.,Endocrinology and Metabolism Clinical science Institute | Moradi M.,Tehran University of Medical Sciences
Journal of Craniofacial Surgery | Year: 2014

BACKGROUND: Endoscopic-assisted tissue expansion has been recently used in plastic surgery. However, there is limited evidence regarding its efficacy in reconstruction of facial burn injuries. AIMS: Our study aimed to evaluate the utility of endoscopic-assisted neck tissue expansion in reconstruction of facial burn deformities. METHODS: Through a prospective study, 42 consecutive patients with facial burn injuries attending a major referral center of plastic and reconstructive surgery in Iran underwent reconstruction of facial defects with endoscopic-assisted neck tissue expansion. Intraoperative events, expansion process, and postoperative outcomes were measured for this group of patients. RESULTS: The mean ± SD injected volume for intraoperative expansion was 66 ± 3.7 mL (range, 35-80 mL). The mean ± SD operative time was 45.6 ± 3.5 minutes. Moreover, the mean ± SD distance between the main access incision and the expander pocket was 5.6 ± 1.2 cm. Time to achieve full expansion ranged between 12 and 16 weeks, and the expanded volume at the time of reconstruction ranged from 400 to 800 mL. All the patients had less than 24 hours of hospital stay after placement of tissue expanders. There were only 2 minor complications during the postoperative follow-up including 1 case of seroma and 1 case of severe pain, which were treated conservatively. CONCLUSIONS: Endoscopic-assisted neck tissue expansion is associated with lower complication rate, shorter duration of hospitalization, reduced operative time, earlier initiation of expansion, and faster expansion process. It could be a feasible alternative to open technique in reconstructing facial burns, allowing smaller incision at port site, far placement of tissue expander, and excellent visualization of operation site. © 2014 by Mutaz B. Habal, MD. Source


Radaei F.,Amirkabir University of Technology | Shirazi S.Y.,Amirkabir University of Technology | Gharibzadeh S.,Amirkabir University of Technology | Khashayar P.,Tehran University of Medical Sciences | And 2 more authors.
2015 22nd Iranian Conference on Biomedical Engineering, ICBME 2015 | Year: 2015

In the present study, a group of people aged 20-85 who visited the bone mineral densitometry center of the Shariati Hospital, were analyzed. Participants were asked to stand up barefoot on Wii balance board and in front of a Kinect sensor. We calculated the center of pressure (COP) and center of mass (COM) using the data from Wii balance board and Kinect, respectively. By evaluating balance parameters, we show that there is a reverse relationship between center of mass acceleration and femur's bone mineral density. Further research in the subject may facilitate the design of equipment that can reduce the rate of falling in patients. © 2015 IEEE. Source


Vala M.,Endocrinology and Metabolism Clinical science Institute | Razmandeh R.,Tehran University of Medical Sciences | Rambod K.,Endocrinology and Metabolism Clinical science Institute | Nasli Esfahani E.,Endocrinology and Metabolism Clinical science Institute | Ghodsi Ghasemabadi R.,Endocrinology and Metabolism Clinical science Institute
Iranian Journal of Endocrinology and Metabolism | Year: 2016

Introduction: About 20-40% of people with diabetes experience varying levels of distress and general symptoms of anxiety and depression. This study aimed to evaluate the effects of mindfulness-based stress reduction group training on depression, anxiety, stress, self-confidence and hemoglobin A1c in young women with type 2 diabetes. Materials and Methods: In this pretestposttest-control group design study, we used instruments such as demographic data and depression, anxiety and stress (DASS-21) and the Rosenberg self-confidence questionnaires. The study population included 60 patients with diabetes randomly divided into 2, the experimental and control groups. The experimental group received the mindfulness intervention with 8 sessions each 2.5 hours while the control group received no intervention. Following this, during the ninth, session both groups again completed the questionnaires. Results: Patients in experimental group reported lower levels intensity of anxiety, stress and HbA1C, but higher self-confidence in comparison to the controls after intervention (P<0.05), although differences in levels of the depression variable between two groups was not significant. In addition, between HbA1c and all variables, (depression, stress, self-confidence) significant correlations were observed. Conclusion: Results suggest that depression, anxiety, stress and self-confidence are associated with HbA1C level and a mindfulness-based stress reduction program can be effective in reducing the psychological symptoms in these patients, leading to increased confidence and improved glycemic control in women with type 2 diabetes. © 2016, Endocrine Research Center. All rights reserved. Source


Tabaeizadeh M.,Endocrinology and Metabolism Clinical science Institute | Haghpanah V.,Endocrinology and Metabolism Clinical science Institute | Keshtkar A.,Tehran University of Medical Sciences | Semnani S.,Golestan University of Medical Sciences | And 9 more authors.
Journal of Gastric Cancer | Year: 2013

Purpose: We designed our study to evaluate the hypothesis that gastric cancer is correlated with iodine deficiency or thyroid dysfunction. Materials and Methods: We investigated the total body iodine reserve, thyroid function status and autoimmune disorder in 40 recently diagnosed gastric adenocarcinoma cases versus 80 healthy controls. The participants came from a region with high gastric cancer rate but sufficient iodine supply due to salt iodination. The investigation included urine iodine level, thyroid gland clinical and ultrasonograph-ic examination, and thyroid function tests. Results: Goiter was detected more frequently in the case group (P=0.001); such a finding, however, was not true for lower than normal urine iodine levels. The free T3 mean level was significantly lower in the case group compared to the control group (P=0.005). Conclusions: The higher prevalence of goiter rather than low levels of urinary iodine in gastric adenocarcinoma cases suggests that goi-ter, perhaps due to protracted but currently adjusted iodine deficiency, is more likely to be associated with gastric adenocarcinoma com-pared to the existing iodine deficiency itself. © 2013 by The Korean Gastric Cancer Association. Source

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