EnBio Ltd.

Dublin, Ireland

EnBio Ltd.

Dublin, Ireland

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A method of treating a substrate, the method comprising: delivering substantially simultaneously a first set of particles comprising a dopant and a second set of particles comprising an abrasive from at least one fluid jet to a surface of the substrate, to impregnate the surface of the substrate with the dopant; wherein the dopant comprises a corrosion-inhibiting or adhesion-promoting species, such as to form a corrosion-inhibiting or adhesion-promoting coating at or on the surface of the substrate. Also provided is an article comprising a substrate having a corrosion-inhibiting or adhesion-promoting coating, the said coating comprising particles of a corrosion- inhibiting or adhesion-promoting species that impregnate the surface of the substrate(e.g. as produced by the above method).


Byrne G.D.,University College Dublin | O'Neill L.,EnBio Ltd. | Twomey B.,EnBio Ltd. | Dowling D.P.,University College Dublin
Surface and Coatings Technology | Year: 2013

In this study, a flow of hydroxyapatite (HA) is combined with either a shot peening or an abrasive blasting processes and comparative testing has been undertaken to determine which technique yields increased coating coverage and adhesion onto a titanium alloy substrate. Both processes were shown to effectively deposit a layer of crystalline HA onto the titanium substrates at a number of air pressures and blasting heights. It was observed for both processes that an increase in particle kinetic energy produced corresponding enhancements in both deposition rate and surface roughness. The surface morphology obtained using the two treatments was significantly different with an increase in the average roughness (Ra) of ≈75% for samples treated with abrasive particles over shot peen particles. The shot peening process however produced a smoother layer of laminar apatite, which was readily removed from the surface using a scratch adhesion test technique. In contrast the combination of a jet of HA and abrasive powders resulted in an increase in surface abrasion and increased interlocking of the HA into the metal surface was observed. The resulting mechanical and chemical bonding resulted in enhanced HA adhesion. © 2012 Elsevier B.V.


Dunne C.F.,University College Dublin | Twomey B.,ENBIO Ltd. | Stanton K.T.,University College Dublin
Materials Letters | Year: 2015

This work investigates the deposition of a hydroxyapatite (HA, Ca10(PO4)6(OH)2) coating onto titanium foam using a blast process and the effect of the process on the macro- and microstructure of the titanium foam. Light microscopy, scanning electron microscopy and energy-dispersive x-ray spectroscopy were used to examine the coating deposition and the macro- and microstructure of the titanium foam. After blasting the macrostructure did not exhibit signs of excessive abrasion or collapsing of the structure that may affect functionality of the foam. Similarly, microstructure was unaffected by the coating process as there is gross plastic deformation and no thermally induced change such as α-case. © 2015 Elsevier B.V. All rights reserved.


Dunne C.F.,University College Dublin | Twomey B.,EnBio Ltd. | O'Neill L.,EnBio Ltd. | Stanton K.T.,University College Dublin
Journal of Biomaterials Applications | Year: 2014

The aim of this work is to assess the influence of two blast media on the deposition of hydroxyapatite onto a titanium substrate using a novel ambient temperature coating technique named CoBlast. CoBlast was developed to address the problems with high temperature coating techniques. The blasting media used in this study were Al2O3 and a sintered apatite powder. The prepared and coated surfaces were compared to plasma sprayed hydroxyapatite on the same substrates using the same hydroxyapatite feedstock powder. X-ray diffraction analysis revealed the coating crystallinity was the same as the original hydroxyapatite feedstock powder for the CoBlast samples while evidence of amorphous hydroxyapatite phases and β-TCP was observed in the plasma sprayed samples. The blast media type significantly influences the adhesive strength of the coating, surface roughness of both the substrate and coating and the microstructure of the substrate. The coating adhesion increased for the CoBlasted samples from 50 MPa to 60 MPa for sintered apatite powder and alumina, respectively, while plasma spray samples were significantly lower (5 MPa) when tested using a modified pull-test. In conclusion, the choice of blast medium is shown to be a key parameter in the CoBlast process. This study indicates that sintered apatite powder is the most suitable candidate for use as a blast medium in the coating of medical devices. © The Author(s) 2013 Reprints and permissions: sagepub.co.uk/journalsPermissions.nav.


Patent
EnBio Ltd. | Date: 2015-12-15

Disclosed herein are methods of treating an article surface. The method comprises removing a metal oxide surface from the metal substrate to expose a metal surface; and delivering particles comprising a dopant from at least one fluid jet to the metal surface to impregnate the surface of the article with the dopant. The method also comprises delivering substantially simultaneously a first set of particles comprising a dopant and a second set of particles comprising an abrasive from at least one fluid jet to a surface of an article to impregnate the surface of the article with the dopant.


Patent
EnBIO Ltd | Date: 2011-12-09

The present invention is directed to methods for producing a coated substrate, including dissolving at least one biomolecule to form a solution; nebulizing the solution to form a liquid aerosol; combining the liquid aerosol and a plasma to form a coating; and depositing, in the absence of reactive monomers, the coating onto a substrate surface. In an aspect, the substrate can be an implantable medical device.


Patent
EnBIO Ltd | Date: 2011-11-30

Disclosed herein are methods of treating an article surface. The method comprises removing a metal oxide surface from the metal substrate to expose a metal surface; and delivering particles comprising a dopant from at least one fluid jet to the metal surface to impregnate the surface of the article with the dopant. The method also comprises delivering substantially simultaneously a first set of particles comprising a dopant and a second set of particles comprising an abrasive from at least one fluid jet to a surface of an article to impregnate the surface of the article with the dopant.


Patent
EnBio Ltd. | Date: 2014-10-17

Disclosed herein are methods of treating an article surface. The method comprises removing a metal oxide surface from the metal substrate to expose a metal surface; and delivering particles comprising a dopant from at least one fluid jet to the metal surface to impregnate the surface of the article with the dopant. The method also comprises delivering substantially simultaneously a first set of particles comprising a dopant and a second set of particles comprising an abrasive from at least one fluid jet to a surface of an article to impregnate the surface of the article with the dopant.


Patent
EnBio Ltd. | Date: 2015-02-02

Disclosed herein are methods of treating an article surface. The method comprises removing a metal oxide surface from the metal substrate to expose a metal surface; and delivering particles comprising a dopant from at least one fluid jet to the metal surface to impregnate the surface of the article with the dopant. The method also comprises delivering substantially simultaneously a first set of particles comprising a dopant and a second set of particles comprising an abrasive from at least one fluid jet to a surface of an article to impregnate the surface of the article with the dopant.


Disclosed herein are methods of treating an article surface. The method comprises delivering a polymer and drug to a medical implant having a porous surface and using at least one particle stream from at least one fluid jet to subsequently remove the polymer from the outer surface of the metal substrate, thereby retaining the therapeutic agent and polymer within the pores of the implant.

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