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Shīrāz, Iran

Shidfar F.,Tehran University of Medical Sciences | Heydari I.,Endocrine Research Center | Hajimiresmaiel S.J.,Islamic Azad University at Sari | Hosseini S.,Islamic Azad University at Sari | And 2 more authors.
Journal of Research in Medical Sciences | Year: 2012

Background: Type 2 diabetic patients are faced with a higher risk of dyslipidemia and cardiovascular disorders. This study was undertaken to assess the effect of consumption of 1 cup cranberry juice by type 2 diabetic patients on serum paraoxonase-1 (PON-1) activity, apoA-1, apoB, glucose, and Lp(a). Methods: In a double-blind randomized clinical trial, 58 type 2 diabetic male patients were randomly divided to receive 1 cup cranberry juice (CJ) or placebo drink daily for 12 weeks. Fasting blood were obtained at beginning and at the end of study (12 th week). Serum glucose and PON-1 activity were measured by enzymatic and colorimetric methods, respectively. ApoB, apoA-I, and Lp(a) were determined immunoturbidimetrically. The data were analyzed by SPSS version 16. Results: There were significant decrease in serum glucose and apoB (P>0.05 and P>0.01, respectively) and significant increase in serum apoA-1 and PON-1 activity (P>0.05 and P<0.01, respectively) at the end of study in CJ group compared with control group. In CJ group at the end of study, there were significant decrease in serum glucose and apoB (P<0.01 and P<0.01, respectively) and significant increase in serum apo A-1 and PON-1 activity (P<0.01 and P<0.01, respectively) compared with initial values. In CJ group, there was no significant change in Lp(a) at the end of study compared with initial values and also compared with control group. Conclusion: 1 cup CJ for 12 weeks is effective in reducing serum glucose and apoB and increasing apoA-1 and PON-1 activity, so may have favorite effects on reducing CVD risk factors in type 2 diabetic male patients. Source

Darbandi M.,Mashhad University of Medical Sciences | Darbandi S.,Mashhad University of Medical Sciences | Mobarhan M.G.,Mashhad University of Medical Sciences | Owji A.A.,Shiraz University of Medical Sciences | And 14 more authors.
Acupuncture in Medicine | Year: 2012

Background Human leptin is a peptide hormone that is released from white adipocytes. The absence of leptin or its receptor leads to uncontrolled food intake, leading to obesity. In the present work, the effects of auricular acupressure combined with low-calorie diet on the leptin hormone level were investigated. Methods Volunteers (n=86) with body mass indices (BMI) between 25 and 45 kg/m 2 were randomised into a case (n=43) or a control (n=43) group. Participants in each group received a low-calorie diet for 6 weeks. The case group was treated with auricular acupressure and the control group received a sham procedure. Plasma leptin levels, body fat mass, body weight and BMI were measured before and after treatment. Results Participants who received auricular acupressure showed signifi cant reductions in their plasma leptin levels (18.57%, p<0.01) as well as in their body fat mass (4%, p<0.05). These changes were not observed in the control group. The reduction in leptin was signifi cantly greater in the acupressure group than the controls. Conclusions Auricular acupressure combined with a low-calorie diet signifi cantly reduced plasma levels of leptin. However, the mechanism of this reduction is not clear. Source

Pankov Y.A.,Endocrine Research Center
Biomeditsinskaya Khimiya | Year: 2010

Single nucleotide polymorphism (SNP) near certain genes revealed association of FAT (fat mass and obesity-associated gene), MC4R (melanocortin 4 receptor gene), and other genes with obesity. Participation of the FAT expression products in the regulation of energy balance remains to be clarified. The fonction of MC4R encoding melanocortin 4 receptor (MC4R) is somewhat better understood. α-, β-, and γ-MSH encoded by the POMC gene bind to MC4R, reduce food intake, and slow down fat accumulation. Expression of POMC that codes MSH is enhanced by leptin binding to the receptor (LepRb) in hypothalamic neurons. Mutations in human and animal MC4R, POMC, and LEP genes are known to be associated with obesity. More than 60 mutations in MC4R, more than 20 mutations in POMC and fewer LEP mutations have been reported. Nonsense mutations and reading frame shifts block gene expression and thereby disrupt protein synthesis. Missense mutations frequently affect protein folding in endoplasmic reticulum; unfolded or misfolded proteins remain in the cytoplasm and undergo degradation. Certain missence mutations do not interfere with gene expression and folding of proteins but impair their functioning at the periphery. P.S127L mutation in MC4R, p.E206X and p.F144L mutations in POMC as well as other mutations in homozygous and heterozygous forms account for disturbed energy balance in man. The LEP gene has been reported to contain G133fsX15, p.R105X, p.R105W, and p.S141C mutations. As a rule, they are associated with obesity and other pathological conditions only in homozygous forms. Source

Mazerkina N.,Burdenko Neurosurgery Institute | Trunin Y.,Burdenko Neurosurgery Institute | Gorelyshev S.,Burdenko Neurosurgery Institute | Golanov A.,Burdenko Neurosurgery Institute | And 5 more authors.
Journal of Pediatric Endocrinology and Metabolism | Year: 2016

Thyrotropinomas (TSHomas) are rare pituitary adenomas, particularly in childhood. We present here the case of an 11-year-old boy with type 1 autoimmune polyglandular syndrome (APS1) and TSHoma which was diagnosed by elevated thyroid - stimulating hormone and thyroid hormones levels without evident clinical signs of hyperthyroidism. He was underwent partial resection of the tumor via transsphenoidal approach and subsequently radiation therapy. Consequently, 1 year after radiotherapy, the patient developed growth hormone deficiency, three and half years after radiation became euthyroid, and five and half years after treatment - hypothyroid. This is the first case of the coexistence of these two rare endocrine diseases in one patient. © 2016 by De Gruyter. Source

Kelishadi R.,Isfahan Cardiovascular Research Center | Hashemipour M.,Endocrine Research Center | Ashtijou P.,Isfahan University of Medical Sciences | Mirmoghtadaee P.,Isfahan University of Medical Sciences | And 3 more authors.
Saudi Medical Journal | Year: 2010

We found significant associations between CBC components and cardiometabolic risk factors in young obese children. These findings are confirmatory evidence of the pro-inflammatory state of obese individuals, even in young children. Source

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