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Huttin C.C.,Endepusresearch Inc | Huttin C.C.,Aix - Marseille University | Liebman M.N.,Strategic Medicine Inc.
Technology and Health Care | Year: 2013

This paper aims to discuss the economics of biobanking. Among the critical issues in evaluating potential ROI for creation of a bio-bank are: scale (e.g. local, national, international), centralized versus virtual/distributed, degree of sample annotation/QC procedures, targeted end-users and uses, types of samples, potential characterization, both of samples and annotations. The paper presents a review on cost models for an economic analysis of biobanking for different steps: data collection (e.g. biospecimens in different types of sites, storage, transport and distribution, information management for the different types of information (e.g. biological information such as cell, gene, and protein)). It also provides additional concepts to process biospecimens from laboratory to clinical practice and will help to identify how changing paradigms in translational medicine affect the economic modeling. © 2013 - IOS Press and the authors. All rights reserved.

Huttin C.C.,Endepusresearch Inc | Huttin C.C.,Aix - Marseille University
Technology and Health Care | Year: 2015

The global burden of diseases is predicted to increase considerably in the coming decades (GBD project, WHO, 2010 [1])-WHO-World Bank study, 1991 [2]); for example, the World Alzheimer Report and the UN Declaration on Non-Communicable Diseases estimate that the burden associated with dementia will increase 2-fold by 2030 and 3-4-fold by 2050. Therefore, urgent needs must be met in order to help policy-makers deal with the increasing societal costs of diseases. Recent technologies can facilitate the detection and prevention of mild cases of cognitive impairments, or integrative genomic medicine can target more individualized genetic traits and pedigrees; however, scientists do not necessarily agree: results from a recent population-based study using population imaging [3] differed from results obtained using integrative genomics approaches [4], and controversy exists between molecular biologists [5,6] and geneticists [7,8] with respect to asthma genetics. These differences have led to different predictive disease models and can influence the assessment of aging and environmental modifiers. This paper highlights implications for the governance of health systems using current debates on the evolution of these major fields of science. In addition, this paper discusses the potential translation of these models for use in clinical practice, particularly with telemedicine and telecare dominated by new IT technologies and challenges of science in transition. © 2015-IOS Press and the authors.

Huttin C.C.,Endepusresearch Inc | Huttin C.C.,Aix - Marseille University
Technology and Health Care | Year: 2012

This paper presents tools and concepts to analyze the business environment of the biopharmaceutical industry. It was presented at MEDETEL 2010. Emerging paradigms appear in that industry and new ways to value life science technologies are developed especially using mobile economics analysis. At a time, mobile computing technologies revolutionize the field of health care, this paper contributes to show how the value chain concept can be useful to analyze the value system in a mobile computing environment. It is also a milestone for the designs of future technology platforms and of health care infrastructure, in order to retain enough value between innovators, new and traditionnal players from life science, IT and other new comers, in a fragmented global competitive environment. © 2012-IOS Press and the authors. All rights reserved.

Huttin C.C.,Endepusresearch Inc | Huttin C.C.,Aix - Marseille University
Technology and Health Care | Year: 2012

This paper aims to propose a new methodological agenda for new price measurement for medical services; it is based on a cost sensitivity index coming from series of pilot studies on physicians, in order to provide adjustment methods to household surveys for health care expenditure budgets. The use of stated-revealed preference models with inclusion of stated preference studies is proposed with an example on a physician cost sensitivity study in Europe; it could also help the ISPOR task for force best practices in conjoint study designs. © 2012-IOS Press and the authors. All rights reserved.

Huttin C.,Aix - Marseille University | Huttin C.,Endepusresearch Inc
Technology and Health Care | Year: 2011

This paper discusses the application of an adaptive technology platform to evaluate clinical pathways, clinical strategies and their application to early genetic testing in Europe. It results from a collaboration between Professor Christine Huttin, who created a technology startup called endepusresearchinc (www.endepusresearchinc-com) in Cambridge USA and Dr Michael Liebman, Managing Director of Strategic Medicine, Inc.(www.strategicmedicine.com) positioned in the translational medicine space with technologies to model disease processes and experience in early genetic testing for breast cancer. Diagnostics was identified as a potential area for application of economic and business models using ENDEPUSresearchinc statistical methods combining implicit and explicit financial information for prospective payment systems in various types of health care financing systems. The new economics resulting from such platforms challenges the constrained environment for public, private laboratories and partnerships, the restrictions imposed by governmental agencies, alliances between stakeholders such as the medical profession and laboratories: such early technologies are clearly identified as a key benefit to the system over time but a major challenge for short term returns. © 2011 - IOS Press and the authors. All rights reserved.

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