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Zhao L.,Shanghai JiaoTong University | Zhao L.,Shanghai Institute of Endocrinology and Metabolism | Zhao L.,Endocrine And Metabolic sts Of Shanghai Universities Eisu | Zhang M.-J.,Shanghai JiaoTong University | And 24 more authors.
Clinical Biochemistry | Year: 2011

Objective: This study was to establish biochemical thresholds for the intravenous calcium suppression test in the early diagnosis of primary hyperparathyroidism (PHPT). Design and methods: One hundred and thirty-three patients were divided into three groups: Group 1: surgically proven hypercalcemic PHPT, Group 2 surgically proven mild PHPT, and Group 3: normocalcemia with elevated serum PTH levels. Intravenous calcium suppression tests were performed in Groups 2 and 3 as well as in 20 controls with normal serum calcium and PTH concentrations. Results: The serum PTH inhibition rate (PTH-IR) was less pronounced in Group 2 compared with Group 3 (P < 0.001) and the controls (P < 0.001). Receiver operating characteristic curve analysis suggests that a serum calcium level higher than 2.43. mmol/L and a PTH-IR less than 73% may differentiate Group 2 from normal controls. Conclusion: It is quite useful to combine serum calcium levels with the PTH-IR to identify patients at early stage of PHPT, even in the presence of vitamin D deficiency. © 2011 The Canadian Society of Clinical Chemists.

Hong J.,Endocrine And Metabolic sts Of Shanghai Universities Eisu | Hong J.,Shanghai JiaoTong University | Gu W.,Endocrine And Metabolic sts Of Shanghai Universities Eisu | Gu W.,Shanghai JiaoTong University | And 17 more authors.
Atherosclerosis | Year: 2011

Aims: Adipocyte and epidermal fatty acid-binding protein (A-FABP, E-FABP) are cytoplasmic proteins which may play an important role in metabolic diseases. In the present study, we investigated the different association of A-FABP and E-FABP with metabolic syndrome (MetS) and coronary artery disease (CAD) in Chinese adults. Methods: A total of 459 subjects (233 MetS and 226 non-MetS) who had undergone coronary angiography were enrolled in the present study. Serum A-FABP and E-FABP levels, glucose, lipid profiles and other biochemical markers were measured. Results: Both serum A-FABP and E-FABP levels were significantly higher in the MetS group than in the non-MetS group (P= 0.040 and 0.045, respectively). Only serum A-FABP levels in the CAD group were significantly higher than in the non-CAD group (12.30 ± 5.45 vs.10.94 ± 4.94 ng/mL, P= 0.008), and significantly increased with the increasing of number of disease vessels (P= 0.004). Serum A-FABP levels were also associated with risk of CAD (odds ratio 2.956 [1.295-6.748]; P= 0.010). Adjusting for age, sex, and other conventional risk factors for CAD did not appreciably change the results. No difference was found in serum E-FABP levels between CAD status. Serum E-FABP levels were correlated with fasting and post load 2h plasma glucose, HbA1c, serum total cholesterol and LDL-C concentrations while serum A-FABP levels were correlated with fasting and post load 2h serum insulin concentrations and HOMA-IR (different P<. 0.05). Conclusions: Our data indicated while both serum A-FABP and E-FABP levels had associations with MetS, only A-FABP was significantly associated with increased risk of CAD in Chinese adults. © 2011 Elsevier Ireland Ltd.

Sun C.,Shanghai JiaoTong University | Cao M.,Shanghai JiaoTong University | Shi J.,Endocrine And Metabolic sts Of Shanghai Universities Eisu | Shi J.,Shanghai JiaoTong University | And 10 more authors.
Gene | Year: 2013

Obesity is one of the most complex human diseases that are widely concerned and studied. More recently, copy number variations (CNVs) emerge as another important genetic marker to influence various human diseases. To elucidate the relationship between obesity and CNVs, this current study selected obesity-related candidate CNVs and analyzed their association with body mass index (BMI). Results showed that a CNV locus, 8q24.3, was significantly different (P = 0.0070) in CNV frequency between the obese and healthy controls in a young eastern Chinese cohort, while no statistical significance was observed in other seven candidate loci including well reported 10q11.22 and 16p11.2 loci. The association of 8q24.3 CNVs with BMI of the subjects only showed marginal significance, while the copy number (CN) of 5p15.33 had a significant correlation with the BMI of the subject. These results suggested that 8q24.3 CN gains was associated with obesity, and 5p15.33 might also contribute to obesity pathogenesis, highlighting the importance of these CNVs for obesity risks, as well as providing new evidence for CNVs in the pathology of common diseases. © 2012 Elsevier B.V.

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